America’s Finest, Inc. (AFI)
Super Curcumin C3 Complex With BioPerine
Healthy joint function can be linked to overall quality of life, from the ability to move around with relative comfort. The basis of mobility can be termed as joint flexibility, which means having a healthy range of motion in the places where muscle, connective tissue and bones meet. The pain and physical disability brought about by joint pain affects social functioning and mental agony, diminishing the patient’s quality of life. The pain is often worse with prolonged walking, standing and sitting, which restricts mobility, as well as when travelling any distance in a vehicle. In addition, it also affects sleep in some individuals.
Joint problems are a diverse group of conditions, which affect the musculoskeletal system and are associated with pain and impaired physical function.
Some of these conditions include:
1. Joint conditions—for example, rheumatoid arthritis, osteoarthritis
2. Back pain/lower back pain
3. Musculoskeletal injuries
4. Inflammatory diseases, which commonly have musculoskeletal manifestations
Joint pain could be a reflection of the diverse joint diseases that could arise from inflammation, cartilage degeneration, crystal deposition, infection and trauma. Inflammation is the major cause of joint health distortion. While inflammation is necessary as a biological response to tissue injury or damage, when not controlled appropriately, it can lead to chronic conditions, such as arthritis. It is thus important that inflammation is addressed at its initial levels and not allowed to reach levels that cause damage to tissues. AFI’s “Super Curcumin C3 Complex with BioPerine” has been clinically substantiated to inhibit inflammation, thus playing a key role in maintaining or supporting joint health.
Curcumin C3 Complex, a patented and clinically-evaluated “Bioprotectant” composition, obtained from the dried rhizomes of Curcuma longa, is standardized for a minimum of 95 percent curcuminoids—curcumin, demethoxycurcumin and bisdemethoxycurcumin. Curcuminoids, a versatile, cascading and long-lasting pronutrient, is undoubtedly the most important and precious gifts to mankind from nature. Turmeric has been known in Asian traditional medicine as a remedy for joint pain and inflammation, and thus curcuminoids can be useful in conditions like osteoarthritis (OA).
Curcumin helps suppress NF-kB activation and hence inflammation, and a host of its manifestations. Similarly, curcuminoids reduce pain and inflammation by inhibiting NF-kB and have shown to possess anti-arthritic activity; which is attributed to its anti-inflammatory, antioxidant and anti-apoptotic activities. Curcumin C3 Complex is clinically proven to be helpful in the management of OA.1
In a six-week, randomized, double-blind, placebo-controlled, parallel-group pilot study carried out at the University of Medical Sciences, Tehran, Iran, 40 patients with knee OA were supplemented with Curcumin C3 Complex capsules (1,500 mg/day in three divided doses; n=19) or placebo (n=21).
Each curcuminoid capsule contained 5 mg BioPerine (patented and clinically-validated extract from black pepper, standardized to 95 percent piperine) to enhance oral bioavailability of curcuminoids. Curcuminoids supplementation resulted in the reduction in the WOMAC scale (Fig. 1A) with a significant decrease in pain, physical function and stiffness; the Lequesne’s pain functional index (LPFI) and VAS scores (Fig. 1B) also showed a significant reduction.
Another important finding of the study was that there was an 84 percent decrease in the number of subjects taking naproxen in curcuminoids group (Fig. 2). Thus curcuminoids represent an effective and safe alternative treatment for OA.2
This sub-study was a part of the randomized trial and the results showed that in presence of curcuminoids, the oxidative stress was reduced significantly with significant increase in serum levels of superoxide dismutase and glutathione, and concurrently there was decrease in malondialdehyde concentration and thus validated the antioxidant effects of curcuminoids in OA.3
In another randomized clinical trial, 40 subjects with mild-to-moderate degree knee OA were supplemented with Curcumin C3 Complex and BioPerine capsules (1,500 mg/day and 5 mg per day, respectively in three divided dose). Serum levels of inflammatory markers were analyzed and it was observed that curcumin significantly reduced interleukin-4, interleukin-6 and hs-CRP levels.4
Today, AFI’s Curcumin C3 Complex enjoys the special status of being the “most extensively studied and clinically-documented” curcuminoids brand available in the world. It has been evaluated through more than 50 human clinical studies published in peer-reviewed journals for its safety and efficacy till date and continues to emphasize on the relevance and importance of curcuminoids in general health and wellness.
1 Majeed et al., Curry Powder to Clinical Significance. 2015; p. 61–183.
2 Panahi et al., Phytother Res. 2014; 28(11):1625–31.
3 Panahi et al., J. Diet. Suppl. 2016; 13(2):209–20.
4 Rahimnia et al. Drug Res .(Stuttg) 2015; 65 (10), 521–5.