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Monograph: Melatonin


Based on a systemic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration.

Melatonin is a hormone produced in the brain by the pineal gland from the amino acid tryptophan.The production and release of melatonin are stimulated by darkness and decreased by light, suggesting that melatonin is involved in circadian rhythm (the internal body clock) and regulation of diverse body functions. Levels of melatonin in the blood are highest prior to bedtime.

The most common use of melatonin is to aid sleep. The strongest evidence supporting the use of melatonin is for delayed sleep phase syndrome, insomnia in children and the elderly, jet lag and sleep problems in people with behavioral, developmental, or mental disorders. The weakest evidence in support of melatonin is for work shift sleep disorder. Good evidence in support of melatonin for other uses is lacking.

New drugs that block the effects of melatonin are being developed. These include BMS-214778 and luzindole, and they may have uses in various disorders.


Acetaminophen toxicity (painkiller overdose), acute respiratory distress syndrome (a severe lung condition causing difficult breathing), adaptogen (reduces sensitivity to stress), addiction, adrenal gland stimulation, aging (general), amenorrhea (lack of menstrual period), amyotrophic lateral sclerosis (disease of nerve cells that control muscle movement), antioxidant, anxiety, arthritis, ataxia (muscle control problem), atopic dermatitis (scaly, itchy rashes), attention deficit hyperactivity disorder (ADHD), autoimmune diseases, betablocker sleep disturbance, bipolar disorder, birth control, bladder disorders, bone diseases, bone healing, brain injuries, cachexia (weight loss/wasting from some diseases), cataracts, chemotherapy side effects, colic, dental conditions, dry skin, Duchenne muscular dystrophy (progressive muscle weakness), eating disorders, eczema (chronic skin inflammation), endometriosis (uterine cells growing in other body parts), erectile dysfunction, esophagitis (esophagus inflammation), exercise recovery, food uses, fragile X syndrome (genetic disorder causing mental disability), growth (growing pains), hair loss, hormone related problems, immune function, infant development/ neonatal care, interstitial cystitis (chronic bladder inflammation), intestinal worms, ischemia-reperfusion injury protection (tissue damage caused by lack of oxygen), itching, jaundice, jellyfish stings, kidney protection, liver protection, lung inflammation, malaria, melatonin deficiency, mental disorders, metabolic disorders (sugar breakdown disorder), mouth and throat inflammation, movement disorders, multiple sclerosis, nervous system disorders, nitrate tolerance (reduced effectiveness of nitrate treatment), noise-induced hearing loss, osteoporosis, ovarian disorders, pancreatitis (pancreas inflammation), parasite infection, phenylketonuria (amino acid breakdown disorder), polycystic ovarian syndrome (female sex hormone imbalance), poisoning (including heavy metals and alcohol), pregnancy support, premenstrual dysphoric disorder (PMDD), pulmonary fibrosis (scarring of the lungs), radiation protection, retinal protection, scalds, sepsis (severe response to infection), shock, skin pigmentation disorders, sleep apnea (breathing pauses during sleep), spinal cord injury, spine problems (abnormal curving), stress, sudden infant death syndrome (SIDS) prevention, sun protection, swelling, testicular damage, tuberculosis (bacterial infection of lungs), uterine disorders, weight loss, Wilson’s disease (high copper levels), withdrawal from narcotics and wound healing.


Adults (18 years and older) 

The time of day that melatonin is taken is important. Melatonin impacts circadian rhythms (the internal clock) differently depending on whether it is taken in the morning, afternoon or early evening.

For age-related macular degeneration (vision loss with age), 3 milligrams of melatonin have been taken by mouth nightly before bedtime for six months.

To improve body temperature regulation in the elderly, 1.5 milligrams of melatonin has been taken by mouth nightly for two weeks.

For Alzheimer’s disease or cognitive decline, melatonin has been taken by mouth in doses of 1-10 milligrams daily for 10 days up to 35 months.

For inflammation, melatonin has been taken by mouth in doses of 10 milligrams nightly for six months or 5 milligrams the night before and one hour before surgery.

For asthma, 3 milligrams of melatonin has been taken by mouth for four weeks.

For withdrawal from benzodiazepines (antianxiety agents), doses of 1-5 milligrams have been taken by mouth daily for from several weeks up to one year.

For cancer, melatonin has been taken by mouth in doses of 1-40 milligrams daily, with 20 milligrams being most common, for several weeks to months. Melatonin has been applied to the skin.

For chronic fatigue syndrome, 5 milligrams of melatonin has been taken by mouth five hours before bed for three months.

For COPD (chronic lung disorder causing breathing difficulty), 3 milligrams of melatonin has been taken by mouth nightly two hours before bed for three months.

For circadian rhythm sleep disorders in people with and without vision problems, melatonin has been taken by mouth as a single dose of 0.5-5 milligrams before bed or as a daily dose for one to three months.

For delayed sleep phase syndrome, melatonin has been taken by mouth in doses of 0. 3-6 milligrams, with 5 milligrams being most common, daily before sleeping for two weeks to three months.

For delirium, 0.5 milligrams of melatonin has been taken by mouth nightly for up to 14 days.

For depression, 6 milligrams of slowrelease melatonin has been taken by mouth at bedtime for four weeks.

For exercise performance, 5-6 milligrams of melatonin has been taken by mouth one hour before exercise or before bedtime.

For fertility, 3 milligrams of melatonin has been taken by mouth nightly from the third to fifth day of the menstrual cycle until hormone injection (human chorionic gonadotropin, HCG) or on the day of hormone injection.

For fibromyalgia, 3-5 milligrams of melatonin has been taken by mouth nightly for four weeks to 60 days.

For stomach and intestine disorders, 3-10 milligrams of melatonin has been taken by mouth nightly for two to 12 weeks.

For headache, 2-10 milligrams of melatonin has been taken by mouth nightly for 14 days to eight weeks.

For liver inflammation, 5 milligrams of melatonin has been taken by mouth twice daily for 12 weeks.

For high blood pressure, melatonin has been taken by mouth in doses of 1-5 milligrams either as a single dose during the day or before bedtime, or daily for one to three months.

For high cholesterol, 5 milligrams of melatonin has been taken by mouth daily for two months.

For insomnia in the elderly, melatonin has been taken by mouth in doses of 0.1-5 milligrams or two hours before bedtime for several months, in the form of melatoninrich night milk or slow-release Circadin. A dose of 0.5 milligrams has been placed in the cheek for four nights.

For jet lag, 0.1-8 milligrams of melatonin has been taken by mouth on the day of travel (close to target bedtime at destination), then daily for several days, in the form of standard or slow-release melatonin (Circadin).

For memory, 3 milligrams of melatonin has been taken by mouth before testing.

For menopause, three milligrams of melatonin has been taken by mouth nightly at bedtime for three to six months.

For Parkinson’s disease, doses of 3-50 milligrams have been taken by mouth nightly before bed for two to 10 weeks. (High doses of 3-6.6 grams of melatonin have also been taken by mouth daily; however, these doses were used in an older 1972 study and are no longer in use.)

For periodic limb movement disorder, 3 milligrams of melatonin has been taken by mouth nightly for six weeks.

For REM sleep behavior disorder, 3-12 milligrams of melatonin has been taken by mouth daily for four weeks.

For restless leg syndrome, a single dose of 3 milligrams of melatonin has been taken by mouth.

For sarcoidosis (chronic widespread inflammation), 20 milligrams of melatonin has been taken by mouth daily for one year, then decreased to 10 milligrams for a second year.

For muscle movement problems in people with schizophrenia, 2-10 milligrams of melatonin has been taken by mouth daily.

For seasonal affective disorder (SAD), 2 milligrams of sustained-release melatonin has been taken by mouth one to two hours nightly for three weeks. A dose of 0.5 milligrams of melatonin has been taken under the tongue for six days.

For seizure disorders, doses of melatonin taken by mouth were 3-10 milligrams daily for two to four weeks to three months.

For sleep (general), doses of melatonin taken by mouth were 0.3-10 milligrams.

For sleep disorders in people with behavioral, developmental, or mental disorders, 0. 1-10 milligrams of melatonin has been taken by mouth daily for up to one year.

For sleep disturbance in Alzheimer’s disease, 1. 5-10 milligrams of melatonin has been taken by mouth nightly for 10 days to 35 months, together with light exposure or in the form of capsules.

For sleep disturbance in those with asthma, 3 milligrams of melatonin has been taken by mouth for four weeks.

For sleep disturbance in those with autism, 0.75-10 milligrams of melatonin has been taken nightly before bedtime for two weeks to six months.

For sleep disturbance in those with COPD, 3 milligrams of melatonin has been taken by mouth nightly.

For sleep disturbance in those with cystic fibrosis, 3 milligrams of melatonin has been taken by mouth nightly at bedtime for 21 days.

For sleep disturbance in those with depression, 0.5-10 milligrams of melatonin has been taken by mouth for three to four weeks, in addition to regular therapy.

For sleep disturbance in healthy people, 0. 1-80 milligrams of melatonin has been taken by mouth, generally nightly before Bed for one or several days up to 26 weeks.A dose of 50 milligrams has been injected into the vein.

For sleep disturbance in people undergoing hemodialysis, 3 milligrams of melatonin has been taken by mouth for six weeks.

For sleep disturbance in hospitalized and medically ill people, 3-5.4 milligrams of melatonin has been taken by mouth nightly.

For sleep disturbance in people with a learning disability, 0.5-9 milligrams of melatonin has been taken by mouth for 32-73 days.

For sleep disturbance in those with Parkinson’s disease, 3-50 milligrams of melatonin has been taken by mouth at bedtime for two to four weeks.

For sleep disturbance after surgery, 5 milligrams of melatonin has been taken by mouth for three nights.

For sleep disturbance in people with mental disorders, 2-12 milligrams of melatonin has been taken by mouth daily before resting for up to 12 weeks.

For sleep disturbance in people with traumatic brain injury, 5 milligrams of melatonin can been taken by mouth for one month.

For sleep disturbance in people with tuberous sclerosis complex (a genetic disorder causing tumors to grow in brain and other organs), 5 milligrams of melatonin has been taken 20 minutes before bed for two weeks.

For smokers, 0.3 milligrams of melatonin has been taken by mouth 3.5 hours after nicotine withdrawal.

For surgery, 3-15 milligrams of melatonin has been taken by mouth or placed under the tongue, and 0.05-0.2 milligrams per kilogram has been placed under the tongue, either alone or with other sedatives, typically 90 minutes before surgery or the night before and 90 minutes before surgery.

For anxiety or sedation before surgery, 3-10 milligrams and/or 0.05-0.5 milligrams per kilogram of melatonin have been injected into the vein, either alone or with other sedatives before surgery.

For tardive dyskinesia (uncontrolled, repetitive movements), 2-20 milligrams of melatonin has been taken by mouth for four to 12 weeks.

For low platelets, 20 milligrams of melatonin has been taken by mouth nightly for two months.

For ringing in the ears, 3 milligrams of melatonin has been taken by mouth daily for up to 80 days.

For ulcers, 5 milligrams of melatonin has been taken by mouth twice daily for 21 days together with other medications.

For nighttime urination, 2 milligrams of melatonin has been taken by mouth daily for four weeks.

For work shift sleep disorder, 1.8-10 milligrams of melatonin has been taken by mouth up to three times daily for up to six days before daytime sleep after a night shift.

For skin sun damage, melatonin has been applied to the skin in the form of a gel (20- 100 milligrams of melatonin in 70 percent ethanol, in concentrations of 0.05-0.5 percent in 0.12 milliliters of gel); 0.6 milligrams per meter squared from 15 minutes before to 240 minutes after sun exposure, alone or with vitamins C and E; 5 percent melatonin in ethanol, propylene glycol and water; and 5.85 microliters of solutions containing 1.2-5 percent melatonin, alone or with vitamins C and E. 

Children (under 18 years old) 

There is limited research on melatonin supplements in children, and their safety is not established. Melatonin may increase seizure risks in children; caution is advised, and use of melatonin should be discussed with a healthcare provider.

For inflammation or respiratory distress syndrome in newborns, 10 doses of melatonin (10 milligrams per kilogram) have been given, with two hours in between the first four doses, four hours in between the fifth and sixth doses, eight hours in between the seventh and eighth doses and 12 hours in between the ninth and tenth doses.

For circadian rhythm sleep disorders in children with and without vision problems, 3-12 milligrams of melatonin has been taken daily by mouth for eight weeks.

For delayed sleep phase syndrome, 3-6 milligrams of melatonin has been taken by mouth daily for 10-28 days.

For insomnia, 1-5 milligrams of melatonin have been taken by mouth once nightly for up to two months. Doses of 0. 05-0.15 milligrams per kilogram of melatonin have been taken by mouth every night for one week.

For Rett’s syndrome, 2.5-7.5 milligrams has been taken by mouth once daily at bedtime for up to two years.

For sedation, 3-6 milligrams of melatonin has been taken by mouth 10 minutes before standard sedation.

For seizure disorder, 1.5-10 milligrams of melatonin has been taken by mouth daily for two weeks to three months.

For sepsis (severe response to infection), two 10-milligram doses, separated by one hour, have been taken by mouth 12 hours after diagnosis.

For sleep disorders in children with behavioral, developmental, or mental disorders, 0. 1-10 milligrams has been taken by mouth daily for one week to 72 months.

For sleep disturbance, 2-10 milligrams of melatonin has been taken by mouth nightly before bedtime for four weeks to three months.

For surgery, 0.1-0.5 milligrams per kilogram of melatonin has been taken by mouth in one to three doses before surgery, with standard painkillers or anesthesia.

For nighttime urination, 5 milligrams of melatonin has been taken by mouth nightly for three months.

For pain, a single dose of 10 milligrams per kilogram of melatonin has been injected into the vein.



Avoid known allergies or sensitivity to melatonin or related products. Melatonin has been linked to allergic skin reactions and autoimmune hepatitis (liver inflammation caused by immune cells attacking the liver).

Side Effects & Warnings 

Melatonin is likely safe when taken by mouth in commonly studied doses for up to three months, typically 1-20 milligrams. In children, melatonin is likely safe for long-term use in recommended doses.

Melatonin may cause abnormal heartbeat, aggression, amnesia, bedwetting (in children), body pain, changes in body temperature or feeling cold, changes in cholesterol levels, changes in the immune system, chest pain, confusion, decreased sperm count, delusions, disorientation, dizziness, eye damage or glaucoma (increased eye pressure), fatigue or irregular sleep-wake schedule, fogginess, hallucinations, headache, hormonal effects, hyperactivity, increased heart rate, increased seizure risk (particularly in children), inflammation, insomnia, irritability, mood changes, muscle control problems or weakness, musculoskeletal disorders, nightmares, nighttime awakening, poor sleep quality, psychotic symptoms, skin reactions (flushing, itching, painful lumps, paleness, and rash), sleepwalking, slow reaction time, stomach or intestinal disorders (changes in appetite, cramping, diarrhea, esophagus inflammation, nausea, odd taste in the mouth, stomach pain, and vomiting), vivid dreaming, weakness, worsened behavior and yawning.

Melatonin may affect blood pressure. Caution is advised in people taking drugs, herbs, or supplements that affect blood pressure.

Melatonin may affect blood sugar levels.Caution is advised in people with diabetes or low blood sugar and those taking drugs, herbs, or supplements that affect blood sugar. Blood sugar levels may need to be monitored by a qualified health care professional, including a pharmacist, and medication adjustments may be necessary.

Melatonin may affect the risk of clotting.Caution is advised in people with bleeding or clotting disorders and those taking drugs that may affect bleeding. Dosing adjustments may be necessary.

Drowsiness or sedation may occur. Use caution in people who are driving or operating heavy machinery (including aircraft) and those taking depressants, stimulants, or sedatives.

Melatonin may interfere with the way the body processes certain drugs using the liver’s cytochrome P450 enzyme system.

Beware of people who have or are at risk of changes in hormone levels, eye disorders, frequently feeling cold, genital or urinary disorders (including children with a history of bedwetting), heart disease, hyperactivity, immune disorders, inflammatory disorders, mental disorders, muscle control problems, nervous system disorders, seizures, skin disorders and stomach and intestinal problems.

Use cautiously in people taking agents that affect the immune system, anti-inflammatory agents, or hormonal agents.

Use cautiously in breastfeeding women, due to a lack of safety information.

Avoid in women who are pregnant or trying to get pregnant. Melatonin may decrease sex drive, increase the risk of developmental disorders, and reduce ovarian function.

Avoid in people with known allergy or sensitivity to melatonin or related products.

Pregnancy & Breast Feeding 

Overall, there is a lack of high quality scientific evidence on the use of melatonin during pregnancy or breastfeeding.

Use cautiously in breastfeeding women, due to a lack of safety information.

Avoid in women who are pregnant or trying to get pregnant. Melatonin may decrease sex drive, increase the risk of developmental disorders, and reduce ovarian function.


Interactions with Drugs 

Note: This section discusses both melatonin in the body and melatonin from other sources, and the effects of other agents on melatonin and when taken with melatonin.

Many drugs may lower natural melatonin levels in the body. These include nonsteroidal anti-inflammatory drugs (NSAIDs, including ibuprofen [Motrin, Advil] or naproxen [Naprosyn, Aleve]), beta-blocker blood pressure medications (including propranolol [Inderal], atenolol [Tenormin], and metoprolol [Lopressor, Toprol]), and agents that lower levels of vitamin B6 in the body (including birth control, hormone replacement therapy, loop diuretics, hydralazine, and theophylline). Other agents that may affect melatonin levels include caffeine, diazepam, estradiol, somatostatin, temazepam, verapamil, and vitamin B12. Melatonin may affect the risk of clotting.Caution is advised in people with bleeding or clotting disorders and those taking drugs that may affect bleeding or clotting. Dosing adjustments may be necessary.

Melatonin may affect blood sugar levels.Caution is advised when using medications that may also affect blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified health care professional, including a pharmacist.Medication adjustments may be necessary.

Melatonin may affect blood pressure.Caution is advised in people taking drugs that may affect blood pressure. 

Melatonin can interfere with the way the body processes certain drugs using the liver’s cytochrome P450 enzyme system. As a result, the levels of these drugs may be altered in the blood and may cause altered effects or potentially serious adverse reactions. People using any medications should check the package insert and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.

Melatonin may increase the amount of drowsiness caused by some drugs. Examples include benzodiazepines such as lorazepam (Ativan) or diazepam (Valium), barbiturates such as phenobarbital, narcotics such as codeine, some antidepressants, and alcohol. Caution is advised while driving or operating machinery.

Melatonin may also interact with ACE inhibitors, agents passed by the kidneys, agents that affect blood vessel width, agents that affect GABA, agents that affect the immune system, agents that affect the nervous system, agents that harm the liver, agents that increase seizure risk, agents that increase urine flow, agents that protect against radiation, agents that regulate body temperature, agents that treat Parkinson’s disease, agents that treat seizures, alcohol, Alzheimer’s agents, anesthetics, antiaging agents, antiarthritis agents, antiasthma agents, anticancer agents, anti-inflammatory agents, antiparasite agents, antipsychotic agents, antiulcer agents, antivirals, anxiety agents, birth control, caffeine, calcium channel blockers, cholesterol-lowering agents, cognitive agents, dental agents, dextromethorphan, ear agents, epithalamin, estrogens, exercise performance agents, eye agents, fertility agents, flumazenil, genital and urinary disorder agents, glaucoma agents, headache agents, heart agents, heart rate-regulating agents, hormonal agents, isoniazid, lithium, lung agents, magnetic fields, methamphetamines, methoxamine, musculoskeletal agents, neuromuscular blockers, opioids, osteoporosis agents, pain relievers, remifentanil, sevoflurane, skin agents, stomach agents, tacrine, thyroid hormones, vaccines, valproic acid and weight loss agents.

Interactions with Herbs & Dietary 


Note: This section discusses both melatonin in the body and melatonin from other sources, and the effects of other agents on melatonin and when taken with melatonin. Many drugs may lower natural melatonin levels in the body. These include nonsteroidal anti-inflammatory drugs (NSAIDs, including ibuprofen [Motrin, Advil] or naproxen [Naprosyn, Aleve]), beta-blocker blood pressure medications (including propranolol [Inderal], atenolol [Tenormin], and metoprolol [Lopressor, Toprol]), and agents that lower levels of vitamin B6 in the body (including birth control, hormone replacement therapy, loop diuretics, hydralazine, and theophylline). Other agents that may affect melatonin levels include caffeine, diazepam, estradiol, somatostatin, temazepam, verapamil and vitamin B12.

Melatonin may affect the risk of clotting. Caution is advised in people with bleeding or clotting disorders and those taking herbs and supplements that may affect bleeding or clotting. Dosing adjustments may be necessary.

Melatonin may affect blood sugar levels.Caution is advised when using herbs or supplements that may also affect blood sugar.Blood glucose levels may require monitoring, and doses may need adjustment.

Melatonin may affect blood pressure.Caution is advised in people taking herbs or supplements that affect blood pressure.

Melatonin may interfere with the way the body processes certain herbs or supplements using the liver’s cytochrome P450 enzyme system. As a result, the levels of other herbs or supplements may alter in the blood. It may also alter the effects that other herbs or supplements possibly have on the cytochrome P450 system.

Melatonin may increase the amount of drowsiness caused by some herbs or supplements.

Melatonin may also interact with 5-HTP, ACE inhibitors, Alzheimer’s herbs and supplements, anesthetics, anti-aging herbs and supplements, anti-arthritis herbs and supplements, antiasthma herbs and supplements, anticancer herbs and supplements, antidepressants, anti-inflammatory herbs and supplements, antioxidants, anti-parasite herbs and supplements, antipsychotic herbs and supplements, antiulcer herbs and supplements, antivirals, anxiety herbs and supplements, birth control, caffeine-containing herbs and supplements, chasteberry, cholesterol-lowering herbs and supplements, cognitive herbs and supplements, dental herbs and supplements, DHEA, ear herbs and supplements, echinacea, exercise performance herbs and supplements, eye herbs and supplements, fertility herbs and supplements, folate, GABA, genital and urinary disorder herbs and supplements, glaucoma herbs and supplements, headache herbs and supplements, heart herbs and supplements, heart rate-regulating herbs and supplements, herbs and supplements passed by the kidneys, herbs and supplements that affect blood vessel width, herbs and supplements that affect GABA, herbs and supplements that affect the immune system, herbs and supplements that affect the nervous system, herbs and supplements that increase seizure risk, herbs and supplements that increase urine flow, herbs and supplements that protect against radiation, herbs and supplements that regulate body temperature, herbs and supplements that treat Parkinson’s disease, herbs and supplements that treat seizures, hormonal herbs and supplements, light therapy, lithium, liver herbs and supplements, lung herbs and supplements, magnetic fields, meditation, musculoskeletal herbs and supplements, music therapy, neuromuscular blockers, osteoporosis herbs and supplements, pain relievers, phytoestrogens, skin herbs and supplements, stomach herbs and supplements, thyroid hormones and weight loss herbs and supplements.


  1. Brzezinski, A. Melatonin in humans. N.Engl.J Med 1-16-1997;336(3):186-195. View Abstract
  2. Iuvone, P. M., Brown, A. D., Haque, R., Weller, J., Zawilska, J. B., Chaurasia, S. S., Ma, M., and Klein, D. C. Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase. Invest Ophthalmol.Vis.Sci. 2002;43(2):564-572. View Abstract
  3. Vachharajani, N. N., Yeleswaram, K., and Boulton, D. W. Preclinical pharmacokinetics and metabolism of BMS-214778, a novel melatonin receptor agonist. J Pharm Sci. 2003;92(4):760-772. View Abstract
  4. Zhou, M. O., Jiao, S., Liu, Z., Zhang, Z. H., and Mei, Y. A. Luzindole, a melatonin receptor antagonist, inhibits the transient outward K+ current in rat cerebellar granule cells. Brain Res 4-25-2003;970(1-2):169-177. View Abstract
  5. Constantinescu, C. S., Hilliard, B., Ventura, E., and Rostami, A. Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. Pathobiology 1997;65(4):190-194. View Abstract
  6. Hardeland, R., Poeggeler, B., Srinivasan, V., Trakht, I., Pandi-Perumal, S. R., and Cardinali, D. P. Melatonergic drugs in clinical practice. Arzneimittelforschung. 2008;58(1):1-10. View Abstract
  7. Mulchahey, J. J., Goldwater, D. R., and Zemlan, F. P. A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog beta-methyl-6-chloromelatonin. Life Sci. 8-27-2004;75(15):1843-1856. View Abstract
  8. Sener, G., Sehirli, A. O., and Ayanoglu-Dulger, G. Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study. J Pineal Res 2003;35(1):61-68. View Abstract
  9. Ilbey, Y. O., Ozbek, E., Cekmen, M., Somay, A., Ozcan, L., Otunctemur, A., Simsek, A., and Mete, F. Melatonin prevents acetaminophen-induced nephrotoxicity in rats. Int.Urol.Nephrol. 2009;41(3):695-702. View Abstract
  10. Shiu, S. Y., Reiter, R. J., Tan, D. X., and Pang, S. F. Urgent search for safe and effective treatments of severe acute respiratory syndrome: is melatonin a promising candidate drug? J Pineal Res 2003;35(1):69-70. View Abstract
  11. Gitto, E., Reiter, R. J., Cordaro, S. P., La Rosa, M., Chiurazzi, P., Trimarchi, G., Gitto, P., Calabro, M. P., and Barberi, I. Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin. Am J Perinatol. 2004;21(4):209-216. View Abstract
  12. Arushanian, E. B. and Naumov, S. S. [Comparative experimental study of the psychotropic and chronotropic activity of adaptogenic phytopreparations and melaxen]. Eksp.Klin.Farmakol. 2010;73(1):7-9. View Abstract
  13. Adan, A. [Circadian rhythmicity and addiction]. Adicciones. 2010;22(1):5-9. View Abstract
  14. Fukai, S. and Akishita, M. [Hormone replacement therapy–growth hormone, melatonin, DHEA and sex hormones]. Nihon Rinsho 2009;67(7):1396-1401. View Abstract
  15. Garcia, J. J., Pinol-Ripoll, G., Martinez-Ballarin, E., Fuentes-Broto, L., Miana-Mena, F. J., Venegas, C., Caballero, B., Escames, G., Coto-Montes, A., and Acuna-Castroviejo, D. Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice. Neurobiol.Aging 2011;32(11):2045-2054. View Abstract
  16. Jagota, A. and Kalyani, D. Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male Wistar rat. Biogerontology. 2010;11(3):299-308. View Abstract
  17. Reiter, R. J., Paredes, S. D., Manchester, L. C., and Tan, D. X. Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin. Crit Rev.Biochem.Mol.Biol. 2009;44(4):175-200. View Abstract
  18. Paredes, S. D., Bejarano, I., Terron, M. P., Barriga, C., Reiter, R. J., and Rodriguez, A. B. Melatonin and tryptophan counteract lipid peroxidation and modulate superoxide dismutase activity in ringdove heterophils in vivo. Effect of antigen-induced activation and age. Age (Dordr.) 2009;31(3):179-188. View Abstract
  19. Carretero, M., Escames, G., Lopez, L. C., Venegas, C., Dayoub, J. C., Garcia, L., and Acuna-Castroviejo, D. Long-term melatonin administration protects brain mitochondria from aging. J.Pineal Res. 2009;47(2):192-200. View Abstract
  20. Magnanou, E., Attia, J., Fons, R., Boeuf, G., and Falcon, J. The timing of the shrew: continuous melatonin treatment maintains youthful rhythmic activity in aging Crocidura russula. PLoS.One. 2009;4(6):e5904. View Abstract
  21. Jung-Hynes, B. and Ahmad, N. SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms. FASEB J. 2009;23(9):2803-2809. View Abstract
  22. Paredes, S. D., Marchena, A. M., Bejarano, I., Espino, J., Barriga, C., Rial, R. V., Reiter, R. J., and Rodriguez, A. B. Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: changes with age. J.Gerontol.A Biol.Sci.Med.Sci. 2009;64(3):340-350. View Abstract
  23. Caballero, B., Vega-Naredo, I., Sierra, V., Huidobro-Fernandez, C., Soria-Valles, C., De Gonzalo-Calvo, D., Tolivia, D., Pallas, M., Camins, A., Rodriguez-Colunga, M. J., and Coto-Montes, A. Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice. J.Pineal Res. 2009;46(1):106-114. View Abstract
  24. Esrefoglu, M., Gul, M., Ates, B., and Yilmaz, I. The ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged rats. Fundam.Clin.Pharmacol. 2010;24(3):305-315. View Abstract
  25. Perego, R., Proverbio, D., Roccabianca, P., and Spada, E. Color dilution alopecia in a blue Doberman pinscher crossbreed. Can.Vet.J. 2009;50(5):511-514. View Abstract
  26. Brzezinski, A., Lynch, H. J., Seibel, M. M., Deng, M. H., Nader, T. M., and Wurtman, R. J. The circadian rhythm of plasma melatonin during the normal menstrual cycle and in amenorrheic women. J Clin Endocrinol Metab 1988;66(5):891-895. View Abstract
  27. Berga, S. L., Mortola, J. F., and Yen, S. S. Amplification of nocturnal melatonin secretion in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab 1988;66(1):242-244. View Abstract
  28. Patel, B. P. and Hamadeh, M. J. Nutritional and exercise-based interventions in the treatment of amyotrophic lateral sclerosis. Clin Nutr. 2009;28(6):604-617. View Abstract
  29. Velkov, Z. A., Velkov, Y. Z., Galunska, B. T., Paskalev, D. N., and Tadjer, A. V. Melatonin: Quantum-chemical and biochemical investigation of antioxidant activity. Eur.J.Med.Chem. 2009;44(7):2834-2839. View Abstract
  30. Kedziora-Kornatowska, K., Szewczyk-Golec, K., Kozakiewicz, M., Pawluk, H., Czuczejko, J., Kornatowski, T., Bartosz, G., and Kedziora, J. Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients. J.Pineal Res. 2009;46(3):333-337. View Abstract
  31. Cruz, A., Tasset, I., Ramirez, L. M., Arjona, A., Segura, J., Tunez, I., Montilla, P., Muntane, J., and Padillo, F. J. Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice. Rev.Esp.Enferm.Dig. 2009;101(7):460-463. View Abstract
  32. Kaur, C., Sivakumar, V., and Ling, E. A. Melatonin protects periventricular white matter from damage due to hypoxia. J.Pineal Res. 2010;48(3):185-193. View Abstract
  33. Malekinejad, H., Farshid, A. A., and Mirzakhani, N. Liquorice plant extract reduces ochratoxin A-induced nephrotoxicity in rats. Exp.Toxicol.Pathol. 2011;63(1-2):125-130. View Abstract
  34. Akmali, M., Ahmadi, R., and Vessal, M. Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism. Arch.Iran Med. 2010;13(2):105-110. View Abstract
  35. Millan-Plano, S., Piedrafita, E., Miana-Mena, F. J., Fuentes-Broto, L., Martinez-Ballarin, E., Lopez-Pingarron, L., Saenz, M. A., and Garcia, J. J. Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage. Int J Mol.Sci 2010;11(1):312-328. View Abstract
  36. Espino, J., Bejarano, I., Ortiz, A., Lozano, G. M., Garcia, J. F., Pariente, J. A., and Rodriguez, A. B. Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa. Fertil.Steril. 2010;94(5):1915-1917. View Abstract
  37. Wiktorska, J. A., Lewinski, A., Stuss, M., Nowak, D., Pietras, T., and Sewerynek, E. Effects of certain antioxidants on lipid peroxidation process in lung homogenates of L thyroxine-receiving rats. Neuro.Endocrinol.Lett. 2010;31(1):137-146. View Abstract
  38. Dilek, M., Naziroglu, M., Baha, Oral H., Suat, Ovey, I, Kucukayaz, M., Mungan, M. T., Kara, H. Y., and Sutcu, R. Melatonin modulates hippocampus NMDA receptors, blood and brain oxidative stress levels in ovariectomized rats. J.Membr.Biol. 2010;233(1-3):135-142. View Abstract
  39. Yurtcu, M., Abasiyanik, A., Bicer, S., and Avunduk, M. C. Efficacy of antioxidant treatment in the prevention of testicular atrophy in experimental testicular torsion. J.Pediatr.Surg. 2009;44(9):1754-1758. View Abstract
  40. Jung, K. H., Hong, S. W., Zheng, H. M., Lee, D. H., and Hong, S. S. Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. J.Pineal Res. 2009;47(2):173-183. View Abstract
  41. Kaji, H., Inukai, Y., Maiguma, T., Ono, H., Teshima, D., Hiramoto, K., and Makino, K. Radical scavenging activity of bisbenzylisoquinoline alkaloids and traditional prophylactics against chemotherapy-induced oral mucositis. J.Clin.Pharm.Ther. 2009;34(2):197-205. View Abstract
  42. Bharti, V. K. and Srivastava, R. S. Fluoride-induced oxidative stress in rat’s brain and its amelioration by buffalo (Bubalus bubalis) pineal proteins and melatonin. Biol.Trace Elem.Res. 2009;130(2):131-140. View Abstract
  43. Pan, L., Fu, J. H., Xue, X. D., Xu, W., Zhou, P., and Wei, B. Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia. World J.Pediatr. 2009;5(3):216-221. View Abstract
  44. Gomez-Moreno, G., Guardia, J., Ferrera, M. J., Cutando, A., and Reiter, R. J. Melatonin in diseases of the oral cavity. Oral Dis. 2010;16(3):242-247. View Abstract
  45. Bekyarova, G., Galunska, B., Ivanova, D., and Yankova, T. Effect of melatonin on burn-induced gastric mucosal injury in rats. Burns 2009;35(6):863-868. View Abstract
  46. Bekyarova, G., Tancheva, S., and Hristova, M. Protective effect of melatonin against oxidative hepatic injury after experimental thermal trauma. Methods Find.Exp.Clin.Pharmacol. 2009;31(1):11-14. View Abstract
  47. Makay, B., Makay, O., Yenisey, C., Icoz, G., Ozgen, G., Unsal, E., Akyildiz, M., and Yetkin, E. The interaction of oxidative stress response with cytokines in the thyrotoxic rat: is there a link? Mediators.Inflamm. 2009;2009:391682. View Abstract
  48. Huang, L. T., Tiao, M. M., Tain, Y. L., Chen, C. C., and Hsieh, C. S. Melatonin ameliorates bile duct ligation-induced systemic oxidative stress and spatial memory deficits in developing rats. Pediatr.Res. 2009;65(2):176-180. View Abstract
  49. Pan, L., Xu, W., Fu, J. H., and Xue, X. D. [Effect of melatonin on hyperoxia-induced oxidant/antioxidant imbalance in the lung of neonatal rats with chronic lung disease]. Zhongguo Dang.Dai Er.Ke.Za Zhi. 2009;11(7):581-584. View Abstract
  50. Xu, S., Zhou, Z., Zhang, L., Yu, Z., Zhang, W., Wang, Y., Wang, X., Li, M., Chen, Y., Chen, C., He, M., Zhang, G., and Zhong, M. Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons. Brain Res. 1-22-2010;1311:189-196. View Abstract
  51. Venkataraman, P., Selvakumar, K., Krishnamoorthy, G., Muthusami, S., Rameshkumar, R., Prakash, S., and Arunakaran, J. Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats. Neurosci.Res. 2010;66(2):189-197. View Abstract
  52. Uluocak, N., Atilgan, D., Erdemir, F., Parlaktas, B. S., Yasar, A., Erkorkmaz, U., and Akbas, A. An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. Int.Urol.Nephrol. 2010;42(4):889-895. View Abstract
  53. Ortega-Gutierrez, S., Lopez-Vicente, M., Lostale, F., Fuentes-Broto, L., Martinez-Ballarin, E., and Garcia, J. J. Protective effect of melatonin against mitomycin C-induced genotoxic damage in peripheral blood of rats. J.Biomed.Biotechnol. 2009;2009:791432. View Abstract
  54. Kumar, A. and Singh, A. Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. Fundam.Clin.Pharmacol. 2009;23(4):439-448. View Abstract
  55. Yoo, Y. M. and Jeung, E. B. Melatonin-induced estrogen receptor alpha-mediated calbindin-D9k expression plays a role in H2O2-mediated cell death in rat pituitary GH3 cells. J.Pineal Res. 2009;47(4):301-307. View Abstract
  56. Venkataraman, P., Krishnamoorthy, G., Selvakumar, K., and Arunakaran, J. Oxidative stress alters creatine kinase system in serum and brain regions of polychlorinated biphenyl (Aroclor 1254)-exposed rats: protective role of melatonin. Basic Clin.Pharmacol.Toxicol. 2009;105(2):92-97. View Abstract
  57. Wisessmith, W., Phansuwan-Pujito, P., Govitrapong, P., and Chetsawang, B. Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells. J.Pineal Res. 2009;46(4):433-440. View Abstract
  58. Arushanian, E. B. [Comparative evaluation of epiphyseal melatonin and benzodiazepine anxiolytics]. Eksp.Klin.Farmakol. 2012;75(3):35-40. View Abstract
  59. Nah, S. S., Won, H. J., Park, H. J., Ha, E., Chung, J. H., Cho, H. Y., and Baik, H. H. Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase/P21(CIP1)/P27(KIP1) pathways. J.Pineal Res. 2009;47(1):70-74. View Abstract
  60. Pei, M., He, F., Wei, L., and Rawson, A. Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes. J.Pineal Res. 2009;46(2):181-187. View Abstract
  61. Takei, A., Okawa, M., Sasaki, H., Hamada, T., and Tashiro, K. [Effective melatonin therapy in a case of Machado-Joseph disease with insomnia]. Rinsho Shinkeigaku 2000;40(7):736-740. View Abstract
  62. Kim, T. H., Jung, J. A., Kim, G. D., Jang, A. H., Ahn, H. J., Park, Y. S., and Park, C. S. Melatonin inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. J.Pineal Res. 2009;47(4):324-329. View Abstract
  63. Hassler, F., Duck, A., Reis, O., and Buchmann, J. [Alternative agents used in ADHD]. Z.Kinder Jugendpsychiatr.Psychother. 2009;37(1):13-24, quiz. View Abstract
  64. van den Heuvel, C. J., Reid, K. J., and Dawson, D. Effect of atenolol on nocturnal sleep and temperature in young men: reversal by pharmacological doses of melatonin. Physiol Behav. 1997;61(6):795-802. View Abstract
  65. Mayeda, A., Mannon, S., Hofstetter, J., Adkins, M., Baker, R., Hu, K., and Nurnberger, J., Jr. Effects of indirect light and propranolol on melatonin levels in normal human subjects. Psychiatry Res 10-19-1998;81(1):9-17. View Abstract
  66. Maldonado, M. D., Perez-San-Gregorio, M. A., and Reiter, R. J. The role of melatonin in the immuno-neuro-psychology of mental disorders. Recent Pat CNS.Drug Discov. 2009;4(1):61-69. View Abstract
  67. Nierenberg, A. A. Low-dose buspirone, melatonin and low-dose bupropion added to mood stabilizers for severe treatment-resistant bipolar depression. Psychother.Psychosom. 2009;78(6):391-393. View Abstract
  68. Maurizi, C. P. A preliminary understanding of mania: roles for melatonin, vasotocin and rapid-eye-movement sleep. Med Hypotheses 2000;54(1):26-29. View Abstract
  69. Nurnberger, J. I., Jr., Adkins, S., Lahiri, D. K., Mayeda, A., Hu, K., Lewy, A., Miller, A., Bowman, E. S., Miller, M. J., Rau, L., Smiley, C., and Davis-Singh, D. Melatonin suppression by light in euthymic bipolar and unipolar patients. Arch.Gen.Psychiatry 2000;57(6):572-579. View Abstract
  70. Etain, B., Dumaine, A., Bellivier, F., Pagan, C., Francelle, L., Goubran-Botros, H., Moreno, S., Deshommes, J., Moustafa, K., Le, Dudal K., Mathieu, F., Henry, C., Kahn, J. P., Launay, J. M., Muhleisen, T. W., Cichon, S., Bourgeron, T., Leboyer, M., and Jamain, S. Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder. Hum.Mol.Genet. 9-15-2012;21(18):4030-4037. View Abstract
  71. Onur, R., Ozcan, M., Tuygun, U., Ozan, T., Ayar, A., and Orhan, I. Effects of combined use of trospium chloride and melatonin on in vitro contractility of rat urinary bladder. Urology 2010;75(4):873-877. View Abstract
  72. Abdel-Wanis, M. E. and Tsuchiya, H. Melatonin deficiency and fibrous dysplasia: might a relation exist? Med Hypotheses 2002;59(5):552-554. View Abstract
  73. Kamath, S. and Bhagwandas, K. Nail-patella syndrome with an emphasis on the risk of renal and ocular findings. Pediatr.Dermatol. 2010;27(1):95-97. View Abstract
  74. Munoz, F., Lopez-Pena, M., Mino, N., Gomez-Moreno, G., Guardia, J., and Cutando, A. Topical application of melatonin and growth hormone accelerates bone healing around dental implants in dogs. Clin.Implant.Dent.Relat Res. 2012;14(2):226-235. View Abstract
  75. Guardia, J., Gomez-Moreno, G., Ferrera, M. J., and Cutando, A. Evaluation of effects of topic melatonin on implant surface at 5 and 8 weeks in Beagle dogs. Clin.Implant.Dent.Relat Res. 2011;13(4):262-268. View Abstract
  76. Calvo-Guirado, J. L., Gomez-Moreno, G., Barone, A., Cutando, A., Alcaraz-Banos, M., Chiva, F., Lopez-Mari, L., and Guardia, J. Melatonin plus porcine bone on discrete calcium deposit implant surface stimulates osteointegration in dental implants. J.Pineal Res. 2009;47(2):164-172. View Abstract
  77. Arushanian, E. B., Naumov, S. S., and Ponomareva, V. A. [Protective effect of melatonin on behavioral and morphological disturbances induced by cerebrocranial trauma in different daytime in rats]. Eksp.Klin.Farmakol. 2009;72(5):18-21. View Abstract
  78. Li, Z. Q., Liang, G. B., Xue, Y. X., and Liu, Y. H. Effects of combination treatment of dexamethasone and melatonin on brain injury in intracerebral hemorrhage model in rats. Brain Res. 4-6-2009;1264:98-103. View Abstract
  79. Lee, S., Jadhav, V., Ayer, R. E., Rojas, H., Hyong, A., Lekic, T., Tang, J., and Zhang, J. H. Dual effects of melatonin on oxidative stress after surgical brain injury in rats. J.Pineal Res. 2009;46(1):43-48. View Abstract
  80. Samantaray, S., Das, A., Thakore, N. P., Matzelle, D. D., Reiter, R. J., Ray, S. K., and Banik, N. L. Therapeutic potential of melatonin in traumatic central nervous system injury. J.Pineal Res. 2009;47(2):134-142. View Abstract
  81. Persson, C., Glimelius, B., Ronnelid, J., and Nygren, P. Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study. Nutrition 2005;21(2):170-178. View Abstract
  82. Mattox, T. W. Treatment of unintentional weight loss in patients with cancer. Nutr Clin Pract. 2005;20(4):400-410. View Abstract
  83. Piasek, A., Bartoszek, A., and Namiesnik, J. [Phytochemicals that counteract the cardiotoxic side effects of cancer chemotherapy]. Postepy Hig.Med.Dosw.(Online.) 2009;63:142-158. View Abstract
  84. Zupancic, D., Vidmar, G., and Jezernik, K. Melatonin prevents the development of hyperplastic urothelium induced by repeated doses of cyclophosphamide. Virchows Arch. 2009;454(6):657-666. View Abstract
  85. Pacini, N. and Borziani, F. Action of melatonin on bone marrow depression induced by cyclophosphamide in acute toxicity phase. Neuro.Endocrinol.Lett. 2009;30(5):582-591. View Abstract
  86. Ilbey, Y. O., Ozbek, E., Simsek, A., Otunctemur, A., Cekmen, M., and Somay, A. Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats. Fertil.Steril. 2009;92(3):1124-1132. View Abstract
  87. Dziegiel, P., Suder, E., Surowiak, P., Jethon, Z., Rabczynski, J., Januszewska, L., Sopel, M., and Zabel, M. Role of exogenous melatonin in reducing the nephrotoxic effect of daunorubicin and doxorubicin in the rat. J Pineal Res 2002;33(2):95-100. View Abstract
  88. Dziegiel, P., Jethon, Z., Suder, E., Sopel, M., Rabczynski, J., Surowiak, P., and Zabel, M. Role of exogenous melatonin in reducing the cardiotoxic effect of daunorubicin and doxorubicin in the rat. Exp.Toxicol.Pathol. 2002;53(6):433-439. View Abstract
  89. Dziegiel, P., Surowiak, P., Rabczynski, J., and Zabel, M. Effect of melatonin on cytotoxic effects of daunorubicin on myocardium and on transplantable Morris hepatoma in rats. Pol.J Pathol. 2002;53(4):201-204. View Abstract
  90. Bubenik, G. A. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig.Dis.Sci. 2002;47(10):2336-2348. View Abstract
  91. Morganti, P., Fabrizi, G., Palombo, P., Palombo, M., Guarneri, F., Cardillo, A., and Morganti, G. New chitin complexes and their anti-aging activity from inside out. J.Nutr.Health Aging 2012;16(3):242-245. View Abstract
  92. Chahbouni, M., Escames, G., Venegas, C., Sevilla, B., Garcia, J. A., Lopez, L. C., Munoz-Hoyos, A., Molina-Carballo, A., and Acuna-Castroviejo, D. Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy. J.Pineal Res. 2010;48(3):282-289. View Abstract
  93. Chahbouni, M., Escames, G., Lopez, L. C., Sevilla, B., Doerrier, C., Munoz-Hoyos, A., Molina-Carballo, A., and Acuna-Castroviejo, D. Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy. Clin.Biochem. 2011;44(10-11):853-858. View Abstract
  94. Papezova, H., Yamamotova, A., and Nedvidkova, J. Pain modulation role of melatonin in eating disorders. Eur Psychiatry 2001;16(1):68-70. View Abstract
  95. Tortosa, F., Puig-Domingo, M., Peinado, M. A., Oriola, J., Webb, S. M., and de Leiva, A. Enhanced circadian rhythm of melatonin in anorexia nervosa. Acta Endocrinol (Copenh) 1989;120(5):574-578. View Abstract
  96. Arushanian, E. B., Al Absi, J. M., and Chebotarev, V. V. [The therapeutic activity of melatonin and its effect on immunological parameters of patients with eczema]. Eksp.Klin.Farmakol. 2003;66(3):59-61. View Abstract
  97. Yildirim, G., Attar, R., Ozkan, F., Kumbak, B., Ficicioglu, C., and Yesildaglar, N. The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study. Fertil.Steril. 2010;93(6):1787-1792. View Abstract
  98. Soares, S. R., Martinez-Varea, A., Hidalgo-Mora, J. J., and Pellicer, A. Pharmacologic therapies in endometriosis: a systematic review. Fertil.Steril. 2012;98(3):529-555. View Abstract
  99. Gur, S., Kadowitz, P. J., and Hellstrom, W. J. A critical appraisal of erectile function in animal models of diabetes mellitus. Int.J.Androl 2009;32(2):93-114. View Abstract
  100. Konturek, S. J., Konturek, P. C., Brzozowski, T., and Bubenik, G. A. Role of melatonin in upper gastrointestinal tract. J Physiol Pharmacol 2007;58 Suppl 6:23-52. View Abstract
  101. Lahiri, S., Singh, P., Singh, S., Rasheed, N., Palit, G., and Pant, K. K. Melatonin protects against experimental reflux esophagitis. J.Pineal Res. 2009;46(2):207-213. View Abstract
  102. Ayaz, M. and Okudan, N. Effects of melatonin supplementation on exercise-induced changes in conduction velocity distributions. Methods Find.Exp.Clin.Pharmacol. 2009;31(3):151-156. View Abstract
  103. Gulcin, I., Buyukokuroglu, M. E., Oktay, M., and Kufrevioglu, O. I. On the in vitro antioxidative properties of melatonin. J Pineal Res 2002;33(3):167-171. View Abstract
  104. Romero-Zerbo, Y., Decara, J., el, Bekay R., Sanchez-Salido, L., Del Arco-Herrera, I., de Fonseca, F. R., and de Diego-Otero, Y. Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome. J.Pineal Res. 2009;46(2):224-234. View Abstract
  105. Makay, B. Is there a role of melatonin in the development of growing pains? Med.Hypotheses 2009;72(2):225. View Abstract
  106. El Sokkary, G. H., Omar, H. M., Hassanein, A. F., Cuzzocrea, S., and Reiter, R. J. Melatonin reduces oxidative damage and increases survival of mice infected with Schistosoma mansoni. Free Radic.Biol.Med 2-15-2002;32(4):319-332. View Abstract
  107. Hong, R. T., Xu, J. M., and Mei, Q. Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. World J.Gastroenterol. 3-28-2009;15(12):1452-1458. View Abstract
  108. Shaker, M. E., Houssen, M. E., Abo-Hashem, E. M., and Ibrahim, T. M. Comparison of vitamin E, L-carnitine and melatonin in ameliorating carbon tetrachloride and diabetes induced hepatic oxidative stress. J Physiol Biochem. 2009;65(3):225-233. View Abstract
  109. Tahan, V., Atug, O., Akin, H., Eren, F., Tahan, G., Tarcin, O., Uzun, H., Ozdogan, O., Tarcin, O., Imeryuz, N., Ozguner, F., Celikel, C., Avsar, E., and Tozun, N. Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. J.Pineal Res. 2009;46(4):401-407. View Abstract
  110. Hu, S., Yin, S., Jiang, X., Huang, D., and Shen, G. Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis. Eur.J.Pharmacol. 8-15-2009;616(1-3):287-292. View Abstract
  111. Ohta, Y., Kongo, M., and Kishikawa, T. Melatonin exerts a therapeutic effect on cholestatic liver injury in rats with bile duct ligation. J Pineal Res 2003;34(2):119-126. View Abstract
  112. Wu, W., Zhang, G., Wang, Y., and He, C. [The change of serum melatonin and diagnosis value in hepatic encephalopathy]. Zhonghua Gan Zang.Bing.Za Zhi 2000;8(5):272-273. View Abstract
  113. Maldonado, M. D., Mora-Santos, M., Naji, L., Carrascosa-Salmoral, M. P., Naranjo, M. C., and Calvo, J. R. Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation. Pharmacol.Res. 2010;62(3):282-287. View Abstract
  114. Lin, G. J., Huang, S. H., Chen, Y. W., Hueng, D. Y., Chien, M. W., Chia, W. T., Chang, D. M., and Sytwu, H. K. Melatonin prolongs islet graft survival in diabetic NOD mice. J.Pineal Res. 2009;47(3):284-292. View Abstract
  115. Yang, F. L., Subeq, Y. M., Lee, C. J., Lee, R. P., Peng, T. C., and Hsu, B. G. Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. J.Surg.Res. 5-15-2011;167(2):e315-e321. View Abstract
  116. Imashuku, S., Morimoto, Y., Morimoto, A., Yamamoto, T., Hibi, S., and Todo, S. Pineal dysfunction (low melatonin production) as a cause of sudden death in a long-term survivor of Langerhans cell histiocytosis? Med Pediatr.Oncol. 2003;41(2):151-153. View Abstract
  117. Gitto, E., Pellegrino, S., Gitto, P., Barberi, I., and Reiter, R. J. Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin. J.Pineal Res. 2009;46(2):128-139. View Abstract
  118. Tian, X. Z., Wen, Q., Shi, J. M., Liang, Wang, Zeng, S. M., Tian, J. H., Zhou, G. B., Zhu, S. E., and Liu, G. S. Effects of melatonin on in vitro development of mouse two-cell embryos cultured in HTF medium. Endocr.Res. 2010;35(1):17-23. View Abstract
  119. Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Garcia-Gonzalez, M. J., Kaski, J. C., Reiter, R. J., and Jimenez-Sosa, A. A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial: study design and rationale. Contemp.Clin Trials 2007;28(4):532-539. View Abstract
  120. Zaouali, M. A., Ben, Abdennebi H., Padrissa-Altes, S., Mahfoudh-Boussaid, A., and Rosello-Catafau, J. Pharmacological strategies against cold ischemia reperfusion injury. Expert.Opin.Pharmacother. 2010;11(4):537-555. View Abstract
  121. Guo, Y., Wang, J., Wang, Z., Yang, Y., Wang, X., and Duan, Q. Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement. J.Huazhong.Univ Sci.Technolog.Med.Sci. 2010;30(1):1-7. View Abstract
  122. Ersoz, N., Guven, A., Cayci, T., Uysal, B., Turk, E., Oztas, E., Akgul, E. O., Korkmaz, A., and Cetiner, S. Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. Ren Fail. 2009;31(8):704-710. View Abstract
  123. Petrosillo, G., Colantuono, G., Moro, N., Ruggiero, F. M., Tiravanti, E., Di, Venosa N., Fiore, T., and Paradies, G. Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Am.J.Physiol Heart Circ.Physiol 2009;297(4):H1487-H1493. View Abstract
  124. Li, Z., Nickkholgh, A., Yi, X., Bruns, H., Gross, M. L., Hoffmann, K., Mohr, E., Zorn, M., Buchler, M. W., and Schemmer, P. Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation. J.Pineal Res. 2009;46(4):365-372. View Abstract
  125. Kesik, V., Guven, A., Vurucu, S., Tunc, T., Uysal, B., Gundogdu, G., Oztas, E., and Korkmaz, A. Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion. J.Surg.Res. 2009;157(1):e97-e105. View Abstract
  126. Sokullu, O., Sanioglu, S., Kurc, E., Sargin, M., Deniz, H., Tartan, Z., Aka, S. A., and Bilgen, F. Does the circadian rhythm of melatonin affect ischemia-reperfusion injury after coronary artery bypass grafting? Heart Surg.Forum 2009;12(2):E95-E99. View Abstract
  127. Kurcer, Z., Hekimoglu, A., Aral, F., Baba, F., and Sahna, E. Effect of melatonin on epididymal sperm quality after testicular ischemia/reperfusion in rats. Fertil.Steril. 3-15-2010;93(5):1545-1549. View Abstract
  128. Wang, X., Figueroa, B. E., Stavrovskaya, I. G., Zhang, Y., Sirianni, A. C., Zhu, S., Day, A. L., Kristal, B. S., and Friedlander, R. M. Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury. Stroke 2009;40(5):1877-1885. View Abstract
  129. Sung, J. H., Cho, E. H., Kim, M. O., and Koh, P. O. Identification of proteins differentially expressed by melatonin treatment in cerebral ischemic injury–a proteomics approach. J.Pineal Res. 2009;46(3):300-306. View Abstract
  130. Diez, E. R., Prados, L. V., Carrion, A., Ponce, Z. A., and Miatello, R. M. A novel electrophysiologic effect of melatonin on ischemia/reperfusion-induced arrhythmias in isolated rat hearts. J.Pineal Res. 2009;46(2):155-160. View Abstract
  131. Chen, Z., Chua, C. C., Gao, J., Chua, K. W., Ho, Y. S., Hamdy, R. C., and Chua, B. H. Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1. J.Pineal Res. 2009;46(2):235-241. View Abstract
  132. Baykara, B., Tekmen, I., Pekcetin, C., Ulukus, C., Tuncel, P., Sagol, O., Ormen, M., and Ozogul, C. The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liver. Acta Histochem. 2009;111(1):42-51. View Abstract
  133. Liang, R., Nickkholgh, A., Hoffmann, K., Kern, M., Schneider, H., Sobirey, M., Zorn, M., Buchler, M. W., and Schemmer, P. Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation. J.Pineal Res. 2009;46(1):8-14. View Abstract
  134. Hamada, F., Watanabe, K., Wakatsuki, A., Nagai, R., Shinohara, K., Hayashi, Y., Imamura, R., and Fukaya, T. Therapeutic effects of maternal melatonin administration on ischemia/reperfusion-induced oxidative cerebral damage in neonatal rats. Neonatology. 2010;98(1):33-40. View Abstract
  135. Bulbuller, N., Akkus, M. A., Cetinkaya, Z., Ilhan, Y. S., Ozercan, I., Kirkil, C., and Dogru, O. Effects of melatonin and lactulose on the liver and kidneys in rats with obstructive jaundice. Pediatr.Surg Int 2002;18(8):677-680. View Abstract
  136. Marino, A., Di, Paola R., Crisafulli, C., Mazzon, E., Morabito, R., Paterniti, I., Galuppo, M., Genovese, T., La, Spada G., and Cuzzocrea, S. Protective effect of melatonin against the inflammatory response elicited by crude venom from isolated nematocysts of Pelagia noctiluca (Cnidaria, Scyphozoa). J.Pineal Res. 2009;47(1):56-69. View Abstract
  137. Tain, Y. L., Hsieh, C. S., Chen, C. C., Sheen, J. M., Lee, C. T., and Huang, L. T. Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation. J.Pineal Res. 2010;48(3):212-221. View Abstract
  138. Wang, Z., Zhang, J., Liu, H., Huang, H., Wang, C., Shen, Y., Li, D., and Jing, H. Melatonin, a potent regulator of hemeoxygenase-1, reduces cardiopulmonary bypass-induced renal damage in rats. J.Pineal Res. 2009;46(3):248-254. View Abstract
  139. Ozbek, E., Ilbey, Y. O., Ozbek, M., Simsek, A., Cekmen, M., and Somay, A. Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression. J.Endourol. 2009;23(7):1165-1173. View Abstract
  140. Ersahin, M., Sehirli, O., Toklu, H. Z., Suleymanoglu, S., Emekli-Alturfan, E., Yarat, A., Tatlidede, E., Yegen, B. C., and Sener, G. Melatonin improves cardiovascular function and ameliorates renal, cardiac and cerebral damage in rats with renovascular hypertension. J.Pineal Res. 2009;47(1):97-106. View Abstract
  141. Parlakpinar, H., Ozer, M. K., Sahna, E., Vardi, N., Cigremis, Y., and Acet, A. Amikacin-induced acute renal injury in rats: protective role of melatonin. J Pineal Res 2003;35(2):85-90. View Abstract
  142. Shang, Y., Xu, S. P., Wu, Y., Jiang, Y. X., Wu, Z. Y., Yuan, S. Y., and Yao, S. L. Melatonin reduces acute lung injury in endotoxemic rats. Chin Med.J.(Engl.) 6-20-2009;122(12):1388-1393. View Abstract
  143. Lee, Y. D., Kim, J. Y., Lee, K. H., Kwak, Y. J., Lee, S. K., Kim, O. S., Song, D. Y., Lee, J. H., Baik, T. K., Kim, B. J., Kim, J. Y., and Baik, H. W. Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice. J.Pineal Res. 2009;46(1):53-57. View Abstract
  144. Srinivasan, V., Spence, D. W., Moscovitch, A., Pandi-Perumal, S. R., Trakht, I., Brown, G. M., and Cardinali, D. P. Malaria: therapeutic implications of melatonin. J.Pineal Res. 2010;48(1):1-8. View Abstract
  145. Fraser, J., Gason, A. A., Wraith, J. E., and Delatycki, M. B. Sleep disturbance in Sanfilippo syndrome: a parental questionnaire study. Arch.Dis.Child 2005;90(12):1239-1242. View Abstract
  146. Claustrat, B., Brun, J., Geoffriau, M., Zaidan, R., Mallo, C., and Chazot, G. Nocturnal plasma melatonin profile and melatonin kinetics during infusion in status migrainosus. Cephalalgia 1997;17(4):511-517. View Abstract
  147. Murialdo, G., Fonzi, S., Costelli, P., Solinas, G. P., Parodi, C., Marabini, S., Fanciullacci, M., and Polleri, A. Urinary melatonin excretion throughout the ovarian cycle in menstrually related migraine. Cephalalgia 1994;14(3):205-209. View Abstract
  148. Salvesen, R. and Bekkelund, S. I. Migraine, as compared to other headaches, is worse during midnight-sun summer than during polar night. A questionnaire study in an Arctic population. Headache 2000;40(10):824-829. View Abstract
  149. Murch, S. J., Simmons, C. B., and Saxena, P. K. Melatonin in feverfew and other medicinal plants. Lancet 11-29-1997;350(9091):1598-1599. View Abstract
  150. Wetterberg, L. Melatonin in humans physiological and clinical studies. J Neural Transm.Suppl 1978;(13):289-310. View Abstract
  151. Evans, R. W. and Peres, M. F. Headaches and pineal cysts. Headache 2010;50(4):666-668. View Abstract
  152. Brun, J., Claustrat, B., Saddier, P., and Chazot, G. Nocturnal melatonin excretion is decreased in patients with migraine without aura attacks associated with menses. Cephalalgia 1995;15(2):136-139. View Abstract
  153. Bhakta, S. G. and Andrade, C. Melatonin treatment of shoulder-and-neck dyskinesia possibly related to fluoxetine treatment. World J.Biol.Psychiatry 2009;10(4 Pt 3):1047-1048. View Abstract
  154. Bloom, C. M., Anch, A. M., and Dyche, J. S. Behavioral effects of chronic melatonin and pregnenolone injections in a myelin mutant rat (taiep). J Gen.Psychol. 2002;129(3):226-237. View Abstract
  155. Sandyk, R. and Awerbuch, G. I. Relationship of nocturnal melatonin levels to duration and course of multiple sclerosis. Int J Neurosci. 1994;75(3-4):229-237. View Abstract
  156. Sandyk, R. Diurnal variations in vision and relations to circadian melatonin secretion in multiple sclerosis. Int J Neurosci. 1995;83(1-2):1-6. View Abstract
  157. Hedstrom, A. K., Akerstedt, T., Hillert, J., Olsson, T., and Alfredsson, L. Shift work at young age is associated with increased risk for multiple sclerosis. Ann.Neurol. 2011;70(5):733-741. View Abstract
  158. Reiter, R. J., Tan, D. X., Manchester, L. C., and Tamura, H. Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage. J Physiol Pharmacol 2007;58 Suppl 6:5-22. View Abstract
  159. Lauterbach, E. C., Victoroff, J., Coburn, K. L., Shillcutt, S. D., Doonan, S. M., and Mendez, M. F. Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data. J.Neuropsychiatry Clin.Neurosci. 2010;22(1):8-18. View Abstract
  160. Tasset, I., Espinola, C., Medina, F. J., Feijoo, M., Ruiz, C., Moreno, E., Gomez, M. M., Collado, J. A., Munoz, C., Muntane, J., Montilla, P., and Tunez, I. Neuroprotective effect of carvedilol and melatonin on 3-nitropropionic acid-induced neurotoxicity in neuroblastoma. J.Physiol Biochem. 2009;65(3):291-296. View Abstract
  161. Atik, B., Erkutlu, I., Tercan, M., Buyukhatipoglu, H., Bekerecioglu, M., and Pence, S. The effects of exogenous melatonin on peripheral nerve regeneration and collagen formation in rats. J.Surg.Res. 2011;166(2):330-336. View Abstract
  162. Hou, J. W. Smith-Magenis syndrome: report of one case. Acta Paediatr.Taiwan. 2003;44(3):161-164. View Abstract
  163. De Leersnyder, H., de Blois, M. C., Bresson, J. L., Sidi, D., Claustrat, B., and Munnich, A. [Inversion of the circadian melatonin rhythm in Smith-Magenis syndrome]. Rev.Neurol.(Paris) 2003;159(11 Suppl):6S21-6S26. View Abstract
  164. Lin, A. M., Feng, S. F., Chao, P. L., and Yang, C. H. Melatonin inhibits arsenite-induced peripheral neurotoxicity. J.Pineal Res. 2009;46(1):64-70. View Abstract
  165. Negi, G., Kumar, A., Kaundal, R. K., Gulati, A., and Sharma, S. S. Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy. Neuropharmacology 2010;58(3):585-592. View Abstract
  166. Grandgirard, D. and Leib, S. L. Strategies to prevent neuronal damage in paediatric bacterial meningitis. Curr.Opin.Pediatr. 2006;18(2):112-118. View Abstract
  167. Tajes, M., Gutierrez-Cuesta, J., Ortuno-Sahagun, D., Camins, A., and Pallas, M. Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway. J.Pineal Res. 2009;47(3):228-237. View Abstract
  168. Olivier, P., Fontaine, R. H., Loron, G., Van, Steenwinckel J., Biran, V., Massonneau, V., Kaindl, A., Dalous, J., Charriaut-Marlangue, C., Aigrot, M. S., Pansiot, J., Verney, C., Gressens, P., and Baud, O. Melatonin promotes oligodendroglial maturation of injured white matter in neonatal rats. PLoS.One. 2009;4(9):e7128. View Abstract
  169. Radogna, F., Nuccitelli, S., Mengoni, F., and Ghibelli, L. Neuroprotection by melatonin on astrocytoma cell death. Ann.N.Y.Acad.Sci. 2009;1171:509-513. View Abstract
  170. Cilio, M. R. and Ferriero, D. M. Synergistic neuroprotective therapies with hypothermia. Semin.Fetal Neonatal Med. 2010;15(5):293-298. View Abstract
  171. Manda, K. and Reiter, R. J. Melatonin maintains adult hippocampal neurogenesis and cognitive functions after irradiation. Prog.Neurobiol. 1-11-2010;90(1):60-68. View Abstract
  172. Ozacmak, V. H., Barut, F., and Ozacmak, H. S. Melatonin provides neuroprotection by reducing oxidative stress and HSP70 expression during chronic cerebral hypoperfusion in ovariectomized rats. J.Pineal Res. 2009;47(2):156-163. View Abstract
  173. Sheth, D. S., Tajuddin, N. F., and Druse, M. J. Antioxidant neuroprotection against ethanol-induced apoptosis in HN2-5 cells. Brain Res. 8-18-2009;1285:14-21. View Abstract
  174. Ramirez-Rodriguez, G., Klempin, F., Babu, H., Benitez-King, G., and Kempermann, G. Melatonin modulates cell survival of new neurons in the hippocampus of adult mice. Neuropsychopharmacology 2009;34(9):2180-2191. View Abstract
  175. Ritzenthaler, T., Nighoghossian, N., Berthiller, J., Schott, A. M., Cho, T. H., Derex, L., Brun, J., Trouillas, P., and Claustrat, B. Nocturnal urine melatonin and 6-sulphatoxymelatonin excretion at the acute stage of ischaemic stroke. J.Pineal Res. 2009;46(3):349-352. View Abstract
  176. Ersahin, M., Toklu, H. Z., Cetinel, S., Yuksel, M., Yegen, B. C., and Sener, G. Melatonin reduces experimental subarachnoid hemorrhage-induced oxidative brain damage and neurological symptoms. J.Pineal Res. 2009;46(3):324-332. View Abstract
  177. Signorini, C., Ciccoli, L., Leoncini, S., Carloni, S., Perrone, S., Comporti, M., Balduini, W., and Buonocore, G. Free iron, total F-isoprostanes and total F-neuroprostanes in a model of neonatal hypoxic-ischemic encephalopathy: neuroprotective effect of melatonin. J.Pineal Res. 2009;46(2):148-154. View Abstract
  178. Chen, H. Y., Hung, Y. C., Chen, T. Y., Huang, S. Y., Wang, Y. H., Lee, W. T., Wu, T. S., and Lee, E. J. Melatonin improves presynaptic protein, SNAP-25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats. J.Pineal Res. 2009;47(3):260-270. View Abstract
  179. Hutton, L. C., Abbass, M., Dickinson, H., Ireland, Z., and Walker, D. W. Neuroprotective properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomys cahirinus). Dev.Neurosci. 2009;31(5):437-451. View Abstract
  180. Olcese, J. M., Cao, C., Mori, T., Mamcarz, M. B., Maxwell, A., Runfeldt, M. J., Wang, L., Zhang, C., Lin, X., Zhang, G., and Arendash, G. W. Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J.Pineal Res. 2009;47(1):82-96. View Abstract
  181. Kongsuphol, P., Mukda, S., Nopparat, C., Villarroel, A., and Govitrapong, P. Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells. J.Pineal Res. 2009;46(2):199-206. View Abstract
  182. Saxena, G., Bharti, S., Kamat, P. K., Sharma, S., and Nath, C. Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats. Pharmacol.Biochem.Behav. 2010;94(3):397-403. View Abstract
  183. Agrawal, R., Tyagi, E., Shukla, R., and Nath, C. A study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia. Neuropharmacology 2009;56(4):779-787. View Abstract
  184. Daglioglu, E., Serdar, Dike M., Kilinc, K., Erdogan, D., Take, G., Ergungor, F., Okay, O., and Biyikli, Z. Neuroprotective effect of melatonin on experimental peripheral nerve injury: an electron microscopic and biochemical study. Cent.Eur.Neurosurg. 2009;70(3):109-114. View Abstract
  185. Ma, J., Shaw, V. E., and Mitrofanis, J. Does melatonin help save dopaminergic cells in MPTP-treated mice? Parkinsonism.Relat Disord. 2009;15(4):307-314. View Abstract
  186. Chetsawang, B., Chetsawang, J., and Govitrapong, P. Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP-treated human neuroblastoma cells with melatonin. J.Pineal Res. 2009;46(1):36-42. View Abstract
  187. Das, A., McDowell, M., Pava, M. J., Smith, J. A., Reiter, R. J., Woodward, J. J., Varma, A. K., Ray, S. K., and Banik, N. L. The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors. J.Pineal Res. 2010;48(2):157-169. View Abstract
  188. Wang, S., Zhang, L., Lim, G., Sung, B., Tian, Y., Chou, C. W., Hernstadt, H., Rusanescu, G., Ma, Y., and Mao, J. A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats. Brain Res. 9-8-2009;1288:42-49. View Abstract
  189. Bonilla, E., Valero, N., Chacin-Bonilla, L., Pons, H., Larreal, Y., Medina-Leendertz, S., and Espina, L. M. Melatonin increases interleukin-1beta and decreases tumor necrosis factor alpha in the brain of mice infected with the Venezuelan equine encephalomyelitis virus. Neurochem.Res 2003;28(5):681-686. View Abstract
  190. O’Rourke, S. T., Hammad, H., Delagrange, P., Scalbert, E., and Vanhoutte, P. M. Melatonin inhibits nitrate tolerance in isolated coronary arteries. Br.J Pharmacol. 2003;139(7):1326-1332. View Abstract
  191. Bas, E., Martinez-Soriano, F., Lainez, J. M., and Marco, J. An experimental comparative study of dexamethasone, melatonin and tacrolimus in noise-induced hearing loss. Acta Otolaryngol. 2009;129(4):385-389. View Abstract
  192. Song, Y. M. and Chen, M. D. Effects of melatonin administration on plasma leptin concentration and adipose tissue leptin secretion in mice. Acta Biol.Hung. 2009;60(4):399-407. View Abstract
  193. Alonso-Vale, M. I., Peres, S. B., Vernochet, C., Farmer, S. R., and Lima, F. B. Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activity. J.Pineal Res. 2009;47(3):221-227. View Abstract
  194. Bertuglia, S. and Reiter, R. J. Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. J.Pineal Res. 2009;46(3):307-313. View Abstract
  195. Tamura, H., Nakamura, Y., Korkmaz, A., Manchester, L. C., Tan, D. X., Sugino, N., and Reiter, R. J. Melatonin and the ovary: physiological and pathophysiological implications. Fertil.Steril. 2009;92(1):328-343. View Abstract
  196. Hemadi, M., Abolhassani, F., Akbari, M., Sobhani, A., Pasbakhsh, P., Ahrlund-Richter, L., Modaresi, M. H., and Salehnia, M. Melatonin promotes the cumulus-oocyte complexes quality of vitrified-thawed murine ovaries; with increased mean number of follicles survival and ovary size following heterotopic transplantation. Eur.J.Pharmacol. 9-15-2009;618(1-3):84-90. View Abstract
  197. Col, C., Dinler, K., Hasdemir, O., Buyukasik, O., and Bugdayci, G. Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis. Hepatobiliary.Pancreat.Dis.Int. 2010;9(1):78-82. View Abstract
  198. Jung, K. H., Hong, S. W., Zheng, H. M., Lee, H. S., Lee, H., Lee, D. H., Lee, S. Y., and Hong, S. S. Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats. J.Pineal Res. 2010;48(3):239-250. View Abstract
  199. Col, C., Dinler, K., Hasdemir, A. O., and Bugdayci, G. The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis. JOP. 2009;10(3):306-309. View Abstract
  200. Gomez-Pinilla, P. J., Camello, P. J., and Pozo, M. J. Pancreatic calcium signaling: role in health and disease. Pancreatology. 2009;9(4):329-333. View Abstract
  201. Gulben, K., Ozdemir, H., Berberoglu, U., Mersin, H., Yrkin, F., Cakyr, E., and Aksaray, S. Melatonin modulates the severity of taurocholate-induced acute pancreatitis in the rat. Dig.Dis.Sci. 2010;55(4):941-946. View Abstract
  202. Sidhu, S., Pandhi, P., Malhotra, S., Vaiphei, K., and Khanduja, K. L. Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis. Eur.J.Pharmacol. 2-25-2010;628(1-3):282-289. View Abstract
  203. Santello, F. H., Del Vecchio, Filipin M., Caetano, L. C., Brazao, V., Caetano, L. N., Dos Santos, C. D., Alonso Toldo, M. P., and do Prado, J. C. J. Influence of melatonin therapy and orchiectomy on T cell subsets in male Wistar rats infected with Trypanosoma cruzi. J.Pineal Res. 2009;47(3):271-276. View Abstract
  204. Martinez-Cruz, F., Pozo, D., Osuna, C., Espinar, A., Marchante, C., and Guerrero, J. M. Oxidative stress induced by phenylketonuria in the rat: Prevention by melatonin, vitamin E, and vitamin C. J Neurosci.Res 8-15-2002;69(4):550-558. View Abstract
  205. Zhu, H., Chen, S., Yao, S., and Wang, W. Protective effect of melatonin on photo-damage to lysozyme. J.Photochem.Photobiol.B 2-9-2009;94(2):125-130. View Abstract
  206. Izykowska, I., Cegielski, M., Gebarowska, E., Podhorska-Okolow, M., Piotrowska, A., Zabel, M., and Dziegiel, P. Effect of melatonin on human keratinocytes and fibroblasts subjected to UVA and UVB radiation In vitro. In Vivo 2009;23(5):739-745. View Abstract
  207. Izykowska, I., Gebarowska, E., Cegielski, M., Podhorska-Okolow, M., Piotrowska, A., Zabel, M., and Dziegiel, P. Effect of melatonin on melanoma cells subjected to UVA and UVB radiation in In vitro studies. In Vivo 2009;23(5):733-738. View Abstract
  208. Cagnacci, A. and Volpe, A. A role for melatonin in PCOS? Fertil.Steril. 2002;77(5):1089. View Abstract
  209. Richter, H. G., Hansell, J. A., Raut, S., and Giussani, D. A. Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy. J.Pineal Res. 2009;46(4):357-364. View Abstract
  210. Andres, S., Sanchez, J., and Jimenez, A. Evaluation of the influence of melatonin implants during the gestation period in sheep from a selenium-deficient region. Am.J.Vet.Res. 2009;70(3):404-408. View Abstract
  211. Parry, B. L., Berga, S. L., Kripke, D. F., Klauber, M. R., Laughlin, G. A., Yen, S. S., and Gillin, J. C. Altered waveform of plasma nocturnal melatonin secretion in premenstrual depression. Arch Gen Psychiatry 1990;47(12):1139-1146. View Abstract
  212. Maldonado, M. D., Reiter, R. J., and Perez-San-Gregorio, M. A. Melatonin as a potential therapeutic agent in psychiatric illness. Hum.Psychopharmacol. 2009;24(5):391-400. View Abstract
  213. Arslan, S. O., Zerin, M., Vural, H., and Coskun, A. The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats. J Pineal Res 2002;32(1):21-25. View Abstract
  214. Vijayalaxmi, Reiter, R. J., Tan, D. X., Herman, T. S., and Thomas, C. R., Jr. Melatonin as a radioprotective agent: a review. Int.J Radiat.Oncol.Biol.Phys. 7-1-2004;59(3):639-653. View Abstract
  215. Sharma, S., Haldar, C., Chaube, S. K., Laxmi, T., and Singh, S. S. Long-term melatonin administration attenuates low-LET gamma-radiation-induced lymphatic tissue injury during the reproductively active and inactive phases of Indian palm squirrels (Funambulus pennanti). Br.J.Radiol. 2010;83(986):137-151. View Abstract
  216. Liu, Y., Zhang, H., Zhang, L., Zhang, X., Xie, Y., and Zhao, W. Melatonin modulates acute testicular damage induced by carbon ions in mice. Pharmazie 2009;64(10):685-689. View Abstract
  217. Assayed, M. E. and Abd El-Aty, A. M. Protection of rat chromosomes by melatonin against gamma radiation-induced damage. Mutat.Res. 2009;677(1-2):14-20. View Abstract
  218. Hamada, N. Recent insights into the biological action of heavy-ion radiation. J.Radiat.Res. 2009;50(1):1-9. View Abstract
  219. Manda, K., Ueno, M., and Anzai, K. Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: attenuation by melatonin pretreatment. J.Pineal Res. 2009;46(1):71-78. View Abstract
  220. Xu, G. X., Xiao, Z. Y., Xie, M. S., Feng, Y. L., Guo, J., and Fu, L. X. [Protective effects of melatonin on cultural human retinal pigment epithelial cells against oxidative damage in vitro]. Zhonghua Yan.Ke.Za Zhi. 2009;45(6):528-532. View Abstract
  221. Baba, K., Pozdeyev, N., Mazzoni, F., Contreras-Alcantara, S., Liu, C., Kasamatsu, M., Martinez-Merlos, T., Strettoi, E., Iuvone, P. M., and Tosini, G. Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor. Proc.Natl.Acad.Sci.U.S.A 9-1-2009;106(35):15043-15048. View Abstract
  222. Kaur, C., Sivakumar, V., Foulds, W. S., Luu, C. D., and Ling, E. A. Cellular and vascular changes in the retina of neonatal rats after an acute exposure to hypoxia. Invest Ophthalmol.Vis.Sci. 2009;50(11):5364-5374. View Abstract
  223. Zhang, J., Hu, D. H., Chen, G., Bai, X. Z., and Tang, C. W. [Protective effect of melatonin on oxidative stress inducing hair follicle injury in scald rat]. Zhonghua Shao Shang Za Zhi. 2009;25(2):129-132. View Abstract
  224. Escames, G., Acuna-Castroviejo, D., Lopez, L. C., Tan, D. X., Maldonado, M. D., Sanchez-Hidalgo, M., Leon, J., and Reiter, R. J. Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence. J Pharm.Pharmacol 2006;58(9):1153-1165. View Abstract
  225. Gitto, E., Karbownik, M., Reiter, R. J., Tan, D. X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimarchi, G., and Barberi, I. Effects of melatonin treatment in septic newborns. Pediatr Res 2001;50(6):756-760. View Abstract
  226. Rinaldi, S., Landucci, F., and De Gaudio, A. R. Antioxidant therapy in critically septic patients. Curr.Drug Targets. 2009;10(9):872-880. View Abstract
  227. Cuzzocrea, S. and Reiter, R. J. Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury. Eur J Pharmacol 8-24-2001;426(1-2):1-10. View Abstract
  228. Maestroni, G. J. Melatonin as a therapeutic agent in experimental endotoxic shock. J Pineal Res 1996;20(2):84-89. View Abstract
  229. Topsakal, C., Kilic, N., Ozveren, F., Akdemir, I., Kaplan, M., Tiftikci, M., and Gursu, F. Effects of Prostaglandin E1, Melatonin, and Oxytetracycline on Lipid Peroxidation, Antioxidant Defense System, Paraoxonase (PON1) Activities, and Homocysteine Levels in an Animal Model of Spinal Cord Injury. Spine 8-1-2003;28(15):1643-1652. View Abstract
  230. Park, K., Lee, Y., Park, S., Lee, S., Hong, Y., Kil, Lee S., and Hong, Y. Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model. J.Pineal Res. 2010;48(3):270-281. View Abstract
  231. Esposito, E., Genovese, T., Caminiti, R., Bramanti, P., Meli, R., and Cuzzocrea, S. Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury. J.Pineal Res. 2009;46(1):79-86. View Abstract
  232. Machida, M., Dubousset, J., Imamura, Y., Miyashita, Y., Yamada, T., and Kimura, J. Melatonin. A possible role in pathogenesis of adolescent idiopathic scoliosis. Spine 5-15-1996;21(10):1147-1152. View Abstract
  233. Machida, M., Dubousset, J., Yamada, T., and Kimura, J. Serum melatonin levels in adolescent idiopathic scoliosis prediction and prevention for curve progression–a prospective study. J.Pineal Res. 2009;46(3):344-348. View Abstract
  234. Papathanassoglou, E. D., Giannakopoulou, M., Mpouzika, M., Bozas, E., and Karabinis, A. Potential effects of stress in critical illness through the role of stress neuropeptides. Nurs.Crit Care 2010;15(4):204-216. View Abstract
  235. Sparks, D. L. and Hunsaker, J. C., III. The pineal gland in sudden infant death syndrome: preliminary observations. J Pineal Res 1988;5(1):111-118. View Abstract
  236. Sturner, W. Q., Lynch, H. J., Deng, M. H., Gleason, R. E., and Wurtman, R. J. Melatonin concentrations in the sudden infant death syndrome. Forensic Sci.Int 1990;45(1-2):171-180. View Abstract
  237. Maurizi, C. P. Could exogenous melatonin prevent sudden infant death syndrome? Med Hypotheses 1997;49(5):425-427. View Abstract
  238. Semercioz, A., Onur, R., Ogras, S., and Orhan, I. Effects of melatonin on testicular tissue nitric oxide level and antioxidant enzyme activities in experimentally induced left varicocele. Neuroendocrinol.Lett. 2003;24(1-2):86-90. View Abstract
  239. El-Sokkary, G. H., Nafady, A. A., and Shabash, E. H. Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat. Ecotoxicol.Environ.Saf 2010;73(3):456-463. View Abstract
  240. Miler, E. A., Nudler, S. I., Quinteros, F. A., Cabilla, J. P., Ronchetti, S. A., and Duvilanski, B. H. Cadmium induced-oxidative stress in pituitary gland is reversed by removing the contamination source. Hum.Exp.Toxicol. 2010;29(10):873-880. View Abstract
  241. Songur, A., Ozen, O. A., and Sarsilmaz, M. The toxic effects of formaldehyde on the nervous system. Rev.Environ.Contam Toxicol. 2010;203:105-118. View Abstract
  242. Rao, M. V. and Chhunchha, B. Protective role of melatonin against the mercury induced oxidative stress in the rat thyroid. Food Chem.Toxicol. 2010;48(1):7-10. View Abstract
  243. Rao, M. V., Purohit, A., and Patel, T. Melatonin protection on mercury-exerted brain toxicity in the rat. Drug Chem.Toxicol. 2010;33(2):209-216. View Abstract
  244. Sirajudeen, M., Gopi, K., Tyagi, J. S., Moudgal, R. P., Mohan, J., and Singh, R. Protective effects of melatonin in reduction of oxidative damage and immunosuppression induced by aflatoxin B1-contaminated diets in young chicks. Environ.Toxicol. 2011;26(2):153-160. View Abstract
  245. Ozen, H., Karaman, M., Cigremis, Y., Tuzcu, M., Ozcan, K., and Erdag, D. Effectiveness of melatonin on aflatoxicosis in chicks. Res.Vet.Sci. 2009;86(3):485-489. View Abstract
  246. Garcia, T., Esparza, J. L., Giralt, M., Romeu, M., Domingo, J. L., and Gomez, M. Protective role of melatonin on oxidative stress status and RNA expression in cerebral cortex and cerebellum of AbetaPP transgenic mice after chronic exposure to aluminum. Biol.Trace Elem.Res. 2010;135(1-3):220-232. View Abstract
  247. Garcia, T., Ribes, D., Colomina, M. T., Cabre, M., Domingo, J. L., and Gomez, M. Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer’s disease. Toxicology 11-9-2009;265(1-2):49-55. View Abstract
  248. Garcia, T., Esparza, J. L., Nogues, M. R., Romeu, M., Domingo, J. L., and Gomez, M. Oxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer’s disease after chronic exposure to aluminum. Hippocampus 2010;20(1):218-225. View Abstract
  249. Mahieu, S., Contini, Mdel C., Gonzalez, M., and Millen, N. Melatonin reduces oxidative damage induced by aluminium in rat kidney. Toxicol.Lett. 10-8-2009;190(1):9-15. View Abstract
  250. Yoo, Y. M. and Jeung, E. B. Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells. J.Pineal Res. 2010;48(3):204-211. View Abstract
  251. Kurus, M., Esrefoglu, M., Sogutlu, G., and Atasever, A. Melatonin prevents cyclosporine-induced hepatotoxicity in rats. Med.Princ.Pract. 2009;18(5):407-410. View Abstract
  252. Rezzani, R., Rodella, L. F., Fraschini, F., Gasco, M. R., Demartini, G., Musicanti, C., and Reiter, R. J. Melatonin delivery in solid lipid nanoparticles: prevention of cyclosporine A induced cardiac damage. J.Pineal Res. 2009;46(3):255-261. View Abstract
  253. Esrefoglu, M., Kurus, M., and Sahna, E. The beneficial effect of melatonin on chronic cyclosporin A nephrotoxicity in rats. J Int Med Res 2003;31(1):42-44. View Abstract
  254. Longoni, B., Migliori, M., Ferretti, A., Origlia, N., Panichi, V., Boggi, U., Filippi, C., Cuttano, M. G., Giovannini, L., and Mosca, F. Melatonin prevents cyclosporine-induced nephrotoxicity in isolated and perfused rat kidney. Free Radic.Res 2002;36(3):357-363. View Abstract
  255. Kim, J. B., Jung, J. Y., Ahn, J. C., Rhee, C. K., and Hwang, H. J. Antioxidant and anti-apoptotic effect of melatonin on the vestibular hair cells of rat utricles. Clin.Exp.Otorhinolaryngol. 2009;2(1):6-12. View Abstract
  256. Ye, L. F., Tao, Z. Z., Hua, Q. Q., Xiao, B. K., Zhou, X. H., Li, J., and Yuan, Y. L. Protective effect of melatonin against gentamicin ototoxicity. J.Laryngol.Otol. 2009;123(6):598-602. View Abstract
  257. El Sokkary, G. H., Kamel, E. S., and Reiter, R. J. Prophylactic effect of melatonin in reducing lead-induced neurotoxicity in the rat. Cell Mol.Biol.Lett. 2003;8(2):461-470. View Abstract
  258. Cemek, M., Emin, Buyukokuroglu M., Yurumez, Y., Yavuz, Y., Aslan, A., Buyukben, A., and Aymelek, F. Tissue trace and major element levels in organophosphate insecticide fenthion (Lebaycid) toxicity in rats: prophylactic and therapeutic effect of exogenous melatonin. Ecotoxicol.Environ.Saf 2010;73(2):206-212. View Abstract
  259. Sarabia, L., Maurer, I., and Bustos-Obregon, E. Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA. Ecotoxicol.Environ.Saf 2009;72(2):663-668. View Abstract
  260. Sarabia, L., Maurer, I., and Bustos-Obregon, E. Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on the mouse testis. Ecotoxicol.Environ.Saf 2009;72(3):938-942. View Abstract
  261. Sonmez, M. F., Narin, F., Akkus, D., and Ozdamar, S. Effect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic rats. Toxicol.Ind.Health 2009;25(6):385-393. View Abstract
  262. Baydas, G., Reiter, R. J., Nedzvetskii, V. S., Yasar, A., Tuzcu, M., Ozveren, F., and Canatan, H. Melatonin protects the central nervous system of rats against toluene-containing thinner intoxication by reducing reactive gliosis. Toxicol.Lett. 2-3-2003;137(3):169-174. View Abstract
  263. Wiid, I., Hoal-van Helden, E., Hon, D., Lombard, C., and van Helden, P. Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin. Antimicrob.Agents Chemother. 1999;43(4):975-977. View Abstract
  264. Schlabritz-Loutsevitch, N., Hellner, N., Middendorf, R., Muller, D., and Olcese, J. The human myometrium as a target for melatonin. J Clin Endocrinol.Metab 2003;88(2):908-913. View Abstract
  265. Parmar, P., Limson, J., Nyokong, T., and Daya, S. Melatonin protects against copper-mediated free radical damage. J Pineal Res 2002;32(4):237-242. View Abstract
  266. Cemek, M., Buyukokuroglu, M. E., Hazman, O., Bulut, S., Konuk, M., and Birdane, Y. Antioxidant enzyme and element status in heroin addiction or heroin withdrawal in rats: effect of melatonin and vitamin E plus Se. Biol.Trace Elem.Res. 2011;139(1):41-54. View Abstract
  267. Wei, Y. M., Xu, Y., Yu, C. X., and Han, J. Melatonin enhances the expression of beta-endorphin in hypothalamic arcuate nucleus of morphine-dependent mice. Sheng Li Xue.Bao. 6-25-2009;61(3):255-262. View Abstract
  268. Basak, P. Y., Agalar, F., Gultekin, F., Eroglu, E., Altuntas, I., and Agalar, C. The effect of thermal injury and melatonin on incisional wound healing. Ulus.Travma.Derg. 2003;9(2):96-101. View Abstract
  269. Kalpakcioglu, B. and Senel, K. The role of melatonin in rheumatic diseases. Infect.Disord.Drug Targets. 2009;9(4):453-456. View Abstract
  270. Jung-Hynes, B., Reiter, R. J., and Ahmad, N. Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J.Pineal Res. 2010;48(1):9-19. View Abstract
  271. Simko, F. and Pechanova, O. Potential roles of melatonin and chronotherapy among the new trends in hypertension treatment. J.Pineal Res. 2009;47(2):127-133. View Abstract
  272. Korkmaz, A., Reiter, R. J., Topal, T., Manchester, L. C., Oter, S., and Tan, D. X. Melatonin: an established antioxidant worthy of use in clinical trials. Mol.Med. 2009;15(1-2):43-50. View Abstract
  273. de Souza, Pereira R. Regression of an esophageal ulcer using a dietary supplement containing melatonin. J Pineal Res 2006;40(4):355-356. View Abstract
  274. Malinovskaia, N. K., Komarova, F. I., Rapoport, S. I., Raikhlin, N. T., Kvetnoi, I. M., Lakshin, A. A., Voznesenskaia, L. A., and Rasulov, M. I. [Melatonin in treatment of duodenal ulcer]. Klin.Med (Mosk) 2006;84(1):5-11. View Abstract
  275. Terry, P. D., Villinger, F., Bubenik, G. A., and Sitaraman, S. V. Melatonin and ulcerative colitis: evidence, biological mechanisms, and future research. Inflamm.Bowel.Dis. 2009;15(1):134-140. View Abstract
  276. Leston, J., Mottolese, C., Champier, J., Jouvet, A., Brun, J., Sindou, M., Chazot, G., Claustrat, B., and Fevre-Montange, M. Contribution of the daily melatonin profile to diagnosis of tumors of the pineal region. J.Neurooncol. 2009;93(3):387-394. View Abstract
  277. Fiorina, P., Lattuada, G., Ponari, O., Silvestrini, C., and DallAglio, P. Impaired nocturnal melatonin excretion and changes of immunological status in ischaemic stroke patients. Lancet 3-9-1996;347(9002):692-693. View Abstract
  278. Kondoh, T., Uneyama, H., Nishino, H., and Torii, K. Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats. Life Sci. 12-20-2002;72(4-5):583-590. View Abstract
  279. Lin, H. W. and Lee, E. J. Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages. Neuropsychiatr.Dis.Treat. 2009;5:157-162. View Abstract
  280. Zarazaga, L. A., Gatica, M. C., Celi, I., Guzman, J. L., and Malpaux, B. Effect of melatonin implants on sexual activity in Mediterranean goat females without separation from males. Theriogenology 10-15-2009;72(7):910-918. View Abstract
  281. Richardson-Andrews, R. C. The sunspot theory of schizophrenia: further evidence, a change of mechanism, and a strategy for the elimination of the disorder. Med.Hypotheses 2009;72(1):95-98. View Abstract
  282. Acikel, M., Buyukokuroglu, M. E., Aksoy, H., Erdogan, F., and Erol, M. K. Protective effects of melatonin against myocardial injury induced by isoproterenol in rats. J Pineal Res 2003;35(2):75-79. View Abstract
  283. Chen, Z., Chua, C. C., Gao, J., Hamdy, R. C., and Chua, B. H. Protective effect of melatonin on myocardial infarction. Am.J Physiol Heart Circ.Physiol 2003;284(5):H1618-H1624. View Abstract
  284. Claustrat, B., Chazot, G., Brun, J., Jordan, D., and Sassolas, G. A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression. Biol Psychiatry 1984;19(8):1215-1228. View Abstract
  285. Beck-Friis, J., Kjellman, B. F., Aperia, B., Unden, F., von Rosen, D., Ljunggren, J. G., and Wetterberg, L. Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand 1985;71(4):319-330. View Abstract
  286. Brown, R., Kocsis, J. H., Caroff, S., Amsterdam, J., Winokur, A., Stokes, P. E., and Frazer, A. Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects. Am J Psychiatry 1985;142(7):811-816. View Abstract
  287. Forbes-Robertson, S., Dudley, E., Vadgama, P., Cook, C., Drawer, S., and Kilduff, L. Circadian disruption and remedial interventions: effects and interventions for jet lag for athletic peak performance. Sports Med. 3-1-2012;42(3):185-208. View Abstract
  288. No author. [Significance of correlation between weather factors and hemodynamic parameters in patients with arterial hypertension and coronary heart desease receiving traditional treatment and combined therapy with melatonin]. Klin.Med.(Mosk) 2011;89(5):49-53. View Abstract
  289. Tabet, N. and Howard, R. Pharmacological treatment for the prevention of delirium: review of current evidence. Int.J.Geriatr.Psychiatry 2009;24(10):1037-1044. View Abstract
  290. Hanania, M. and Kitain, E. Melatonin for treatment and prevention of postoperative delirium. Anesth.Analg. 2002;94(2):338-9, table. View Abstract
  291. Ito, T. [Delirium, insomnia in hospitalization and ramelteon]. Nihon Rinsho 2012;70(5):907-913. View Abstract
  292. Berra, B. and Rizzo, A. M. Melatonin: circadian rhythm regulator, chronobiotic, antioxidant and beyond. Clin.Dermatol. 2009;27(2):202-209. View Abstract
  293. Dong, W., Huang, F., Fan, W., Cheng, S., Chen, Y., Zhang, W., Shi, H., and He, H. Differential effects of melatonin on amyloid-beta peptide 25-35-induced mitochondrial dysfunction in hippocampal neurons at different stages of culture. J.Pineal Res. 2010;48(2):117-125. View Abstract
  294. Spuch, C., Antequera, D., Isabel Fernandez-Bachiller, M., Isabel Rodriguez-Franco, M., and Carro, E. A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer’s disease. Neurotox.Res. 2010;17(4):421-431. View Abstract
  295. Hoppe, J. B., Frozza, R. L., Horn, A. P., Comiran, R. A., Bernardi, A., Campos, M. M., Battastini, A. M., and Salbego, C. Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation. J.Pineal Res. 2010;48(3):230-238. View Abstract
  296. Acuna-Castroviejo, D., Escames, G., Macias, M., Munoz, Hoyos A., Molina, Carballo A., Arauzo, M., and Montes, R. Cell protective role of melatonin in the brain. J Pineal Res 1995;19(2):57-63. View Abstract
  297. Srinivasan, V., Pandi-Perumal, S. R., Spence, D. W., Moscovitch, A., Trakht, I., Brown, G. M., and Cardinali, D. P. Potential use of melatonergic drugs in analgesia: mechanisms of action. Brain Res.Bull. 3-16-2010;81(4-5):362-371. View Abstract
  298. Ambriz-Tututi, M., Rocha-Gonzalez, H. I., Cruz, S. L., and Granados-Soto, V. Melatonin: a hormone that modulates pain. Life Sci. 4-10-2009;84(15-16):489-498. View Abstract
  299. Dominguez-Rodriguez, A., Abreu-Gonzalez, P., and Reiter, R. J. Clinical aspects of melatonin in the acute coronary syndrome. Curr.Vasc.Pharmacol. 2009;7(3):367-373. View Abstract
  300. Rodella, L. F., Filippini, F., Bonomini, F., Bresciani, R., Reiter, R. J., and Rezzani, R. Beneficial effects of melatonin on nicotine-induced vasculopathy. J.Pineal Res. 2010;48(2):126-132. View Abstract
  301. Simko, F., Pechanova, O., Pelouch, V., Krajcirovicova, K., Mullerova, M., Bednarova, K., Adamcova, M., and Paulis, L. Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats. J.Hypertens.Suppl 2009;27(6):S5-10. View Abstract
  302. Paulis, L., Pechanova, O., Zicha, J., Krajcirovicova, K., Barta, A., Pelouch, V., Adamcova, M., and Simko, F. Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats. J.Hypertens.Suppl 2009;27(6):S11-S16. View Abstract
  303. Dong, W. G., Mei, Q., Yu, J. P., Xu, J. M., Xiang, L., and Xu, Y. Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis. World J Gastroenterol. 2003;9(6):1307-1311. View Abstract
  304. Jan, J. E. and Freeman, R. D. Re: Mann–melatonin for ulcerative colitis? Am.J Gastroenterol. 2003;98(6):1446. View Abstract
  305. Mann, S. Melatonin for ulcerative colitis? Am.J Gastroenterol. 2003;98(1):232-233. View Abstract
  306. Lisitsa, G. V., Zaslavskaia, R. M., and Kalinina, E. V. [Effectiveness of metabolic preparations in complex treatment of elderly patients with postinfarction cardiosclerosis and circulatory insufficiency]. Klin.Med (Mosk) 2005;83(3):54-57. View Abstract
  307. Moezi, L., Nasiripoor, S., Mohajer, V., Maghsoodi, M., Samini, M., and Dehpour, A. R. Gastric healing effect of melatonin against different gastroinvasive agents in cholestatic rats. Pathophysiology. 2010;17(1):65-70. View Abstract
  308. Ganguly, K. and Swarnakar, S. Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. J.Pineal Res. 2009;47(1):43-55. View Abstract
  309. Jaworek, J., Brzozowski, T., and Konturek, S. J. Melatonin as an organoprotector in the stomach and the pancreas. J Pineal Res 2005;38(2):73-83. View Abstract
  310. Thor, P. J., Krolczyk, G., Gil, K., Zurowski, D., and Nowak, L. Melatonin and serotonin effects on gastrointestinal motility. J Physiol Pharmacol 2007;58 Suppl 6:97-103. View Abstract
  311. Pereira, Rde S. Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole. J Pineal Res 2006;41(3):195-200. View Abstract
  312. Delagrange, P., Atkinson, J., Boutin, J. A., Casteilla, L., Lesieur, D., Misslin, R., Pellissier, S., Penicaud, L., and Renard, P. Therapeutic perspectives for melatonin agonists and antagonists. J Neuroendocrinol. 2003;15(4):442-448. View Abstract
  313. Leardi, S., Tavone, E., Cianca, G., Barnabei, R., Necozione, S., Citone, G., and Simi, M. [The role of melatonin in the immediate postoperative period in elderly patients]. Minerva Chir 2000;55(11):745-750. View Abstract
  314. Ersoz, N., Ozler, M., Altinel, O., Sadir, S., Ozerhan, I. H., Uysal, B., Topal, T., Guven, A., and Korkmaz, A. Melatonin prevents peritoneal adhesions in rats. J.Gastroenterol.Hepatol. 2009;24(11):1763-1767. View Abstract
  315. Kucukakin, B., Gogenur, I., Reiter, R. J., and Rosenberg, J. Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin? J.Surg.Res. 2009;152(2):338-347. View Abstract
  316. Saeidi, M., Sobhani, R., Movahedi, M., Alsaeidi, S., and Samani, R. E. Effect of melatonin in the prevention of postoperative pericardial adhesion formation. Interact.Cardiovasc.Thorac.Surg. 2009;9(1):26-28. View Abstract
  317. Tasset, I., Medina, F. J., Pena, J., Jimena, I., Del Carmen, Munoz M., Salcedo, M., Ruiz, C., Feijoo, M., Montilla, P., and Tunez, I. Olfactory bulbectomy induced oxidative and cell damage in rat: protective effect of melatonin. Physiol Res. 2010;59(1):105-112. View Abstract
  318. Aritas, Y., Akcan, A., Erdogan, A. R., Akgun, H., Saraymen, R., and Akyildiz, H. Effects of melatonin and phospholipid on adhesion formation and correlation with vascular endothelial growth factor expression in rats. Ulus.Travma.Acil.Cerrahi.Derg. 2009;15(5):416-422. View Abstract
  319. Koc, O., Duran, B., Topcuoglu, A., Bugdayci, G., Yilmaz, F., and Donmez, M. Intraperitoneal administration of single dose type I collagen or low dose melatonin to prevent intraperitoneal adhesion formation: a comparative study. Eur.J.Obstet.Gynecol.Reprod.Biol. 2009;145(2):209-213. View Abstract
  320. Erol, F. S., Kavakli, A., Ilhan, N., Ozercan, I. H., and Sarsilmaz, M. Efects of melatonin and octreotide on peridural fibrosis in an animal model of laminectomy. Turk.Neurosurg. 2010;20(1):50-56. View Abstract
  321. Wilhelmsen, M., Rosenberg, J., and Gogenur, I. [Anxiolytical, analgesic and sedative effects of melatonin in the perioperative phase]. Ugeskr.Laeger 5-16-2011;173(20):1424-1427. View Abstract
  322. Attenburrow, M. E., Dowling, B. A., Sharpley, A. L., and Cowen, P. J. Case-control study of evening melatonin concentration in primary insomnia. BMJ 5-18-1996;312(7041):1263-1264. View Abstract
  323. Arendt, J. Melatonin. BMJ 5-18-1996;312(7041):1242-1243. View Abstract
  324. Perrig, S., Espa-Cervena, K., and Pepin, J. L. [Sleep disorder and pain: the good hypnotic]. Rev.Med.Suisse 6-29-2011;7(301):1414-8, 1420. View Abstract
  325. Boyko, Y., Ording, H., and Jennum, P. Sleep disturbances in critically ill patients in ICU: how much do we know? Acta Anaesthesiol.Scand. 2012;56(8):950-958. View Abstract
  326. Moura, L. M., Bezerra, J. M., and Fleming, N. R. Treatment of hemicrania continua: case series and literature review. Rev.Bras.Anestesiol. 2012;62(2):173-187. View Abstract
  327. Baksheev, V. I. and Kolomoets, N. M. [Melatonin in the system of neurohormonal regulation in man. Part 1]. Klin.Med.(Mosk) 2011;89(1):4-10. View Abstract
  328. Sekeroglu, M. R., Huyut, Z., and Him, A. The susceptibility of erythrocytes to oxidation during storage of blood: effects of melatonin and propofol. Clin.Biochem. 2012;45(4-5):315-319. View Abstract
  329. Girschik, J., Glass, D., Ambrosini, G. L., and Fritschi, L. Could mining be protective against prostate cancer? A study and literature review. Occup.Environ.Med. 2010;67(6):365-374. View Abstract
  330. Bjorvatn, B. and Pallesen, S. A practical approach to circadian rhythm sleep disorders. Sleep Med.Rev. 2009;13(1):47-60. View Abstract
  331. Kamperis, K., Hagstroem, S., Radvanska, E., Rittig, S., and Djurhuus, J. C. Excess diuresis and natriuresis during acute sleep deprivation in healthy adults. Am.J.Physiol Renal Physiol 2010;299(2):F404-F411. View Abstract
  332. Dijk, D. J., Duffy, J. F., Silva, E. J., Shanahan, T. L., Boivin, D. B., and Czeisler, C. A. Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans. PLoS.One. 2012;7(2):e30037. View Abstract
  333. Figueiro, M. G., Wood, B., Plitnick, B., and Rea, M. S. The impact of light from computer monitors on melatonin levels in college students. Neuro.Endocrinol.Lett. 2011;32(2):158-163. View Abstract
  334. Mishima, K., Okawa, M., Shimizu, T., and Hishikawa, Y. Diminished melatonin secretion in the elderly caused by insufficient environmental illumination. J.Clin.Endocrinol.Metab 2001;86(1):129-134. View Abstract
  335. Commentz, J. C., Uhlig, H., Henke, A., Hellwege, H. H., and Willig, R. P. Melatonin and 6-hydroxymelatonin sulfate excretion is inversely correlated with gonadal development in children. Horm.Res. 1997;47(3):97-101. View Abstract
  336. Salti, R., Galluzzi, F., Bindi, G., Perfetto, F., Tarquini, R., Halberg, F., and Cornelissen, G. Nocturnal melatonin patterns in children. J.Clin.Endocrinol.Metab 2000;85(6):2137-2144. View Abstract
  337. Webb, E. A., O’Reilly, M. A., Orgill, J., Dale, N., Salt, A., Gringras, P., and Dattani, M. T. Rest-activity disturbances in children with septo-optic dysplasia characterized by actigraphy and 24-hour plasma melatonin profiles. J.Clin.Endocrinol.Metab 2010;95(10):E198-E203. View Abstract
  338. Sivan, Y., Laudon, M., Kuint, J., and Zisapel, N. Low melatonin production in infants with a life-threatening event. Dev.Med.Child Neurol. 2000;42(7):487-491. View Abstract
  339. Taub, L. F. Making the diagnosis: idiopathic rapid eye movement sleep behavior disorder. J.Am.Acad.Nurse Pract. 2010;22(7):346-351. View Abstract
  340. Carter, K. A., Lettieri, C. J., and Pena, J. M. An unusual cause of insomnia following IED-induced traumatic brain injury. J.Clin.Sleep Med. 4-15-2010;6(2):205-206. View Abstract
  341. Bazil, C. W., Short, D., Crispin, D., and Zheng, W. Patients with intractable epilepsy have low melatonin, which increases following seizures. Neurology 12-12-2000;55(11):1746-1748. View Abstract
  342. Schapel, G. J., Beran, R. G., Kennaway, D. L., McLoughney, J., and Matthews, C. D. Melatonin response in active epilepsy. Epilepsia 1995;36(1):75-78. View Abstract
  343. Burgess, H. J., Swanson, G. R., and Keshavarzian, A. Endogenous melatonin profiles in asymptomatic inflammatory bowel disease. Scand.J.Gastroenterol. 2010;45(6):759-761. View Abstract
  344. Peres, M. F., Seabra, M. L., Zukerman, E., and Tufik, S. Cluster headache and melatonin. Lancet 1-8-2000;355(9198):147. View Abstract
  345. Dhillon, K. S., Singh, J., and Lyall, J. S. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses 2011;77(1):147-151. View Abstract
  346. Duman, O., Durmaz, E., Akcurin, S., Serteser, M., and Haspolat, S. Spontaneous endogenous hypermelatoninemia: a new disease? Horm.Res.Paediatr. 2010;74(6):444-448. View Abstract
  347. Sanders, D. C., Chaturvedi, A. K., and Hordinsky, J. R. Melatonin: aeromedical, toxicopharmacological, and analytical aspects. J.Anal.Toxicol. 1999;23(3):159-167. View Abstract
  348. Sigurdardottir, L. G., Valdimarsdottir, U. A., Fall, K., Rider, J. R., Lockley, S. W., Schernhammer, E., and Mucci, L. A. Circadian disruption, sleep loss, and prostate cancer risk: a systematic review of epidemiologic studies. Cancer Epidemiol.Biomarkers Prev. 2012;21(7):1002-1011. View Abstract
  349. Golnik, A. E. and Ireland, M. Complementary alternative medicine for children with autism: a physician survey. J.Autism Dev.Disord. 2009;39(7):996-1005. View Abstract
  350. Nikles, J., Lo, V., Giam, J. A., and Saini, B. Exploring melatonin prescribing among customers of compounding pharmacies in Australia. Med.J.Aust. 4-2-2012;196(6):384-385. View Abstract
  351. Ghielmini, M., Pagani, O., de Jong, J., Pampallona, S., Conti, A., Maestroni, G., Sessa, C., and Cavalli, F. Double-blind randomized study on the myeloprotective effect of melatonin in combination with carboplatin and etoposide in advanced lung cancer. Br J Cancer 1999;80(7):1058-1061. View Abstract
  352. van Geijlswijk, I. M., Mol, R. H., Egberts, T. C., and Smits, M. G. Evaluation of sleep, puberty and mental health in children with long-term melatonin treatment for chronic idiopathic childhood sleep onset insomnia. Psychopharmacology (Berl) 2011;216(1):111-120. View Abstract
  353. Rossignol, D. A. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann.Clin Psychiatry 2009;21(4):213-236. View Abstract
  354. Guenole, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., and Baleyte, J. M. Melatonin for disordered sleep in individuals with autism spectrum disorders: systematic review and discussion. Sleep Med.Rev. 2011;15(6):379-387. View Abstract
  355. Rossignol, D. A. and Frye, R. E. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev.Med.Child Neurol. 2011;53(9):783-792. View Abstract
  356. van Geijlswijk, I. M., van der Heijden, K. B., Egberts, A. C., Korzilius, H. P., and Smits, M. G. Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT. Psychopharmacology (Berl) 2010;212(3):379-391. View Abstract
  357. Bendz, L. M. and Scates, A. C. Melatonin treatment for insomnia in pediatric patients with attention-deficit/hyperactivity disorder. Ann.Pharmacother. 2010;44(1):185-191. View Abstract
  358. van der Heijden, K. B., Smits, M. G., van Someren, E. J., Ridderinkhof, K. R., and Gunning, W. B. Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia. J Am Acad.Child Adolesc.Psychiatry 2007;46(2):233-241. View Abstract
  359. Cagnacci, A., Arangino, S., Angiolucci, M., Maschio, E., and Melis, G. B. Influences of melatonin administration on the circulation of women. Am J Physiol 1998;274(2 Pt 2):R335-R338. View Abstract
  360. Harris, A. S., Burgess, H. J., and Dawson, D. The effects of day-time exogenous melatonin administration on cardiac autonomic activity. J Pineal Res 2001;31(3):199-205. View Abstract
  361. Arangino, S., Cagnacci, A., Angiolucci, M., Vacca, A. M., Longu, G., Volpe, A., and Melis, G. B. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am.J Cardiol. 5-1-1999;83(9):1417-1419. View Abstract
  362. Kitajima, T., Kanbayashi, T., Saitoh, Y., Ogawa, Y., Sugiyama, T., Kaneko, Y., Sasaki, Y., Aizawa, R., and Shimisu, T. The effects of oral melatonin on the autonomic function in healthy subjects. Psychiatry Clin Neurosci. 2001;55(3):299-300. View Abstract
  363. Nishiyama, K., Yasue, H., Moriyama, Y., Tsunoda, R., Ogawa, H., Yoshimura, M., and Kugiyama, K. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men. Am Heart J 2001;141(5):E9. View Abstract
  364. Cagnacci, A., Arangino, S., Angiolucci, M., Melis, G. B., Facchinetti, F., Malmusi, S., and Volpe, A. Effect of exogenous melatonin on vascular reactivity and nitric oxide in postmenopausal women: role of hormone replacement therapy. Clin Endocrinol (Oxf) 2001;54(2):261-266. View Abstract
  365. Burgess, H. J., Sletten, T., Savic, N., Gilbert, S. S., and Dawson, D. Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night. J Appl.Physiol 2001;91(3):1214-1222. View Abstract
  366. Ismail, S. A. and Mowafi, H. A. Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia. Anesth.Analg. 2009;108(4):1146-1151. View Abstract
  367. Otmani, S., Metzger, D., Guichard, N., Danjou, P., Nir, T., Zisapel, N., and Katz, A. Effects of prolonged-release melatonin and zolpidem on postural stability in older adults. Hum.Psychopharmacol. 2012;27(3):270-276. View Abstract
  368. Lusardi, P., Piazza, E., and Fogari, R. Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. Br.J Clin Pharmacol 2000;49(5):423-427. View Abstract
  369. Zaslavskaia, R. M., Shcherban’, E. A., Lilitsa, G. V., and Logvinenko, S. I. [Melatonin in the combined treatment of cardiovascular diseases]. Klin.Med.(Mosk) 2010;88(3):26-30. View Abstract
  370. Claustrat, B., Brun, J., David, M., Sassolas, G., and Chazot, G. Melatonin and jet lag: confirmatory result using a simplified protocol. Biol.Psychiatry 10-15-1992;32(8):705-711. View Abstract
  371. Herxheimer, A. and Petrie, K. J. Melatonin for the prevention and treatment of jet lag. Cochrane Database.Syst Rev 2002;(2):CD001520. View Abstract
  372. U.S.Food and Drug Administration. Special Nutritionals Adverse Events Monitoring System: registered case reports.
  373. Wade, A. G., Ford, I., Crawford, G., McConnachie, A., Nir, T., Laudon, M., and Zisapel, N. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC.Med. 2010;8:51. View Abstract
  374. Wade, A. G., Crawford, G., Ford, I., McConnachie, A., Nir, T., Laudon, M., and Zisapel, N. Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response. Curr.Med.Res.Opin. 2011;27(1):87-98. View Abstract
  375. Rechcinski, T., Trzos, E., Wierzbowska-Drabik, K., Krzeminska-Pakula, M., and Kurpesa, M. Melatonin for nondippers with coronary artery disease: assessment of blood pressure profile and heart rate variability. Hypertens.Res. 2010;33(1):56-61. View Abstract
  376. Cook, J. S., Sauder, C. L., and Ray, C. A. Melatonin differentially affects vascular blood flow in humans. Am.J.Physiol Heart Circ.Physiol 2011;300(2):H670-H674. View Abstract
  377. Scheer, F. A., Van Montfrans, G. A., van Someren, E. J., Mairuhu, G., and Buijs, R. M. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension 2004;43(2):192-197. View Abstract
  378. Cagnacci, A., Cannoletta, M., Renzi, A., Baldassari, F., Arangino, S., and Volpe, A. Prolonged melatonin administration decreases nocturnal blood pressure in women. Am J Hypertens. 2005;18(12 Pt 1):1614-1618. View Abstract
  379. Garfinkel, D., Laudon, M., Nof, D., and Zisapel, N. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 8-26-1995;346(8974):541-544. View Abstract
  380. Elkhayat, H. A., Hassanein, S. M., Tomoum, H. Y., Abd-Elhamid, I. A., Asaad, T., and Elwakkad, A. S. Melatonin and sleep-related problems in children with intractable epilepsy. Pediatr.Neurol. 2010;42(4):249-254. View Abstract
  381. Papavasiliou, P. S., Cotzias, G. C., Duby, S. E., Steck, A. J., Bell, M., and Lawrence, W. H. Melatonin and parkinsonism. JAMA 7-3-1972;221(1):88-89. View Abstract
  382. Guardiola-Lemaitre, B. Toxicology of melatonin. J Biol Rhythms 1997;12(6):697-706. View Abstract
  383. Rasmussen, D. D., Boldt, B. M., Wilkinson, C. W., Yellon, S. M., and Matsumoto, A. M. Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels. Endocrinology 1999;140(2):1009-1012. View Abstract
  384. Cagnacci, A., Arangino, S., Renzi, A., Paoletti, A. M., Melis, G. B., Cagnacci, P., and Volpe, A. Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women. Clin Endocrinol.(Oxf) 2001;54(3):339-346. View Abstract
  385. Chiodera, P., Volpi, R., Capretti, L., Giuliani, N., Caffarri, G., and Coiro, V. Melatonin inhibits oxytocin response to insulin-induced hypoglycemia, but not to angiotensin II in normal men. J Neural Transm. 1998;105(2-3):173-180. View Abstract
  386. Hussain, S. A., Khadim, H. M., Khalaf, B. H., Ismail, S. H., Hussein, K. I., and Sahib, A. S. Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin. Saudi.Med J 2006;27(10):1483-1488. View Abstract
  387. Kadhim, H. M., Ismail, S. H., Hussein, K. I., Bakir, I. H., Sahib, A. S., Khalaf, B. H., and Hussain, S. A. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J Pineal Res 2006;41(2):189-193. View Abstract
  388. Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Vohra, S., Klassen, T. P., and Baker, G. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ 2-18-2006;332(7538):385-393. View Abstract
  389. Lemoine, P., Nir, T., Laudon, M., and Zisapel, N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res 2007;16(4):372-380. View Abstract
  390. van Geijlswijk, I. M., Korzilius, H. P., and Smits, M. G. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 2010;33(12):1605-1614. View Abstract
  391. Wagner, J., Wagner, M. L., and Hening, W. A. Beyond benzodiazepines: alternative pharmacologic agents for the treatment of insomnia. Ann.Pharmacother. 1998;32(6):680-691. View Abstract
  392. Smits, M. G., van Stel, H. F., van der, Heijden K., Meijer, A. M., Coenen, A. M., and Kerkhof, G. A. Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial. J Am Acad.Child Adolesc.Psychiatry 2003;42(11):1286-1293. View Abstract
  393. Ellis, C. M., Lemmens, G., and Parkes, J. D. Melatonin and insomnia. J Sleep Res 1996;5(1):61-65. View Abstract
  394. Hong, Y. G. and Riegler, J. L. Is melatonin associated with the development of autoimmune hepatitis? J Clin Gastroenterol 1997;25(1):376-378. View Abstract
  395. Calvo, J. R., Guerrero, J. M., Osuna, C., Molinero, P., and Carrillo-Vico, A. Melatonin triggers Crohn’s disease symptoms. J Pineal Res 2002;32(4):277-278. View Abstract
  396. Norsa, A. and Martino, V. Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status. Cancer Biother.Radiopharm. 2006;21(1):68-73. View Abstract
  397. Gupta, M., Aneja, S., and Kohli, K. Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial. J.Child Neurol. 2005;20(2):112-115. View Abstract
  398. Lancioni, G. E., O’Reilly, M. F., and Basili, G. Review of strategies for treating sleep problems in persons with severe or profound mental retardation or multiple handicaps. Am J Ment.Retard. 1999;104(2):170-186. View Abstract
  399. Wirtz, P. H., Spillmann, M., Bartschi, C., Ehlert, U., and von Kanel, R. Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men. J Pineal Res 2008;44(2):127-133. View Abstract
  400. Lamberg, L. Melatonin potentially useful but safety, efficacy remain uncertain. JAMA 10-2-1996;276(13):1011-1014. View Abstract
  401. Regodon, S., del Prado, Miguez M., Jardin, I., Lopez, J. J., Ramos, A., Paredes, S. D., and Rosado, J. A. Melatonin, as an adjuvant-like agent, enhances platelet responsiveness. J.Pineal Res. 2009;46(3):275-285. View Abstract
  402. Lissoni, P., Bucovec, R., Bonfanti, A., Giani, L., Mandelli, A., Roselli, M. G., Rovelli, F., and Fumagalli, L. Thrombopoietic properties of 5-methoxytryptamine plus melatonin versus melatonin alone in the treatment of cancer-related thrombocytopenia. J Pineal Res 2001;30(2):123-126. View Abstract
  403. Lissoni, P., Tancini, G., Paolorossi, F., Mandala, M., Ardizzoia, A., Malugani, F., Giani, L., and Barni, S. Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study. J Pineal Res 1999;26(3):169-173. View Abstract
  404. Lissoni, P., Cazzaniga, M., Tancini, G., Scardino, E., Musci, R., Barni, S., Maffezzini, M., Meroni, T., Rocco, F., Conti, A., and Maestroni, G. Reversal of clinical resistance to LHRH analogue in metastatic prostate cancer by the pineal hormone melatonin: efficacy of LHRH analogue plus melatonin in patients progressing on LHRH analogue alone. Eur Urol. 1997;31(2):178-181. View Abstract
  405. Barni S, Lissoni P, Paolorossi F, and et al. Prevention of chemotherapy-induced thrombocytopenia by the pineal hormone melatonin (MLT) [abstract]. Proc Annu Meet Am Soc Clin Oncol 1996;15:528.
  406. Viviani, S., Negretti, E., Orazi, A., Sozzi, G., Santoro, A., Lissoni, P., Esposti, G., and Fraschini, F. Preliminary studies on melatonin in the treatment of myelodysplastic syndromes following cancer chemotherapy. J Pineal Res 1990;8(4):347-354. View Abstract
  407. Lissoni, P., Barni, S., Brivio, F., Rossini, F., Fumagalli, L., Ardizzoia, A., and Tancini, G. A biological study on the efficacy of low-dose subcutaneous interleukin- 2 plus melatonin in the treatment of cancer-related thrombocytopenia. Oncology 1995;52(5):360-362. View Abstract
  408. Lissoni, P., Barni, S., Brivio, F., Rossini, F., Fumagalli, L., and Tancini, G. Treatment of cancer-related thrombocytopenia by low-dose subcutaneous interleukin-2 plus the pineal hormone melatonin: a biological phase II study. J Biol Regul.Homeost.Agents 1995;9(2):52-54. View Abstract
  409. Todisco, M., Casaccia, P., and Rossi, N. Severe bleeding symptoms in refractory idiopathic thrombocytopenic purpura: a case successfully treated with melatonin. Am.J Ther 2003;10(2):135-136. View Abstract
  410. Todisco, M. and Rossi, N. Melatonin for refractory idiopathic thrombocytopenic purpura: a report of 3 cases. Am.J Ther 2002;9(6):524-526. View Abstract
  411. Arendt, J., Borbely, A. A., Franey, C., and Wright, J. The effects of chronic, small doses of melatonin given in the late afternoon on fatigue in man: a preliminary study. Neurosci.Lett 4-6-1984;45(3):317-321. View Abstract
  412. Lieberman, H. R., Waldhauser, F., Garfield, G., Lynch, H. J., and Wurtman, R. J. Effects of melatonin on human mood and performance. Brain Res 12-10-1984;323(2):201-207. View Abstract
  413. Lieberman, H. R. Behavior, sleep and melatonin. J Neural Transm.Suppl 1986;21:233-241. View Abstract
  414. Arendt, J., Aldhous, M., and Wright, J. Synchronisation of a disturbed sleep-wake cycle in a blind man by melatonin treatment. Lancet 4-2-1988;1(8588):772-773. View Abstract
  415. Nickelsen, T., Demisch, L., Demisch, K., Radermacher, B., and Schoffling, K. Influence of subchronic intake of melatonin at various times of the day on fatigue and hormonal levels: a placebo-controlled, double-blind trial. J Pineal Res 1989;6(4):325-334. View Abstract
  416. Petrie, K., Conaglen, J. V., Thompson, L., and Chamberlain, K. Effect of melatonin on jet lag after long haul flights. BMJ 3-18-1989;298(6675):705-707. View Abstract
  417. MacFarlane, J. G., Cleghorn, J. M., Brown, G. M., and Streiner, D. L. The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study. Biol.Psychiatry 8-15-1991;30(4):371-376. View Abstract
  418. Dollins, A. B., Lynch, H. J., Wurtman, R. J., Deng, M. H., Kischka, K. U., Gleason, R. E., and Lieberman, H. R. Effect of pharmacological daytime doses of melatonin on human mood and performance. Psychopharmacology (Berl) 1993;112(4):490-496. View Abstract
  419. Petrie, K., Dawson, A. G., Thompson, L., and Brook, R. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol.Psychiatry 4-1-1993;33(7):526-530. View Abstract
  420. Middleton, B. A., Stone, B. M., and Arendt, J. Melatonin and fragmented sleep patterns. Lancet 8-24-1996;348(9026):551-552. View Abstract
  421. Arendt, J. Safety of melatonin in long-term use (?). J Biol Rhythms 1997;12(6):673-681. View Abstract
  422. Holliman, B. J. and Chyka, P. A. Problems in assessment of acute melatonin overdose. South.Med J 1997;90(4):451-453. View Abstract
  423. Rogers, N. L., Phan, O., Kennaway, D. J., and Dawson, D. Effect of daytime oral melatonin administration on neurobehavioral performance in humans. J Pineal Res 1998;25(1):47-53. View Abstract
  424. Suhner, A., Schlagenhauf, P., Johnson, R., Tschopp, A., and Steffen, R. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol.Int 1998;15(6):655-666. View Abstract
  425. Suhner A, Schlagenhauf P, Hoefer I, and et al. Efficacy and tolerability of melatonin and zolpidem for the alleviation of jet-lag. 6th Conference of the International Society of Travel Medicine, Montreal, Canada.1999.
  426. Edwards, B. J., Atkinson, G., Waterhouse, J., Reilly, T., Godfrey, R., and Budgett, R. Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics 2000;43(10):1501-1513. View Abstract
  427. Stone, B. M., Turner, C., Mills, S. L., and Nicholson, A. N. Hypnotic activity of melatonin. Sleep 8-1-2000;23(5):663-669. View Abstract
  428. Graw, P., Werth, E., Krauchi, K., Gutzwiller, F., Cajochen, C., and Wirz-Justice, A. Early morning melatonin administration impairs psychomotor vigilance. Behav Brain Res 2001;121(1-2):167-172. View Abstract
  429. Herxheimer, A. and Petrie, K. J. Melatonin for preventing and treating jet lag. Cochrane Database.Syst Rev 2001;(1):CD001520. View Abstract
  430. Morera, A. L., Henry, M., and de, La, V. [Safety in melatonin use]. Actas Esp.Psiquiatr 2001;29(5):334-337. View Abstract
  431. Smits, M. G., Nagtegaal, E. E., van der, Heijden J., Coenen, A. M., and Kerkhof, G. A. Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial. J Child Neurol 2001;16(2):86-92. View Abstract
  432. Suhner, A., Schlagenhauf, P., Hofer, I., Johnson, R., Tschopp, A., and Steffen, R. Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag. Aviat.Space Environ.Med. 2001;72(7):638-646. View Abstract
  433. Tjon Pian Gi, C. V., Broeren, J. P., Starreveld, J. S., and Versteegh, F. G. Melatonin for treatment of sleeping disorders in children with attention deficit/hyperactivity disorder: a preliminary open label study. Eur.J Pediatr. 2003;162(7-8):554-555. View Abstract
  434. Cavallo, A., Ris, M. D., Succop, P., and Jaskiewicz, J. Melatonin treatment of pediatric residents for adaptation to night shift work. Ambul.Pediatr. 2005;5(3):172-177. View Abstract
  435. Dowling, G. A., Mastick, J., Colling, E., Carter, J. H., Singer, C. M., and Aminoff, M. J. Melatonin for sleep disturbances in Parkinson’s disease. Sleep Med 2005;6(5):459-466. View Abstract
  436. Weiss, M. D., Wasdell, M. B., Bomben, M. M., Rea, K. J., and Freeman, R. D. Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia. J Am Acad.Child Adolesc.Psychiatry 2006;45(5):512-519. View Abstract
  437. Bjorvatn, B., Stangenes, K., Oyane, N., Forberg, K., Lowden, A., Holsten, F., and Akerstedt, T. Randomized placebo-controlled field study of the effects of bright light and melatonin in adaptation to night work. Scand.J Work Environ.Health 2007;33(3):204-214. View Abstract
  438. Saha, L., Malhotra, S., Rana, S., Bhasin, D., and Pandhi, P. A preliminary study of melatonin in irritable bowel syndrome. J Clin Gastroenterol. 2007;41(1):29-32. View Abstract
  439. Bonafide, C. P., Aucutt-Walter, N., Divittore, N., King, T., Bixler, E. O., and Cronin, A. J. Remifentanil inhibits rapid eye movement sleep but not the nocturnal melatonin surge in humans. Anesthesiology 2008;108(4):627-633. View Abstract
  440. Alstadhaug, K. B., Odeh, F., Salvesen, R., and Bekkelund, S. I. Prophylaxis of migraine with melatonin: a randomized controlled trial. Neurology 10-26-2010;75(17):1527-1532. View Abstract
  441. Aurora, R. N., Zak, R. S., Maganti, R. K., Auerbach, S. H., Casey, K. R., Chowdhuri, S., Karippot, A., Ramar, K., Kristo, D. A., and Morgenthaler, T. I. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J.Clin.Sleep Med. 2-15-2010;6(1):85-95. View Abstract
  442. Al-Aama, T., Brymer, C., Gutmanis, I., Woolmore-Goodwin, S. M., Esbaugh, J., and Dasgupta, M. Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. Int.J.Geriatr.Psychiatry 2011;26(7):687-694. View Abstract
  443. Grossman, E., Laudon, M., and Zisapel, N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc.Health Risk Manag. 2011;7:577-584. View Abstract
  444. Seppi, K., Weintraub, D., Coelho, M., Perez-Lloret, S., Fox, S. H., Katzenschlager, R., Hametner, E. M., Poewe, W., Rascol, O., Goetz, C. G., and Sampaio, C. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson’s disease. Mov Disord. 2011;26 Suppl 3:S42-S80. View Abstract
  445. Gonciarz, M., Gonciarz, Z., Bielanski, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., and Konturek, S. J. The effects of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study. J.Physiol Pharmacol. 2012;63(1):35-40. View Abstract
  446. Zhdanova, I. V., Wurtman, R. J., Regan, M. M., Taylor, J. A., Shi, J. P., and Leclair, O. U. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab 2001;86(10):4727-4730. View Abstract
  447. Dawson, D., Rogers, N. L., van den Heuvel, C. J., Kennaway, D. J., and Lushington, K. Effect of sustained nocturnal transbuccal melatonin administration on sleep and temperature in elderly insomniacs. J Biol Rhythms 1998;13(6):532-538. View Abstract
  448. Satomura, T., Sakamoto, T., Shirakawa, S., Tsutsumi, Y., Mukai, M., Ohyama, T., Uchimura, N., and Maeda, H. Hypnotic action of melatonin during daytime administration and its comparison with triazolam. Psychiatry Clin Neurosci. 2001;55(3):303-304. View Abstract
  449. Munoz-Hoyos, A., Sanchez-Forte, M., Molina-Carballo, A., Escames, G., Martin-Medina, E., Reiter, R. J., Molina-Font, J. A., and Acuna-Castroviejo, D. Melatonin’s role as an anticonvulsant and neuronal protector: experimental and clinical evidence. J Child Neurol 1998;13(10):501-509. View Abstract
  450. Sandyk, R., Tsagas, N., and Anninos, P. A. Melatonin as a proconvulsive hormone in humans. Int.J.Neurosci. 1992;63(1-2):125-135. View Abstract
  451. Sheldon, S. H. Pro-convulsant effects of oral melatonin in neurologically disabled children. Lancet 4-25-1998;351(9111):1254. View Abstract
  452. Jan, J. E., Hamilton, D., Seward, N., Fast, D. K., Freeman, R. D., and Laudon, M. Clinical trials of controlled-release melatonin in children with sleep- wake cycle disorders. J Pineal Res 2000;29(1):34-39. View Abstract
  453. Brueske V, Allen J, Kepic T, and et al. Melatonin inhibition of seizure activity in man [abstract]. Electroencephalog Clin Neurophysiol 1981;51:20P.
  454. Fauteck, J., Schmidt, H., Lerchl, A., Kurlemann, G., and Wittkowski, W. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol.Signals Recept. 1999;8(1-2):105-110. View Abstract
  455. Jan, J. E., Connolly, M. B., Hamilton, D., Freeman, R. D., and Laudon, M. Melatonin treatment of non-epileptic myoclonus in children. Dev.Med Child Neurol. 1999;41(4):255-259. View Abstract
  456. Molina-Carballo, A., Munoz-Hoyos, A., Reiter, R. J., Sanchez-Forte, M., Moreno-Madrid, F., Rufo-Campos, M., Molina-Font, J. A., and Acuna-Castroviejo, D. Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years’ experience. J Pineal Res 1997;23(2):97-105. View Abstract
  457. Rufo-Campos, M. [Melatonin and epilepsy]. Rev Neurol. 2002;35 Suppl 1:S51-S58. View Abstract
  458. Siddiqui MA, Nazmi AS, Karim S, and et al. Effect of melatonin and valproate in epilepsy and depression. Indian J Pharmacol 2001;33:378-381.
  459. Yi, C., Pan, X., Yan, H., Guo, M., and Pierpaoli, W. Effects of melatonin in age-related macular degeneration. Ann.N.Y Acad.Sci. 2005;1057:384-392. View Abstract
  460. Samples, J. R., Krause, G., and Lewy, A. J. Effect of melatonin on intraocular pressure. Curr Eye Res 1988;7(7):649-653. View Abstract
  461. Viggiano, S. R., Koskela, T. K., Klee, G. G., Samples, J. R., Arnce, R., and Brubaker, R. F. The effect of melatonin on aqueous humor flow in humans during the day. Ophthalmology 1994;101(2):326-331. View Abstract
  462. Force, R. W., Hansen, L., and Bedell, M. Psychotic episode after melatonin. Ann Pharmacother. 1997;31(11):1408. View Abstract
  463. Carman, J. S., Post, R. M., Buswell, R., and Goodwin, F. K. Negative effects of melatonin on depression. Am J Psychiatry 1976;133(10):1181-1186. View Abstract
  464. Forrest, C. M., Mackay, G. M., Stoy, N., Stone, T. W., and Darlington, L. G. Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. Br.J Clin Pharmacol 2007;64(4):517-526. View Abstract
  465. Scott, G. N. and Elmer, G. W. Update on natural product–drug interactions. Am J Health Syst.Pharm 2-15-2002;59(4):339-347. View Abstract
  466. von Bahr, C., Ursing, C., Yasui, N., Tybring, G., Bertilsson, L., and Rojdmark, S. Fluvoxamine but not citalopram increases serum melatonin in healthy subjects– an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin. Eur J Clin Pharmacol 2000;56(2):123-127. View Abstract
  467. Hartter, S., Wang, X., Weigmann, H., Friedberg, T., Arand, M., Oesch, F., and Hiemke, C. Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. J Clin Psychopharmacol 2001;21(2):167-174. View Abstract
  468. El-Batch, M., Hassan, A. M., and Mahmoud, H. A. Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats. J Agric.Food Chem 5-11-2011;59(9):4995-5000. View Abstract
  469. Luboshitzky, R., Shen-Orr, Z., Shochat, T., Herer, P., and Lavie, P. Melatonin administered in the afternoon decreases next-day luteinizing hormone levels in men: lack of antagonism by flumazenil. J Mol.Neurosci. 1999;12(1):75-80. View Abstract
  470. Luboshitzky, R., Levi, M., Shen-Orr, Z., Blumenfeld, Z., Herer, P., and Lavie, P. Long-term melatonin administration does not alter pituitary-gonadal hormone secretion in normal men. Hum Reprod. 2000;15(1):60-65. View Abstract
  471. Etzioni, A., Luboshitzky, R., Tiosano, D., Ben Harush, M., Goldsher, D., and Lavie, P. Melatonin replacement corrects sleep disturbances in a child with pineal tumor. Neurology 1996;46(1):261-263. View Abstract
  472. Cagnacci, A., Paoletti, A. M., Soldani, R., Orru, M., Maschio, E., and Melis, G. B. Melatonin enhances the luteinizing hormone and follicle-stimulating hormone responses to gonadotropin-releasing hormone in the follicular, but not in the luteal, menstrual phase. J Clin Endocrinol Metab 1995;80(4):1095-1099. View Abstract
  473. Cagnacci, A., Soldani, R., and Yen, S. S. Exogenous melatonin enhances luteinizing hormone levels of women in the follicular but not in the luteal menstrual phase. Fertil.Steril. 1995;63(5):996-999. View Abstract
  474. Cagnacci, A., Elliott, J. A., and Yen, S. S. Amplification of pulsatile LH secretion by exogenous melatonin in women. J Clin Endocrinol Metab 1991;73(1):210-212. View Abstract
  475. de Leiva, A., Tortosa, F., Peinado, M. A., Serrano, J., Rodriguez-Espinosa, J., and Puig-Domingo, M. Episodic nyctohemeral secretion of melatonin in adult humans: lack of relation with LH pulsatile pattern. Acta Endocrinol (Copenh) 1990;122(1):76-82. View Abstract
  476. Nordlund, J. J. and Lerner, A. B. The effects of oral melatonin on skin color and on the release of pituitary hormones. J Clin Endocrinol.Metab 1977;45(4):768-774. View Abstract
  477. Azpeleta, C., Martinez-Alvarez, R. M., Delgado, M. J., Isorna, E., and De, Pedro N. Melatonin reduces locomotor activity and circulating cortisol in goldfish. Horm.Behav. 2010;57(3):323-329. View Abstract
  478. Fischer, S., Smolnik, R., Herms, M., Born, J., and Fehm, H. L. Melatonin acutely improves the neuroendocrine architecture of sleep in blind individuals. J Clin Endocrinol.Metab 2003;88(11):5315-5320. View Abstract
  479. Brivio, F., Fumagalli, L., Fumagalli, G., Pescia, S., Brivio, R., DI, Fede G., Rovelli, F., and Lissoni, P. Synchronization of cortisol circadian rhythm by the pineal hormone melatonin in untreatable metastatic solid tumor patients and its possible prognostic significance on tumor progression. In Vivo 2010;24(2):239-241. View Abstract
  480. Hack, L. M., Lockley, S. W., Arendt, J., and Skene, D. J. The effects of low-dose 0.5-mg melatonin on the free-running circadian rhythms of blind subjects. J Biol.Rhythms 2003;18(5):420-429. View Abstract
  481. Cagnacci, A., Soldani, R., and Yen, S. S. Melatonin enhances cortisol levels in aged but not young women. Eur.J Endocrinol. 1995;133(6):691-695. View Abstract
  482. Voordouw, B. C., Euser, R., Verdonk, R. E., Alberda, B. T., de Jong, F. H., Drogendijk, A. C., Fauser, B. C., and Cohen, M. Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation. J.Clin.Endocrinol.Metab 1992;74(1):108-117. View Abstract
  483. Brzezinski, A., Fibich, T., Cohen, M., Schenker, J. G., and Laufer, N. Effects of melatonin on progesterone production by human granulosa lutein cells in culture. Fertil.Steril. 1992;58(3):526-529. View Abstract
  484. Srivastava, R. K. and Krishna, A. Melatonin affects steroidogenesis and delayed ovulation during winter in vespertilionid bat, Scotophilus heathi. J.Steroid Biochem.Mol.Biol. 2010;118(1-2):107-116. View Abstract
  485. Taketani, T., Tamura, H., Takasaki, A., Lee, L., Kizuka, F., Tamura, I., Taniguchi, K., Maekawa, R., Asada, H., Shimamura, K., Reiter, R. J., and Sugino, N. Protective role of melatonin in progesterone production by human luteal cells. J.Pineal Res. 2011;51(2):207-213. View Abstract
  486. Lewinski, A. and Karbownik, M. REVIEW. Melatonin and the thyroid gland. Neuroendocrinol.Lett 2002;23 Suppl 1:73-78. View Abstract
  487. Ramadan, T. A., Taha, T. A., Samak, M. A., and Hassan, A. Effectiveness of exposure to longday followed by melatonin treatment on semen characteristics of Damascus male goats during breeding and non-breeding seasons. Theriogenology 2009;71(3):458-468. View Abstract
  488. Bellipanni, G., Bianchi, P., Pierpaoli, W., Bulian, D., and Ilyia, E. Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study. Exp Gerontol 2001;36(2):297-310. View Abstract
  489. Valenti, S. and Giusti, M. Melatonin participates in the control of testosterone secretion from rat testis: an overview of our experience. Ann.N.Y.Acad.Sci. 2002;966:284-289. View Abstract
  490. Forsling, M. L., Wheeler, M. J., and Williams, A. J. The effect of melatonin administration on pituitary hormone secretion in man. Clin Endocrinol.(Oxf) 1999;51(5):637-642. View Abstract
  491. Valcavi, R., Zini, M., Maestroni, G. J., Conti, A., and Portioli, I. Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone. Clin Endocrinol.(Oxf) 1993;39(2):193-199. View Abstract
  492. Meeking, D. R., Wallace, J. D., Cuneo, R. C., Forsling, M., and Russell-Jones, D. L. Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects. Eur J Endocrinol 1999;141(1):22-26. View Abstract
  493. Valcavi, R., Dieguez, C., Azzarito, C., Edwards, C. A., Dotti, C., Page, M. D., Portioli, I., and Scanlon, M. F. Effect of oral administration of melatonin on GH responses to GRF 1-44 in normal subjects. Clin Endocrinol (Oxf) 1987;26(4):453-458. View Abstract
  494. Smythe, G. A. and Lazarus, L. Growth hormone responses to melatonin in man. Science 6-28-1974;184(144):1373-1374. View Abstract
  495. Perras, B., Ozcan, S., Fehm, H. L., and Born, J. Melatonin does not inhibit hypothalamic-pituitary-adrenal activity in waking young men. J Neuroendocrinol. 2005;17(12):811-816. View Abstract
  496. Terzolo, M., Revelli, A., Guidetti, D., Piovesan, A., Cassoni, P., Paccotti, P., Angeli, A., and Massobrio, M. Evening administration of melatonin enhances the pulsatile secretion of prolactin but not of LH and TSH in normally cycling women. Clin Endocrinol (Oxf) 1993;39(2):185-191. View Abstract
  497. Ninomiya, T., Iwatani, N., Tomoda, A., and Miike, T. Effects of exogenous melatonin on pituitary hormones in humans. Clin Physiol 2001;21(3):292-299. View Abstract
  498. Waldhauser, F., Lieberman, H. R., Lynch, H. J., Waldhauser, M., Herkner, K., Frisch, H., Vierhapper, H., Waldhausl, W., Schemper, M., Wurtman, R. J., and . A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone or cortisol. Neuroendocrinology 1987;46(2):125-130. View Abstract
  499. Petterborg LJ, Thalen BE, Kjellman BF, and et al. Effect of melatonin replacement on serum hormone rhythms in a patient lacking endogenous melatonin. Brain Res Bull 1991;27:181-185.
  500. Kostoglou-Athanassiou, I., Treacher, D. F., Wheeler, M. J., and Forsling, M. L. Melatonin administration and pituitary hormone secretion. Clin Endocrinol (Oxf) 1998;48(1):31-37. View Abstract
  501. Juszczak, M. and Boczek-Leszczyk, E. Hypothalamic gonadotropin-releasing hormone receptor activation stimulates oxytocin release from the rat hypothalamo-neurohypophysial system while melatonin inhibits this process. Brain Res.Bull. 1-15-2010;81(1):185-190. View Abstract
  502. Bojanowska, E. and Forsling, M. L. The effects of melatonin on vasopressin secretion in vivo: interactions with acetylcholine and prostaglandins. Brain Res Bull 1997;42(6):457-461. View Abstract
  503. Mogulkoc, R. and Baltaci, A. K. Effect of melatonin supplementation on plasma vasopressin response to different conditions in rats with hyperthyroidism induced by L-thyroxine. Regul.Pept. 4-9-2010;161(1-3):38-42. View Abstract
  504. Chowdhury, V. S., Yamamoto, K., Ubuka, T., Bentley, G. E., Hattori, A., and Tsutsui, K. Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus. Endocrinology 2010;151(1):271-280. View Abstract
  505. Cagnacci, A., Zanni, A. L., Veneri, M. G., Menozzi, R., Volpe, A., and Rio, G. D. Influence of exogenous melatonin on catecholamine levels in postmenopausal women prior and during oestradiol replacement. Clin Endocrinol (Oxf) 2000;53(3):367-372. View Abstract
  506. Cagnacci, A., Arangino, S., Angiolucci, M., Maschio, E., Longu, G., and Melis, G. B. Potentially beneficial cardiovascular effects of melatonin administration in women. J Pineal Res 1997;22(1):16-19. View Abstract
  507. Cagnacci, A., Arangino, S., Angiolucci, M., Melis, G. B., Tarquini, R., Renzi, A., and Volpe, A. Different circulatory response to melatonin in postmenopausal women without and with hormone replacement therapy. J Pineal Res 2000;29(3):152-158. View Abstract
  508. Mero, A. A., Vahalummukka, M., Hulmi, J. J., Kallio, P., and von Wright, A. Effects of resistance exercise session after oral ingestion of melatonin on physiological and performance responses of adult men. Eur.J Appl.Physiol 2006;96(6):729-739. View Abstract
  509. Neri, B., Fiorelli, C., Moroni, F., Nicita, G., Paoletti, M. C., Ponchietti, R., Raugei, A., Santoni, G., Trippitelli, A., and Grechi, G. Modulation of human lymphoblastoid interferon activity by melatonin in metastatic renal cell carcinoma. A phase II study. Cancer 6-15-1994;73(12):3015-3019. View Abstract
  510. Aldeghi, R., Lissoni, P., Barni, S., Ardizzoia, A., Tancini, G., Piperno, A., Pozzi, M., Ricci, G., Conti, A., and Maestroni, G. J. Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. Eur J Cancer 1994;30A(2):167-170. View Abstract
  511. Barni, S., Lissoni, P., Cazzaniga, M., Ardizzoia, A., Paolorossi, F., Brivio, F., Perego, M., Tancini, G., Conti, A., and Maestroni, G. Neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin as a second-line treatment in metastatic colorectal carcinoma. Tumori 12-31-1992;78(6):383-387. View Abstract
  512. Barni, S., Lissoni, P., Cazzaniga, M., Ardizzoia, A., Meregalli, S., Fossati, V., Fumagalli, L., Brivio, F., and Tancini, G. A randomized study of low-dose subcutaneous interleukin-2 plus melatonin versus supportive care alone in metastatic colorectal cancer patients progressing under 5-fluorouracil and folates. Oncology 1995;52(3):243-245. View Abstract
  513. Bregani, E. R., Lissoni, P., Rossini, F., Barni, S., Tancini, G., Brivio, F., Conti, A., and Maestroni, G. J. Prevention of interleukin-2-induced thrombocytopenia during the immunotherapy of cancer by a concomitant administration of the pineal hormone melatonin. Recenti Prog.Med 1995;86(6):231-233. View Abstract
  514. Brivio F, Lissoni P, Fumagalli L, and et al. Preoperative neuroimmunotherapy with subcutaneous low-dose interleukin-2 and melatonin in patients with gastrointestinal tumors: its efficacy in preventing surgery-induced lymphocytopenia. Oncology Reports 1995;2:597-599.
  515. Lissoni, P., Brivio, F., Barni, S., Tancini, G., Cattaneo, G., Archili, C., Conti, A., and Maestroni, G. J. Neuroimmunotherapy of human cancer with interleukin-2 and the neurohormone melatonin: its efficacy in preventing hypotension. Anticancer Res 1990;10(6):1759-1761. View Abstract
  516. Lissoni, P., Brivio, F., Ardizzoia, A., Tancini, G., and Barni, S. Subcutaneous therapy with low-dose interleukin-2 plus the neurohormone melatonin in metastatic gastric cancer patients with low performance status. Tumori 12-31-1993;79(6):401-404. View Abstract
  517. Lissoni, P., Barni, S., Ardizzoia, A., Olivini, G., Brivio, F., Tisi, E., Tancini, G., Characiejus, D., and Kothari, L. Cancer immunotherapy with low-dose interleukin-2 subcutaneous administration: potential efficacy in most solid tumor histotypes by a concomitant treatment with the pineal hormone melatonin. J Biol Regul Homeost.Agents 1993;7(4):121-125. View Abstract
  518. Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A., Rovelli, F., Cazzaniga, M., Brivio, F., Piperno, A., Aldeghi, R., Fossati, D., and . Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract. Br J Cancer 1993;67(6):1404-1407. View Abstract
  519. Lissoni, P., Barni, S., Rovelli, F., Brivio, F., Ardizzoia, A., Tancini, G., Conti, A., and Maestroni, G. J. Neuroimmunotherapy of advanced solid neoplasms with single evening subcutaneous injection of low-dose interleukin-2 and melatonin: preliminary results. Eur J Cancer 1993;29A(2):185-189. View Abstract
  520. Lissoni, P., Barni, S., Cazzaniga, M., Ardizzoia, A., Rovelli, F., Brivio, F., and Tancini, G. Efficacy of the concomitant administration of the pineal hormone melatonin in cancer immunotherapy with low-dose IL-2 in patients with advanced solid tumors who had progressed on IL-2 alone. Oncology 1994;51(4):344-347. View Abstract
  521. Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A., Ricci, G., Aldeghi, R., Brivio, F., Tisi, E., Rovelli, F., Rescaldani, R., and . A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. Br J Cancer 1994;69(1):196-199. View Abstract
  522. Lissoni, P., Barni, S., Tancini, G., Mainini, E., Piglia, F., Maestroni, G. J., and Lewinski, A. Immunoendocrine therapy with low-dose subcutaneous interleukin-2 plus melatonin of locally advanced or metastatic endocrine tumors. Oncology 1995;52(2):163-166. View Abstract
  523. Lissoni, P., Barni, S., Fossati, V., Ardizzoia, A., Cazzaniga, M., Tancini, G., and Frigerio, F. A randomized study of neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin compared to supportive care alone in patients with untreatable metastatic solid tumour. Support.Care Cancer 1995;3(3):194-197. View Abstract
  524. Lissoni, P., Brivio, F., Brivio, O., Fumagalli, L., Gramazio, F., Rossi, M., Emanuelli, G., Alderi, G., and Lavorato, F. Immune effects of preoperative immunotherapy with high-dose subcutaneous interleukin-2 versus neuroimmunotherapy with low-dose interleukin-2 plus the neurohormone melatonin in gastrointestinal tract tumor patients. J Biol Regul.Homeost.Agents 1995;9(1):31-33. View Abstract
  525. Lissoni, P., Pittalis, S., Ardizzoia, A., Brivio, F., Barni, S., Tancini, G., Pelizzoni, F., Maestroni, G. J., Zubelewicz, B., and Braczkowski, R. Prevention of cytokine-induced hypotension in cancer patients by the pineal hormone melatonin. Support.Care Cancer 1996;4(4):313-316. View Abstract
  526. Lissoni, P., Fumagalli, L., Paolorossi, F., Rovelli, F., Roselli, M. G., and Maestroni, G. J. Anticancer neuroimmunomodulation by pineal hormones other than melatonin: preliminary phase II study of the pineal indole 5- methoxytryptophol in association with low-dose IL-2 and melatonin. J Biol Regul.Homeost.Agents 1997;11(3):119-122. View Abstract
  527. Lissoni P, Barni S, Ardizzoia A, and et al. Immunotherapy with low-dose interleukin-2 in association with melatonin as salvage therapy for metastatic soft tissue sarcomas. Oncology Reports 1997;4:157-159.
  528. Lissoni, P., Barni, S., Mandala, M., Ardizzoia, A., Paolorossi, F., Vaghi, M., Longarini, R., Malugani, F., and Tancini, G. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status. Eur J Cancer 1999;35(12):1688-1692. View Abstract
  529. Brackowski, R., Zubelewicz, B., Romanowski, W., Lissoni, P., Barni, S., Tancini, G., and Maestroni, G. J. Preliminary study on modulation of the biological effects of tumor necrosis factor-alpha in advanced cancer patients by the pineal hormone melatonin. J Biol Regul Homeost.Agents 1994;8(3):77-80. View Abstract
  530. Braczkowski, R., Zubelewicz, B., Romanowski, W., Lissoni, P., and Barni, S. Modulation of tumor necrosis factor-alpha (TNF-alpha) toxicity by the pineal hormone melatonin (MLT) in metastatic solid tumor patients. Ann N Y Acad Sci 9-30-1995;768:334-336. View Abstract
  531. Pignone, A. M., Rosso, A. D., Fiori, G., Matucci-Cerinic, M., Becucci, A., Tempestini, A., Livi, R., Generini, S., Gramigna, L., Benvenuti, C., Carossino, A. M., Conforti, M. L., and Perfetto, F. Melatonin is a safe and effective treatment for chronic pulmonary and extrapulmonary sarcoidosis. J Pineal Res 2006;41(2):95-100. View Abstract
  532. Regodon, S., Ramos, A., Morgado, S., Tarazona, R., Martin-Palomino, P., Rosado, J. A., and Miguez, Mdel P. Melatonin enhances the immune response to vaccination against A1 and C strains of Dichelobacter nodosus. Vaccine 3-4-2009;27(10):1566-1570. View Abstract
  533. Vissers, F. H., Knipschild, P. G., and Crebolder, H. F. Is melatonin helpful in stopping the long-term use of hypnotics? A discontinuation trial. Pharm.World Sci. 2007;29(6):641-646. View Abstract
  534. Maestroni, G. J. The immunotherapeutic potential of melatonin. Expert.Opin Investig Drugs 2001;10(3):467-476. View Abstract
  535. Chen, G., Huo, Y., Tan, D. X., Liang, Z., Zhang, W., and Zhang, Y. Melatonin in Chinese medicinal herbs. Life Sci. 5-23-2003;73(1):19-26. View Abstract
  536. Chen, J. C., Ng, C. J., Chiu, T. F., and Chen, H. M. Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion. J Pineal Res 2003;34(4):260-264. View Abstract
  537. Chen, K. B., Lin, A. M., and Chiu, T. H. Oxidative injury to the locus coeruleus of rat brain: neuroprotection by melatonin. J Pineal Res 2003;35(2):109-117. View Abstract
  538. Baeza, I., Alvarado, C., Alvarez, P., Salazar, V., Castillo, C., Ariznavarreta, C., Fdez-Tresguerres, J. A., and De la Fuente, M. Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens. J.Reprod.Immunol. 2009;80(1-2):70-79. View Abstract
  539. Terron, M. P., Delgado, J., Paredes, S. D., Barriga, C., Reiter, R. J., and Rodriguez, A. B. Effect of melatonin and tryptophan on humoral immunity in young and old ringdoves (Streptopelia risoria). Exp.Gerontol. 2009;44(10):653-658. View Abstract
  540. Cernysiov, V., Gerasimcik, N., Mauricas, M., and Girkontaite, I. Regulation of T-cell-independent and T-cell-dependent antibody production by circadian rhythm and melatonin. Int.Immunol. 2010;22(1):25-34. View Abstract
  541. Tamura, E. K., Cecon, E., Monteiro, A. W., Silva, C. L., and Markus, R. P. Melatonin inhibits LPS-induced NO production in rat endothelial cells. J.Pineal Res. 2009;46(3):268-274. View Abstract
  542. Pedrosa, A. M., Weinlich, R., Mognol, G. P., Robbs, B. K., Viola, J. P., Campa, A., and Amarante-Mendes, G. P. Melatonin protects CD4+ T cells from activation-induced cell death by blocking NFAT-mediated CD95 ligand upregulation. J.Immunol. 4-1-2010;184(7):3487-3494. View Abstract
  543. Zhou, W., Wang, P., and Tao, L. Effect of melatonin on proliferation of neonatal cord blood mononuclear cells. World J.Pediatr. 2009;5(4):300-303. View Abstract
  544. Lissoni, P., Vigore, L., Rescaldani, R., Rovelli, F., Brivio, F., Giani, L., Barni, S., Tancini, G., Ardizzoia, A., and Vigano, M. G. Neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin in AIDS patients with CD4 cell number below 200/mm3: a biological phase-II study. J Biol Regul.Homeost.Agents 1995;9(4):155-158. View Abstract
  545. Vigore, L., Messina, G., Brivio, F., Fumagalli, L., Rovelli, F., DI, Fede G., and Lissoni, P. Psychoneuroendocrine modulation of regulatory T lymphocyte system: in vivo and in vitro effects of the pineal immunomodulating hormone melatonin. In Vivo 2010;24(5):787-789. View Abstract
  546. Abd-Allah, A. R., El Sayed, el SM, Abdel-Wahab, M. H., and Hamada, F. M. Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats. Pharmacol.Res 2003;47(4):349-354. View Abstract
  547. Ciesla, W. Low ACTH and high melatonin concentrations in amniotic fluid as hormonal markers of high risk of fetal abnormalities. Preliminary studies. Prenat.Diagn. 1998;18(9):980-983. View Abstract
  548. Gwayi, N. and Bernard, R. T. The effects of melatonin on sperm motility in vitro in Wistar rats. Andrologia 2002;34(6):391-396. View Abstract
  549. Luboshitzky, R., Shen-Orr, Z., Nave, R., Lavi, S., and Lavie, P. Melatonin administration alters semen quality in healthy men. J Androl 2002;23(4):572-578. View Abstract
  550. Bardazzi F, Placucci F, Neri I, and et al. Fixed drug eruption due to melatonin. Acta Derm Venereol 1997;78:69-70.
  551. Camfield, P., Gordon, K., Dooley, J., and Camfield, C. Melatonin appears ineffective in children with intellectual deficits and fragmented sleep: six “N of 1” trials. J Child Neurol 1996;11(4):341-343. View Abstract
  552. Gitto, E., Aversa, S., Salpietro, C. D., Barberi, I., Arrigo, T., Trimarchi, G., Reiter, R. J., and Pellegrino, S. Pain in neonatal intensive care: role of melatonin as an analgesic antioxidant. J.Pineal Res. 2012;52(3):291-295. View Abstract
  553. Lewy, A. J., Ahmed, S., Jackson, J. M., and Sack, R. L. Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol.Int 1992;9(5):380-392. View Abstract
  554. Gubin, D. G., Gubin, G. D., Waterhouse, J., and Weinert, D. The circadian body temperature rhythm in the elderly: effect of single daily melatonin dosing. Chronobiol.Int. 2006;23(3):639-658. View Abstract
  555. Jean-Louis, G., von Gizycki, H., and Zizi, F. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res 1998;25(3):177-183. View Abstract
  556. Brusco, L. I., Marquez, M., and Cardinali, D. P. Monozygotic twins with Alzheimer’s disease treated with melatonin: Case report. J Pineal Res 1998;25(4):260-263. View Abstract
  557. Asayama, K., Yamadera, H., Ito, T., Suzuki, H., Kudo, Y., and Endo, S. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch 2003;70(4):334-341. View Abstract
  558. Peck, J. S., LeGoff, D. B., Ahmed, I., and Goebert, D. Cognitive effects of exogenous melatonin administration in elderly persons: a pilot study. Am J Geriatr.Psychiatry 2004;12(4):432-436. View Abstract
  559. Serfaty, M., Kennell-Webb, S., Warner, J., Blizard, R., and Raven, P. Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr.Psychiatry 2002;17(12):1120-1127. View Abstract
  560. Singer, C., Tractenberg, R. E., Kaye, J., Schafer, K., Gamst, A., Grundman, M., Thomas, R., and Thal, L. J. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer’s disease. Sleep 11-1-2003;26(7):893-901. View Abstract
  561. Jansen, S. L., Forbes, D. A., Duncan, V., and Morgan, D. G. Melatonin for cognitive impairment. Cochrane.Database.Syst.Rev. 2006;(1):CD003802. View Abstract
  562. de, Jonghe A., Korevaar, J. C., van Munster, B. C., and de Rooij, S. E. Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. Int.J.Geriatr.Psychiatry 2010;25(12):1201-1208. View Abstract
  563. Caumo, W., Torres, F., Moreira, N. L., Jr., Auzani, J. A., Monteiro, C. A., Londero, G., Ribeiro, D. F., and Hidalgo, M. P. The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesth.Analg. 2007;105(5):1263-71, table. View Abstract
  564. Campos, F. L., Silva-Junior, F. P., de Bruin, V. M., and de Bruin, P. F. Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study. Am.J.Respir.Crit Care Med. 11-1-2004;170(9):947-951. View Abstract
  565. Cardinali DP, Gvozdenovich E, and Kaplan MR. A double blind-placebo controlled study on melatonin efficacy to reduce anxiolytic benzodiazepine use in the elderly. Neuroendocrinol.Lett 2002;23(1):55-60.
  566. Dagan, Y., Zisapel, N., Nof, D., Laudon, M., and Atsmon, J. Rapid reversal of tolerance to benzodiazepine hypnotics by treatment with oral melatonin: a case report. Eur Neuropsychopharmacol. 1997;7(2):157-160. View Abstract
  567. Garfinkel D, Laudon M, and Zisapel N. Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs. Arch Gerontol Geriat 1997;24:223-231.
  568. Garfinkel, D., Zisapel, N., Wainstein, J., and Laudon, M. Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach. Arch Intern Med 11-8-1999;159(20):2456-2460. View Abstract
  569. Peles, E., Hetzroni, T., Bar-Hamburger, R., Adelson, M., and Schreiber, S. Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial. Addiction 2007;102(12):1947-1953. View Abstract
  570. Berk, L., Berkey, B., Rich, T., Hrushesky, W., Blask, D., Gallagher, M., Kudrimoti, M., McGarry, R. C., Suh, J., and Mehta, M. Randomized phase II trial of high-dose melatonin and radiation therapy for RPA class 2 patients with brain metastases (RTOG 0119). Int.J Radiat.Oncol.Biol.Phys. 7-1-2007;68(3):852-857. View Abstract
  571. Cerea, G., Vaghi, M., Ardizzoia, A., Villa, S., Bucovec, R., Mengo, S., Gardani, G., Tancini, G., and Lissoni, P. Biomodulation of cancer chemotherapy for metastatic colorectal cancer: a randomized study of weekly low-dose irinotecan alone versus irinotecan plus the oncostatic pineal hormone melatonin in metastatic colorectal cancer patients progressing on 5-fluorouracil-containing combinations. Anticancer Res 2003;23(2C):1951-1954. View Abstract
  572. Lissoni, P., Malugani, F., Bukovec, R., Bordin, V., Perego, M., Mengo, S., Ardizzoia, A., and Tancini, G. Reduction of cisplatin-induced anemia by the pineal indole 5-methoxytryptamine in metastatic lung cancer patients. Neuro.Endocrinol.Lett. 2003;24(1-2):83-85. View Abstract
  573. Lissoni, P., Chilelli, M., Villa, S., Cerizza, L., and Tancini, G. Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial. J Pineal Res 2003;35(1):12-15. View Abstract
  574. Lissoni, P., Malugani, F., Brivio, F., Piazza, A., Vintimilla, C., Giani, L., and Tancini, G. Total pineal endocrine substitution therapy (TPEST) as a new neuroendocrine palliative treatment of untreatable metastatic solid tumor patients: a phase II study. Neuro.Endocrinol.Lett. 2003;24(3-4):259-262. View Abstract
  575. Lissoni, P. Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms. Pathol.Biol.(Paris) 2007;55(3-4):201-204. View Abstract
  576. Yan, J. J., Shen, F., Wang, K., and Wu, M. C. Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study. Hepatobiliary.Pancreat.Dis.Int. 2002;1(2):183-186. View Abstract
  577. Wang, Y. M., Jin, B. Z., Ai, F., Duan, C. H., Lu, Y. Z., Dong, T. F., and Fu, Q. L. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials. Cancer Chemother.Pharmacol. 2012;69(5):1213-1220. View Abstract
  578. van Heukelom, R. O., Prins, J. B., Smits, M. G., and Bleijenberg, G. Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion. Eur.J Neurol. 2006;13(1):55-60. View Abstract
  579. Williams, G., Waterhouse, J., Mugarza, J., Minors, D., and Hayden, K. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur J Clin Invest 2002;32(11):831-837. View Abstract
  580. de Matos, Cavalcante A. G., de Bruin, P. F., de Bruin, V. M., Nunes, D. M., Pereira, E. D., Cavalcante, M. M., and Andrade, G. M. Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled study. J.Pineal Res. 2012;53(3):238-244. View Abstract
  581. Khan, S. A., Heussler, H., McGuire, T., Dakin, C., Pache, D., Norris, R., Cooper, D., and Charles, B. Therapeutic options in the management of sleep disorders in visually impaired children: a systematic review. Clin.Ther. 2011;33(2):168-181. View Abstract
  582. Paul, M. A., Gray, G. W., Lieberman, H. R., Love, R. J., Miller, J. C., Trouborst, M., and Arendt, J. Phase advance with separate and combined melatonin and light treatment. Psychopharmacology (Berl) 2011;214(2):515-523. View Abstract
  583. Dagan, Y., Yovel, I., Hallis, D., Eisenstein, M., and Raichik, I. Evaluating the role of melatonin in the long-term treatment of delayed sleep phase syndrome (DSPS). Chronobiol.Int 1998;15(2):181-190. View Abstract
  584. Dahlitz, M., Alvarez, B., Vignau, J., English, J., Arendt, J., and Parkes, J. D. Delayed sleep phase syndrome response to melatonin. Lancet 5-11-1991;337(8750):1121-1124. View Abstract
  585. Mundey, K., Benloucif, S., Harsanyi, K., Dubocovich, M. L., and Zee, P. C. Phase-dependent treatment of delayed sleep phase syndrome with melatonin. Sleep 10-1-2005;28(10):1271-1278. View Abstract
  586. Nagtegaal, J. E., Kerkhof, G. A., Smits, M. G., Swart, A. C., and Van Der Meer, Y. G. Delayed sleep phase syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. J Sleep Res 1998;7(2):135-143. View Abstract
  587. Wasdell, M. B., Jan, J. E., Bomben, M. M., Freeman, R. D., Rietveld, W. J., Tai, J., Hamilton, D., and Weiss, M. D. A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. J Pineal Res 2008;44(1):57-64. View Abstract
  588. Yang, C. M., Spielman, A. J., D’Ambrosio, P., Serizawa, S., Nunes, J., and Birnbaum, J. A single dose of melatonin prevents the phase delay associated with a delayed weekend sleep pattern. Sleep 5-1-2001;24(3):272-281. View Abstract
  589. Rahman, S. A., Kayumov, L., and Shapiro, C. M. Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. Sleep Med. 2010;11(2):131-136. View Abstract
  590. Kayumov, L., Brown, G., Jindal, R., Buttoo, K., and Shapiro, C. M. A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome. Psychosom.Med 2001;63(1):40-48. View Abstract
  591. Nagtegaal, J. E., Laurant, M. W., Kerkhof, G. A., Smits, M. G., Van Der Meer, Y. G., and Coenen, A. M. Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. J.Psychosom.Res. 2000;48(1):45-50. View Abstract
  592. Serfaty, M. A., Osborne, D., Buszewicz, M. J., Blizard, R., and Raven, P. W. A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood. Int.Clin.Psychopharmacol. 2010;25(3):132-142. View Abstract
  593. Atkinson, G., Buckley, P., Edwards, B., Reilly, T., and Waterhouse, J. Are there hangover-effects on physical performance when melatonin is ingested by athletes before nocturnal sleep? Int J Sports Med 2001;22(3):232-234. View Abstract
  594. Eryilmaz, O. G., Devran, A., Sarikaya, E., Aksakal, F. N., Mollamahmutoglu, L., and Cicek, N. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. J.Assist.Reprod.Genet. 2011;28(9):815-820. View Abstract
  595. Batioglu, A. S., Sahin, U., Gurlek, B., Ozturk, N., and Unsal, E. The efficacy of melatonin administration on oocyte quality. Gynecol.Endocrinol. 2012;28(2):91-93. View Abstract
  596. Citera, G., Arias, M. A., Maldonado-Cocco, J. A., Lazaro, M. A., Rosemffet, M. G., Brusco, L. I., Scheines, E. J., and Cardinalli, D. P. The effect of melatonin in patients with fibromyalgia: a pilot study. Clin Rheumatol. 2000;19(1):9-13. View Abstract
  597. Hussain, S. A., Al-Khalifa, I. I., Jasim, N. A., and Gorial, F. I. Adjuvant use of melatonin for treatment of fibromyalgia. J.Pineal Res. 2011;50(3):267-271. View Abstract
  598. Klupinska, G., Poplawski, T., Drzewoski, J., Harasiuk, A., Reiter, R. J., Blasiak, J., and Chojnacki, J. Therapeutic effect of melatonin in patients with functional dyspepsia. J.Clin.Gastroenterol. 2007;41(3):270-274. View Abstract
  599. Song, G. H., Leng, P. H., Gwee, K. A., Moochhala, S. M., and Ho, K. Y. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study. Gut 2005;54(10):1402-1407. View Abstract
  600. Lu, W. Z., Gwee, K. A., Moochhalla, S., and Ho, K. Y. Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. Aliment.Pharmacol Ther 11-15-2005;22(10):927-934. View Abstract
  601. Lu, W. Z., Song, G. H., Gwee, K. A., and Ho, K. Y. The effects of melatonin on colonic transit time in normal controls and IBS patients. Dig.Dis.Sci. 2009;54(5):1087-1093. View Abstract
  602. Kandil, T. S., Mousa, A. A., El-Gendy, A. A., and Abbas, A. M. The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease. BMC.Gastroenterol. 2010;10:7. View Abstract
  603. Mozaffari, S., Rahimi, R., and Abdollahi, M. Implications of melatonin therapy in irritable bowel syndrome: a systematic review. Curr.Pharm.Des 2010;16(33):3646-3655. View Abstract
  604. Spears, R. C. Hemicrania continua: a case in which a patient experienced complete relief on melatonin. Headache 2006;46(3):524-527. View Abstract
  605. Leone, M., D’Amico, D., Moschiano, F., Fraschini, F., and Bussone, G. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia 1996;16(7):494-496. View Abstract
  606. Francis, G. J., Becker, W. J., and Pringsheim, T. M. Acute and preventive pharmacologic treatment of cluster headache. Neurology 8-3-2010;75(5):463-473. View Abstract
  607. Karadas, O., Ipekdal, I. H., Ulas, U. H., and Odabasi, Z. Nocturnal headache associated with melatonin deficiency due to a pineal gland cyst. J.Clin.Neurosci. 2012;19(2):330-332. View Abstract
  608. Grossman, E., Laudon, M., Yalcin, R., Zengil, H., Peleg, E., Sharabi, Y., Kamari, Y., Shen-Orr, Z., and Zisapel, N. Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am J Med 2006;119(10):898-902. View Abstract
  609. Kozirog, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., and Broncel, M. Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. J.Pineal Res. 2011;50(3):261-266. View Abstract
  610. Baskett, J. J., Broad, J. B., Wood, P. C., Duncan, J. R., Pledger, M. J., English, J., and Arendt, J. Does melatonin improve sleep in older people? A randomised crossover trial. Age Ageing 2003;32(2):164-170. View Abstract
  611. Haimov, I. and Lavie, P. Potential of melatonin replacement therapy in older patients with sleep disorders. Drugs Aging 1995;7(2):75-78. View Abstract
  612. Haimov, I., Lavie, P., Laudon, M., Herer, P., Vigder, C., and Zisapel, N. Melatonin replacement therapy of elderly insomniacs. Sleep 1995;18(7):598-603. View Abstract
  613. Wade, A. G., Ford, I., Crawford, G., McMahon, A. D., Nir, T., Laudon, M., and Zisapel, N. Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr.Med Res Opin. 2007;23(10):2597-2605. View Abstract
  614. Wurtman, R. J. and Zhdanova, I. Improvement of sleep quality by melatonin. Lancet 12-2-1995;346(8988):1491. View Abstract
  615. Luthringer, R., Muzet, M., Zisapel, N., and Staner, L. The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia. Int.Clin.Psychopharmacol. 2009;24(5):239-249. View Abstract
  616. Garzon, C., Guerrero, J. M., Aramburu, O., and Guzman, T. Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study. Aging Clin.Exp.Res. 2009;21(1):38-42. View Abstract
  617. Siegrist, C., Benedetti, C., Orlando, A., Beltran, J. M., Tuchscherr, L., Noseda, C. M., Brusco, L. I., and Cardinali, D. P. Lack of changes in serum prolactin, FSH, TSH, and estradiol after melatonin treatment in doses that improve sleep and reduce benzodiazepine consumption in sleep-disturbed, middle-aged, and elderly patients. J Pineal Res 2001;30(1):34-42. View Abstract
  618. Valtonen, M., Niskanen, L., Kangas, A. P., and Koskinen, T. Effect of melatonin-rich night-time milk on sleep and activity in elderly institutionalized subjects. Nord.J Psychiatry 2005;59(3):217-221. View Abstract
  619. Spitzer, R. L., Terman, M., Williams, J. B., Terman, J. S., Malt, U. F., Singer, F., and Lewy, A. J. Jet lag: clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trial. Am J Psychiatry 1999;156(9):1392-1396. View Abstract
  620. Arendt, J., Aldhous, M., and Marks, V. Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial. Br.Med J (Clin Res Ed) 5-3-1986;292(6529):1170. View Abstract
  621. Arendt J and Aldhous M. Further evaluation of the treatment of jet-lag by melatonin: a double-blind crossover study. Annu Rev Chronopharmacol 1988;5:53-55.
  622. Beaumont, M., Batejat, D., Pierard, C., Van Beers, P., Denis, J. B., Coste, O., Doireau, P., Chauffard, F., French, J., and Lagarde, D. Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel. J.Appl.Physiol 2004;96(1):50-58. View Abstract
  623. Paul, M. A., Gray, G., Sardana, T. M., and Pigeau, R. A. Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews. Aviat.Space Environ.Med 2004;75(5):439-443. View Abstract
  624. Spitzer RL, Terman M, Malt U, and et al. Failure of melatonin to affect jet lag in a randomized double blind trial. Abstracts of the Annual Meeting of the Society for Light Treatment and Biological Rhythms 1997;9:1.
  625. Rimmele, U., Spillmann, M., Bartschi, C., Wolf, O. T., Weber, C. S., Ehlert, U., and Wirtz, P. H. Melatonin improves memory acquisition under stress independent of stress hormone release. Psychopharmacology (Berl) 2009;202(4):663-672. View Abstract
  626. Secreto, G., Chiechi, L. M., Amadori, A., Miceli, R., Venturelli, E., Valerio, T., and Marubini, E. Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study. Maturitas 1-20-2004;47(1):11-20. View Abstract
  627. Kelley, K. W. and Carroll, D. G. Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women. J.Am.Pharm.Assoc.(2003.) 2010;50(5):e106-e115. View Abstract
  628. Kotlarczyk, M. P., Lassila, H. C., O’Neil, C. K., D’Amico, F., Enderby, L. T., Witt-Enderby, P. A., and Balk, J. L. Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women. J.Pineal Res. 2012;52(4):414-426. View Abstract
  629. Kunz, D. and Bes, F. Exogenous melatonin in periodic limb movement disorder: an open clinical trial and a hypothesis. Sleep 3-15-2001;24(2):183-187. View Abstract
  630. Takeuchi, N., Uchimura, N., Hashizume, Y., Mukai, M., Etoh, Y., Yamamoto, K., Kotorii, T., Ohshima, H., Ohshima, M., and Maeda, H. Melatonin therapy for REM sleep behavior disorder. Psychiatry Clin Neurosci. 2001;55(3):267-269. View Abstract
  631. Kunz, D. and Bes, F. Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations. Neuropsychobiology 1997;36(4):211-214. View Abstract
  632. Kunz, D. and Mahlberg, R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J.Sleep Res. 2010;19(4):591-596. View Abstract
  633. Whittom, S., Dumont, M., Petit, D., Desautels, A., Adam, B., Lavigne, G., and Montplaisir, J. Effects of melatonin and bright light administration on motor and sensory symptoms of RLS. Sleep Med. 2010;11(4):351-355. View Abstract
  634. Anderson, G. and Maes, M. Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects. Metab Brain Dis. 2012;27(2):113-119. View Abstract
  635. Leppamaki, S., Partonen, T., Vakkuri, O., Lonnqvist, J., Partinen, M., and Laudon, M. Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour. Eur.Neuropsychopharmacol. 2003;13(3):137-145. View Abstract
  636. Danilenko, K. V. and Putilov, A. A. Melatonin treatment of winter depression following total sleep deprivation: waking EEG and mood correlates. Neuropsychopharmacology 2005;30(7):1345-1352. View Abstract
  637. Brigo, F. and Del, Felice A. Melatonin as add-on treatment for epilepsy. Cochrane.Database.Syst.Rev. 2012;6:CD006967. View Abstract
  638. Hollway, J. A. and Aman, M. G. Pharmacological treatment of sleep disturbance in developmental disabilities: a review of the literature. Res.Dev.Disabil. 2011;32(3):939-962. View Abstract
  639. Brusco, L. I., Fainstein, I., Marquez, M., and Cardinali, D. P. Effect of melatonin in selected populations of sleep-disturbed patients. Biol Signals Recept. 1999;8(1-2):126-131. View Abstract
  640. Andrade, C., Srihari, B. S., Reddy, K. P., and Chandramma, L. Melatonin in medically ill patients with insomnia: a double-blind, placebo-controlled study. J Clin Psychiatry 2001;62(1):41-45. View Abstract
  641. Dowling, G. A., Burr, R. L., van Someren, E. J., Hubbard, E. M., Luxenberg, J. S., Mastick, J., and Cooper, B. A. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. J Am Geriatr.Soc. 2008;56(2):239-246. View Abstract
  642. Gehrman, P. R., Connor, D. J., Martin, J. L., Shochat, T., Corey-Bloom, J., and Ancoli-Israel, S. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am.J.Geriatr.Psychiatry 2009;17(2):166-169. View Abstract
  643. Galli-Carminati, G., Deriaz, N., and Bertschy, G. Melatonin in treatment of chronic sleep disorders in adults with autism: a retrospective study. Swiss.Med.Wkly. 5-16-2009;139(19-20):293-296. View Abstract
  644. Shilo, L., Dagan, Y., Smorjik, Y., Weinberg, U., Dolev, S., Komptel, B., and Shenkman, L. Effect of melatonin on sleep quality of COPD intensive care patients: a pilot study. Chronobiol.Int. 2000;17(1):71-76. View Abstract
  645. de Castro-Silva, C., de Bruin, V. M., Cunha, G. M., Nunes, D. M., Medeiros, C. A., and de Bruin, P. F. Melatonin improves sleep and reduces nitrite in the exhaled breath condensate in cystic fibrosis–a randomized, double-blind placebo-controlled study. J.Pineal Res. 2010;48(1):65-71. View Abstract
  646. Dalton, E. J., Rotondi, D., Levitan, R. D., Kennedy, S. H., and Brown, G. M. Use of slow-release melatonin in treatment-resistant depression. J Psychiatry Neurosci. 2000;25(1):48-52. View Abstract
  647. Dolberg, O. T., Hirschmann, S., and Grunhaus, L. Melatonin for the treatment of sleep disturbances in major depressive disorder. Am.J Psychiatry 1998;155(8):1119-1121. View Abstract
  648. Almeida Montes, L. G., Ontiveros Uribe, M. P., Cortes, Sotres J., and Heinze, Martin G. Treatment of primary insomnia with melatonin: a double-blind, placebo-controlled, crossover study. J Psychiatry Neurosci. 2003;28(3):191-196. View Abstract
  649. Dollins, A. B., Zhdanova, I. V., Wurtman, R. J., Lynch, H. J., and Deng, M. H. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc.Natl.Acad.Sci U.S.A 3-1-1994;91(5):1824-1828. View Abstract
  650. James, S. P., Mendelson, W. B., Sack, D. A., Rosenthal, N. E., and Wehr, T. A. The effect of melatonin on normal sleep. Neuropsychopharmacology 1987;1(1):41-44. View Abstract
  651. James, S. P., Sack, D. A., Rosenthal, N. E., and Mendelson, W. B. Melatonin administration in insomnia. Neuropsychopharmacology 1990;3(1):19-23. View Abstract
  652. Kunz, D., Mahlberg, R., Muller, C., Tilmann, A., and Bes, F. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J Clin Endocrinol.Metab 2004;89(1):128-134. View Abstract
  653. Nave, R., Peled, R., and Lavie, P. Melatonin improves evening napping. Eur J Pharmacol 3-6-1995;275(2):213-216. View Abstract
  654. Paul, M. A., Gray, G., MacLellan, M., and Pigeau, R. A. Sleep-inducing pharmaceuticals: a comparison of melatonin, zaleplon, zopiclone, and temazepam. Aviat.Space Environ.Med 2004;75(6):512-519. View Abstract
  655. Waldhauser, F., Saletu, B., and Trinchard-Lugan, I. Sleep laboratory investigations on hypnotic properties of melatonin. Psychopharmacology (Berl) 1990;100(2):222-226. View Abstract
  656. Wyatt, J. K., Dijk, D. J., Ritz-de Cecco, A., Ronda, J. M., and Czeisler, C. A. Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep 5-1-2006;29(5):609-618. View Abstract
  657. Zhdanova, I. V., Wurtman, R. J., Lynch, H. J., Ives, J. R., Dollins, A. B., Morabito, C., Matheson, J. K., and Schomer, D. L. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995;57(5):552-558. View Abstract
  658. Zhdanova, I. V., Wurtman, R. J., Morabito, C., Piotrovska, V. R., and Lynch, H. J. Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep 1996;19(5):423-431. View Abstract
  659. Brzezinski, A., Vangel, M. G., Wurtman, R. J., Norrie, G., Zhdanova, I., Ben Shushan, A., and Ford, I. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005;9(1):41-50. View Abstract
  660. Pinto, L. R., Jr., Seabra, Mde L., and Tufik, S. Different criteria of sleep latency and the effect of melatonin on sleep consolidation. Sleep 9-15-2004;27(6):1089-1092. View Abstract
  661. Cajochen, C., Krauchi, K., von Arx, M. A., Mori, D., Graw, P., and Wirz-Justice, A. Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG. Neurosci.Lett. 4-5-1996;207(3):209-213. View Abstract
  662. Tzischinsky, O. and Lavie, P. Melatonin possesses time-dependent hypnotic effects. Sleep 1994;17(7):638-645. View Abstract
  663. Hughes, R. J. and Badia, P. Sleep-promoting and hypothermic effects of daytime melatonin administration in humans. Sleep 1997;20(2):124-131. View Abstract
  664. Koch, B. C., Nagtegaal, J. E., Hagen, E. C., van der Westerlaken, M. M., Boringa, J. B., Kerkhof, G. A., and Ter Wee, P. M. The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients: a randomized, placebo-controlled, cross-over study (EMSCAP study). Br.J.Clin.Pharmacol. 2009;67(1):68-75. View Abstract
  665. Ibrahim, M. G., Bellomo, R., Hart, G. K., Norman, T. R., Goldsmith, D., Bates, S., and Egi, M. A double-blind placebo-controlled randomised pilot study of nocturnal melatonin in tracheostomised patients. Crit Care Resusc. 2006;8(3):187-191. View Abstract
  666. Braam, W., Smits, M. G., Didden, R., Korzilius, H., van Geijlswijk, I. M., and Curfs, L. M. Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis. Dev.Med.Child Neurol. 2009;51(5):340-349. View Abstract
  667. Medeiros, C. A., Carvalhedo de Bruin, P. F., Lopes, L. A., Magalhaes, M. C., de Lourdes, Seabra M., and de Bruin, V. M. Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson’s disease. A randomized, double blind, placebo-controlled study. J Neurol. 2007;254(4):459-464. View Abstract
  668. Gogenur, I., Kucukakin, B., Bisgaard, T., Kristiansen, V., Hjortso, N. C., Skene, D. J., and Rosenberg, J. The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial. Anesth.Analg. 2009;108(4):1152-1156. View Abstract
  669. Bersani, G. and Garavini, A. Melatonin add-on in manic patients with treatment resistant insomnia. Prog.Neuropsychopharmacol.Biol.Psychiatry 2000;24(2):185-191. View Abstract
  670. Leibenluft, E., Feldman-Naim, S., Turner, E. H., Wehr, T. A., and Rosenthal, N. E. Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. J Clin Psychiatry 1997;58(9):383-388. View Abstract
  671. Shamir, E., Barak, Y., Plopsky, I., Zisapel, N., Elizur, A., and Weizman, A. Is melatonin treatment effective for tardive dyskinesia? J Clin Psychiatry 2000;61(8):556-558. View Abstract
  672. Shamir, E., Rotenberg, V. S., Laudon, M., Zisapel, N., and Elizur, A. First-night effect of melatonin treatment in patients with chronic schizophrenia. J Clin Psychopharmacol 2000;20(6):691-694. View Abstract
  673. Suresh Kumar, P. N., Andrade, C., Bhakta, S. G., and Singh, N. M. Melatonin in schizophrenic outpatients with insomnia: a double-blind, placebo-controlled study. J Clin Psychiatry 2007;68(2):237-241. View Abstract
  674. Kemp, S., Biswas, R., Neumann, V., and Coughlan, A. The value of melatonin for sleep disorders occurring post-head injury: a pilot RCT. Brain Inj. 2004;18(9):911-919. View Abstract
  675. O’Callaghan, F. J., Clarke, A. A., Hancock, E., Hunt, A., and Osborne, J. P. Use of melatonin to treat sleep disorders in tuberous sclerosis. Dev Med Child Neurol 1999;41(2):123-126. View Abstract
  676. Zhdanova, I. V. and Piotrovskaya, V. R. Melatonin treatment attenuates symptoms of acute nicotine withdrawal in humans. Pharmacol Biochem Behav. 2000;67(1):131-135. View Abstract
  677. Acil, M., Basgul, E., Celiker, V., Karagoz, A. H., Demir, B., and Aypar, U. Perioperative effects of melatonin and midazolam premedication on sedation, orientation, anxiety scores and psychomotor performance. Eur.J.Anaesthesiol. 2004;21(7):553-557. View Abstract
  678. Capuzzo, M., Zanardi, B., Schiffino, E., Buccoliero, C., Gragnaniello, D., Bianchi, S., and Alvisi, R. Melatonin does not reduce anxiety more than placebo in the elderly undergoing surgery. Anesth.Analg. 2006;103(1):121-3, table. View Abstract
  679. Naguib, M., Samarkandi, A. H., Moniem, M. A., Mansour, Eel, Alshaer, A. A., Al Ayyaf, H. A., Fadin, A., and Alharby, S. W. The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study. Anesth.Analg. 2006;103(6):1448-1452. View Abstract
  680. Turkistani, A., Abdullah, K. M., Al Shaer, A. A., Mazen, K. F., and Alkatheri, K. Melatonin premedication and the induction dose of propofol. Eur.J Anaesthesiol. 2007;24(5):399-402. View Abstract
  681. Caumo, W., Levandovski, R., and Hidalgo, M. P. Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. J.Pain 2009;10(1):100-108. View Abstract
  682. Borazan, H., Tuncer, S., Yalcin, N., Erol, A., and Otelcioglu, S. Effects of preoperative oral melatonin medication on postoperative analgesia, sleep quality, and sedation in patients undergoing elective prostatectomy: a randomized clinical trial. J.Anesth. 2010;24(2):155-160. View Abstract
  683. Yousaf, F., Seet, E., Venkatraghavan, L., Abrishami, A., and Chung, F. Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials. Anesthesiology 2010;113(4):968-976. View Abstract
  684. Shamir, E., Barak, Y., Shalman, I., Laudon, M., Zisapel, N., Tarrasch, R., Elizur, A., and Weizman, R. Melatonin treatment for tardive dyskinesia: a double-blind, placebo- controlled, crossover study. Arch Gen.Psychiatry 2001;58(11):1049-1052. View Abstract
  685. Castro, F., Carrizo, E., Prieto de, Rincon D., Rincon, C. A., Asian, T., Medina-Leendertz, S., and Bonilla, E. Effectiveness of melatonin in tardive dyskinesia. Invest Clin. 2011;52(3):252-260. View Abstract
  686. Lissoni, P., Tancini, G., Barni, S., Paolorossi, F., Rossini, F., Maffe, P., and Di Bella, L. The pineal hormone melatonin in hematology and its potential efficacy in the treatment of thrombocytopenia. Recenti Prog Med 1996;87(12):582-585. View Abstract
  687. Lopez-Gonzalez, M. A., Santiago, A. M., and Esteban-Ortega, F. Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway. J Otolaryngol. 2007;36(4):213-219. View Abstract
  688. Megwalu, U. C., Finnell, J. E., and Piccirillo, J. F. The effects of melatonin on tinnitus and sleep. Otolaryngol.Head Neck Surg. 2006;134(2):210-213. View Abstract
  689. Neri, G., Baffa, C., De, Stefano A., Poliandri, A., Kulamarva, G., Di, Giovanni P., Petrucci, A. G., Castriotta, A., Citraro, L., Cerrone, D., D’ Orazio, F., and Croce, A. Management of tinnitus: oral treatment with melatonin and sulodexide. J.Biol.Regul.Homeost.Agents 2009;23(2):103-110. View Abstract
  690. Neri, G., De, Stefano A., Baffa, C., Kulamarva, G., Di, Giovanni P., Petrucci, G., Poliandri, A., Dispenza, F., Citraro, L., and Croce, A. Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled study. Acta Otorhinolaryngol.Ital. 2009;29(2):86-91. View Abstract
  691. Hurtuk, A., Dome, C., Holloman, C. H., Wolfe, K., Welling, D. B., Dodson, E. E., and Jacob, A. Melatonin: can it stop the ringing? Ann.Otol.Rhinol.Laryngol. 2011;120(7):433-440. View Abstract
  692. Celinski, K., Konturek, P. C., Konturek, S. J., Slomka, M., Cichoz-Lach, H., Brzozowski, T., and Bielanski, W. Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans. J.Physiol Pharmacol. 2011;62(5):521-526. View Abstract
  693. Celinski, K., Konturek, S. J., Konturek, P. C., Brzozowski, T., Cichoz-Lach, H., Slomka, M., Malgorzata, P., Bielanski, W., and Reiter, R. J. Melatonin or L-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole. J.Pineal Res. 2011;50(4):389-394. View Abstract
  694. Drake, M. J., Mills, I. W., and Noble, J. G. Melatonin pharmacotherapy for nocturia in men with benign prostatic enlargement. J Urol. 2004;171(3):1199-1202. View Abstract
  695. Sugaya, K., Nishijima, S., Miyazato, M., Kadekawa, K., and Ogawa, Y. Effects of melatonin and rilmazafone on nocturia in the elderly. J Int.Med Res 2007;35(5):685-691. View Abstract
  696. Crowley, S. J., Lee, C., Tseng, C. Y., Fogg, L. F., and Eastman, C. I. Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work. J Biol.Rhythms 2003;18(6):513-523. View Abstract
  697. Dawson, D., Encel, N., and Lushington, K. Improving adaptation to simulated night shift: timed exposure to bright light versus daytime melatonin administration. Sleep 1995;18(1):11-21. View Abstract
  698. Folkard, S., Arendt, J., and Clark, M. Can melatonin improve shift workers’ tolerance of the night shift? Some preliminary findings. Chronobiol.Int. 1993;10(5):315-320. View Abstract
  699. James, M., Tremea, M. O., Jones, J. S., and Krohmer, J. R. Can melatonin improve adaptation to night shift? Am J Emerg.Med 1998;16(4):367-370. View Abstract
  700. Jockovich, M., Cosentino, D., Cosentino, L., Wears, R. L., and Seaberg, D. C. Effect of exogenous melatonin on mood and sleep efficiency in emergency medicine residents working night shifts. Acad Emerg.Med 2000;7(8):955-958. View Abstract
  701. Jorgensen, K. M. and Witting, M. D. Does exogenous melatonin improve day sleep or night alertness in emergency physicians working night shifts? Ann Emerg.Med 1998;31(6):699-704. View Abstract
  702. Sharkey, K. M., Fogg, L. F., and Eastman, C. I. Effects of melatonin administration on daytime sleep after simulated night shift work. J Sleep Res 2001;10(3):181-192. View Abstract
  703. Smith, M. R., Lee, C., Crowley, S. J., Fogg, L. F., and Eastman, C. I. Morning melatonin has limited benefit as a soporific for daytime sleep after night work. Chronobiol.Int. 2005;22(5):873-888. View Abstract
  704. Wright, S. W., Lawrence, L. M., Wrenn, K. D., Haynes, M. L., Welch, L. W., and Schlack, H. M. Randomized clinical trial of melatonin after night-shift work: efficacy and neuropsychologic effects. Ann Emerg.Med 1998;32(3 Pt 1):334-340. View Abstract
  705. Zhdanova, I. V. and Raz, D. J. Effects of melatonin ingestion on cAMP and cGMP levels in human plasma. J Endocrinol 1999;163(3):457-462. View Abstract
  706. Samarkandi, A., Naguib, M., Riad, W., Thalaj, A., Alotibi, W., Aldammas, F., and Albassam, A. Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. Eur.J.Anaesthesiol. 2005;22(3):189-196. View Abstract
  707. Kain, Z. N., MacLaren, J. E., Herrmann, L., Mayes, L., Rosenbaum, A., Hata, J., and Lerman, J. Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. Anesthesiology 2009;111(1):44-49. View Abstract
  708. Slominski, A., Fischer, T. W., Zmijewski, M. A., Wortsman, J., Semak, I., Zbytek, B., Slominski, R. M., and Tobin, D. J. On the role of melatonin in skin physiology and pathology. Endocrine. 2005;27(2):137-148. View Abstract
  709. Bangha, E., Elsner, P., and Kistler, G. S. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). Influence of the application time point. Dermatology 1997;195(3):248-252. View Abstract
  710. Bangha, E., Elsner, P., and Kistler, G. S. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). A dose response study. Arch Dermatol Res 1996;288(9):522-526. View Abstract
  711. Fischer, T., Bangha, E., Elsner, P., and Kistler, G. S. Suppression of UV-induced erythema by topical treatment with melatonin. Influence of the application time point. Biol Signals Recept. 1999;8(1-2):132-135. View Abstract
  712. Dreher, F., Gabard, B., Schwindt, D. A., and Maibach, H. I. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo. Br J Dermatol. 1998;139(2):332-339. View Abstract
  713. Howes, R. A., Halliday, G. M., and Damian, D. L. Effect of topical melatonin on ultraviolet radiation-induced suppression of Mantoux reactions in humans. Photodermatol.Photoimmunol.Photomed. 2006;22(5):267-269. View Abstract
  714. Dreher, F., Denig, N., Gabard, B., Schwindt, D. A., and Maibach, H. I. Effect of topical antioxidants on UV-induced erythema formation when administered after exposure. Dermatology 1999;198(1):52-55. View Abstract
  715. Ivanenko, A., Crabtree, V. M., Tauman, R., and Gozal, D. Melatonin in children and adolescents with insomnia: a retrospective study. Clin Pediatr.(Phila) 2003;42(1):51-58. View Abstract
  716. van der Heijden, K. B., Smits, M. G., van Someren, E. J., and Boudewijn, Gunning W. Prediction of melatonin efficacy by pretreatment dim light melatonin onset in children with idiopathic chronic sleep onset insomnia. J Sleep Res 2005;14(2):187-194. View Abstract
  717. McArthur, A. J. and Budden, S. S. Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment. Dev.Med Child Neurol. 1998;40(3):186-192. View Abstract
  718. Miyamoto, A., Oki, J., Takahashi, S., and Okuno, A. Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome. Brain Dev. 1999;21(1):59-62. View Abstract
  719. Sury, M. R. and Fairweather, K. The effect of melatonin on sedation of children undergoing magnetic resonance imaging. Br.J Anaesth. 2006;97(2):220-225. View Abstract
  720. Gupta, M., Gupta, Y. K., Agarwal, S., Aneja, S., Kalaivani, M., and Kohli, K. Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. Epilepsia 2004;45(12):1636-1639. View Abstract
  721. Peled, N., Shorer, Z., Peled, E., and Pillar, G. Melatonin effect on seizures in children with severe neurologic deficit disorders. Epilepsia 2001;42(9):1208-1210. View Abstract
  722. Saracz, J. and Rosdy, B. [Effect of melatonin on intractable epilepsies]. Orv.Hetil. 12-19-2004;145(51):2583-2587. View Abstract
  723. Gupta, M., Aneja, S., and Kohli, K. Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial. Epilepsy Behav. 2004;5(3):316-321. View Abstract
  724. Coppola, G., Iervolino, G., Mastrosimone, M., La Torre, G., Ruiu, F., and Pascotto, A. Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. Brain Dev. 2004;26(6):373-376. View Abstract
  725. Garstang, J. and Wallis, M. Randomized controlled trial of melatonin for children with autistic spectrum disorders and sleep problems. Child Care Health Dev. 2006;32(5):585-589. View Abstract
  726. Jan, M. M. Melatonin for the treatment of handicapped children with severe sleep disorders. Pediatr Neurol 2000;23(3):229-232. View Abstract
  727. Masters, K. J. Melatonin for sleep problems. J Am Acad Child Adolesc Psychiatry 1996;35(6):704. View Abstract
  728. Paavonen, E. J., Nieminen-Von Wendt, T., Vanhala, R., Aronen, E. T., and Von Wendt, L. Effectiveness of melatonin in the treatment of sleep disturbances in children with asperger disorder. J Child Adolesc.Psychopharmacol. 2003;13(1):83-95. View Abstract
  729. Pillar, G., Shahar, E., Peled, N., Ravid, S., Lavie, P., and Etzioni, A. Melatonin improves sleep-wake patterns in psychomotor retarded children. Pediatr Neurol 2000;23(3):225-228. View Abstract
  730. Braam, W., Didden, R., Smits, M., and Curfs, L. Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study. J Intellect.Disabil.Res 2008;52(Pt 3):256-264. View Abstract
  731. Wirojanan, J., Jacquemont, S., Diaz, R., Bacalman, S., Anders, T. F., Hagerman, R. J., and Goodlin-Jones, B. L. The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. J.Clin.Sleep Med. 4-15-2009;5(2):145-150. View Abstract
  732. Braam, W., Didden, R., Smits, M. G., and Curfs, L. M. Melatonin for chronic insomnia in Angelman syndrome: a randomized placebo-controlled trial. J.Child Neurol. 2008;23(6):649-654. View Abstract
  733. Braam, W., Didden, R., Maas, A. P., Korzilius, H., Smits, M. G., and Curfs, L. M. Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia. J.Intellect.Disabil.Res. 1-1-2010;54(1):52-59. View Abstract
  734. Malow, B. A., Byars, K., Johnson, K., Weiss, S., Bernal, P., Goldman, S. E., Panzer, R., Coury, D. L., and Glaze, D. G. A practice pathway for the identification, evaluation, and management of insomnia in children and adolescents with autism spectrum disorders. Pediatrics 2012;130 Suppl 2:S106-S124. View Abstract
  735. Wright, B., Sims, D., Smart, S., Alwazeer, A., Alderson-Day, B., Allgar, V., Whitton, C., Tomlinson, H., Bennett, S., Jardine, J., McCaffrey, N., Leyland, C., Jakeman, C., and Miles, J. Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: a randomised controlled crossover trial. J.Autism Dev.Disord. 2011;41(2):175-184. View Abstract
  736. De, Leersnyder H., Zisapel, N., and Laudon, M. Prolonged-release melatonin for children with neurodevelopmental disorders. Pediatr.Neurol. 2011;45(1):23-26. View Abstract
  737. Niederhofer, H., Staffen, W., Mair, A., and Pittschieler, K. Brief report: melatonin facilitates sleep in individuals with mental retardation and insomnia. J Autism Dev.Disord. 2003;33(4):469-472. View Abstract
  738. Jan, J. E., Abroms, I. F., Freeman, R. D., Brown, G. M., Espezel, H., and Connolly, M. B. Rapid cycling in severely multidisabled children: a form of bipolar affective disorder? Pediatr Neurol 1994;10(1):34-39. View Abstract
  739. Ross, C., Morris, B., and Whitehouse, W. ‘Melatonin treatment of sleep-wake cycle disorders in children and adolescents’. Dev Med Child Neurol 1999;41(12):850. View Abstract
  740. Zhdanova, I. V., Wurtman, R. J., and Wagstaff, J. Effects of a low dose of melatonin on sleep in children with Angelman syndrome. J Pediatr Endocrinol Metab 1999;12(1):57-67. View Abstract
  741. Kocher, L., Brun, J., Borson-Chazot, F., Gonnaud, P. M., and Claustrat, B. Increased REM sleep associated with melatonin deficiency after pinealectomy: a case study. Chronobiol.Int. 2006;23(4):889-901. View Abstract
  742. Hancock, E., O’Callaghan, F., English, J., and Osborne, J. P. Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin. J Child Neurol. 2005;20(1):21-25. View Abstract
  743. Hancock, E., O’Callaghan, F., and Osborne, J. P. Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex. J.Child Neurol. 2005;20(1):78-80. View Abstract
  744. Uberos, J., Augustin-Morales, M. C., Molina, Carballo A., Florido, J., Narbona, E., and Munoz-Hoyos, A. Normalization of the sleep-wake pattern and melatonin and 6-sulphatoxy-melatonin levels after a therapeutic trial with melatonin in children with severe epilepsy. J.Pineal Res. 2011;50(2):192-196. View Abstract
  745. Ozcengiz, D., Gunes, Y., and Ozmete, O. Oral melatonin, dexmedetomidine, and midazolam for prevention of postoperative agitation in children. J.Anesth. 2011;25(2):184-188. View Abstract
  746. Merks, B. T., Burger, H., Willemsen, J., van Gool, J. D., and de Jong, T. P. Melatonin treatment in children with therapy-resistant monosymptomatic nocturnal enuresis. J.Pediatr.Urol. 2012;8(4):416-420. View Abstract
  747. Schernhammer, E. S., Giobbie-Hurder, A., Gantman, K., Savoie, J., Scheib, R., Parker, L. M., and Chen, W. Y. A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers. Cancer Causes Control 2012;23(4):609-616. View Abstract
  748. Huston, B., Mills, K., Froloff, V., and McGee, M. Bladder rupture after intentional medication overdose. Am.J.Forensic Med.Pathol. 2012;33(2):184-185. View Abstract
  749. de Lourdes, M., Seabra, V., Bignotto, M., Pinto, L. R., Jr., and Tufik, S. Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J Pineal Res 2000;29(4):193-200. View Abstract
  750. Naylor, S. and Gleich, G. J. Over-the-counter melatonin products and contamination. Am.Fam.Physician 1-15-1999;59(2):284, 287-284, 288. View Abstract
  751. Williamson, B. L., Tomlinson, A. J., Naylor, S., and Gleich, G. J. Contaminants in commercial preparations of melatonin. Mayo Clin.Proc. 1997;72(11):1094-1095. View Abstract
  752. Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Baker, G., Klassen, T. P., and Vohra, S. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen.Intern.Med 2005;20(12):1151-1158. View Abstract
  753. Khan, S., Heussler, H., McGuire, T., Dakin, C., Pache, D., Cooper, D., Norris, R., Flenady, V., and Charles, B. Melatonin for non-respiratory sleep disorders in visually impaired children. Cochrane.Database.Syst.Rev. 2011;(11):CD008473. View Abstract
  754. Nickkholgh, A., Schneider, H., Sobirey, M., Venetz, W. P., Hinz, U., Pelzl, le H., Gotthardt, D. N., Cekauskas, A., Manikas, M., Mikalauskas, S., Mikalauskene, L., Bruns, H., Zorn, M., Weigand, M. A., Buchler, M. W., and Schemmer, P. The use of high-dose melatonin in liver resection is safe: first clinical experience. J.Pineal Res. 2011;50(4):381-388. View Abstract
  755. Gooneratne, N. S., Edwards, A. Y., Zhou, C., Cuellar, N., Grandner, M. A., and Barrett, J. S. Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adults. J.Pineal Res. 2012;52(4):437-445. View Abstract
  756. Weekley, L. B. Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists. J Pineal Res 1991;11(1):28-34. View Abstract
  757. Wakatsuki, A., Okatani, Y., Ikenoue, N., Kaneda, C., and Fukaya, T. Effects of short-term melatonin administration on lipoprotein metabolism in normolipidemic postmenopausal women. Maturitas 4-20-2001;38(2):171-177. View Abstract
  758. Esquifino, A., Agrasal, C., Velazquez, E., Villanua, M. A., and Cardinali, D. P. Effect of melatonin on serum cholesterol and phospholipid levels, and on prolactin, thyroid-stimulating hormone and thyroid hormone levels, in hyperprolactinemic rats. Life Sci 1997;61(11):1051-1058. View Abstract
  759. Pita, M. L., Hoyos, M., Martin-Lacave, I., Osuna, C., Fernandez-Santos, J. M., and Guerrero, J. M. Long-term melatonin administration increases polyunsaturated fatty acid percentage in plasma lipids of hypercholesterolemic rats. J Pineal Res 2002;32(3):179-186. View Abstract
  760. Tailleux, A., Torpier, G., Bonnefont-Rousselot, D., Lestavel, S., Lemdani, M., Caudeville, B., Furman, C., Foricher, R., Gardes-Albert, M., Lesieur, D., Rolando, C., Teissier, E., Fruchart, J. C., Clavey, V., Fievet, C., and Duriez, P. Daily melatonin supplementation in mice increases atherosclerosis in proximal aorta. Biochem.Biophys.Res Commun. 5-10-2002;293(3):1114-1123. View Abstract
  761. Cichoz-Lach, H., Celinski, K., Konturek, P. C., Konturek, S. J., and Slomka, M. The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis. J.Physiol Pharmacol. 2010;61(5):577-580. View Abstract
  762. Maldonado, M. D., Manfredi, M., Ribas-Serna, J., Garcia-Moreno, H., and Calvo, J. R. Melatonin administrated immediately before an intense exercise reverses oxidative stress, improves immunological defenses and lipid metabolism in football players. Physiol Behav. 3-20-2012;105(5):1099-1103. View Abstract
  763. Yegin, Z. Mutluay R. Elbeg S. Karakus R. and Cakir N. The Impact of Melatonin on Glucose Homeostasis. Turkish Journal of Endocrinology and Metabolism 2009;13(3):52-55.
  764. Buscemi, N., Vandermeer, B., Pandya, R., Hooton, N., Tjosvold, L., Hartling, L., Baker, G., Vohra, S., and Klassen, T. Melatonin for treatment of sleep disorders. Evid.Rep.Technol.Assess.(Summ.) 2004;(108):1-7. View Abstract
  765. Kasimay, O., Cakir, B., Devseren, E., and Yegen, B. C. Exogenous melatonin delays gastric emptying rate in rats: role of CCK2 and 5-HT3 receptors. J Physiol Pharmacol 2005;56(4):543-553. View Abstract
  766. Lee, P. P. and Pang, S. F. Melatonin and its receptors in the gastrointestinal tract. Biol.Signals 1993;2(4):181-193. View Abstract
  767. Jean-Louis G, Zizi F, Von Gizycki H, and et al. Acute effects of melatonin therapy on behavior, mood, and cognition [abstract]. Sleep Res 1997;26:108.
  768. Tapias, V., Cannon, J. R., and Greenamyre, J. T. Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson’s disease model. J.Neurosci.Res. 2-1-2010;88(2):420-427. View Abstract
  769. Gagne, A. M., Danilenko, K. V., Rosolen, S. G., and Hebert, M. Impact of oral melatonin on the electroretinogram cone response. J.Circadian.Rhythms 2009;7:14. View Abstract
  770. Rechcinski, T., Uznanska-Loch, B., Trzos, E., Wierzbowska-Drabik, K., Krzeminska-Pakula, M., Kasprzak, J. D., and Kurpesa, M. Melatonin – a somniferous option which does not aggravate sleep-disordered breathing in cardiac risk patients: a Holter ECG based study. Kardiol.Pol. 2012;70(1):24-29. View Abstract
  771. Kucukakin, B., Wilhelmsen, M., Lykkesfeldt, J., Reiter, R. J., Rosenberg, J., and Gogenur, I. No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial. Eur.J.Vasc.Endovasc.Surg. 2010;40(4):461-467. View Abstract
  772. Cubero, J., Valero, V., Sanchez, J., Rivero, M., Parvez, H., Rodriguez, A. B., and Barriga, C. The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn. Neuro.Endocrinol.Lett. 2005;26(6):657-661. View Abstract
  773. Illnerova, H., Buresova, M., and Presl, J. Melatonin rhythm in human milk. J.Clin.Endocrinol.Metab 1993;77(3):838-841. View Abstract
  774. Kimata, H. Laughter elevates the levels of breast-milk melatonin. J.Psychosom.Res. 2007;62(6):699-702. View Abstract
  775. Briceno-Perez, C., Briceno-Sanabria, L., and Vigil-De, Gracia P. Prediction and prevention of preeclampsia. Hypertens.Pregnancy. 2009;28(2):138-155. View Abstract
  776. Lapwood, K. R., Bhagat, L., and Simpson, M. P. Analgesic effects on endogenous melatonin secretion. J Pineal Res 1997;22(1):20-25. View Abstract
  777. Murphy, P. J., Myers, B. L., and Badia, P. Nonsteroidal anti-inflammatory drugs alter body temperature and suppress melatonin in humans. Physiol Behav. 1996;59(1):133-139. View Abstract
  778. Hanssen, T., Heyden, T., Sundberg, I., Alfredsson, G., Nyback, H., and Wetterberg, L. Propranolol in schizophrenia. Clinical, metabolic, and pharmacological findings. Arch.Gen.Psychiatry 1980;37(6):685-690. View Abstract
  779. Brismar, K., Hylander, B., Eliasson, K., Rossner, S., and Wetterberg, L. Melatonin secretion related to side-effects of beta-blockers from the central nervous system. Acta Med Scand 1988;223(6):525-530. View Abstract
  780. Stoschitzky, K., Sakotnik, A., Lercher, P., Zweiker, R., Maier, R., Liebmann, P., and Lindner, W. Influence of beta-blockers on melatonin release. Eur J Clin Pharmacol 1999;55(2):111-115. View Abstract
  781. Munoz-Hoyos, A., Amoros-Rodriguez, I., Molina-Carballo, A., Uberos-Fernandez, J., and Acuna-Castroviejo, D. Pineal response after pyridoxine test in children. J Neural Transm.Gen Sect. 1996;103(7):833-842. View Abstract
  782. Djeridane, Y. and Touitou, Y. Chronic diazepam administration differentially affects melatonin synthesis in rat pineal and Harderian glands. Psychopharmacology (Berl) 2001;154(4):403-407. View Abstract
  783. Wakabayashi, H., Shimada, K., and Satoh, T. Effects of diazepam administration on melatonin synthesis in the rat pineal gland in vivo. Chem Pharm Bull (Tokyo) 1991;39(10):2674-2676. View Abstract
  784. Ozaki, Y., Wurtman, R. J., Alonso, R., and Lynch, H. J. Melatonin secretion decreases during the proestrous stage of the rat estrous cycle. Proc Natl Acad Sci U S A 1978;75(1):531-534. View Abstract
  785. Arai, Y. C., Ueda, W., Okatani, Y., Fukaya, T., and Manabe, M. Isoflurane increases, but sevoflurane decreases blood concentrations of melatonin in women. J Anesth. 2004;18(3):228-231. View Abstract
  786. Babkoff, H., French, J., Whitmore, J., and Sutherlin, R. Single-dose bright light and/or caffeine effect on nocturnal performance. Aviat.Space Environ.Med. 2002;73(4):341-350. View Abstract
  787. Ursing, C., Wikner, J., Brismar, K., and Rojdmark, S. Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2. J.Endocrinol.Invest 2003;26(5):403-406. View Abstract
  788. Hartter, S., Nordmark, A., Rose, D. M., Bertilsson, L., Tybring, G., and Laine, K. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Br.J.Clin.Pharmacol. 2003;56(6):679-682. View Abstract
  789. Bartsch, C., Seeger, H., Muck, A. O., and Lippert, T. H. The effect of estradiol on the production of melatonin in postmenopausal women. Int.J Clin Pharmacol Ther 1995;33(7):401-403. View Abstract
  790. Honma, K., Kohsaka, M., Fukuda, N., Morita, N., and Honma, S. Effects of vitamin B12 on plasma melatonin rhythm in humans: increased light sensitivity phase-advances the circadian clock? Experientia 8-15-1992;48(8):716-720. View Abstract
  791. Wikner, J., Wetterberg, L., and Rojdmark, S. Does hypercalcaemia or calcium antagonism affect human melatonin secretion or renal excretion? Eur J Clin Invest 1997;27(5):374-379. View Abstract
  792. Norman, T. R., Piccolo, J., Voudouris, N., and Burrows, G. D. The effect of single oral doses of zopiclone on nocturnal melatonin secretion in healthy male volunteers. Prog Neuropsychopharmacol.Biol Psychiatry 2001;25(4):825-833. View Abstract
  793. Wikner, J., Wetterberg, L., and Rojdmark, S. The role of somatostatin (octreotide) in the regulation of melatonin secretion in healthy volunteers and in patients with primary hypothyroidism. J Endocrinol Invest 1999;22(7):527-534. View Abstract
  794. Hartman, T. J., Mahabir, S., Baer, D. J., Stevens, R. G., Albert, P. S., Dorgan, J. F., Kesner, J. S., Meadows, J. W., Shields, R., and Taylor, P. R. Moderate alcohol consumption and 24-hour urinary levels of melatonin in postmenopausal women. J.Clin.Endocrinol.Metab 2012;97(1):E65-E68. View Abstract
  795. Savaskan, E., Olivieri, G., Brydon, L., Jockers, R., Krauchi, K., Wirz-Justice, A., and Muller-Spahn, F. Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer’s disease. Neurosci Lett 7-27-2001;308(1):9-12. View Abstract
  796. Savaskan, E., Olivieri, G., Meier, F., Brydon, L., Jockers, R., Ravid, R., Wirz-Justice, A., and Muller-Spahn, F. Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer’s disease patients. J Pineal Res 2002;32(1):59-62. View Abstract
  797. Skene, D. J. and Swaab, D. F. Melatonin rhythmicity: effect of age and Alzheimer’s disease. Exp.Gerontol 2003;38(1-2):199-206. View Abstract
  798. Wang, J. Z. and Wang, Z. F. Role of melatonin in Alzheimer-like neurodegeneration. Acta Pharmacol Sin. 2006;27(1):41-49. View Abstract
  799. Wang, S., Zhu, L., Shi, H., Zheng, H., Tian, Q., Wang, Q., Liu, R., and Wang, J. Z. Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5. Neurochem.Res 2007;32(8):1329-1335. View Abstract
  800. Zhou, J. N., Liu, R. Y., Kamphorst, W., Hofman, M. A., and Swaab, D. F. Early neuropathological Alzheimer’s changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J Pineal Res 2003;35(2):125-130. View Abstract
  801. Rodriguez-Franco, M. I., Fernandez-Bachiller, M. I., Perez, C., Hernandez-Ledesma, B., and Bartolome, B. Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties. J Med Chem. 1-26-2006;49(2):459-462. View Abstract
  802. Castro, M. R., Pastor, A. B., Alcantud, J. F., Salvan, J. H., Osado, I. R., and Roca, A. P. [Altered plasma melatonin concentrations after administration of propofol in continuous infusion]. Rev.Esp.Anestesiol.Reanim. 2007;54(8):469-474. View Abstract
  803. Naguib, M. and Samarkandi, A. H. Premedication with melatonin: a double-blind, placebo-controlled comparison with midazolam. Br.J.Anaesth. 1999;82(6):875-880. View Abstract
  804. Naguib, M. and Samarkandi, A. H. The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: a double-blinded, placebo-controlled study. Anesth.Analg. 2000;91(2):473-479. View Abstract
  805. Naguib, M., Schmid, P. G., III, and Baker, M. T. The electroencephalographic effects of IV anesthetic doses of melatonin: comparative studies with thiopental and propofol. Anesth.Analg. 2003;97(1):238-43, table. View Abstract
  806. Naguib, M., Hammond, D. L., Schmid, P. G., III, Baker, M. T., Cutkomp, J., Queral, L., and Smith, T. Pharmacological effects of intravenous melatonin: comparative studies with thiopental and propofol. Br.J Anaesth. 2003;90(4):504-507. View Abstract
  807. Evagelidis, P., Paraskeva, A., Petropoulos, G., Staikou, C., and Fassoulaki, A. Melatonin premedication does not enhance induction of anaesthesia with sevoflurane as assessed by bispectral index monitoring. Singapore Med.J. 2009;50(1):78-81. View Abstract
  808. Dispersyn, G., Pain, L., and Touitou, Y. Propofol anesthesia significantly alters plasma blood levels of melatonin in rats. Anesthesiology 2010;112(2):333-337. View Abstract
  809. Fei, G. H., Liu, R. Y., Zhang, Z. H., and Zhou, J. N. [Relationships between melatonin and cortisol and the status of disease in patients with bronchial asthma]. Zhonghua Jie.He.He.Hu Xi.Za Zhi. 2003;26(11):679-682. View Abstract
  810. Fei, G. H., Liu, R. Y., Zhang, Z. H., and Zhou, J. N. Alterations in circadian rhythms of melatonin and cortisol in patients with bronchial asthma. Acta Pharmacol Sin. 2004;25(5):651-656. View Abstract
  811. Sutherland, E. R., Ellison, M. C., Kraft, M., and Martin, R. J. Elevated serum melatonin is associated with the nocturnal worsening of asthma. J Allergy Clin Immunol. 2003;112(3):513-517. View Abstract
  812. Sutherland, E. R. Nocturnal asthma. J Allergy Clin Immunol. 2005;116(6):1179-1186. View Abstract
  813. Sanchez-Forte H, Moreno-Madrid, F., Munoz-Hoyos A, and et al. Efecto de la melatonina como anticonvulsivante y protector neuronal. Revista de Neurologia 1997;25:1229-1234.
  814. Bikjdaouene, L., Escames, G., Leon, J., Ferrer, J. M., Khaldy, H., Vives, F., and Acuna-Castroviejo, D. Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures. J Pineal Res 2003;35(1):54-60. View Abstract
  815. Solmaz, I., Gurkanlar, D., Gokcil, Z., Goksoy, C., Ozkan, M., and Erdogan, E. Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures. Neurol.Res. 2009;31(9):989-995. View Abstract
  816. Gupta, M., Gupta, Y. K., Agarwal, S., Aneja, S., and Kohli, K. A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes. Br.J.Clin.Pharmacol. 2004;58(5):542-547. View Abstract
  817. Avakian, G. N., Oleinikova, O. M., Kareva, E. N., Bogomazova, M. A., Lagutin, IuV, and Avakian, G. G. [Concentrations of urine 6-sulfatoxymelatonin during the treatment of patients with epilepsy: a pilot clinical trial]. Zh.Nevrol.Psikhiatr.Im S.S.Korsakova 2012;112(4):32-36. View Abstract
  818. Hallam, K. T., Olver, J. S., and Norman, T. R. Effect of sodium valproate on nocturnal melatonin sensitivity to light in healthy volunteers. Neuropsychopharmacology 2005;30(7):1400-1404. View Abstract
  819. Carvalho, L. A., Gorenstein, C., Moreno, R., Pariante, C., and Markus, R. P. Effect of antidepressants on melatonin metabolite in depressed patients. J.Psychopharmacol. 2009;23(3):315-321. View Abstract
  820. Sunami, E., Usuda, K., Nishiyama, Y., Otori, T., Katsura, K., and Katayama, Y. A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. Intern.Med. 2012;51(10):1187-1193. View Abstract
  821. Philip, N. S., Carpenter, L. L., Tyrka, A. R., and Price, L. H. Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era. Expert.Opin.Pharmacother. 2010;11(5):709-722. View Abstract
  822. Hartter, S., Grozinger, M., Weigmann, H., Roschke, J., and Hiemke, C. Increased bioavailability of oral melatonin after fluvoxamine coadministration. Clin Pharmacol Ther 2000;67(1):1-6. View Abstract
  823. Grozinger, M., Hartter, S., Wang, X., Roschke, J., Hiemke, C., and Rose, D. M. Fluvoxamine strongly inhibits melatonin metabolism in a patient with low-amplitude melatonin profile. Arch.Gen.Psychiatry 2000;57(8):812-813. View Abstract
  824. Hallam, K. T., Begg, D. P., Olver, J. S., and Norman, T. R. An investigation of the effect of immediate and extended release venlafaxine on nocturnal melatonin and cortisol release in healthy adult volunteers. Hum.Psychopharmacol. 2008;23(2):129-137. View Abstract
  825. Li, H. L., Kang, Y. M., Yu, L., Xu, H. Y., and Zhao, H. Melatonin reduces blood pressure in rats with stress-induced hypertension via GABAA receptors. Clin.Exp.Pharmacol.Physiol 2009;36(4):436-440. View Abstract
  826. Zaslavskaia, R. M., Komarov, F. I., Shakirova, A. N., Teiblium, M. M., and Akhmetov, K. Z. [Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial hypertension]. Klin.Med (Mosk) 2000;78(4):41-44. View Abstract
  827. Zaslavskaia, R. M., Biiasilov, N. S., Akhmetov, K. Z., and Teiblium, M. M. [Capozide-50 alone and in combination with melatonin in therapy of hypertension]. Klin.Med (Mosk) 2000;78(11):39-41. View Abstract
  828. Zaslavskaia, R. M., Shakirova, A. N., Komarov, F. I., Teiblium, M. M., and Akhmetov, K. Z. [Effects of melatonin alone and in combination with aceten on chronostructure of diurnal hemodynamic rhythms in patients with hypertension stage II]. Ter Arkh. 1999;71(12):21-24. View Abstract
  829. Birau N, Peterssen U, Meyer C, and et al. Hypotensive effect of melatonin in essential hypertension. IRCS Med Sci 1981;9:905-906.
  830. Zeman, M., Szantoova, K., Stebelova, K., Mravec, B., and Herichova, I. Effect of rhythmic melatonin administration on clock gene expression in the suprachiasmatic nucleus and the heart of hypertensive TGR(mRen2)27 rats. J.Hypertens.Suppl 2009;27(6):S21-S26. View Abstract
  831. Reiter, R. J., Calvo, J. R., Karbownik, M., Qi, W., and Tan, D. X. Melatonin and its relation to the immune system and inflammation. Ann N.Y.Acad Sci 2000;917:376-386. View Abstract
  832. Fang, Q., Chen, G., Zhu, W., Dong, W., and Wang, Z. Influence of melatonin on cerebrovascular proinflammatory mediators expression and oxidative stress following subarachnoid hemorrhage in rabbits. Mediators.Inflamm. 2009;426346. View Abstract
  833. Bilici, D., Akpinar, E., and Kiziltunc, A. Protective effect of melatonin in carrageenan-induced acute local inflammation. Pharmacol.Res 2002;46(2):133-139. View Abstract
  834. Bilici, D., Suleyman, H., Banoglu, Z. N., Kiziltunc, A., Avci, B., Ciftcioglu, A., and Bilici, S. Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. Dig.Dis.Sci. 2002;47(4):856-861. View Abstract
  835. Kucukakin, B., Klein, M., Lykkesfeldt, J., Reiter, R. J., Rosenberg, J., and Gogenur, I. No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial. Acta Anaesthesiol.Scand. 2010;54(9):1121-1127. View Abstract
  836. Ravindra, T., Lakshmi, N. K., and Ahuja, Y. R. Melatonin in pathogenesis and therapy of cancer. Indian J Med Sci. 2006;60(12):523-535. View Abstract
  837. Barni, S., Lissoni, P., Paolorossi, F., Crispino, S., Archili, C., and Tancini, G. A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates. Tumori 2-28-1990;76(1):58-60. View Abstract
  838. Block, K. I., Koch, A. C., Mead, M. N., Tothy, P. K., Newman, R. A., and Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials. Cancer Treat.Rev. 2007;33(5):407-418. View Abstract
  839. Gonzalez, R., Sanchez, A., Ferguson, J. A., Balmer, C., Daniel, C., Cohn, A., and Robinson, W. A. Melatonin therapy of advanced human malignant melanoma. Melanoma Res 1991;1(4):237-243. View Abstract
  840. Italian Study Group for the Di Bella Multitherapy Trials. Evaluation of an unconventional cancer treatment (the Di Bella multitherapy): results of phase II trials in Italy. Italian Study Group for the Di Bella Multitherapy Trails. BMJ 1-23-1999;318(7178):224-228. View Abstract
  841. Lamson, D. W. and Brignall, M. S. Antioxidants in cancer therapy; their actions and interactions with oncologic therapies. Altern.Med Rev. 1999;4(5):304-329. View Abstract
  842. Lissoni, P., Barni, S., Tancini, G., Crispino, S., Paolorossi, F., Lucini, V., Mariani, M., Cattaneo, G., Esposti, D., Esposti, G., and . Clinical study of melatonin in untreatable advanced cancer patients. Tumori 10-31-1987;73(5):475-480. View Abstract
  843. Lissoni, P., Barni, S., Crispino, S., Tancini, G., and Fraschini, F. Endocrine and immune effects of melatonin therapy in metastatic cancer patients. Eur J Cancer Clin Oncol. 1989;25(5):789-795. View Abstract
  844. Lissoni, P., Barni, S., Cattaneo, G., Tancini, G., Esposti, G., Esposti, D., and Fraschini, F. Clinical results with the pineal hormone melatonin in advanced cancer resistant to standard antitumor therapies. Oncology 1991;48(6):448-450. View Abstract
  845. Lissoni, P., Barni, S., Ardizzoia, A., Paolorossi, F., Crispino, S., Tancini, G., Tisi, E., Archili, C., De Toma, D., Pipino, G., and . Randomized study with the pineal hormone melatonin versus supportive care alone in advanced nonsmall cell lung cancer resistant to a first- line chemotherapy containing cisplatin. Oncology 1992;49(5):336-339. View Abstract
  846. Lissoni, P., Tisi, E., Barni, S., Ardizzoia, A., Rovelli, F., Rescaldani, R., Ballabio, D., Benenti, C., Angeli, M., Tancini, G., and . Biological and clinical results of a neuroimmunotherapy with interleukin-2 and the pineal hormone melatonin as a first line treatment in advanced non-small cell lung cancer. Br J Cancer 1992;66(1):155-158. View Abstract
  847. Lissoni, P., Barni, S., Ardizzoia, A., Tancini, G., Conti, A., and Maestroni, G. A randomized study with the pineal hormone melatonin versus supportive care alone in patients with brain metastases due to solid neoplasms. Cancer 2-1-1994;73(3):699-701. View Abstract
  848. Lissoni, P., Meregalli, S., Fossati, V., Paolorossi, F., Barni, S., Tancini, G., and Frigerio, F. A randomized study of immunotherapy with low-dose subcutaneous interleukin-2 plus melatonin vs chemotherapy with cisplatin and etoposide as first-line therapy for advanced non-small cell lung cancer. Tumori 12-31-1994;80(6):464-467. View Abstract
  849. Lissoni, P., Barni, S., Tancini, G., Fossati, V., and Frigerio, F. Pineal-opioid system interactions in the control of immunoinflammatory responses. Ann N Y Acad Sci 11-25-1994;741:191-196. View Abstract
  850. Lissoni, P., Paolorossi, F., Tancini, G., Ardizzoia, A., Barni, S., Brivio, F., Maestroni, G. J., and Chilelli, M. A phase II study of tamoxifen plus melatonin in metastatic solid tumour patients. Br J Cancer 1996;74(9):1466-1468. View Abstract
  851. Lissoni, P., Meregalli, S., Nosetto, L., Barni, S., Tancini, G., Fossati, V., and Maestroni, G. Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone. Oncology 1996;53(1):43-46. View Abstract
  852. Lissoni, P., Paolorossi, F., Tancini, G., Barni, S., Ardizzoia, A., Brivio, F., Zubelewicz, B., and Chatikhine, V. Is there a role for melatonin in the treatment of neoplastic cachexia? Eur.J Cancer 1996;32A(8):1340-1343. View Abstract
  853. Lissoni, P., Brivio, O., Brivio, F., Barni, S., Tancini, G., Crippa, D., and Meregalli, S. Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma. J Pineal Res 1996;21(4):239-242. View Abstract
  854. Lissoni, P., Paolorossi, F., Ardizzoia, A., Barni, S., Chilelli, M., Mancuso, M., Tancini, G., Conti, A., and Maestroni, G. J. A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state. J Pineal Res 1997;23(1):15-19. View Abstract
  855. Lissoni, P., Rovelli, F., Meregalli, S., Fumagalli, L., Musco, F., Brivio, F., Brivio, O., and Esposti, G. Melatonin as a new possible anti-inflammatory agent. J Biol Regul.Homeost.Agents 1997;11(4):157-159. View Abstract
  856. Lissoni, P., Giani, L., Zerbini, S., Trabattoni, P., and Rovelli, F. Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus aloe vera in untreatable advanced solid neoplasms. Nat Immun. 1998;16(1):27-33. View Abstract
  857. Lissoni, P., Rovelli, F., Malugani, F., Bucovec, R., Conti, A., and Maestroni, G. J. Anti-angiogenic activity of melatonin in advanced cancer patients. Neuroendocrinol.Lett 2001;22(1):45-47. View Abstract
  858. Lissoni, P., Vaghi, M., Ardizzoia, A., Malugani, F., Fumagalli, E., Bordin, V., Fumagalli, L., Bordoni, A., Mengo, S., Gardani, G. S., and Tancini, G. A phase II study of chemoneuroimmunotherapy with platinum, subcutaneous low-dose interleukin-2 and the pineal neurohormone melatonin (P.I.M.) as a second-line therapy in metastatic melanoma patients progressing on dacarbazine plus interferon-alpha. In Vivo 2002;16(2):93-96. View Abstract
  859. Mills, E., Wu, P., Seely, D., and Guyatt, G. Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J Pineal Res 2005;39(4):360-366. View Abstract
  860. Neri, B., de, Leonardis, V, Gemelli, M. T., di Loro, F., Mottola, A., Ponchietti, R., Raugei, A., and Cini, G. Melatonin as biological response modifier in cancer patients. Anticancer Res 1998;18(2B):1329-1332. View Abstract
  861. Todisco, M., Casaccia, P., and Rossi, N. Cyclophosphamide plus somatostatin, bromocriptin, retinoids, melatonin and ACTH in the treatment of low-grade non-Hodgkin’s lymphomas at advanced stage: results of a phase II trial. Cancer Biother.Radiopharm. 2001;16(2):171-177. View Abstract
  862. Lissoni, P., Barni, S., Meregalli, S., Fossati, V., Cazzaniga, M., Esposti, D., and Tancini, G. Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone. Br J Cancer 1995;71(4):854-856. View Abstract
  863. Lissoni P, Ardizzoia A, Barni S, and et al. A randomized study of tamoxifen alone versus tamoxifen plus melatonin in estrogen receptor-negative heavily pretreated metastatic breast cancer patients. Oncology Reports 1995;2:871-873.
  864. Lissoni, P., Tancini, G., Barni, S., Paolorossi, F., Ardizzoia, A., Conti, A., and Maestroni, G. Treatment of cancer chemotherapy-induced toxicity with the pineal hormone melatonin. Support.Care Cancer 1997;5(2):126-129. View Abstract
  865. Casado-Zapico, S., Rodriguez-Blanco, J., Garcia-Santos, G., Martin, V., Sanchez-Sanchez, A. M., Antolin, I., and Rodriguez, C. Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway. J.Pineal Res. 2010;48(1):72-80. View Abstract
  866. Miller, S. C., Pandi-Perumal, S. R., Esquifino, A. I., Cardinali, D. P., and Maestroni, G. J. The role of melatonin in immuno-enhancement: potential application in cancer. Int.J Exp Pathol. 2006;87(2):81-87. View Abstract
  867. Orendas, P., Kassayova, M., Kajo, K., Ahlers, I., Kubatka, P., Bojkova, B., Pec, M., and Ahlersova, E. Celecoxib and melatonin in prevention of female rat mammary carcinogenesis. Neoplasma 2009;56(3):252-258. View Abstract
  868. Lissoni, P. Modulation of anticancer cytokines IL-2 and IL-12 by melatonin and the other pineal indoles 5-methoxytryptamine and 5-methoxytryptophol in the treatment of human neoplasms. Ann N Y Acad Sci 2000;917:560-567. View Abstract
  869. Suwanjang, W., Phansuwan-Pujito, P., Govitrapong, P., and Chetsawang, B. The protective effect of melatonin on methamphetamine-induced calpain-dependent death pathway in human neuroblastoma SH-SY5Y cultured cells. J.Pineal Res. 2010;48(2):94-101. View Abstract
  870. Sonmez, M. F., Narin, F., and Balcioglu, E. Melatonin and vitamin C attenuates alcohol-induced oxidative stress in aorta. Basic Clin.Pharmacol.Toxicol. 2009;105(6):410-415. View Abstract
  871. Sadowska-Woda, I., Wojcik, N., Karowicz-Bilinska, A., and Bieszczad-Bedrejczuk, E. Effect of selected antioxidants in beta-cyfluthrin-induced oxidative stress in human erythrocytes in vitro. Toxicol.In Vitro 2010;24(3):879-884. View Abstract
  872. Murawska-Cialowicz, E., Jethon, Z., Magdalan, J., Januszewska, L., Podhorska-Okolow, M., Zawadzki, M., Sozanski, T., and Dziegiel, P. Effects of melatonin on lipid peroxidation and antioxidative enzyme activities in the liver, kidneys and brain of rats administered with benzo(a)pyrene. Exp.Toxicol.Pathol. 2011;63(1-2):97-103. View Abstract
  873. Velarde, E., Alonso-Gomez, A. L., Azpeleta, C., Isorna, E., and Delgado, M. J. Melatonin attenuates the acetylcholine-induced contraction in isolated intestine of a teleost fish. J.Comp Physiol B 2009;179(8):951-959. View Abstract
  874. Mantele, S., Otway, D. T., Middleton, B., Bretschneider, S., Wright, J., Robertson, M. D., Skene, D. J., and Johnston, J. D. Daily rhythms of plasma melatonin, but not plasma leptin or leptin mRNA, vary between lean, obese and type 2 diabetic men. PLoS.One. 2012;7(5):e37123. View Abstract
  875. Kuehn, C. C., Rodrigues Oliveira, L. G., Santos, C. D., Ferreira, D. S., Alonso Toldo, M. P., de, Albuquerque S., and do Prado, J. C. J. Melatonin and dehydroepiandrosterone combination: does this treatment exert a synergistic effect during experimental Trypanosoma cruzi infection? J.Pineal Res. 2009;47(3):253-259. View Abstract
  876. Monteleone, P., Natale, M., La Rocca, A., and Maj, M. Decreased nocturnal secretion of melatonin in drug-free schizophrenics: no change after subchronic treatment with antipsychotics. Neuropsychobiology 1997;36(4):159-163. View Abstract
  877. Sandyk, R., Kay, S. R., and Gillman, M. A. The role of melatonin in the antipsychotic and motor-side effects of neuroleptics: a hypothesis. Int.J Neurosci. 1992;64(1-4):203-207. View Abstract
  878. Nelson, L. A., McGuire, J. M., and Hausafus, S. N. Melatonin for the treatment of tardive dyskinesia. Ann.Pharmacother. 2003;37(7-8):1128-1131. View Abstract
  879. Naidu, P. S., Singh, A., Kaur, P., Sandhir, R., and Kulkarni, S. K. Possible mechanism of action in melatonin attenuation of haloperidol-induced orofacial dyskinesia. Pharmacol.Biochem.Behav 2003;74(3):641-648. View Abstract
  880. Naidu, P. S., Singh, A., and Kulkarni, S. K. Effect of Withania somnifera root extract on haloperidol-induced orofacial dyskinesia: possible mechanisms of action. J.Med.Food 2003;6(2):107-114. View Abstract
  881. Bhattacharya, S. K., Bhattacharya, D., Sairam, K., and Ghosal, S. Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia. Phytomedicine. 2002;9(2):167-170. View Abstract
  882. Cohrs, S., Pohlmann, K., Guan, Z., Jordan, W., Meier, A., Huether, G., Ruther, E., and Rodenbeck, A. Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects. Psychopharmacology (Berl) 2004;174(3):414-420. View Abstract
  883. Valero, N., Nery, A., Bonilla, E., Espina, L. M., Chacin-Bonilla, L., Anez, F., Maldonado, M., and Melean, E. Antagonistic effect of luzindole in mice treated with melatonin during the infection with the venezuelan equine encephalomyelitis virus. Neurochem.Res. 2009;34(2):268-273. View Abstract
  884. Ferini-Strambi, L., Zucconi, M., Biella, G., Stankov, B., Fraschini, F., Oldani, A., and Smirne, S. Effect of melatonin on sleep microstructure: preliminary results in healthy subjects. Sleep 1993;16(8):744-747. View Abstract
  885. Wright, K. P., Jr., Badia, P., Myers, B. L., Plenzler, S. C., and Hakel, M. Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. Brain Res 1-30-1997;747(1):78-84. View Abstract
  886. Myslobodsky, M. The paradox of caffeine-zolpidem interaction: a network analysis. Curr.Drug Targets. 2009;10(10):1009-1020. View Abstract
  887. Wright, K. P., Jr., Myers, B. L., Plenzler, S. C., Drake, C. L., and Badia, P. Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. Brain Res 8-11-2000;873(2):310-317. View Abstract
  888. MacKenzie, T., Comi, R., Sluss, P., Keisari, R., Manwar, S., Kim, J., Larson, R., and Baron, J. A. Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial. Metabolism 2007;56(12):1694-1698. View Abstract
  889. Nikolakopoulou, D. and Stamatakis A. The Role of Melatonin in the Pathology of the Cardiovascular System. Nosileftiki 2009;48:143-149.
  890. Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Jimenez-Sosa, A., Avanzas, P., Bosa-Ojeda, F., and Kaski, J. C. Usefulness of intraplatelet melatonin levels to predict angiographic no-reflow after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. Am.J.Cardiol. 12-1-2010;106(11):1540-1544. View Abstract
  891. Sletten, T., Burgess, H., Savic, N., Gilbert, S., and Dawson, D. The effects of bright light and nighttime melatonin administration on cardiac activity. J Hum.Ergol.(Tokyo) 2001;30(1-2):273-278. View Abstract
  892. Paul, M. A., Gray, G., Kenny, G., and Pigeau, R. A. Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance. Aviat.Space Environ.Med 2003;74(12):1263-1270. View Abstract
  893. Rogers, N. L., Kennaway, D. J., and Dawson, D. Neurobehavioural performance effects of daytime melatonin and temazepam administration. J Sleep Res 2003;12(3):207-212. View Abstract
  894. Gibb, J. W., Bush, L., and Hanson, G. R. Exacerbation of methamphetamine-induced neurochemical deficits by melatonin. J Pharmacol Exp Ther 1997;283(2):630-635. View Abstract
  895. Manev, H. and Uz, T. Dosing time-dependent actions of psychostimulants. Int.Rev.Neurobiol. 2009;88:25-41. View Abstract
  896. Singer C, Wild K, Sack R, and et al. High dose melatonin is well tolerated by the elderly [abstract]. Sleep Research 1994;23:86.
  897. Rizzo, P., Raffone, E., and Benedetto, V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur.Rev.Med.Pharmacol.Sci. 2010;14(6):555-561. View Abstract
  898. Casao, A., Mendoza, N., Perez-Pe, R., Grasa, P., Abecia, J. A., Forcada, F., Cebrian-Perez, J. A., and Muino-Blanco, T. Melatonin prevents capacitation and apoptotic-like changes of ram spermatozoa and increases fertility rate. J.Pineal Res. 2010;48(1):39-46. View Abstract
  899. Manjunatha, B. M., Devaraj, M., Gupta, P. S., Ravindra, J. P., and Nandi, S. Effect of taurine and melatonin in the culture medium on buffalo in vitro embryo development. Reprod.Domest.Anim 2009;44(1):12-16. View Abstract
  900. Kang, J. T., Koo, O. J., Kwon, D. K., Park, H. J., Jang, G., Kang, S. K., and Lee, B. C. Effects of melatonin on in vitro maturation of porcine oocyte and expression of melatonin receptor RNA in cumulus and granulosa cells. J.Pineal Res. 2009;46(1):22-28. View Abstract
  901. Shi, J. M., Tian, X. Z., Zhou, G. B., Wang, L., Gao, C., Zhu, S. E., Zeng, S. M., Tian, J. H., and Liu, G. S. Melatonin exists in porcine follicular fluid and improves in vitro maturation and parthenogenetic development of porcine oocytes. J.Pineal Res. 2009;47(4):318-323. View Abstract
  902. Vazquez, M. I., Forcada, F., Casao, A., Abecia, J. A., Sosa, C., and Palacin, I. Undernutrition and exogenous melatonin can affect the in vitro developmental competence of ovine oocytes on a seasonal basis. Reprod.Domest.Anim 2010;45(4):677-684. View Abstract
  903. Reiter, R. J., Tan, D. X., Manchester, L. C., Paredes, S. D., Mayo, J. C., and Sainz, R. M. Melatonin and reproduction revisited. Biol.Reprod. 2009;81(3):445-456. View Abstract
  904. Faigl, V., Keresztes, M., Kulcsar, M., Nagy, S., Keresztes, Z., Amiridis, G. S., Solti, L., Huszenicza, G., and Cseh, S. Testicular function and semen characteristics of Awassi rams treated with melatonin out of the breeding season. Acta Vet.Hung. 2009;57(4):531-540. View Abstract
  905. Tsiligianni, T., Valasi, I., Cseh, S., Vainas, E., Faigl, V., Samartzi, F., Papanikolaou, T., Dovolou, E., and Amiridis, G. S. Effects of melatonin treatment on follicular development and oocyte quality in Chios ewes – short communication. Acta Vet.Hung. 2009;57(2):331-335. View Abstract
  906. Berlinguer, F., Leoni, G. G., Succu, S., Spezzigu, A., Madeddu, M., Satta, V., Bebbere, D., Contreras-Solis, I., Gonzalez-Bulnes, A., and Naitana, S. Exogenous melatonin positively influences follicular dynamics, oocyte developmental competence and blastocyst output in a goat model. J.Pineal Res. 2009;46(4):383-391. View Abstract
  907. Scott, P. R., Sargison, N. D., Macrae, A. I., and Gough, M. R. Melatonin treatment prior to the normal breeding season increases fetal number in United Kingdom sheep flocks. Vet.J. 2009;182(2):198-202. View Abstract
  908. Vazquez, M. I., Forcada, F., Casao, A., Sosa, C., Palacin, I., and Abecia, J. A. Effects of melatonin and undernutrition on the viability of ovine embryos during anestrus and the breeding season. Anim Reprod.Sci. 2009;112(1-2):83-94. View Abstract
  909. Arrebola, F. A., Abecia, J. A., Forcada, F., Garcia, A., Martin, R. A., and Mesa, O. Effects of annual rainfall and farm on lamb production after treatment with melatonin implants in Merino sheep: a 4-year study. N.Z.Vet.J. 2009;57(3):141-145. View Abstract
  910. Yeleswaram, K., Vachharajani, N., and Santone, K. Involvement of cytochrome P-450 isozymes in melatonin metabolism and clinical implications. J Pineal Res 1999;26(3):190-191. View Abstract
  911. Faber, M. S., Jetter, A., and Fuhr, U. Assessment of CYP1A2 activity in clinical practice: why, how, and when? Basic Clin Pharmacol Toxicol. 2005;97(3):125-134. View Abstract
  912. Ursing, C., von Bahr, C., Brismar, K., and Rojdmark, S. Influence of cigarette smoking on melatonin levels in man. Eur.J Clin Pharmacol 2005;61(3):197-201. View Abstract
  913. Srinath, R., Acharya, A. B., and Thakur, S. L. Salivary and gingival crevicular fluid melatonin in periodontal health and disease. J.Periodontol. 2010;81(2):277-283. View Abstract
  914. Feng, Y., Zhang, L. X., and Chao, D. M. [Role of melatonin in spatial learning and memory in rats and its mechanism]. Sheng Li Xue.Bao. 2-25-2002;54(1):65-70. View Abstract
  915. Cardinali, D. P., Ladizesky, M. G., Boggio, V., Cutrera, R. A., and Mautalen, C. Melatonin effects on bone: experimental facts and clinical perspectives. J Pineal Res 2003;34(2):81-87. View Abstract
  916. Koyama, H., Nakade, O., Takada, Y., Kaku, T., and Lau, K. H. Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation. J Bone Miner.Res 2002;17(7):1219-1229. View Abstract
  917. Roth, J. A., Kim, B. G., Lin, W. L., and Cho, M. I. Melatonin promotes osteoblast differentiation and bone formation. J Biol Chem 7-30-1999;274(31):22041-22047. View Abstract
  918. Korkushko, O. V., Khavinson, V. K., Shatilo, V. B., and Antonyk-Sheglova, I. A. Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-up. Bull.Exp.Biol.Med. 2011;151(3):366-369. View Abstract
  919. Sanchez-Barcelo, E. J., Cos, S., Mediavilla, D., Martinez-Campa, C., Gonzalez, A., and Alonso-Gonzalez, C. Melatonin-estrogen interactions in breast cancer. J Pineal Res 2005;38(4):217-222. View Abstract
  920. Blask, D. E., Sauer, L. A., and Dauchy, R. T. Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr.Top.Med Chem. 2002;2(2):113-132. View Abstract
  921. Girgert, R., Hanf, V., Emons, G., and Grundker, C. Membrane-bound melatonin receptor MT1 down-regulates estrogen responsive genes in breast cancer cells. J.Pineal Res. 2009;47(1):23-31. View Abstract
  922. Martinez-Campa, C., Gonzalez, A., Mediavilla, M. D., Alonso-Gonzalez, C., Alvarez-Garcia, V., Sanchez-Barcelo, E. J., and Cos, S. Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells. Br.J.Cancer 11-3-2009;101(9):1613-1619. View Abstract
  923. Gonzalez, A., Martinez-Campa, C., Mediavilla, M. D., Alonso-Gonzalez, C., Alvarez-Garcia, V., Sanchez-Barcelo, E. J., and Cos, S. Inhibitory effects of melatonin on sulfatase and 17beta-hydroxysteroid dehydrogenase activity and expression in glioma cells. Oncol.Rep. 2010;23(4):1173-1178. View Abstract
  924. Molis, T. M., Spriggs, L. L., Jupiter, Y., and Hill, S. M. Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer. J Pineal Res 1995;18(2):93-103. View Abstract
  925. Granzotto, M., Rapozzi, V., Decorti, G., and Giraldi, T. Effects of melatonin on doxorubicin cytotoxicity in sensitive and pleiotropically resistant tumor cells. J Pineal Res 2001;31(3):206-213. View Abstract
  926. Danforth, D. N., Jr., Tamarkin, L., and Lippman, M. E. Melatonin increases oestrogen receptor binding activity of human breast cancer cells. Nature 9-22-1983;305(5932):323-325. View Abstract
  927. Danforth, D. N., Jr., Tamarkin, L., Mulvihill, J. J., Bagley, C. S., and Lippman, M. E. Plasma melatonin and the hormone-dependency of human breast cancer. J Clin Oncol 1985;3(7):941-948. View Abstract
  928. Bukowska, A. [Anticarcinogenic role of melatonin–potential mechanisms]. Med.Pr 2011;62(4):425-434. View Abstract
  929. Ochoa, J. J., Diaz-Castro, J., Kajarabille, N., Garcia, C., Guisado, I. M., De, Teresa C., and Guisado, R. Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. J.Pineal Res. 2011;51(4):373-380. View Abstract
  930. Golombek, D. A., Escolar, E., Burin, L. J., Brito Sanchez, M. G., Fernandez, Duque D., and Cardinali, D. P. Chronopharmacology of melatonin: inhibition by benzodiazepine antagonism. Chronobiol.Int. 1992;9(2):124-131. View Abstract
  931. Rakhimova, O. I. [Use of melatonin in combined treatment for inflammatory bowel diseases]. Ter.Arkh. 2010;82(12):64-68. View Abstract
  932. Sood, M. R. Treatment approaches to irritable bowel syndrome. Pediatr.Ann. 2009;38(5):272-276. View Abstract
  933. Gagnier, J. J. The therapeutic potential of melatonin in migraines and other headache types. Altern Med Rev 2001;6(4):383-389. View Abstract
  934. Nagtegaal, J. E., Smits, M. G., Swart, A. C., Kerkhof, G. A., and Van Der Meer, Y. G. Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. Headache 1998;38(4):303-307. View Abstract
  935. Rozen, T. D. Melatonin responsive hemicrania continua. Headache 2006;46(7):1203-1204. View Abstract
  936. Peres, M. F., Zukerman, E., da Cunha, Tanuri F., Moreira, F. R., and Cipolla-Neto, J. Melatonin, 3 mg, is effective for migraine prevention. Neurology 8-24-2004;63(4):757. View Abstract
  937. Rozen, T. D. Melatonin as treatment for idiopathic stabbing headache. Neurology 9-23-2003;61(6):865-866. View Abstract
  938. Ulas, U. H., Korkmaz, A., Karadas, O., Odabasi, Z., and Reiter, R. J. Sunrise-related headache: case report. Cephalalgia 2010;30(1):118-122. View Abstract
  939. Ferrante, E., Rossi, P., Tassorelli, C., Lisotto, C., and Nappi, G. Focus on therapy of primary stabbing headache. J.Headache Pain 2010;11(2):157-160. View Abstract
  940. Marrin, K., Drust, B., Gregson, W., Morris, C. J., Chester, N., and Atkinson, G. Diurnal variation in the salivary melatonin responses to exercise: relation to exercise-mediated tachycardia. Eur.J.Appl.Physiol 2011;111(11):2707-2714. View Abstract
  941. Kos-Kudla, B., Ostrowska, Z., Kozlowski, A., Marek, B., Ciesielska-Kopacz, N., Kudla, M., Kajdaniuk, D., Strzelczyk, J., and Staszewicz, P. Circadian rhythm of melatonin in patients with colorectal carcinoma. Neuroendocrinol.Lett. 2002;23(3):239-242. View Abstract
  942. Kos-Kudla, B., Ostrowska, Z., Marek, B., Kajdaniuk, D., Ciesielska-Kopacz, N., Kudla, M., Mazur, B., Glogowska-Szelag, J., and Nasiek, M. Circadian rhythm of melatonin in postmenopausal asthmatic women with hormone replacement therapy. Neuroendocrinol.Lett. 2002;23(3):243-248. View Abstract
  943. Weinberg, U., Weitzman, E. D., Fukushima, D. K., Cancel, G. F., and Rosenfeld, R. S. Melatonin does not suppress the pituitary luteinizing hormone response to luteinizing hormone-releasing hormone in men. J Clin Endocrinol Metab 1980;51(1):161-162. View Abstract
  944. Weinberg, U., Weitzman, E. D., Horowitz, Z. D., and Burg, A. C. Lack of an effect of melatonin on the basal and L-dopa stimulated growth hormone secretion in men. J Neural Transm. 1981;52(1-2):117-121. View Abstract
  945. Caufriez, A., Leproult, R., L’Hermite-Baleriaux, M., Kerkhofs, M., and Copinschi, G. Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women. J.Clin.Endocrinol.Metab 2011;96(4):E614-E623. View Abstract
  946. Hallam, K. T., Olver, J. S., Horgan, J. E., McGrath, C., and Norman, T. R. Low doses of lithium carbonate reduce melatonin light sensitivity in healthy volunteers. Int.J Neuropsychopharmacol. 2005;8(2):255-259. View Abstract
  947. Touitou, Y., Lambrozo, J., Camus, F., and Charbuy, H. Magnetic fields and the melatonin hypothesis: a study of workers chronically exposed to 50-Hz magnetic fields. Am.J Physiol Regul.Integr.Comp Physiol 2003;284(6):R1529-R1535. View Abstract
  948. Karasek, M., Czernicki, J., Woldanska-Okonska, M., Zylinska, K., and Swietoslawski, J. Chronic exposure to 25-80-microT, 200-Hz magnetic field does not influence serum melatonin concentrations in patients with low back pain. J Pineal Res 2000;29(2):81-85. View Abstract
  949. Karasek, M. and Lerchl, A. Melatonin and magnetic fields. Neuroendocrinol.Lett 2002;23 Suppl 1:84-87. View Abstract
  950. Jarupat, S., Kawabata, A., Tokura, H., and Borkiewicz, A. Effects of the 1900 MHz electromagnetic field emitted from cellular phone on nocturnal melatonin secretion. J Physiol Anthropol.Appl.Human Sci. 2003;22(1):61-63. View Abstract
  951. Jajte, J., Zmyslony, M., and Rajkowska, E. [Protective effect of melatonin and vitamin E against prooxidative action of iron ions and static magnetic field]. Med Pr 2003;54(1):23-28. View Abstract
  952. Pei, Z., Pang, S. F., and Cheung, R. T. Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Stroke 2003;34(3):770-775. View Abstract
  953. Pei, Z., Fung, P. C., and Cheung, R. T. Melatonin reduces nitric oxide level during ischemia but not blood-brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2003;34(2):110-118. View Abstract
  954. Reiter, R. J., Sainz, R. M., Lopez-Burillo, S., Mayo, J. C., Manchester, L. C., and Tan, D. X. Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke. Ann.N.Y.Acad.Sci. 2003;993:35-47. View Abstract
  955. Chaudhary, G., Sharma, U., Jagannathan, N. R., and Gupta, Y. K. Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats. Clin Exp.Pharmacol Physiol 2003;30(5-6):399-404. View Abstract
  956. Gupta, Y. K., Chaudhary, G., and Sinha, K. Enhanced protection by melatonin and meloxicam combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat. Can J Physiol Pharmacol. 2002;80(3):210-217. View Abstract
  957. Pei, Z., Pang, S. F., and Cheung, R. T. Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2002;32(3):168-172. View Abstract
  958. Pei, Z., Ho, H. T., and Cheung, R. T. Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat. Neurosci.Lett. 2-1-2002;318(3):141-144. View Abstract
  959. Adams, J. D., Jr., Yang, J., Mishra, L. C., and Singh, B. B. Effects of ashwagandha in a rat model of stroke. Altern Ther Health Med 2002;8(5):18-19. View Abstract
  960. Wang, X. The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS.Neurosci.Ther. 2009;15(4):345-357. View Abstract
  961. Odaci, E. and Kaplan, S. Chapter 16: Melatonin and nerve regeneration. Int.Rev.Neurobiol. 2009;87:317-335. View Abstract
  962. Uchida, K., Aoki, T., Satoh, H., and Tajiri, O. [Effects of melatonin on muscle contractility and neuromuscular blockade produced by muscle relaxants]. Masui 1997;46(2):205-212. View Abstract
  963. Vojnikovic, B. and Vojnikovic, D. Chromotherapy of macular degeneration with transitions lenses and green-yellow medical filters and special programme for psychoorganic disturbances. Coll.Antropol. 2010;34 Suppl 2:89-93. View Abstract
  964. Hu, R. F., Jiang, X. Y., Zeng, Y. M., Chen, X. Y., and Zhang, Y. H. Effects of earplugs and eye masks on nocturnal sleep, melatonin and cortisol in a simulated intensive care unit environment. Crit Care 2010;14(2):R66. View Abstract
  965. Zhou, Y. H., Huo, Z. Y., and Qiu, X. C. [Inhibitory effect of melatonin on morphine withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice]. Yao Xue.Xue.Bao. 2002;37(3):175-177. View Abstract
  966. Raghavendra, V. and Kulkarni, S. K. Reversal of morphine tolerance and dependence by melatonin: possible role of central and peripheral benzodiazepine receptors. Brain Res 7-10-1999;834(1-2):178-181. View Abstract
  967. Cook, J. S. and Ray, C. A. Melatonin attenuates the vestibulosympathetic but not vestibulocollic reflexes in humans: selective impairment of the utricles. J.Appl.Physiol 2010;109(6):1697-1701. View Abstract
  968. Jang, S. S., Kim, W. D., and Park, W. Y. Melatonin exerts differential actions on X-ray radiation-induced apoptosis in normal mice splenocytes and Jurkat leukemia cells. J.Pineal Res. 2009;47(2):147-155. View Abstract
  969. Kopjar, N., Miocic, S., Ramic, S., Milic, M., and Viculin, T. Assessment of the radioprotective effects of amifostine and melatonin on human lymphocytes irradiated with gamma-rays in vitro. Arh.Hig.Rada Toksikol. 2006;57(2):155-163. View Abstract
  970. Shirazi, A., Ghobadi, G., and Ghazi-Khansari, M. A radiobiological review on melatonin: a novel radioprotector. J Radiat.Res (Tokyo) 2007;48(4):263-272. View Abstract
  971. Luchetti, F., Betti, M., Canonico, B., Arcangeletti, M., Ferri, P., Galli, F., and Papa, S. ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells. Free Radic.Biol.Med. 2-1-2009;46(3):339-351. View Abstract
  972. Johnson, K., Page, A., Williams, H., Wassemer, E., and Whitehouse, W. The use of melatonin as an alternative to sedation in uncooperative children undergoing an MRI examination. Clin Radiol. 2002;57(6):502-506. View Abstract
  973. Kostopanagiotou, G., Kalimeris, K., Kesidis, K., Matsota, P., Dima, C., Economou, M., and Papageorgiou, C. Sevoflurane impairs post-operative olfactory memory but preserves olfactory function. Eur.J.Anaesthesiol. 2011;28(1):63-68. View Abstract
  974. Cagnacci, A., Elliott, J. A., and Yen, S. S. Melatonin: a major regulator of the circadian rhythm of core temperature in humans. J Clin Endocrinol.Metab 1992;75(2):447-452. View Abstract
  975. Reid, K., Van den, Heuvel C., and Dawson, D. Day-time melatonin administration: effects on core temperature and sleep onset latency. J Sleep Res 1996;5(3):150-154. View Abstract
  976. Deacon, S., English, J., and Arendt, J. Acute phase-shifting effects of melatonin associated with suppression of core body temperature in humans. Neurosci.Lett. 8-29-1994;178(1):32-34. View Abstract
  977. Slotten, H. A. and Krekling, S. Does melatonin have an effect on cognitive performance? Psychoneuroendocrinology 1996;21(8):673-680. View Abstract
  978. Dawson, D., Gibbon, S., and Singh, P. The hypothermic effect of melatonin on core body temperature: is more better? J Pineal Res 1996;20(4):192-197. View Abstract
  979. Mazzoccoli, G., Giuliani, A., Carughi, S., De Cata, A., Puzzolante, F., La Viola, M., Urbano, N., Perfetto, F., and Tarquini, R. The hypothalamic-pituitary-thyroid axis and melatonin in humans: possible interactions in the control of body temperature. Neuro.Endocrinol.Lett. 2004;25(5):368-372. View Abstract
  980. van der Helm-van Mil AH, van Someren, E. J., van den, Boom R., van Buchem, M. A., de Craen, A. J., and Blauw, G. J. No influence of melatonin on cerebral blood flow in humans. J Clin Endocrinol.Metab 2003;88(12):5989-5994. View Abstract
  981. Leu-Semenescu, S., Arnulf, I., Decaix, C., Moussa, F., Clot, F., Boniol, C., Touitou, Y., Levy, R., Vidailhet, M., and Roze, E. Sleep and rhythm consequences of a genetically induced loss of serotonin. Sleep 3-1-2010;33(3):307-314. View Abstract
  982. Acuna, C. D., Escames, G., Carazo, A., Leon, J., Khaldy, H., and Reiter, R. J. Melatonin, mitochondrial homeostasis and mitochondrial-related diseases. Curr.Top.Med Chem. 2002;2(2):133-151. View Abstract
  983. Allegra, M., Gentile, C., Tesoriere, L., and Livrea, M. A. Protective effect of melatonin against cytotoxic actions of malondialdehyde: an in vitro study on human erythrocytes. J Pineal Res 2002;32(3):187-193. View Abstract
  984. Awney, H. A., Attih, A. M., Habib, S. L., and Mostafa, M. H. Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1). Toxicology 3-20-2002;172(2):143-148. View Abstract
  985. Bonnefont-Rousselot, D., Cheve, G., Gozzo, A., Tailleux, A., Guilloz, V., Caisey, S., Teissier, E., Fruchart, J. C., Delattre, J., Jore, D., Lesieur, D., Duriez, P., and Gardes-Albert, M. Melatonin related compounds inhibit lipid peroxidation during copper or free radical-induced LDL oxidation. J Pineal Res 2002;33(2):109-117. View Abstract
  986. Celebi, S., Dilsiz, N., Yilmaz, T., and Kukner, A. S. Effects of melatonin, vitamin E and octreotide on lipid peroxidation during ischemia-reperfusion in the guinea pig retina. Eur.J Ophthalmol. 2002;12(2):77-83. View Abstract
  987. Cheung, R. T. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J Pineal Res 2003;34(3):153-160. View Abstract
  988. Fischer, T. W., Scholz, G., Knoll, B., Hipler, U. C., and Elsner, P. Melatonin reduces UV-induced reactive oxygen species in a dose- dependent manner in IL-3-stimulated leukocytes. J Pineal Res 2001;31(1):39-45.
  989. Fischer, T. W., Scholz, G., Knoll, B., Hipler, U. C., and Elsner, P. Melatonin suppresses reactive oxygen species in UV-irradiated leukocytes more than vitamin C and trolox. Skin Pharmacol.Appl.Skin Physiol 2002;15(5):367-373. View Abstract
  990. Kaptanoglu, E., Palaoglu, S., Demirpence, E., Akbiyik, F., Solaroglu, I., and Kilinc, A. Different responsiveness of central nervous system tissues to oxidative conditions and to the antioxidant effect of melatonin. J Pineal Res 2003;34(1):32-35. View Abstract
  991. Kim, B. C., Shon, B. S., Ryoo, Y. W., Kim, S. P., and Lee, K. S. Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts. J Dermatol Sci 2001;26(3):194-200. View Abstract
  992. Koc, M., Buyukokuroglu, M. E., and Taysi, S. The effect of melatonin on peripheral blood cells during total body irradiation in rats. Biol.Pharm Bull. 2002;25(5):656-657. View Abstract
  993. Koc, M., Taysi, S., Emin, Buyukokuroglu M., and Bakan, N. The effect of melatonin against oxidative damage during total-body irradiation in rats. Radiat.Res 2003;160(2):251-255. View Abstract
  994. Lee, Y. M., Chen, H. R., Hsiao, G., Sheu, J. R., Wang, J. J., and Yen, M. H. Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. J Pineal Res 2002;33(2):72-80. View Abstract
  995. Li, X. J., Zhang, L. M., Gu, J., Zhang, A. Z., and Sun, F. Y. Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion. Zhongguo Yao Li Xue.Bao. 1997;18(5):394-396. View Abstract
  996. Manev, H. and Uz, T. Oral melatonin in neurologically disabled children. Lancet 6-27-1998;351(9120):1963. View Abstract
  997. Mayo, J. C., Sainz, R. M., Uria, H., Antolin, I., Esteban, M. M., and Rodriguez. Inhibition of cell proliferation: a mechanism likely to mediate the prevention of neuronal cell death by melatonin. J Pineal Res 1998;25(1):12-18. View Abstract
  998. Mohanan, P. V. and Yamamoto, H. A. Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. Toxicol.Lett. 3-24-2002;129(1-2):99-105. View Abstract
  999. Okatani, Y., Wakatsuki, A., and Reiter, R. J. Melatonin counteracts potentiation by homocysteine of KCL-induced vasoconstriction in human umbilical artery: relation to calcium influx. Biochem Biophys Res Commun. 1-26-2001;280(3):940-944. View Abstract
  1000. Pei, Z. and Cheung, R. T. Melatonin protects SHSY5Y neuronal cells but not cultured astrocytes from ischemia due to oxygen and glucose deprivation. J Pineal Res 2003;34(3):194-201. View Abstract
  1001. Pierrefiche, G., Topall, G., Courboin, G., Henriet, I., and Laborit, H. Antioxidant activity of melatonin in mice. Res Commun Chem Pathol.Pharmacol 1993;80(2):211-223. View Abstract
  1002. Reiter RJ, Tan DX, and Manchester LC. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys 2001;34(2):237-256.
  1003. Reiter, R. J., Acuna-Castroviejo, D., Tan, D. X., and Burkhardt, S. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann N Y Acad Sci 2001;939:200-215. View Abstract
  1004. Ressmeyer, A. R., Mayo, J. C., Zelosko, V., Sainz, R. M., Tan, D. X., Poeggeler, B., Antolin, I., Zsizsik, B. K., Reiter, R. J., and Hardeland, R. Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction. Redox.Rep. 2003;8(4):205-213. View Abstract
  1005. Reiter, R. J. and Tan, D. X. Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovasc.Res 4-1-2003;58(1):10-19. View Abstract
  1006. Reiter, R. J. Melatonin: clinical relevance. Best.Pract.Res Clin Endocrinol.Metab 2003;17(2):273-285. View Abstract
  1007. Reiter, R. J. and Tan, D. X. What constitutes a physiological concentration of melatonin? J Pineal Res 2003;34(1):79-80. View Abstract
  1008. Sahna, E., Acet, A., Ozer, M. K., and Olmez, E. Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin. J Pineal Res 2002;33(4):234-238. View Abstract
  1009. Sahna, E., Olmez, E., and Acet, A. Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced? J Pineal Res 2002;32(3):194-198. View Abstract
  1010. Sahna, E., Parlakpinar, H., Ozturk, F., Cigremis, Y., and Acet, A. The protective effects of physiological and pharmacological concentrations of melatonin on renal ischemia-reperfusion injury in rats. Urol.Res 2003;31(3):188-193. View Abstract
  1011. Sener, G., Tosun, O., Sehirli, A. O., Kacmaz, A., Arbak, S., Ersoy, Y., and Ayanoglu-Dulger, G. Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci. 5-2-2003;72(24):2707-2718. View Abstract
  1012. Sener, G., Sehirli, A. O., Paskaloglu, K., Dulger, G. A., and Alican, I. Melatonin treatment protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder. J Pineal Res 2003;34(3):226-230. View Abstract
  1013. Taysi, S., Koc, M., Buyukokuroglu, M. E., Altinkaynak, K., and Sahin, Y. N. Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J Pineal Res 2003;34(3):173-177. View Abstract
  1014. Vijayalaxmi, Reiter, R. J., and Meltz, M. L. Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutat.Res 1995;346(1):23-31. View Abstract
  1015. Wakatsuki, A., Okatani, Y., Ikenoue, N., Shinohara, K., Watanabe, K., and Fukaya, T. Melatonin protects against oxidized low-density lipoprotein-induced inhibition of nitric oxide production in human umbilical artery. J Pineal Res 2001;31(3):281-288. View Abstract
  1016. Zhang, J., Guo, J. D., Xing, S. H., Gu, S. L., and Dai, T. J. [The protective effects of melatonin on global cerebral ischemia-reperfusion injury in gerbils]. Yao Xue.Xue.Bao. 2002;37(5):329-333. View Abstract
  1017. Zhang, Z. and Yu, C. X. [Effect of melatonin on learning and memory impairment induced by aluminum chloride and its mechanism]. Yao Xue.Xue.Bao. 2002;37(9):682-686. View Abstract
  1018. Aladag, M. A., Turkoz, Y., Parlakpinar, H., Ozen, H., Egri, M., and Unal, S. C. Melatonin ameliorates cerebral vasospasm after experimental subarachnoidal haemorrhage correcting imbalance of nitric oxide levels in rats. Neurochem.Res. 2009;34(11):1935-1944. View Abstract
  1019. Maciel, F. E., Ramos, B. P., Geihs, M. A., Vargas, M. A., Cruz, B. P., Meyer-Rochow, V. B., Vakkuri, O., Allodi, S., Monserrat, J. M., and Nery, L. E. Effects of melatonin in connection with the antioxidant defense system in the gills of the estuarine crab Neohelice granulata. Gen.Comp Endocrinol. 1-15-2010;165(2):229-236. View Abstract
  1020. Geihs, M. A., Vargas, M. A., Maciel, F. E., Caldas, S. S., Cruz, B. P., Primel, E. G., Monserrat, J. M., and Nery, L. E. Effect of melatonin in the antioxidant defense system in the locomotor muscles of the estuarine crab Neohelice granulata (Decapoda, Brachyura). Gen.Comp Endocrinol. 3-1-2010;166(1):72-82. View Abstract
  1021. Franca, E. L., Feliciano, N. D., Silva, K. A., Ferrari, C. K., and Honorio-Franca, A. C. Modulatory role of melatonin on superoxide release by spleen macrophages isolated from alloxan-induced diabetic rats. Bratisl.Lek.Listy 2009;110(9):517-522. View Abstract
  1022. Huang, S. H., Cao, X. J., Liu, W., Shi, X. Y., and Wei, W. Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice. J.Pineal Res. 2010;48(2):109-116. View Abstract
  1023. Espino, J., Bejarano, I., Paredes, S. D., Gonzalez, D., Barriga, C., Reiter, R. J., Pariente, J. A., and Rodriguez, A. B. Melatonin counteracts alterations in oxidative metabolism and cell viability induced by intracellular calcium overload in human leucocytes: changes with age. Basic Clin.Pharmacol.Toxicol. 2010;107(1):590-597. View Abstract
  1024. Lopez-Burillo, S., Tan, D. X., Mayo, J. C., Sainz, R. M., Manchester, L. C., and Reiter, R. J. Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions. J Pineal Res 2003;34(4):269-277. View Abstract
  1025. Montilla-Lopez, P., Munoz-Agueda, M. C., Feijoo, Lopez M., Munoz-Castaneda, J. R., Bujalance-Arenas, I., and Tunez-Finana, I. Comparison of melatonin versus vitamin C on oxidative stress and antioxidant enzyme activity in Alzheimer’s disease induced by okadaic acid in neuroblastoma cells. Eur.J Pharmacol. 9-20-2002;451(3):237-243. View Abstract
  1026. Pappolla, M. A., Simovich, M. J., Bryant-Thomas, T., Chyan, Y. J., Poeggeler, B., Dubocovich, M., Bick, R., Perry, G., Cruz-Sanchez, F., and Smith, M. A. The neuroprotective activities of melatonin against the Alzheimer beta- protein are not mediated by melatonin membrane receptors. J Pineal Res 2002;32(3):135-142. View Abstract
  1027. Hardeland, R., Reiter, R. J., Poeggeler, B., and Tan, D. X. The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substances. Neurosci.Biobehav.Rev 1993;17(3):347-357. View Abstract
  1028. Mayo, J. C., Tan, D. X., Sainz, R. M., Natarajan, M., Lopez-Burillo, S., and Reiter, R. J. Protection against oxidative protein damage induced by metal-catalyzed reaction or alkylperoxyl radicals: comparative effects of melatonin and other antioxidants. Biochim.Biophys.Acta 3-17-2003;1620(1-3):139-150. View Abstract
  1029. Mayo, J. C., Tan, D. X., Sainz, R. M., Lopez-Burillo, S., and Reiter, R. J. Oxidative damage to catalase induced by peroxyl radicals: functional protection by melatonin and other antioxidants. Free Radic.Res 2003;37(5):543-553. View Abstract
  1030. Pieri, C., Marra, M., Moroni, F., Recchioni, R., and Marcheselli, F. Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci 1994;55(15):L271-L276. View Abstract
  1031. Reiter RJ, Poeggeler B, Tan D, and et al. Antioxidant capacity of melatonin: a novel action not requiring a receptor. Neuroendocrinol.Lett. 1993;15(1+2):103-116.
  1032. Reiter, R. J., Melchiorri, D., Sewerynek, E., Poeggeler, B., Barlow-Walden, L., Chuang, J., Ortiz, G. G., and Acuna-Castroviejo, D. A review of the evidence supporting melatonin’s role as an antioxidant. J Pineal Res 1995;18(1):1-11. View Abstract
  1033. Tan, D. X., Hardeland, R., Manchester, L. C., Poeggeler, B., Lopez-Burillo, S., Mayo, J. C., Sainz, R. M., and Reiter, R. J. Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical. J Pineal Res 2003;34(4):249-259. View Abstract
  1034. Tan, D. X., Manchester, L. C., Hardeland, R., Lopez-Burillo, S., Mayo, J. C., Sainz, R. M., and Reiter, R. J. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 2003;34(1):75-78. View Abstract
  1035. Edwards, R. B., Manzana, E. J., and Chen, W. J. Melatonin (an antioxidant) does not ameliorate alcohol-induced Purkinje cell loss in the developing cerebellum. Alcohol Clin Exp.Res 2002;26(7):1003-1009. View Abstract
  1036. Wiechmann, A. F. and O’Steen, W. K. Melatonin increases photoreceptor susceptibility to light-induced damage. Invest Ophthalmol Vis Sci 1992;33(6):1894-1902. View Abstract
  1037. Dericks-Tan, J. S., Schwinn, P., and Hildt, C. Dose-dependent stimulation of melatonin secretion after administration of agnus castus. Exp.Clin Endocrinol.Diabetes 2003;111(1):44-46. View Abstract
  1038. Inserra, P., Zhang, Z., Ardestani, S. K., Araghi-Niknam, M., Liang, B., Jiang, S., Shaw, D., Molitor, M., Elliott, K., and Watson, R. R. Modulation of cytokine production by dehydroepiandrosterone (DHEA) plus melatonin (MLT) supplementation of old mice. Proc Soc Exp Biol Med 1998;218(1):76-82. View Abstract
  1039. Currier, N. L., Sicotte, M., and Miller, S. C. Deleterious effects of Echinacea purpurea and melatonin on myeloid cells in mouse spleen and bone marrow. J Leukoc.Biol 2001;70(2):274-276. View Abstract
  1040. Fournier, I., Ploye, F., Cottet-Emard, J. M., Brun, J., and Claustrat, B. Folate deficiency alters melatonin secretion in rats. J Nutr. 2002;132(9):2781-2784. View Abstract
  1041. Niederhofer, H. and von, Klitzing K. Bright light treatment as mono-therapy of non-seasonal depression for 28 adolescents. Int.J.Psychiatry Clin.Pract. 2012;16(3):233-237. View Abstract
  1042. Lieverse, R., van Someren, E. J., Nielen, M. M., Uitdehaag, B. M., Smit, J. H., and Hoogendijk, W. J. Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial. Arch.Gen.Psychiatry 2011;68(1):61-70. View Abstract
  1043. Claustrat, B., Brun, J., Borson-Chazot, F., Cohen-Tannoudji, D., Claustrat, F., Julien, J., and Lemoine, P. Suppression of melatonin secretion in healthy subjects with eyeglass LED delivery system. Neuro.Endocrinol.Lett. 2010;31(3):330-335. View Abstract
  1044. Chellappa, S. L., Steiner, R., Blattner, P., Oelhafen, P., Gotz, T., and Cajochen, C. Non-visual effects of light on melatonin, alertness and cognitive performance: can blue-enriched light keep us alert? PLoS.One. 2011;6(1):e16429. View Abstract
  1045. Zeitzer, J. M., Friedman, L., and Yesavage, J. A. Effectiveness of evening phototherapy for insomnia is reduced by bright daytime light exposure. Sleep Med. 2011;12(8):805-807. View Abstract
  1046. Pail, G., Huf, W., Pjrek, E., Winkler, D., Willeit, M., Praschak-Rieder, N., and Kasper, S. Bright-light therapy in the treatment of mood disorders. Neuropsychobiology 2011;64(3):152-162. View Abstract
  1047. Tooley, G. A., Armstrong, S. M., Norman, T. R., and Sali, A. Acute increases in night-time plasma melatonin levels following a period of meditation. Biol.Psychol. 2000;53(1):69-78. View Abstract
  1048. Kumar, A. M., Tims, F., Cruess, D. G., Mintzer, M. J., Ironson, G., Loewenstein, D., Cattan, R., Fernandez, J. B., Eisdorfer, C., and Kumar, M. Music therapy increases serum melatonin levels in patients with Alzheimer’s disease. Altern.Ther.Health Med. 1999;5(6):49-57. View Abstract
  1049. Martin, M. T., Azpiroz, F., and Malagelada, J. R. Melatonin and the gastrointestinal tract. Therapie 1998;53(5):453-458. View Abstract
  1050. Ceinos, R. M., Polakof, S., Illamola, A. R., Soengas, J. L., and Miguez, J. M. Food deprivation and refeeding effects on pineal indoles metabolism and melatonin synthesis in the rainbow trout Oncorhynchus mykiss. Gen.Comp Endocrinol. 4-1-2008;156(2):410-417. View Abstract
  1051. Flemstrom, G., Bengtsson, M. W., Makela, K., and Herzig, K. H. Effects of short-term food deprivation on orexin-A-induced intestinal bicarbonate secretion in comparison with related secretagogues. Acta Physiol (Oxf) 2010;198(3):373-380. View Abstract
  1052. Lane, E. A. and Moss, H. B. Pharmacokinetics of melatonin in man: first pass hepatic metabolism. J Clin Endocrinol Metab 1985;61(6):1214-1216. View Abstract
  1053. Waldhauser, F., Waldhauser, M., Lieberman, H. R., Deng, M. H., Lynch, H. J., and Wurtman, R. J. Bioavailability of oral melatonin in humans. Neuroendocrinology 1984;39(4):307-313. View Abstract
  1054. Garrido, M., Espino, J., Gonzalez-Gomez, D., Lozano, M., Barriga, C., Paredes, S. D., and Rodriguez, A. B. The consumption of a Jerte Valley cherry product in humans enhances mood, and increases 5-hydroxyindoleacetic acid but reduces cortisol levels in urine. Exp.Gerontol. 2012;47(8):573-580. View Abstract
  1055. Garrido, M., Paredes, S. D., Cubero, J., Lozano, M., Toribio-Delgado, A. F., Munoz, J. L., Reiter, R. J., Barriga, C., and Rodriguez, A. B. Jerte Valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans. J.Gerontol.A Biol.Sci.Med.Sci. 2010;65(9):909-914. View Abstract
  1056. Oba, S., Nakamura, K., Sahashi, Y., Hattori, A., and Nagata, C. Consumption of vegetables alters morning urinary 6-sulfatoxymelatonin concentration. J Pineal Res 2008;45(1):17-23. View Abstract
  1057. Sander, J., Shamdeen, M. G., Gottschling, S., Gortner, L., Graber, S., and Meyer, S. Melatonin does not influence sleep deprivation electroencephalogram recordings in children. Eur.J.Pediatr. 2012;171(4):675-679. View Abstract
  1058. Di, W. L., Kadva, A., Johnston, A., and Silman, R. Variable bioavailability of oral melatonin. N.Engl.J Med 4-3-1997;336(14):1028-1029. View Abstract
  1059. Iamshanov, V. A. and Koshelevskii, V. K. [The influence of circadian rhythms of geomagnetic field variations and the background cosmic radiation on nitric oxide production in human organism]. Adv.Gerontol. 2012;25(3):405-408. View Abstract
  1060. Thestrup-Pedersen, K. and Sondergaard, K. Melatonin used for tanning induces and augments lentigines and naevi. Acta Derm.Venereol. 2010;90(6):643-644. View Abstract
  1061. Langan, E. A. and Rhodes, L. E. Melanotropic peptides: what exactly is meant by “melanotan”? Acta Derm.Venereol. 2011;91(3):377-378. View Abstract
  1062. Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., and Cardinali, D. P. Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Travel.Med Infect.Dis. 2008;6(1-2):17-28. View Abstract
  1063. Abilio, V. C., Vera, J. A., Jr., Ferreira, L. S., Duarte, C. R., Martins, C. R., Torres-Leite, D., Ribeiro, Rde A., and Frussa-Filho, R. Effects of melatonin on behavioral dopaminergic supersensitivity. Life Sci. 5-16-2003;72(26):3003-3015. View Abstract
  1064. Kvetnoy, I. M., Ingel, I. E., Kvetnaia, T. V., Malinovskaya, N. K., Rapoport, S. I., Raikhlin, N. T., Trofimov, A. V., and Yuzhakov, V. V. Gastrointestinal melatonin: cellular identification and biological role. Neuroendocrinol.Lett. 2002;23(2):121-132. View Abstract
  1065. Reiter, R. J., Rollag, M. D., Panke, E. S., and Banks, A. F. Melatonin: reproductive effects. J Neural Transm.Suppl 1978;(13):209-223. View Abstract
  1066. Hajak, G., Huether, G., Blanke, J., Blomer, M., Freyer, C., Poeggeler, B., Reimer, A., Rodenbeck, A., Schulz-Varszegi, M., and Ruther, E. The influence of intravenous L-tryptophan on plasma melatonin and sleep in men. Pharmacopsychiatry 1991;24(1):17-20. View Abstract
  1067. Szczepanik, M. Melatonin and its influence on immune system. J Physiol Pharmacol 2007;58 Suppl 6:115-124. View Abstract
  1068. Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., and Markey, S. P. Light suppresses melatonin secretion in humans. Science 12-12-1980;210(4475):1267-1269. View Abstract
  1069. Regelson, W. and Pierpaoli, W. Melatonin: a rediscovered antitumor hormone? Its relation to surface receptors; sex steroid metabolism, immunologic response, and chronobiologic factors in tumor growth and therapy. Cancer Invest 1987;5(4):379-385. View Abstract
  1070. Cagnacci, A., Soldani, R., and Yen, S. S. Contemporaneous melatonin administration modifies the circadian response to nocturnal bright light stimuli. Am J Physiol 1997;272(2 Pt 2):R482-R486. View Abstract
  1071. Brainard, G. C., Rollag, M. D., Hanifin, J. P., van den, Beld G., and Sanford, B. The effect of polarized versus nonpolarized light on melatonin regulation in humans. Photochem.Photobiol. 2000;71(6):766-770. View Abstract
  1072. Rea, M. S., Bullough, J. D., and Figueiro, M. G. Human melatonin suppression by light: a case for scotopic efficiency. Neurosci.Lett 2-16-2001;299(1-2):45-48. View Abstract
  1073. Czeisler, C. A., Shanahan, T. L., Klerman, E. B., Martens, H., Brotman, D. J., Emens, J. S., Klein, T., and Rizzo, J. F., III. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med 1-5-1995;332(1):6-11. View Abstract
  1074. Hatonen, T., Laakso, M. L., Heiskala, H., Alila-Johansson, A., Sainio, K., and Santavuori, P. Bright light suppresses melatonin in blind patients with neuronal ceroid-lipofuscinoses. Neurology 1998;50(5):1445-1450. View Abstract
  1075. Cowen, P. J., Fraser, S., Sammons, R., and Green, A. R. Atenolol reduces plasma melatonin concentration in man. Br J Clin Pharmacol 1983;15(5):579-581. View Abstract
  1076. Hanssen, T., Heyden, T., Sundberg, I., and Wetterberg, L. Effect of propranolol on serum-melatonin. Lancet 8-6-1977;2(8032):309-310. View Abstract
  1077. Cowen, P. J., Bevan, J. S., Gosden, B., and Elliott, S. A. Treatment with beta-adrenoceptor blockers reduces plasma melatonin concentration. Br J Clin Pharmacol 1985;19(2):258-260. View Abstract
  1078. Munoz-Hoyos, A., Hubber, E., Escames, G., Molina-Carballo, A., Macias, M., Valenzuela-Ruiz, A., Fernandez-Garcia, J. M., and Acuna-Castroviejo, D. Effect of propranolol plus exercise on melatonin and growth hormone levels in children with growth delay. J Pineal Res 2001;30(2):75-81. View Abstract
  1079. Palazidou, E., Franey, C., Arendt, J., Stahl, S., and Checkley, S. Evidence for a functional role of alpha-1 adrenoceptors in the regulation of melatonin secretion in man. Psychoneuroendocrinology 1989;14(1-2):131-135. View Abstract
  1080. Palazidou, E., Papadopoulos, A., Sitsen, A., Stahl, S., and Checkley, S. An alpha 2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man. Psychopharmacology (Berl) 1989;97(1):115-117. View Abstract
  1081. Lewy, A. J., Siever, L. J., Uhde, T. W., and Markey, S. P. Clonidine reduces plasma melatonin levels. J Pharm Pharmacol 1986;38(7):555-556. View Abstract
  1082. Birdsall TC. The biological effects and clinical uses of the pineal hormone melatonin. Altern Med Rev 1996;1(2):94-102.
  1083. Palazidou, E., Skene, D., Arendt, J., Everitt, B., and Checkley, S. A. The acute and chronic effects of (+) and (-) oxaprotiline upon melatonin secretion in normal subjects. Psychol Med 1992;22(1):61-67. View Abstract
  1084. Monteleone, P., Orazzo, C., Natale, M., and Maj, M. Lack of effect of short-term fluoxetine administration on nighttime plasma melatonin levels in healthy subjects. Biol Psychiatry 1-15-1994;35(2):139-142. View Abstract
  1085. Wurtman, R. J. and Ozaki, Y. Physiological control of melatonin synthesis and secretion: mechanisms, generating rhythms in melatonin, methoxytryptophol, and arginine vasotocin levels and effects on the pineal of endogenous catecholamines, the estrous cycle, and environmental lighting. J Neural Transm.Suppl 1978;(13):59-70. View Abstract
  1086. Goh, V. H., Tong, T. Y., Lim, C. L., Low, E. C., and Lee, L. K. Effects of one night of sleep deprivation on hormone profiles and performance efficiency. Mil.Med 2001;166(5):427-431. View Abstract
  1087. Laughlin, G. A., Loucks, A. B., and Yen, S. S. Marked augmentation of nocturnal melatonin secretion in amenorrheic athletes, but not in cycling athletes: unaltered by opioidergic or dopaminergic blockade. J Clin Endocrinol Metab 1991;73(6):1321-1326. View Abstract
  1088. Brugger, P., Marktl, W., and Herold, M. Impaired nocturnal secretion of melatonin in coronary heart disease. Lancet 6-3-1995;345(8962):1408. View Abstract
  1089. Fourtillan, J. B., Brisson, A. M., Fourtillan, M., Ingrand, I., Decourt, J. P., and Girault, J. Melatonin secretion occurs at a constant rate in both young and older men and women. Am J Physiol Endocrinol Metab 2001;280(1):E11-E22. View Abstract
  1090. Ardura, J., Gutierrez, R., Andres, J., and Agapito, T. Emergence and evolution of the circadian rhythm of melatonin in children. Horm.Res 2003;59(2):66-72. View Abstract
  1091. Sandyk, R. Melatonin and maturation of REM sleep. Int J Neurosci 1992;63(1-2):105-114. View Abstract
  1092. Cardinali, D. P., Del Zar, M. M., and Vacas, M. I. The effects of melatonin in human platelets. Acta Physiol Pharmacol Ther Latinoam. 1993;43(1-2):1-13. View Abstract
  1093. Vacas, M. I. and Cardinali, D. P. Diurnal changes in melatonin binding sites of hamster and rat brains. Correlations with neuroendocrine responsiveness to melatonin. Neurosci Lett 1979;15(2-3):259-263. View Abstract
  1094. Becker-Andre, M., Wiesenberg, I., Schaeren-Wiemers, N., Andre, E., Missbach, M., Saurat, J. H., and Carlberg, C. Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J Biol Chem 11-18-1994;269(46):28531-28534. View Abstract
  1095. Short, R. V. Melatonin. BMJ 10-16-1993;307(6910):952-953. View Abstract
  1096. Sack, R. L., Hughes, R. J., Edgar, D. M., and Lewy, A. J. Sleep-promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanisms? Sleep 1997;20(10):908-915. View Abstract
  1097. Zhdanova, I. V., Lynch, H. J., and Wurtman, R. J. Melatonin: a sleep-promoting hormone. Sleep 1997;20(10):899-907. View Abstract
  1098. Matsumoto, M., Sack, R. L., Blood, M. L., and Lewy, A. J. The amplitude of endogenous melatonin production is not affected by melatonin treatment in humans. J Pineal Res 1997;22(1):42-44. View Abstract
  1099. Cavallo, A. The pineal gland in human beings: relevance to pediatrics. J Pediatr 1993;123(6):843-851. View Abstract
  1100. Monti, J. M. and Cardinali, D. P. A critical assessment of the melatonin effect on sleep in humans. Biol Signals Recept. 2000;9(6):328-339. View Abstract
  1101. Reiter, R. J. The melatonin message: duration versus coincidence hypotheses. Life Sci 6-1-1987;40(22):2119-2131. View Abstract
  1102. Bothorel, B., Barassin, S., Saboureau, M., Perreau, S., Vivien-Roels, B., Malan, A., and Pevet, P. In the rat, exogenous melatonin increases the amplitude of pineal melatonin secretion by a direct action on the circadian clock. Eur.J Neurosci. 2002;16(6):1090-1098. View Abstract
  1103. Monteleone, P., Tortorella, A., Borriello, R., Natale, M., Cassandro, P., and Maj, M. Suppression of nocturnal plasma melatonin levels by evening administration of sodium valproate in healthy humans. Biol Psychiatry 2-1-1997;41(3):336-341. View Abstract
  1104. Monteleone, P., Forziati, D., Orazzo, C., and Maj, M. Preliminary observations on the suppression of nocturnal plasma melatonin levels by short-term administration of diazepam in humans. J Pineal Res 1989;6(3):253-258. View Abstract
  1105. Ekman, A. C., Leppaluoto, J., Huttunen, P., Aranko, K., and Vakkuri, O. Ethanol inhibits melatonin secretion in healthy volunteers in a dose- dependent randomized double blind cross-over study. J Clin Endocrinol Metab 1993;77(3):780-783. View Abstract
  1106. Johnson, S. Micronutrient accumulation and depletion in schizophrenia, epilepsy, autism and Parkinson’s disease? Med Hypotheses 2001;56(5):641-645. View Abstract
  1107. Luboshitzky, R., Lavi, S., Thuma, I., and Lavie, P. Testosterone treatment alters melatonin concentrations in male patients with gonadotropin-releasing hormone deficiency. J Clin Endocrinol Metab 1996;81(2):770-774. View Abstract
  1108. Luboshitzky, R., Wagner, O., Lavi, S., Herer, P., and Lavie, P. Abnormal melatonin secretion in hypogonadal men: the effect of testosterone treatment. Clin Endocrinol.(Oxf) 1997;47(4):463-469. View Abstract
  1109. Nakamura, Y., Tamura, H., Kashida, S., Takayama, H., Yamagata, Y., Karube, A., Sugino, N., and Kato, H. Changes of serum melatonin level and its relationship to feto-placental unit during pregnancy. J Pineal Res 2001;30(1):29-33. View Abstract
  1110. Kennaway, D. J., Flanagan, D. E., Moore, V. M., Cockington, R. A., Robinson, J. S., and Phillips, D. I. The impact of fetal size and length of gestation on 6- sulphatoxymelatonin excretion in adult life. J Pineal Res 2001;30(3):188-192. View Abstract
  1111. Viviani, S., Bidoli, P., Spinazze, S., Rovelli, F., and Lissoni, P. Normalization of the light/dark rhythm of melatonin after prolonged subcutaneous administration of interleukin-2 in advanced small cell lung cancer patients. J Pineal Res 1992;12(3):114-117. View Abstract
  1112. Deacon, S. and Arendt, J. Posture influences melatonin concentrations in plasma and saliva in humans. Neurosci.Lett 2-14-1994;167(1-2):191-194. View Abstract
  1113. Fraschini, F., Cesarani, A., Alpini, D., Esposti, D., and Stankov, B. M. Melatonin influences human balance. Biol.Signals Recept. 1999;8(1-2):111-119. View Abstract
  1114. Stewart, J. W. and Halbreich, U. Plasma melatonin levels in depressed patients before and after treatment with antidepressant medication. Biol Psychiatry 1989;25(1):33-38. View Abstract
  1115. Bordet, R., Devos, D., Brique, S., Touitou, Y., Guieu, J. D., Libersa, C., and Destee, A. Study of circadian melatonin secretion pattern at different stages of Parkinson’s disease. Clin Neuropharmacol. 2003;26(2):65-72. View Abstract
  1116. Franey, C., Aldhous, M., Burton, S., Checkley, S., and Arendt, J. Acute treatment with desipramine stimulates melatonin and 6-sulphatoxy melatonin production in man. Br J Clin Pharmacol 1986;22(1):73-79. View Abstract
  1117. Buxton, O. M., Lee, C. W., L’Hermite-Baleriaux, M., Turek, F. W., and Van Cauter, E. Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase. Am.J Physiol Regul.Integr.Comp Physiol 2003;284(3):R714-R724. View Abstract
  1118. Cavallo, A., Richards, G. E., Meyer, W. J., III, and Waldrop, R. D. Evaluation of 5-hydroxytryptophan administration as a test of pineal function in humans. Horm Res 1987;27(2):69-73. View Abstract
  1119. Kancheva, R., Zofkova, I., Hill, M., and Kanchev, L. Lack of melatonin response to acute administration of nifedipine and diltiazem in healthy men. Physiol Res 2000;49 Suppl 1:S119-S124. View Abstract
  1120. Munoz-Hoyos, A., Heredia, F., Moreno, F., Garcia, J. J., Molina-Carballo, A., Escames, G., and Acuna-Castroviejo, D. Evaluation of plasma levels of melatonin after midazolam or sodium thiopental anesthesia in children. J Pineal Res 2002;32(4):253-256. View Abstract
  1121. Wetterberg, L., Eriksson, O., Friberg, Y., and Vangbo, B. A simplified radioimmunoassay for melatonin and its application to biological fluids. Preliminary observations on the half-life of plasma melatonin in man. Clin Chim.Acta 1978;86(2):169-177. View Abstract
  1122. Cugini, P., Touitou, Y., Bogdan, A., Auzeby, A., Pellegrino, A. M., Fontana, S., Vacca, K., Siena, G. D., Di Rosa, R., Zannella, F. P., Zannella, P., Zannella, A., Sepe, F. A., and Sepe, L. Is melatonin circadian rhythm a physiological feature associated with healthy longevity? A study of long-living subjects and their progeny. Chronobiol Int 2001;18(1):99-107. View Abstract
  1123. Kripke, D. F., Elliot, J. A., Youngstedt, S. D., and Smith, J. S. Melatonin: marvel or marker? Ann.Med 1998;30(1):81-87. View Abstract
  1124. Pepping, J. Melatonin. Am J Health Syst.Pharm 12-15-1999;56(24):2520, 2523-2524, 2527. View Abstract
  1125. Sack, R. L., Lewy, A. J., Erb, D. L., Vollmer, W. M., and Singer, C. M. Human melatonin production decreases with age. J Pineal Res 1986;3(4):379-388. View Abstract
  1126. Nathan, P. J., Burrows, G. D., and Norman, T. R. The effect of age and pre-light melatonin concentration on the melatonin sensitivity to dim light. Int Clin Psychopharmacol. 1999;14(3):189-192. View Abstract
  1127. Zeitzer, J. M., Daniels, J. E., Duffy, J. F., Klerman, E. B., Shanahan, T. L., Dijk, D. J., and Czeisler, C. A. Do plasma melatonin concentrations decline with age? Am J Med 1999;107(5):432-436. View Abstract
  1128. Mishima, K., Tozawa, T., Satoh, K., Matsumoto, Y., Hishikawa, Y., and Okawa, M. Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer’s type with disturbed sleep-waking. Biol Psychiatry 2-15-1999;45(4):417-421. View Abstract
  1129. Lewy, A. J. and Newsome, D. A. Different types of melatonin circadian secretory rhythms in some blind subjects. J Clin Endocrinol Metab 1983;56(6):1103-1107. View Abstract
  1130. Nakagawa, H., Sack, R. L., and Lewy, A. J. Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person. Sleep 1992;15(4):330-336. View Abstract
  1131. Lockley, S., Tabandeh, H., Skene, D., Buttery, R., Bird, A., Defrace, R., and Arendt, J. Day-time naps and melatonin in blind people. Lancet 12-2-1995;346(8988):1491. View Abstract
  1132. Lewy, A. J., Emens, J. S., Sack, R. L., Hasler, B. P., and Bernert, R. A. Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period. Chronobiol.Int 2002;19(3):649-658. View Abstract
  1133. Oren, D. A., Turner, E. H., and Wehr, T. A. Abnormal circadian rhythms of plasma melatonin and body temperature in the delayed sleep phase syndrome. J Neurol Neurosurg Psychiatry 1995;58(3):379. View Abstract
  1134. Waldhauser, F., Vierhapper, H., and Pirich, K. Abnormal circadian melatonin secretion in night-shift workers. N.Engl.J Med 12-18-1986;315(25):1614. View Abstract
  1135. Harma, M., Laitinen, J., Partinen, M., and Suvanto, S. The effect of four-day round trip flights over 10 time zones on the circadian variation of salivary melatonin and cortisol in airline flight attendants. Ergonomics 1994;37(9):1479-1489. View Abstract
  1136. Shochat, T., Haimov, I., and Lavie, P. Melatonin–the key to the gate of sleep. Ann.Med 1998;30(1):109-114. View Abstract
  1137. Claustrat, B., Brun, J., Garry, P., Roussel, B., and Sassolas, G. A once-repeated study of nocturnal plasma melatonin patterns and sleep recordings in six normal young men. J Pineal Res 1986;3(4):301-310. View Abstract
  1138. Youngstedt, S. D., Kripke, D. F., and Elliott, J. A. Melatonin excretion is not related to sleep in the elderly. J Pineal Res 1998;24(3):142-145. View Abstract
  1139. Rommel, T. and Demisch, L. Influence of chronic beta-adrenoreceptor blocker treatment on melatonin secretion and sleep quality in patients with essential hypertension. J Neural Transm.Gen.Sect. 1994;95(1):39-48. View Abstract
  1140. Ebadi, M., Govitrapong, P., Phansuwan-Pujito, P., Nelson, F., and Reiter, R. J. Pineal opioid receptors and analgesic action of melatonin. J.Pineal Res. 1998;24(4):193-200. View Abstract
  1141. Esteban, S., Garau, C., Aparicio, S., Moranta, D., Barcelo, P., Fiol, M. A., and Rial, R. Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain. J.Pineal Res. 2010;48(2):170-177. View Abstract
  1142. Rai, S., Haldar, C., and Singh, R. Modulation of immunity in young-adult and aged squirrel, Funambulus pennanti by melatonin and p-chlorophenylalanine. Immun.Ageing 2009;6:5. View Abstract
  1143. Tajes, Orduna M., Pelegri, Gabalda C., Vilaplana, Hortensi J., Pallas, Lliberia M., and Camins, Espuny A. An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis. J.Pineal Res. 2009;46(3):262-267. View Abstract
  1144. Blask, D. E., Dauchy, R. T., Sauer, L. A., Krause, J. A., and Brainard, G. C. Light during darkness, melatonin suppression and cancer progression. Neuroendocrinol.Lett. 2002;23 Suppl 2:52-56. View Abstract
  1145. Paternoster, L., Radogna, F., Accorsi, A., Cristina, Albertini M., Gualandi, G., and Ghibelli, L. Melatonin as a modulator of apoptosis in B-lymphoma cells. Ann.N.Y.Acad.Sci. 2009;1171:345-349. View Abstract
  1146. Martin, V., Garcia-Santos, G., Rodriguez-Blanco, J., Casado-Zapico, S., Sanchez-Sanchez, A., Antolin, I., Medina, M., and Rodriguez, C. Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death. Cancer Lett. 1-28-2010;287(2):216-223. View Abstract
  1147. Bejarano, I., Redondo, P. C., Espino, J., Rosado, J. A., Paredes, S. D., Barriga, C., Reiter, R. J., Pariente, J. A., and Rodriguez, A. B. Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells. J.Pineal Res. 2009;46(4):392-400. View Abstract
  1148. Joo, S. S. and Yoo, Y. M. Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer. J.Pineal Res. 2009;47(1):8-14. View Abstract
  1149. Cucina, A., Proietti, S., D’Anselmi, F., Coluccia, P., Dinicola, S., Frati, L., and Bizzarri, M. Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells. J.Pineal Res. 2009;46(2):172-180. View Abstract
  1150. Korkmaz, A., Sanchez-Barcelo, E. J., Tan, D. X., and Reiter, R. J. Role of melatonin in the epigenetic regulation of breast cancer. Breast Cancer Res.Treat. 2009;115(1):13-27. View Abstract
  1151. Park, J. W., Hwang, M. S., Suh, S. I., and Baek, W. K. Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells. J.Pineal Res. 2009;46(4):415-421. View Abstract
  1152. Ozdemir, F., Deniz, O., Kaynar, K., Arslan, M., Kavgaci, H., Yildiz, B., and Aydin, F. The effects of melatonin on human hepatoma (Hep G2) cell line. Bratisl.Lek.Listy 2009;110(5):276-279. View Abstract
  1153. Danielczyk, K. and Dziegiel, P. [MT1 melatonin receptors and their role in the oncostatic action of melatonin]. Postepy Hig.Med.Dosw.(Online.) 2009;63:425-434. View Abstract
  1154. Dauchy, R. T., Blask, D. E., Dauchy, E. M., Davidson, L. K., Tirrell, P. C., Greene, M. W., Tirrell, R. P., Hill, C. R., and Sauer, L. A. Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. J.Pineal Res. 2009;47(1):32-42. View Abstract
  1155. Benitez-King, G., Soto-Vega, E., and Ramirez-Rodriguez, G. Melatonin modulates microfilament phenotypes in epithelial cells: implications for adhesion and inhibition of cancer cell migration. Histol.Histopathol. 2009;24(6):789-799. View Abstract
  1156. Ortiz-Lopez, L., Morales-Mulia, S., Ramirez-Rodriguez, G., and Benitez-King, G. ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration. J.Pineal Res. 2009;46(1):15-21. View Abstract
  1157. Korkmaz, A., Tamura, H., Manchester, L. C., Ogden, G. B., Tan, D. X., and Reiter, R. J. Combination of melatonin and a peroxisome proliferator-activated receptor-gamma agonist induces apoptosis in a breast cancer cell line. J.Pineal Res. 2009;46(1):115-116. View Abstract
  1158. Nishimura, J., Saegusa, Y., Dewa, Y., Jin, M., Kawai, M., Kemmochi, S., Harada, T., Hayashi, S. M., Shibutani, M., and Mitsumori, K. Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats. Arch.Toxicol. 2010;84(2):143-153. View Abstract
  1159. Carbajo-Pescador, S., Martin-Renedo, J., Garcia-Palomo, A., Tunon, M. J., Mauriz, J. L., and Gonzalez-Gallego, J. Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells. J.Pineal Res. 2009;47(4):330-338. View Abstract
  1160. Hill, S. M., Frasch, T., Xiang, S., Yuan, L., Duplessis, T., and Mao, L. Molecular mechanisms of melatonin anticancer effects. Integr.Cancer Ther. 2009;8(4):337-346. View Abstract
  1161. Karasek, M., Gruszka, A., Lawnicka, H., Kunert-Radek, J., and Pawlikowski, M. Melatonin inhibits growth of diethylstilbestrol-induced prolactin-secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors. J Pineal Res 2003;34(4):294-296. View Abstract
  1162. Blask, D. E. and Hill, S. M. Effects of melatonin on cancer: studies on MCF-7 human breast cancer cells in culture. J Neural Transm.Suppl 1986;21:433-449. View Abstract
  1163. Blask DE, Hill SM, Pelletier DB, and et al. Melatonin: an anticancer hormone of the pineal gland. In: Reiter RJ and Pang SF. Advances in Pineal Research. London, England: John Libbey;1989.
  1164. Bartsch, H., Buchberger, A., Franz, H., Bartsch, C., Maidonis, I., Mecke, D., and Bayer, E. Effect of melatonin and pineal extracts on human ovarian and mammary tumor cells in a chemosensitivity assay. Life Sci 11-3-2000;67(24):2953-2960. View Abstract
  1165. Grin, W. and Grunberger, W. A significant correlation between melatonin deficiency and endometrial cancer. Gynecol Obstet Invest 1998;45(1):62-65. View Abstract
  1166. Karasek, M., Kowalski, A. J., and Zylinska, K. Serum melatonin circadian profile in women suffering from the genital tract cancers. Neuroendocrinol.Lett 2000;21(2):109-113. View Abstract
  1167. Jonage-Canonico, M. B., Lenoir, V., Martin, A., Scholler, R., and Kerdelhue, B. Long term inhibition by Estradiol or Progesterone of Melatonin secretion after administration of a mammary carcinogen, the dimethyl benz(a)anthracene, in Sprague-Dawley female rat; inhibitory effect of Melatonin on mammary carcinogenesis. Breast Cancer Res Treat. 2003;79(3):365-377. View Abstract
  1168. Dillon, D. C., Easley, S. E., Asch, B. B., Cheney, R. T., Brydon, L., Jockers, R., Winston, J. S., Brooks, J. S., Hurd, T., and Asch, H. L. Differential expression of high-affinity melatonin receptors (MT1) in normal and malignant human breast tissue. Am.J Clin Pathol. 2002;118(3):451-458. View Abstract
  1169. Marelli, M. M., Limonta, P., Maggi, R., Motta, M., and Moretti, R. M. Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cells. Prostate 11-1-2000;45(3):238-244. View Abstract
  1170. Shiu, S. Y., Law, I. C., Lau, K. W., Tam, P. C., Yip, A. W., and Ng, W. T. Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype. J Pineal Res 2003;35(3):177-182. View Abstract
  1171. Dai, J., Ram, P. T., Yuan, L., Spriggs, L. L., and Hill, S. M. Transcriptional repression of RORalpha activity in human breast cancer cells by melatonin. Mol.Cell Endocrinol 5-15-2001;176(1-2):111-120. View Abstract
  1172. L’Hermite-Baleriaux, M. and de Launoit, Y. Is melatonin really an in vitro inhibitor of human breast cancer cell proliferation? In Vitro Cell Dev.Biol 1992;28A(9-10):583-584. View Abstract
  1173. Bubis, M. and Zisapel, N. Modulation by melatonin of protein secretion from melanoma cells: is cAMP involved? Mol.Cell Endocrinol. 8-11-1995;112(2):169-175. View Abstract
  1174. Bizzarri, M., Cucina, A., Valente, M. G., Tagliaferri, F., Borrelli, V., Stipa, F., and Cavallaro, A. Melatonin and vitamin D3 increase TGF-beta1 release and induce growth inhibition in breast cancer cell cultures. J Surg Res 2003;110(2):332-337. View Abstract
  1175. Cos, S. and Sanchez-Barcelo, E. J. Melatonin and mammary pathological growth. Front Neuroendocrinol. 2000;21(2):133-170. View Abstract
  1176. Dauchy, R. T., Sauer, L. A., Blask, D. E., and Vaughan, G. M. Light contamination during the dark phase in “photoperiodically controlled” animal rooms: effect on tumor growth and metabolism in rats. Lab Anim Sci 1997;47(5):511-518. View Abstract
  1177. Fariello, R. G., Bubenik, G. A., Brown, G. M., and Grota, L. J. Epileptogenic action of intraventricularly injected antimelatonin antibody. Neurology 1977;27(6):567-570. View Abstract
  1178. Shieh, J. M., Wu, H. T., Cheng, K. C., and Cheng, J. T. Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCzeta-Akt-GSK3beta pathway in hepatic cells. J.Pineal Res. 2009;47(4):339-344. View Abstract
  1179. Mulder, H., Nagorny, C. L., Lyssenko, V., and Groop, L. Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene. Diabetologia 2009;52(7):1240-1249. View Abstract
  1180. Srivastava, R. K. and Krishna, A. Melatonin modulates glucose homeostasis during winter dormancy in a vespertilionid bat, Scotophilus heathi. Comp Biochem.Physiol A Mol.Integr.Physiol 2010;155(3):392-400. View Abstract
  1181. Bazwinsky-Wutschke, I., Muhlbauer, E., Wolgast, S., and Peschke, E. Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1). Horm.Metab Res. 2009;41(11):805-813. View Abstract
  1182. No author. [Relationship between insulin, leptin, and melatonin contents in patients with metabolic syndrome]. Klin.Med.(Mosk) 2011;89(6):46-49. View Abstract
  1183. Veneroso, C., Tunon, M. J., Gonzalez-Gallego, J., and Collado, P. S. Melatonin reduces cardiac inflammatory injury induced by acute exercise. J.Pineal Res. 2009;47(2):184-191. View Abstract
  1184. Radogna, F., Sestili, P., Martinelli, C., Paolillo, M., Paternoster, L., Albertini, M. C., Accorsi, A., Gualandi, G., and Ghibelli, L. Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism. Toxicol.Appl.Pharmacol. 7-15-2009;238(2):170-177. View Abstract
  1185. Cuzzocrea, S. and Reiter, R. J. Pharmacological actions of melatonin in acute and chronic inflammation. Curr.Top.Med Chem. 2002;2(2):153-165. View Abstract
  1186. Reiter RJ, Tan DX, Acuña-Castroviejo D, and et al. Melatonin: mechanisms and actions as an antioxidant. Curr Top Biophys 2000;24:171-183.
  1187. Reiter, R. J., Tan, D. X., Manchester, L. C., and El Sawi, M. R. Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging. Ann.N.Y.Acad.Sci 2002;959:238-250. View Abstract
  1188. Reiter, R. J. and Tan, D. X. Melatonin: an antioxidant in edible plants. Ann.N.Y.Acad.Sci. 2002;957:341-344. View Abstract
  1189. Sainz, R. M., Mayo, J. C., Tan, D. X., Lopez-Burillo, S., Natarajan, M., and Reiter, R. J. Antioxidant activity of melatonin in Chinese hamster ovarian cells: changes in cellular proliferation and differentiation. Biochem.Biophys.Res Commun. 3-14-2003;302(3):625-634. View Abstract
  1190. Pieri C, Moroni M, Marcheselli F, and et al. Melatonin is an efficient antioxidant. Arch Gerontol Geriatr 1995;20:159-165.
  1191. Gulcin, I., Buyukokuroglu, M. E., and Kufrevioglu, O. I. Metal chelating and hydrogen peroxide scavenging effects of melatonin. J Pineal Res 2003;34(4):278-281. View Abstract
  1192. Baeza, I., Fdez-Tresguerres, J., Ariznavarreta, C., and De la Fuente, M. Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats. Biogerontology. 2010;11(6):687-701. View Abstract
  1193. Yiannakopoulou, E., Nikiteas, N., Perrea, D., and Tsigris, C. Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review. Surg.Laparosc.Endosc.Percutan.Tech. 2012;22(3):200-204. View Abstract
  1194. Fowler, G., Daroszewska, M., and Ingold, K. U. Melatonin does not “directly scavenge hydrogen peroxide”: demise of another myth. Free Radic.Biol.Med 1-1-2003;34(1):77-83. View Abstract
  1195. Beloosesky, Y., Grinblat, J., Laudon, M., Grosman, B., Streifler, J. Y., and Zisapel, N. Melatonin rhythms in stroke patients. Neurosci.Lett. 2-15-2002;319(2):103-106. View Abstract
  1196. Mrowicka, M., Garncarek, P., Miller, E., Kedziora, J., Smigielski, J., Malinowska, K., and Mrowicki, J. [Effect of melatonin on activity of superoxide dismutase (CuZn-SOD) in erythrocytes of patients during short- and long-term hypokinesis]. Wiad.Lek. 2010;63(1):3-9. View Abstract
  1197. Ferri, C. and Grassi, D. Antioxidants and beneficial microvascular effects: is this the remedy? Hypertension 2010;55(6):1310-1311. View Abstract
  1198. Rezzani, R., Porteri, E., De, Ciuceis C., Bonomini, F., Rodella, L. F., Paiardi, S., Boari, G. E., Platto, C., Pilu, A., Avanzi, D., Rizzoni, D., and Agabiti, Rosei E. Effects of melatonin and Pycnogenol on small artery structure and function in spontaneously hypertensive rats. Hypertension 2010;55(6):1373-1380. View Abstract
  1199. Sewerynek, E. Melatonin and the cardiovascular system. Neuroendocrinol.Lett 2002;23 Suppl 1:79-83. View Abstract
  1200. Paulis, L., Pechanova, O., Zicha, J., Barta, A., Gardlik, R., Celec, P., Kunes, J., and Simko, F. Melatonin interactions with blood pressure and vascular function during L-NAME-induced hypertension. J.Pineal Res. 2010;48(2):102-108. View Abstract
  1201. Ray, C. A. Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans. J Physiol 9-15-2003;551(Pt 3):1043-1048. View Abstract
  1202. Dollins, A. B., Lynch, H. J., Wurtman, R. J., Deng, M. H., and Lieberman, H. R. Effects of illumination on human nocturnal serum melatonin levels and performance. Physiol Behav. 1993;53(1):153-160. View Abstract
  1203. Ferrari, E., Foppa, S., Bossolo, P. A., Comis, S., Esposti, G., Licini, V., Fraschini, F., and Brambilla, F. Melatonin and pituitary-gonadal function in disorders of eating behavior. J Pineal Res 1989;7(2):115-124. View Abstract
  1204. Fideleff, H., Aparicio, N. J., Guitelman, A., Debeljuk, L., Mancini, A., and Cramer, C. Effect of melatonin on the basal and stimulated gonadotropin levels in normal men and postmenopausal women. J Clin Endocrinol Metab 1976;42(6):1014-1017. View Abstract
  1205. Aleem, F. A., Weitzman, E. D., and Weinberg, U. Suppression of basal luteinizing hormone concentrations by melatonin in postmenopausal women. Fertil.Steril. 1984;42(6):923-925. View Abstract
  1206. Strassman, R. J., Qualls, C. R., Lisansky, E. J., and Peake, G. T. Sleep deprivation reduces LH secretion in men independently of melatonin. Acta Endocrinol (Copenh) 1991;124(6):646-651. View Abstract
  1207. Paccotti, P., Terzolo, M., Torta, M., Vignani, A., Schena, M., Piovesan, A., and Angeli, A. Acute administration of melatonin at two opposite circadian stages does not change responses to gonadotropin releasing hormone, thyrotropin releasing hormone and ACTH in healthy adult males. J Endocrinol Invest 1987;10(5):471-477. View Abstract
  1208. Vriend, J., Sheppard, M. S., and Borer, K. T. Melatonin increases serum growth hormone and insulin-like growth factor I (IGF-I) levels in male Syrian hamsters via hypothalamic neurotransmitters. Growth Dev.Aging 1990;54(4):165-171. View Abstract
  1209. Smythe, G. A. and Lazarus, L. Growth hormone regulation by melatonin and serotonin. Nature 7-27-1973;244(5413):230-231. View Abstract
  1210. Smythe, G. A. and Lazarus, L. Suppression of human growth hormone secretion by melatonin and cyproheptadine. J Clin Invest 1974;54(1):116-121. View Abstract
  1211. Coiro, V., Volpi, R., Capretti, L., Giuliani, N., Caffarri, G., Colla, R., Marchesi, C., and Chiodera, P. Different effects of naloxone on the growth hormone response to melatonin and pyridostigmine in normal men. Metabolism 1998;47(7):814-816. View Abstract
  1212. Esposti, D., Lissoni, P., Mauri, R., Rovelli, F., Orsenigo, L., Pescia, S., Vegetti, G., Esposti, G., and Fraschini, F. The pineal gland-opioid system relation: melatonin-naloxone interactions in regulating GH and LH releases in man. J Endocrinol Invest 1988;11(2):103-106. View Abstract
  1213. Wright, J., Aldhous, M., Franey, C., English, J., and Arendt, J. The effects of exogenous melatonin on endocrine function in man. Clin Endocrinol (Oxf) 1986;24(4):375-382. View Abstract
  1214. Doyle, S. E., Grace, M. S., McIvor, W., and Menaker, M. Circadian rhythms of dopamine in mouse retina: the role of melatonin. Vis.Neurosci. 2002;19(5):593-601. View Abstract
  1215. Okatani, Y. and Sagara, Y. Role of melatonin in nocturnal prolactin secretion in women with normoprolactinemia and mild hyperprolactinemia. Am J Obstet Gynecol 1993;168(3 Pt 1):854-861. View Abstract
  1216. McIntyre, I. M., Norman, T. R., Burrows, G. D., and Armstrong, S. M. Alterations to plasma melatonin and cortisol after evening alprazolam administration in humans. Chronobiol Int 1993;10(3):205-213. View Abstract
  1217. Chiodera, P., Volpi, R., Capretti, L., Giuliani, N., Maffei, M. L., and Coiro, V. Effect of melatonin on arginine vasopressin secretion stimulated by physical exercise or angiotensin II in normal men. Neuropeptides 1998;32(2):125-129. View Abstract
  1218. Jaworek, J. Ghrelin and melatonin in the regulation of pancreatic exocrine secretion and maintaining of integrity. J Physiol Pharmacol 2006;57 Suppl 5:83-96. View Abstract
  1219. Cabeza, J., Alarcon-de-la-Lastra, C., Jimenez, D., Martin, M. J., and Motilva, V. Melatonin modulates the effects of gastric injury in rats: role of prostaglandins and nitric oxide. Neurosignals. 2003;12(2):71-77. View Abstract
  1220. Singh, P., Bhargava, V. K., and Garg, S. K. Effect of melatonin and beta-carotene on indomethacin induced gastric mucosal injury. Indian J Physiol Pharmacol. 2002;46(2):229-234. View Abstract
  1221. Sjoblom, M., Jedstedt, G., and Flemstrom, G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest 2001;108(4):625-633. View Abstract
  1222. Maity, P., Bindu, S., Dey, S., Goyal, M., Alam, A., Pal, C., Reiter, R., and Bandyopadhyay, U. Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis. J.Pineal Res. 2009;46(3):314-323. View Abstract
  1223. Friedman, O., Orvieto, R., Fisch, B., Felz, C., Freud, E., Ben-Haroush, A., and Abir, R. Possible improvements in human ovarian grafting by various host and graft treatments. Hum.Reprod. 2012;27(2):474-482. View Abstract
  1224. Lissoni, P., Ardizzoia, A., Tisi, E., Rossini, F., Barni, S., Tancini, G., Conti, A., and Maestroni, G. J. Amplification of eosinophilia by melatonin during the immunotherapy of cancer with interleukin-2. J Biol Regul.Homeost.Agents 1993;7(1):34-36. View Abstract
  1225. Lissoni, P., Barni, S., Ardizzoia, A., Brivio, F., Tancini, G., Conti, A., and Maestroni, G. J. Immunological effects of a single evening subcutaneous injection of low- dose interleukin-2 in association with the pineal hormone melatonin in advanced cancer patients. J Biol Regul Homeost.Agents 1992;6(4):132-136. View Abstract
  1226. Maestroni, G. J. The immunoneuroendocrine role of melatonin. J.Pineal Res. 1993;14(1):1-10. View Abstract
  1227. Arias, J., Melean, E., Valero, N., Pons, H., Chacin-Bonilla, L., Larreal, Y., and Bonilla, E. [Effect of melatonin on lymphocyte proliferation and production of interleukin-2 (IL-2) and interleukin-1 beta (IL-1 beta) in mice splenocytes]. Invest Clin 2003;44(1):41-50. View Abstract
  1228. Maestroni, G. J., Conti, A., and Pierpaoli, W. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol. 1986;13(1):19-30. View Abstract
  1229. Poon, A. M., Liu, Z. M., Pang, C. S., Brown, G. M., and Pang, S. F. Evidence for a direct action of melatonin on the immune system. Biol Signals 1994;3(2):107-117. View Abstract
  1230. Chung, S. Y. and Han, S. H. Melatonin attenuates kainic acid-induced hippocampal neurodegeneration and oxidative stress through microglial inhibition. J Pineal Res 2003;34(2):95-102. View Abstract
  1231. Peres, M. F., Masruha, M. R., Zukerman, E., Moreira-Filho, C. A., and Cavalheiro, E. A. Potential therapeutic use of melatonin in migraine and other headache disorders. Expert.Opin.Investig.Drugs 2006;15(4):367-375. View Abstract
  1232. Huang, J. Y., Hong, Y. T., and Chuang, J. I. Fibroblast growth factor 9 prevents MPP+-induced death of dopaminergic neurons and is involved in melatonin neuroprotection in vivo and in vitro. J.Neurochem. 2009;109(5):1400-1412. View Abstract
  1233. Tapias, V., Escames, G., Lopez, L. C., Lopez, A., Camacho, E., Carrion, M. D., Entrena, A., Gallo, M. A., Espinosa, A., and Acuna-Castroviejo, D. Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice. J.Neurosci.Res. 2009;87(13):3002-3010. View Abstract
  1234. Borah, A. and Mohanakumar, K. P. Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents. J.Pineal Res. 2009;47(4):293-300. View Abstract
  1235. Guizar-Sahagun, G., Rodriguez-Balderas, C. A., Franco-Bourland, R. E., Martinez-Cruz, A., Grijalva, I., Ibarra, A., and Madrazo, I. Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions. Spinal Cord. 2009;47(2):156-160. View Abstract
  1236. Chang, H. M., Wu, U. I., and Lan, C. T. Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats. J.Pineal Res. 2009;47(3):211-220. View Abstract
  1237. Ucar, E., Lehtinen, E. K., Glenthoj, B. Y., and Oranje, B. The effect of acute exogenous melatonin on P50 suppression in healthy male volunteers stratified for low and high gating levels. J.Psychopharmacol. 2012;26(8):1113-1118. View Abstract
  1238. Gingerich, S., Wang, X., Lee, P. K., Dhillon, S. S., Chalmers, J. A., Koletar, M. M., and Belsham, D. D. The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons. Neuroscience 9-15-2009;162(4):1134-1140. View Abstract
  1239. Takasaki, A., Tamura, H., Taniguchi, K., Asada, H., Taketani, T., Matsuoka, A., Yamagata, Y., Shimamura, K., Morioka, H., and Sugino, N. Luteal blood flow and luteal function. J.Ovarian.Res. 2009;2:1. View Abstract
  1240. Gimenez, F., Stornelli, M. C., Tittarelli, C. M., Savignone, C. A., Dorna, I. V., de la Sota, R. L., and Stornelli, M. A. Suppression of estrus in cats with melatonin implants. Theriogenology 9-1-2009;72(4):493-499. View Abstract
  1241. Cetin, Y., Sagcan, S., Gungor, O., Ozyurtlu, N., and Uslu, B. A. Effects of CIDR-G and melatonin implants, and their combination on the efficacy of oestrus induction and fertility of Kilis goats. Reprod.Domest.Anim 2009;44(4):659-662. View Abstract
  1242. Renuka, K. and Joshi, B. N. Melatonin-induced changes in ovarian function in the freshwater fish Channa punctatus (Bloch) held in long days and continuous light. Gen.Comp Endocrinol. 1-1-2010;165(1):42-46. View Abstract
  1243. Wang, F., Li, J., Wu, C., Yang, J., Xu, F., and Zhao, Q. The GABA(A) receptor mediates the hypnotic activity of melatonin in rats. Pharmacol.Biochem.Behav 2003;74(3):573-578. View Abstract
  1244. Nave, R., Herer, P., Haimov, I., Shlitner, A., and Lavie, P. Hypnotic and hypothermic effects of melatonin on daytime sleep in humans: lack of antagonism by flumazenil. Neurosci.Lett 8-23-1996;214(2-3):123-126. View Abstract
  1245. Gorfine, T., Assaf, Y., Goshen-Gottstein, Y., Yeshurun, Y., and Zisapel, N. Sleep-anticipating effects of melatonin in the human brain. Neuroimage. 5-15-2006;31(1):410-418. View Abstract
  1246. Revell, V. L., Burgess, H. J., Gazda, C. J., Smith, M. R., Fogg, L. F., and Eastman, C. I. Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. J Clin Endocrinol.Metab 2006;91(1):54-59. View Abstract
  1247. Rajaratnam, S. M., Middleton, B., Stone, B. M., Arendt, J., and Dijk, D. J. Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities in humans. J Physiol 11-15-2004;561(Pt 1):339-351. View Abstract
  1248. Wirz-Justice, A., Werth, E., Renz, C., Muller, S., and Krauchi, K. No evidence for a phase delay in human circadian rhythms after a single morning melatonin administration. J Pineal Res 2002;32(1):1-5. View Abstract
  1249. Vandewalle, G., Middleton, B., Rajaratnam, S. M., Stone, B. M., Thorleifsdottir, B., Arendt, J., and Dijk, D. J. Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod. J Sleep Res 2007;16(2):148-155. View Abstract
  1250. Rajaratnam, S. M., Dijk, D. J., Middleton, B., Stone, B. M., and Arendt, J. Melatonin phase-shifts human circadian rhythms with no evidence of changes in the duration of endogenous melatonin secretion or the 24-hour production of reproductive hormones. J Clin Endocrinol.Metab 2003;88(9):4303-4309. View Abstract
  1251. Krauchi, K., Cajochen, C., Mori, D., Graw, P., and Wirz-Justice, A. Early evening melatonin and S-20098 advance circadian phase and nocturnal regulation of core body temperature. Am J Physiol 1997;272(4 Pt 2):R1178-R1188. View Abstract
  1252. Hatonen, T., Alila, A., and Laakso, M. L. Exogenous melatonin fails to counteract the light-induced phase delay of human melatonin rhythm. Brain Res 2-26-1996;710(1-2):125-130. View Abstract
  1253. Deacon, S. and Arendt, J. Melatonin-induced temperature suppression and its acute phase-shifting effects correlate in a dose-dependent manner in humans. Brain Res 8-7-1995;688(1-2):77-85. View Abstract
  1254. Steinlechner, S. Melatonin as a chronobiotic: PROS and CONS. Acta Neurobiol.Exp (Warsz.) 1996;56(1):363-372. View Abstract
  1255. Lewy, A. J. and Sack, R. L. Exogenous melatonin’s phase-shifting effects on the endogenous melatonin profile in sighted humans: a brief review and critique of the literature. J Biol Rhythms 1997;12(6):588-594. View Abstract
  1256. Zaidan, R., Geoffriau, M., Brun, J., Taillard, J., Bureau, C., Chazot, G., and Claustrat, B. Melatonin is able to influence its secretion in humans: description of a phase-response curve. Neuroendocrinology 1994;60(1):105-112. View Abstract
  1257. Cagnacci, A., Krauchi, K., Wirz-Justice, A., and Volpe, A. Homeostatic versus circadian effects of melatonin on core body temperature in humans. J Biol.Rhythms 1997;12(6):509-517. View Abstract
  1258. Gilbert, S. S., van den Heuvel, C. J., and Dawson, D. Daytime melatonin and temazepam in young adult humans: equivalent effects on sleep latency and body temperatures. J Physiol 2-1-1999;514 ( Pt 3):905-914. View Abstract
  1259. Sisecioglu, M., Cankaya, M., Gulcin, I., and Ozdemir, H. Interactions of melatonin and serotonin with lactoperoxidase enzyme. J.Enzyme Inhib.Med.Chem. 2010;25(6):779-783. View Abstract
  1260. DeMuro, R. L., Nafziger, A. N., Blask, D. E., Menhinick, A. M., and Bertino, J. S., Jr. The absolute bioavailability of oral melatonin. J Clin Pharmacol 2000;40(7):781-784. View Abstract
  1261. Lee, B. J., Parrott, K. A., Ayres, J. W., and Sack, R. L. Preliminary evaluation of transdermal delivery of melatonin in human subjects. Res Commun Mol Pathol.Pharmacol 1994;85(3):337-346. View Abstract
  1262. Benes, L., Claustrat, B., Horriere, F., Geoffriau, M., Konsil, J., Parrott, K. A., DeGrande, G., McQuinn, R. L., and Ayres, J. W. Transmucosal, oral controlled-release, and transdermal drug administration in human subjects: a crossover study with melatonin. J Pharm Sci 1997;86(10):1115-1119. View Abstract
  1263. Antolin, I., Mayo, J. C., Sainz, R. M., del Brio, Mde L., Herrera, F., Martin, V., and Rodriguez, C. Protective effect of melatonin in a chronic experimental model of Parkinson’s disease. Brain Res 7-12-2002;943(2):163-173. View Abstract
  1264. Waldhauser, F., Weiszenbacher, G., Frisch, H., Zeitlhuber, U., Waldhauser, M., and Wurtman, R. J. Fall in nocturnal serum melatonin during prepuberty and pubescence. Lancet 2-18-1984;1(8373):362-365. View Abstract
  1265. Bojkowski, C. J., Arendt, J., Shih, M. C., and Markey, S. P. Melatonin secretion in humans assessed by measuring its metabolite, 6- sulfatoxymelatonin. Clin Chem 1987;33(8):1343-1348. View Abstract
  1266. Laakso, M. L., Porkka-Heiskanen, T., Alila, A., Stenberg, D., and Johansson, G. Correlation between salivary and serum melatonin: dependence on serum melatonin levels. J Pineal Res 1990;9(1):39-50. View Abstract
  1267. Nowak, R., McMillen, I. C., Redman, J., and Short, R. V. The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: two non-invasive techniques for monitoring human circadian rhythmicity. Clin Endocrinol (Oxf) 1987;27(4):445-452. View Abstract
  1268. Kovacs, J., Brodner, W., Kirchlechner, V., Arif, T., and Waldhauser, F. Measurement of urinary melatonin: a useful tool for monitoring serum melatonin after its oral administration. J.Clin.Endocrinol.Metab 2000;85(2):666-670. View Abstract
  1269. Pullman, R. E., Roepke, S. E., and Duffy, J. F. Laboratory validation of an in-home method for assessing circadian phase using dim light melatonin onset (DLMO). Sleep Med. 2012;13(6):703-706. View Abstract
  1270. de Almeida, E. A., Di, Mascio P., Harumi, T., Spence, D. W., Moscovitch, A., Hardeland, R., Cardinali, D. P., Brown, G. M., and Pandi-Perumal, S. R. Measurement of melatonin in body fluids: standards, protocols and procedures. Childs Nerv.Syst. 2011;27(6):879-891. View Abstract
  1271. Steindl, P. E., Ferenci, P., and Marktl, W. Impaired hepatic catabolism of melatonin in cirrhosis. Ann Intern Med 9-15-1997;127(6):494. View Abstract
  1272. Braam, W., van, Geijlswijk, I, Keijzer, H., Smits, M. G., Didden, R., and Curfs, L. M. Loss of response to melatonin treatment is associated with slow melatonin metabolism. J.Intellect.Disabil.Res. 2010;54(6):547-555. View Abstract
  1273. Nathan, P. J., Wyndham, E. L., Burrows, G. D., and Norman, T. R. The effect of gender on the melatonin suppression by light: a dose response relationship. J.Neural Transm. 2000;107(3):271-279. View Abstract
  1274. Dagan, Y., Zisapel, N., Nof, D., Laudon, M., and Atsmon, J. Rapid reversal of tolerance to benzodiazepine hypnotics by treatment with oral melatonin: a case report. Eur Neuropsychopharmacol. 1997;7(2):157-160.
  1275. Aldhous, M., Franey, C., Wright, J., and Arendt, J. Plasma concentrations of melatonin in man following oral absorption of different preparations. Br J Clin Pharmacol 1985;19(4):517-521. View Abstract
  1276. Cavallo, A. and Ritschel, W. A. Pharmacokinetics of melatonin in human sexual maturation. J Clin Endocrinol.Metab 1996;81(5):1882-1886. View Abstract
  1277. Hahm, H., Kujawa, J., and Augsburger, L. Comparison of melatonin products against USP’s nutritional supplements standards and other criteria. J Am Pharm Assoc (Wash.) 1999;39(1):27-31. View Abstract
  1278. Shah, J., Langmuir, V., and Gupta, S. K. Feasibility and functionality of OROS melatonin in healthy subjects. J Clin Pharmacol 1999;39(6):606-612. View Abstract
  1279. Lopez-Munoz, F., Marin, F., and Alamo, C. [The historical background of the pineal gland: II. From the seat of the soul to a neuroendocrine organ]. Rev.Neurol. 1-16-2010;50(2):117-125. View Abstract
  1280. Wurtman, R. J. Melatonin as a hormone in humans: a history. Yale J Biol.Med 1985;58(6):547-552. View Abstract
  1281. Laurant M, Nagtegaal JE Smits MG Kerkhof GA Coenen AML. Influence of melatonin on vigilance and cognitive functions in delayed sleep phase syndrome. Int Chronobiol 1997;8:79-82.
  1282. Holmes, A. L., Gilbert, S. S., and Dawson, D. Melatonin and zopiclone: the relationship between sleep propensity and body temperature. Sleep 5-1-2002;25(3):301-306. View Abstract
  1283. Mishima, K., Satoh, K., Shimizu, T., and Hishikawa, Y. Hypnotic and hypothermic action of daytime-administered melatonin. Psychopharmacology (Berl) 1997;133(2):168-171. View Abstract
  1284. Terlo L, Laudon M Tarasch R. et al. Effects of low doses of melatonin on late afternoon napping and mood. Biol Rhythm Res. 1997;28(1):2-15.
  1285. Attenburrow, M. E., Cowen, P. J., and Sharpley, A. L. Low dose melatonin improves sleep in healthy middle-aged subjects. Psychopharmacology (Berl) 1996;126(2):179-181. View Abstract
  1286. Cajochen, C., Krauchi, K., Danilenko, K. V., and Wirz-Justice, A. Evening administration of melatonin and bright light: interactions on the EEG during sleep and wakefulness. J.Sleep Res. 1998;7(3):145-157. View Abstract
  1287. Cajochen, C., Krauchi, K., Mori, D., Graw, P., and Wirz-Justice, A. Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis. Am.J.Physiol 1997;272(4 Pt 2):R1189-R1196. View Abstract
  1288. Matsumoto, M. The hypnotic effects of melatonin treatment on diurnal sleep in humans. Psychiatry Clin.Neurosci. 1999;53(2):243-245. View Abstract
  1289. Pires, M. L., Benedito-Silva, A. A., Pinto, L., Souza, L., Vismari, L., and Calil, H. M. Acute effects of low doses of melatonin on the sleep of young healthy subjects. J.Pineal Res. 2001;31(4):326-332. View Abstract
  1290. Zisapel N, Tarash R Laudon M. Effects of fast- and controlled-release melatonin formulations on daytime sleep and mood. 7th Colloquium 1996;1.
  1291. Dodge, N. N. and Wilson, G. A. Melatonin for treatment of sleep disorders in children with developmental disabilities. J Child Neurol 2001;16(8):581-584. View Abstract
  1292. Shamir, E., Laudon, M., Barak, Y., Anis, Y., Rotenberg, V., Elizur, A., and Zisapel, N. Melatonin improves sleep quality of patients with chronic schizophrenia. J Clin Psychiatry 2000;61(5):373-377. View Abstract
  1293. Serfaty MA, Osborne D Buszewicz M J. et al. The Effect of Exogeneous Melatonin in Major Depression. Chronobiol Int. 2003;20:1191-1192.
  1294. Jan, J. E., Espezel, H., and Appleton, R. E. The treatment of sleep disorders with melatonin. Dev.Med Child Neurol 1994;36(2):97-107. View Abstract
  1295. Waldhauser F, Waldhauser M Lieberman HR Deng M Lynch HJ Wurtman RJ. Bioavailability of oral melatonin in humans. Neuroendocrinology 1984;39:307-313.
  1296. Jan, J. E. and O’Donnell, M. E. Use of melatonin in the treatment of paediatric sleep disorders. J.Pineal Res. 1996;21(4):193-199. View Abstract
  1297. van, Maanen A., Meijer, A. M., Smits, M. G., and Oort, F. J. Termination of short term melatonin treatment in children with delayed Dim Light Melatonin Onset: effects on sleep, health, behavior problems, and parenting stress. Sleep Med. 2011;12(9):875-879. View Abstract
  1298. Abbas, A., Raju, J., Milles, J., and Ramachandran, S. A circadian rhythm sleep disorder: melatonin resets the biological clock. J.R.Coll.Physicians Edinb. 2010;40(4):311-313. View Abstract
  1299. Owens, J. A., Rosen, C. L., and Mindell, J. A. Medication use in the treatment of pediatric insomnia: results of a survey of community-based pediatricians. Pediatrics 2003;111(5 Pt 1):e628-e635. View Abstract
  1300. Jan, J. E., Freeman, R. D., and Fast, D. K. Melatonin treatment of sleep-wake cycle disorders in children and adolescents. Dev.Med Child Neurol. 1999;41(7):491-500. View Abstract
  1301. Leger, D., Laudon, M., and Zisapel, N. Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy. Am J Med 1-15-2004;116(2):91-95. View Abstract
  1302. Rondanelli, M., Opizzi, A., Monteferrario, F., Antoniello, N., Manni, R., and Klersy, C. The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J.Am.Geriatr.Soc. 2011;59(1):82-90. View Abstract
  1303. Paul, M. A., Miller, J. C., Gray, G. W., Love, R. J., Lieberman, H. R., and Arendt, J. Melatonin treatment for eastward and westward travel preparation. Psychopharmacology (Berl) 2010;208(3):377-386. View Abstract
  1304. Arendt J, Aldhous M, English J, and et al. Some effects of jet-lag and their alleviation by melatonin. Ergonomics 1987;30:1379-1393.
  1305. Nickelsen T, Lang A, and Bergau L. The effect of 6-, 9- and 11-hour time shifts on circadian rhythms: adaptation of sleep parameters and hormonal patterns following the intake of melatonin or placebo. In: Arendt J and Pevet P. Advances in Pineal Research. London: John Libbey;1991.
  1306. Ross, C., Davies, P., and Whitehouse, W. Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study. Dev Med Child Neurol 2002;44(5):339-344. View Abstract
  1307. Tanaka, H., Araki, A., Ito, J., Tasaki, T., Miyamoto, A., and Cho, K. Improvement of hypertonus after treatment for sleep disturbances in three patients with severe brain damage. Brain Dev. 1997;19(4):240-244. View Abstract
  1308. Hayashi, E. Effect of melatonin on sleep-wake rhythm: the sleep diary of an autistic male. Psychiatry Clin Neurosci. 2000;54(3):383-384. View Abstract
  1309. Dagan, Y. and Ayalon, L. Case study: psychiatric misdiagnosis of non-24-hours sleep-wake schedule disorder resolved by melatonin. J Am Acad.Child Adolesc.Psychiatry 2005;44(12):1271-1275. View Abstract
  1310. Miano, S. and Ferri, R. Epidemiology and management of insomnia in children with autistic spectrum disorders. Paediatr.Drugs 4-1-2010;12(2):75-84. View Abstract
  1311. Giannotti, F., Cortesi, F., Cerquiglini, A., and Bernabei, P. An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism. J.Autism Dev.Disord. 2006;36(6):741-752. View Abstract
  1312. Polimeni, M. A., Richdale, A. L., and Francis, A. J. A survey of sleep problems in autism, Asperger’s disorder and typically developing children. J.Intellect.Disabil.Res. 2005;49(Pt 4):260-268. View Abstract
  1313. Melke, J., Goubran, Botros H., Chaste, P., Betancur, C., Nygren, G., Anckarsater, H., Rastam, M., Stahlberg, O., Gillberg, I. C., Delorme, R., Chabane, N., Mouren-Simeoni, M. C., Fauchereau, F., Durand, C. M., Chevalier, F., Drouot, X., Collet, C., Launay, J. M., Leboyer, M., Gillberg, C., and Bourgeron, T. Abnormal melatonin synthesis in autism spectrum disorders. Mol.Psychiatry 2008;13(1):90-98. View Abstract
  1314. Leu, R. M., Beyderman, L., Botzolakis, E. J., Surdyka, K., Wang, L., and Malow, B. A. Relation of melatonin to sleep architecture in children with autism. J.Autism Dev.Disord. 2011;41(4):427-433. View Abstract
  1315. Owens, J. A., Rosen, C. L., Mindell, J. A., and Kirchner, H. L. Use of pharmacotherapy for insomnia in child psychiatry practice: A national survey. Sleep Med. 2010;11(7):692-700. View Abstract
  1316. Chaste, P., Clement, N., Mercati, O., Guillaume, J. L., Delorme, R., Botros, H. G., Pagan, C., Perivier, S., Scheid, I., Nygren, G., Anckarsater, H., Rastam, M., Stahlberg, O., Gillberg, C., Serrano, E., Lemiere, N., Launay, J. M., Mouren-Simeoni, M. C., Leboyer, M., Gillberg, C., Jockers, R., and Bourgeron, T. Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. PLoS.One. 2010;5(7):e11495. View Abstract
  1317. Toma, C., Rossi, M., Sousa, I., Blasi, F., Bacchelli, E., Alen, R., Vanhala, R., Monaco, A. P., Jarvela, I., and Maestrini, E. Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations. Mol.Psychiatry 2007;12(11):977-979. View Abstract
  1318. Horrigan, J. P. and Barnhill, L. J. More on melatonin. J Am Acad Child Adolesc.Psychiatry 1997;36(8):1014. View Abstract
  1319. Aman, M. G., Lam, K. S., and Collier-Crespin, A. Prevalence and patterns of use of psychoactive medicines among individuals with autism in the Autism Society of Ohio. J.Autism Dev.Disord. 2003;33(5):527-534. View Abstract
  1320. Andersen, I. M., Kaczmarska, J., McGrew, S. G., and Malow, B. A. Melatonin for insomnia in children with autism spectrum disorders. J.Child Neurol. 2008;23(5):482-485. View Abstract
  1321. Cai, G., Edelmann, L., Goldsmith, J. E., Cohen, N., Nakamine, A., Reichert, J. G., Hoffman, E. J., Zurawiecki, D. M., Silverman, J. M., Hollander, E., Soorya, L., Anagnostou, E., Betancur, C., and Buxbaum, J. D. Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: efficient identification of known microduplications and identification of a novel microduplication in ASMT. BMC.Med.Genomics 2008;1:50. View Abstract
  1322. Green, V. A., Pituch, K. A., Itchon, J., Choi, A., O’Reilly, M., and Sigafoos, J. Internet survey of treatments used by parents of children with autism. Res.Dev.Disabil. 2006;27(1):70-84. View Abstract
  1323. Gupta, R. and Hutchins, J. Melatonin: a panacea for desperate parents? (Hype or truth). Arch.Dis.Child 2005;90(9):986-987. View Abstract
  1324. Ishizaki, A., Sugama, M., and Takeuchi, N. [Usefulness of melatonin for developmental sleep and emotional/behavior disorders–studies of melatonin trial on 50 patients with developmental disorders]. No To Hattatsu 1999;31(5):428-437. View Abstract
  1325. Jan, J. E., Freeman, R. D., Wasdell, M. B., and Bomben, M. M. ‘A child with severe night terrors and sleep-walking responds to melatonin therapy’. Dev.Med.Child Neurol. 2004;46(11):789. View Abstract
  1326. Jonsson, L., Ljunggren, E., Bremer, A., Pedersen, C., Landen, M., Thuresson, K., Giacobini, M., and Melke, J. Mutation screening of melatonin-related genes in patients with autism spectrum disorders. BMC.Med.Genomics 2010;3:10. View Abstract
  1327. Kulman, G., Lissoni, P., Rovelli, F., Roselli, M. G., Brivio, F., and Sequeri, P. Evidence of pineal endocrine hypofunction in autistic children. Neuro.Endocrinol.Lett. 2000;21(1):31-34. View Abstract
  1328. Mulder, E. J., Anderson, G. M., Kemperman, R. F., Oosterloo-Duinkerken, A., Minderaa, R. B., and Kema, I. P. Urinary excretion of 5-hydroxyindoleacetic acid, serotonin and 6-sulphatoxymelatonin in normoserotonemic and hyperserotonemic autistic individuals. Neuropsychobiology 2010;61(1):27-32. View Abstract
  1329. Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., and Lerner, Y. Brief report: circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. J.Autism Dev.Disord. 1995;25(6):641-654. View Abstract
  1330. Ritvo ER, Ritvo R Yuwiler A Brothers A Freeman BJ Plotkin S. Elevated daytime melatonin concentrations in autism: a pilot study. Eur Child Adolesc Psychiatry 1993;2:75-78.
  1331. Tordjman, S., Anderson, G. M., Pichard, N., Charbuy, H., and Touitou, Y. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biol.Psychiatry 1-15-2005;57(2):134-138. View Abstract
  1332. Yamashita, Y., Matsuishi, T., Murakami, Y., and Kato, H. Sleep disorder in Rett syndrome and melatonin treatment. Brain Dev. 1999;21(8):570. View Abstract
  1333. Malow, B., Adkins, K. W., McGrew, S. G., Wang, L., Goldman, S. E., Fawkes, D., and Burnette, C. Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. J.Autism Dev.Disord. 2012;42(8):1729-1737. View Abstract
  1334. Ackerstedt T, Gillberg M. Subjective and objective sleepiness in the active individual. Int J Neurosci 1990;52:29-37.
  1335. Hoebert, M., van der Heijden, K. B., van Geijlswijk, I. M., and Smits, M. G. Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia. J.Pineal Res. 2009;47(1):1-7. View Abstract
  1336. Phillips, L. and Appleton, R. E. Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment. Dev.Med Child Neurol. 2004;46(11):771-775. View Abstract
  1337. Espezel H, Jan JE, O’Donnell ME, and et al. The use of melatonin to treat sleep-wake-rhythm disorders in children who are visually impaired. J Vis Impair Blind 1996;90:34-50.
  1338. Jan, J. E. and Espezel, H. Melatonin treatment of chronic sleep disorders. Dev.Med Child Neurol 1995;37(3):279-280. View Abstract
  1339. Palm, L., Blennow, G., and Wetterberg, L. Correction of non-24-hour sleep/wake cycle by melatonin in a blind retarded boy. Ann.Neurol. 1991;29(3):336-339. View Abstract
  1340. Palm, L., Blennow, G., and Wetterberg, L. Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances. Dev.Med.Child Neurol. 1997;39(5):319-325. View Abstract
  1341. Sherk, Y., Smith, B. A., and Miller, B. D. Liquid melatonin via gastrostomy as an alternative hypnotic in a child with pervasive developmental disorder. J.Child Adolesc.Psychopharmacol. 2011;21(3):291-293. View Abstract
  1342. Van, Thillo A., Devriendt, K., and Willekens, D. [Sleep disturbances in Smith-Magenis syndrome: treatment with melatonin and beta-adrenergic antagonists]. Tijdschr.Psychiatr. 2010;52(10):719-723. View Abstract
  1343. Wesensten, N. J., Balkin, T. J., Reichardt, R. M., Kautz, M. A., Saviolakis, G. A., and Belenky, G. Daytime sleep and performance following a zolpidem and melatonin cocktail. Sleep 1-1-2005;28(1):93-103. View Abstract
  1344. Cramer, H., Rudolph, J., Consbruch, U., and Kendel, K. On the effects of melatonin on sleep and behavior in man. Adv Biochem Psychopharmacol 1974;11(0):187-191. View Abstract
  1345. Hughes, R. J., Sack, R. L., and Lewy, A. J. The role of melatonin and circadian phase in age-related sleep- maintenance insomnia: assessment in a clinical trial of melatonin replacement. Sleep 1998;21(1):52-68. View Abstract
  1346. Morera, A. L., Henry, M., Villaverde-Ruiz, M. L., and Gracia-Marco, R. [Efficiency of melatonin in the treatment of insomnia]. Actas Esp.Psiquiatr. 2000;28(5):325-329. View Abstract
  1347. Rondanelli, M., Opizzi, A., Faliva, M., Mozzoni, M., Antoniello, N., Cazzola, R., Savare, R., Cerutti, R., Grossi, E., and Cestaro, B. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. Nutr.Neurosci. 2012;15(2):46-54. View Abstract
  1348. Cardinali, D. P., Brusco, L. I., Liberczuk, C., and Furio, A. M. The use of melatonin in Alzheimer’s disease. Neuro.Endocrinol.Lett. 2002;23 Suppl 1:20-23. View Abstract
  1349. Brusco LI, Marquez M, and Cardinali DP. Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer’s disease. Neuroendocrinol Lett 1998;19(13):111-115.
  1350. Cohen-Mansfield, J., Garfinkel, D., and Lipson, S. Melatonin for treatment of sundowning in elderly persons with dementia – a preliminary study. Arch.Gerontol.Geriatr. 8-1-2000;31(1):65-76. View Abstract
  1351. Mahlberg, R., Kunz, D., Sutej, I., Kuhl, K. P., and Hellweg, R. Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy. J.Clin.Psychopharmacol. 2004;24(4):456-459. View Abstract
  1352. Baandrup, L., Fagerlund, B., Jennum, P., Lublin, H., Hansen, J. L., Winkel, P., Gluud, C., Oranje, B., and Glenthoj, B. Y. Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial – the SMART trial protocol. BMC.Psychiatry 2011;11:160. View Abstract
  1353. Todisco, M. Relapse of high-grade non-Hodgkin’s lymphoma after autologous stem cell transplantation: a case successfully treated with cyclophosphamide plus somatostatin, bromocriptine, melatonin, retinoids, and ACTH. Am J Ther 2006;13(6):556-557. View Abstract
  1354. Di, Bella G. and Colori, B. The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck. Neuro.Endocrinol.Lett. 2012;33(3):249-256. View Abstract
  1355. Di, Bella G. The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 122 cases of breast cancer. Neuro.Endocrinol.Lett. 2011;32(6):751-762. View Abstract
  1356. Kocak, G., Erbil, K. M., Ozdemir, I., Aydemir, S., Sunar, B., Tuncel, M., and Atalay, S. The protective effect of melatonin on adriamycin-induced acute cardiac injury. Can J Cardiol. 2003;19(5):535-541. View Abstract
  1357. Morishima, I., Matsui, H., Mukawa, H., Hayashi, K., Toki, Y., Okumura, K., Ito, T., and Hayakawa, T. Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats. Life Sci 1998;63(7):511-521. View Abstract
  1358. Reiter, R. J., Tan, D. X., Sainz, R. M., Mayo, J. C., and Lopez-Burillo, S. Melatonin: reducing the toxicity and increasing the efficacy of drugs. J Pharm Pharmacol. 2002;54(10):1299-1321. View Abstract
  1359. Greenlee, H., Hershman, D. L., and Jacobson, J. S. Use of antioxidant supplements during breast cancer treatment: a comprehensive review. Breast Cancer Res.Treat. 2009;115(3):437-452. View Abstract
  1360. Mazzoccoli, G., Vendemiale, G., De, Cata A., Carughi, S., and Tarquini, R. Altered time structure of neuro-endocrine-immune system function in lung cancer patients. BMC.Cancer 2010;10:314. View Abstract
  1361. Erren, T. C. and Piekarski, C. Does winter darkness in the Artic protect against cancer? The melatonin hypothesis revisited. Med.Hypotheses 1999;53(1):1-5. View Abstract
  1362. Grant, S. G., Melan, M. A., Latimer, J. J., and Witt-Enderby, P. A. Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. Expert.Rev.Mol.Med. 2009;11:e5. View Abstract
  1363. Todisco, M. Chronic lymphocytic leukemia: long-lasting remission with combination of cyclophosphamide, somatostatin, bromocriptine, retinoids, melatonin, and ACTH. Cancer Biother.Radiopharm. 2009;24(3):353-355. View Abstract
  1364. Tanaka, T., Yasui, Y., Tanaka, M., Tanaka, T., Oyama, T., and Rahman, K. M. Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. Chem.Biol.Interact. 1-27-2009;177(2):128-136. View Abstract
  1365. Di, Bella G. and Madarena, M. Complete objective response of oesophageal squamocellular carcinoma to biological treatment. Neuro.Endocrinol.Lett. 2009;30(3):312-321. View Abstract
  1366. Di Bella, G. and Colori, B. Complete objective response of neuroblastoma to biological treatment. Neuro.Endocrinol.Lett. 2009;30(4):437-449. View Abstract
  1367. Yan J, Shen F Wang K Wu M. Co-antitumor effect and hepatic protection of melatonin on advanced primary liver cancer treated by transcatheter arterial chemoembolization. Acad J Sec Mil Med Univ 2001;22:858-886.
  1368. Lissoni, P. Biochemotherapy with immunomodulating pineal hormones other than melatonin: 5-methoxytryptamine as a new oncostatic pineal agent. Pathol.Biol.(Paris) 2007;55(3-4):198-200. View Abstract
  1369. Ernst, E., Schmidt, K., and Baum, M. Complementary/Alternative therapies for the treatment of breast cancer. A systematic review of randomized clinical trials and a critique of current terminology. Breast J 2006;12(6):526-530. View Abstract
  1370. Skene, D. J., Lockley, S. W., and Arendt, J. Melatonin in circadian sleep disorders in the blind. Biol Signals Recept. 1999;8(1-2):90-95. View Abstract
  1371. Sack, R. L., Lewy, A. J., Blood, M. L., Stevenson, J., and Keith, L. D. Melatonin administration to blind people: phase advances and entrainment. J Biol Rhythms 1991;6(3):249-261. View Abstract
  1372. Sack, R. L., Brandes, R. W., Kendall, A. R., and Lewy, A. J. Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med 10-12-2000;343(15):1070-1077. View Abstract
  1373. Lockley, S. W., Skene, D. J., James, K., Thapan, K., Wright, J., and Arendt, J. Melatonin administration can entrain the free-running circadian system of blind subjects. J Endocrinol 2000;164(1):R1-R6. View Abstract
  1374. Sack, R. L. and Lewy, A. J. Melatonin as a chronobiotic: treatment of circadian desynchrony in night workers and the blind. J Biol Rhythms 1997;12(6):595-603. View Abstract
  1375. Rivkees, S. A. Arrhythmicity in a child with septo-optic dysplasia and establishment of sleep-wake cyclicity with melatonin. J Pediatr 2001;139(3):463-465. View Abstract
  1376. Pillar, G., Etzioni, A., Shahar, E., and Lavie, P. Melatonin treatment in an institutionalised child with psychomotor retardation and an irregular sleep-wake pattern. Arch Dis Child 1998;79(1):63-64. View Abstract
  1377. McArthur, A. J., Lewy, A. J., and Sack, R. L. Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment. Sleep 1996;19(7):544-553. View Abstract
  1378. Lapierre, O. and Dumont, M. Melatonin treatment of a non-24-hour sleep-wake cycle in a blind retarded child. Biol Psychiatry 7-15-1995;38(2):119-122. View Abstract
  1379. Tzischinsky, O., Pal, I., Epstein, R., Dagan, Y., and Lavie, P. The importance of timing in melatonin administration in a blind man. J Pineal Res 1992;12(3):105-108. View Abstract
  1380. Folkard, S., Arendt, J., Aldhous, M., and Kennett, H. Melatonin stabilises sleep onset time in a blind man without entrainment of cortisol or temperature rhythms. Neurosci.Lett 5-31-1990;113(2):193-198. View Abstract
  1381. Lewy, A. J., Emens, J., Sack, R. L., Hasler, B. P., and Bernert, R. A. Zeitgeber hierarchy in humans: resetting the circadian phase positions of blind people using melatonin. Chronobiol.Int. 2003;20(5):837-852. View Abstract
  1382. Kamei, Y., Hayakawa, T., Urata, J., Uchiyama, M., Shibui, K., Kim, K., Kudo, Y., and Okawa, M. Melatonin treatment for circadian rhythm sleep disorders. Psychiatry Clin Neurosci. 2000;54(3):381-382. View Abstract
  1383. Brown, M. A., Quan, S. F., and Eichling, P. S. Circadian rhythm sleep disorder, free-running type in a sighted male with severe depression, anxiety, and agoraphobia. J.Clin.Sleep Med. 2-15-2011;7(1):93-94. View Abstract
  1384. de, Jonghe A., van Munster, B. C., van Oosten, H. E., Goslings, J. C., Kloen, P., van, Rees C., Wolvius, R., van, Velde R., Levi, M. M., Korevaar, J. C., and de Rooij, S. E. The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial. BMC.Geriatr. 2011;11:34. View Abstract
  1385. Kulkarni, S. K. and Dhir, A. Current investigational drugs for major depression. Expert.Opin.Investig.Drugs 2009;18(6):767-788. View Abstract
  1386. Detanico, B. C., Piato, A. L., Freitas, J. J., Lhullier, F. L., Hidalgo, M. P., Caumo, W., and Elisabetsky, E. Antidepressant-like effects of melatonin in the mouse chronic mild stress model. Eur.J.Pharmacol. 4-1-2009;607(1-3):121-125. View Abstract
  1387. Ashkenazy, T., Einat, H., and Kronfeld-Schor, N. We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. Int.J.Neuropsychopharmacol. 2009;12(1):83-93. View Abstract
  1388. Hidalgo, M. P., Caumo, W., Dantas, G., Franco, D. G., Torres, I. L., Pezzi, J., Elisabetsky, E., Detanico, B. C., Piato, A., and Markus, R. P. 6-Sulfatoxymelatonin as a predictor of clinical outcome in depressive patients. Hum.Psychopharmacol. 2011;26(3):252-257. View Abstract
  1389. Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Curr.Diab.Rep. 2011;11(2):142-148. View Abstract
  1390. Unfer, V., Raffone, E., Rizzo, P., and Buffo, S. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. Gynecol.Endocrinol. 2011;27(11):857-861. View Abstract
  1391. Klupinska, G., Poplawski, T., Smigielski, J., Blasiak, J., and Chojnacki, J. [The effect of melatonin on oxidative DNA damage in gastric mucosa cells of patients with functional dyspepsia]. Pol.Merkur Lekarski. 2009;26(155):366-369. View Abstract
  1392. Komarov, F. I., Raikhlin, N. T., Rapoport, S. I., Malinovskaia, N. K., Voznesenskaia, L. A., and Rumiantseva, A. I. [Irritated bowel syndrome: clinicomorphological aspects of treatment with melaxen]. Klin.Med.(Mosk) 2006;84(11):30-36. View Abstract
  1393. Stepien, A., Moskwa-Fortuna, A., Wisniewska-Jarosinska, M., Harasiuk, A., and Chojnacki, J. [Melatonin secretion and metabolism in patients with irritable bowel syndrome]. Pol.Merkur Lekarski. 2009;26(155):440-443. View Abstract
  1394. Radwan, P., Skrzydlo-Radomanska, B., Radwan-Kwiatek, K., Burak-Czapiuk, B., and Strzemecka, J. Is melatonin involved in the irritable bowel syndrome? J.Physiol Pharmacol. 2009;60 Suppl 3:67-70. View Abstract
  1395. Chojnacki, C., Wisniewska-Jarosinska, M., Walecka-Kapica, E., Klupinska, G., Jaworek, J., and Chojnacki, J. Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. J.Physiol Pharmacol. 2011;62(3):327-334. View Abstract
  1396. Taylor, F. R. Headache prevention with complementary and alternative medicine. Headache 2009;49(6):966-968. View Abstract
  1397. Molina-Martinez, F. J., Jimenez-Martinez, M. C., and Vives-Pastor, B. Some questions provoked by a chronic headache (with mixed migraine and cluster headache features) in a woman with a pineal cyst. Answers from a literature review. Cephalalgia 2010;30(9):1031-1040. View Abstract
  1398. Pringsheim, T., Magnoux, E., Dobson, C. F., Hamel, E., and Aube, M. Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study. Headache 2002;42(8):787-792. View Abstract
  1399. Cerminara, C., Compagnone, E., Coniglio, A., Margiotta, M., Curatolo, P., Villa, M. P., and Parisi, P. Hypnic headache in children. Cephalalgia 2011;31(16):1673-1676. View Abstract
  1400. Gonciarz, M., Gonciarz, Z., Bielanski, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., and Konturek, S. J. The pilot study of 3-month course of melatonin treatment of patients with nonalcoholic steatohepatitis: effect on plasma levels of liver enzymes, lipids and melatonin. J.Physiol Pharmacol. 2010;61(6):705-710. View Abstract
  1401. Shatilo, V. B., Bondarenko, E. V., and Antoniuk-Shcheglova, I. A. [Metabolic disorders in elderly patients with hypertension and their correction with melatonin]. Adv.Gerontol. 2012;25(1):84-89. View Abstract
  1402. Cavallo, A., Daniels, S. R., Dolan, L. M., Khoury, J. C., and Bean, J. A. Blood pressure response to melatonin in type 1 diabetes. Pediatr.Diabetes 2004;5(1):26-31. View Abstract
  1403. Lusardi, P., Preti, P., Savino, S., Piazza, E., Zoppi, A., and Fogari, R. Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects. Blood Press Monit. 1997;2(2):99-103. View Abstract
  1404. Zesiewicz, T. A. and Evatt, M. L. Potential influences of complementary therapy on motor and non-motor complications in Parkinson’s disease. CNS.Drugs 10-1-2009;23(10):817-835. View Abstract
  1405. Billiard, M. REM sleep behavior disorder and narcolepsy. CNS.Neurol.Disord.Drug Targets. 2009;8(4):264-270. View Abstract
  1406. Limousin, N., Dehais, C., Gout, O., Heran, F., Oudiette, D., and Arnulf, I. A brainstem inflammatory lesion causing REM sleep behavior disorder and sleepwalking (parasomnia overlap disorder). Sleep Med. 2009;10(9):1059-1062. View Abstract
  1407. Leu-Semenescu, S. and Arnulf, I. [Disruptive nocturnal behavior in elderly subjects: could it be a parasomnia?]. Psychol.Neuropsychiatr.Vieil. 2010;8(2):97-109. View Abstract
  1408. Anderson, K. N. and Shneerson, J. M. Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. J.Clin.Sleep Med. 6-15-2009;5(3):235-239. View Abstract
  1409. Kunz, D. and Bes, F. Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation. Mov Disord. 1999;14(3):507-511. View Abstract
  1410. Boeve, B. F., Silber, M. H., and Ferman, T. J. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med. 2003;4(4):281-284. View Abstract
  1411. Anderson, K. N., Jamieson, S., Graham, A. J., and Shneerson, J. M. REM sleep behaviour disorder treated with melatonin in a patient with Alzheimer’s disease. Clin.Neurol.Neurosurg. 2008;110(5):492-495. View Abstract
  1412. Badoe, E. V. Classical Rett Syndrome in a Ghanaian child: a case report. West Afr.J.Med. 2009;28(2):134-136. View Abstract
  1413. Miller, A. L. Epidemiology, etiology, and natural treatment of seasonal affective disorder. Altern.Med Rev. 2005;10(1):5-13. View Abstract
  1414. Srinivasan, V., Smits, M., Spence, W., Lowe, A. D., Kayumov, L., Pandi-Perumal, S. R., Parry, B., and Cardinali, D. P. Melatonin in mood disorders. World J Biol.Psychiatry 2006;7(3):138-151. View Abstract
  1415. McIntyre, I. M., Norman, T. R., Burrows, G. D., and Armstrong, S. M. Melatonin supersensitivity to dim light in seasonal affective disorder. Lancet 2-24-1990;335(8687):488. View Abstract
  1416. Danilenko, K. V., Putilov, A. A., Russkikh, G. S., Duffy, L. K., and Ebbesson, S. O. Diurnal and seasonal variations of melatonin and serotonin in women with seasonal affective disorder. Arctic Med Res 1994;53(3):137-145. View Abstract
  1417. Childs, P. A., Rodin, I., Martin, N. J., Allen, N. H., Plaskett, L., Smythe, P. J., and Thompson, C. Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls. Br J Psychiatry 1995;166(2):196-198. View Abstract
  1418. Avery, D., Lenz, M., and Landis, C. Guidelines for prescribing melatonin. Ann.Med 1998;30(1):122-130. View Abstract
  1419. Lewy, A. J., Bauer, V. K., Cutler, N. L., and Sack, R. L. Melatonin treatment of winter depression: a pilot study. Psychiatry Res 1-16-1998;77(1):57-61. View Abstract
  1420. Wirz-Justice, A., Graw, P., Krauchi, K., Gisin, B., Arendt, J., Aldhous, M., and Poldinger, W. Morning or night-time melatonin is ineffective in seasonal affective disorder. J Psychiatr.Res 1990;24(2):129-137. View Abstract
  1421. Sherer, M. A., Weingartner, H., James, S. P., and Rosenthal, N. E. Effects of melatonin on performance testing in patients with seasonal affective disorder. Neurosci.Lett 8-5-1985;58(3):277-282. View Abstract
  1422. Rosenthal, N. E., Sack, D. A., Jacobsen, F. M., James, S. P., Parry, B. L., Arendt, J., Tamarkin, L., and Wehr, T. A. Melatonin in seasonal affective disorder and phototherapy. J Neural Transm.Suppl 1986;21:257-267. View Abstract
  1423. Winton, F., Corn, T., Huson, L. W., Franey, C., Arendt, J., and Checkley, S. A. Effects of light treatment upon mood and melatonin in patients with seasonal affective disorder. Psychol Med 1989;19(3):585-590. View Abstract
  1424. Guo, J. F. and Yao, B. Z. [Serum melatonin levels in children with epilepsy or febrile seizures]. Zhongguo Dang.Dai Er.Ke.Za Zhi. 2009;11(4):288-290. View Abstract
  1425. Srivastava, A. K., Gupta, S. K., Jain, S., and Gupta, Y. K. Effect of melatonin and phenytoin on an intracortical ferric chloride model of posttraumatic seizures in rats. Methods Find.Exp.Clin Pharmacol. 2002;24(3):145-149. View Abstract
  1426. Ashrafi, M. R., Mohammadi, M., Tafarroji, J., Shabanian, R., Salamati, P., and Zamani, G. R. Melatonin versus chloral hydrate for recording sleep EEG. Eur.J.Paediatr.Neurol. 2010;14(3):235-238. View Abstract
  1427. Singer CM, Moffit MT, Colling ED, and et al. Low dose melatonin administration and nocturnal activity levels in patients with Alzheimer’s disease [abstract]. Sleep Res 1997;26:752.
  1428. Cardinali DP, Brusco LI, and Liberczuk C. The use of melatonin in Alzheimer’s disease. Neuroendocrinol Lett 2002;23(Suppl 1):20-23.
  1429. Becker, P. M. and Sattar, M. Treatment of sleep dysfunction and psychiatric disorders. Curr.Treat.Options.Neurol. 2009;11(5):349-357. View Abstract
  1430. Livianos, L., Sierra, P., Arques, S., Garcia, A., and Rojo, L. Is melatonin an adjunctive stabilizer? Psychiatry Clin.Neurosci. 2012;66(1):82-83. View Abstract
  1431. Koch, B. C., Nagtegaal, J. E., Kerkhof, G. A., and Ter Wee, P. M. Circadian sleep-wake rhythm disturbances in end-stage renal disease. Nat.Rev.Nephrol. 2009;5(7):407-416. View Abstract
  1432. Lehmann, E. D., Cockerell, O. C., and Rudge, P. Somnolence associated with melatonin deficiency after pinealectomy. Lancet 2-3-1996;347(8997):323. View Abstract
  1433. Siebler, M., Steinmetz, H., and Freund, H. J. Therapeutic entrainment of circadian rhythm disorder by melatonin in a non-blind patient. J Neurol 1998;245(6-7):327-328. View Abstract
  1434. Kohyama, J. A newly proposed disease condition produced by light exposure during night: asynchronization. Brain Dev. 2009;31(4):255-273. View Abstract
  1435. Simon Padilla, O. J., De Linares Del, Rio C., Godden, P., Granizo, E., Pinilla, M., and Rodriguez, C. [Use of combined treatment with melatonin and clomethiazole in circadian rhythm sleep disorder in the elderly with dementia]. Rev.Esp.Geriatr.Gerontol. 2009;44(4):233-234. View Abstract
  1436. deVries, M. W. and Peeters, F. P. Melatonin as a therapeutic agent in the treatment of sleep disturbance in depression. J Nerv.Ment.Dis 1997;185(3):201-202. View Abstract
  1437. Kripke, D. F., Youngstedt, S. D., Rex, K. M., Klauber, M. R., and Elliott, J. A. Melatonin excretion with affect disorders over age 60. Psychiatry Res 5-1-2003;118(1):47-54. View Abstract
  1438. Shaw, K. M., Stern, G. M., and Sandler, M. Melatonin and parkinsonism [abstract]. Lancet 2-3-1973;1(7797):271. View Abstract
  1439. Robertson, J. M. and Tanguay, P. E. Case study: the use of melatonin in a boy with refractory bipolar disorder. J Am Acad Child Adolesc Psychiatry 1997;36(6):822-825. View Abstract
  1440. Potter, M., Moses, A., and Wozniak, J. Alternative treatments in pediatric bipolar disorder. Child Adolesc.Psychiatr.Clin.N.Am. 2009;18(2):483-514, xi. View Abstract
  1441. Tzischinsky, O., Skene, D., Epstein, R., and Lavie, P. Circadian rhythms in 6-sulphatoxymelatonin and nocturnal sleep in blind children. Chronobiol.Int 1991;8(3):168-175. View Abstract
  1442. Zamotaev, IuN. [The use of melatonin for correction of sleep disturbances in assembly-line shift workers with arterial hypertension]. Klin.Med.(Mosk) 2012;90(3):44-46. View Abstract
  1443. Schmidt, C. M., Knief, A., Deuster, D., Matulat, P., and am Zehnhoff-Dinnesen, A. G. Melatonin is a useful alternative to sedation in children undergoing brainstem audiometry with an age dependent success rate–a field report of 250 investigations. Neuropediatrics 2007;38(1):2-4. View Abstract
  1444. Ionescu D, Badescu C Ilie A Acalovschi I. Melatonin as premedication for laparoscopic cholecystectomy: A double- blind, placebo-controlled study: Scientific letter. SAJAA 2008;57:8-11.
  1445. Mowafi, H. A. and Ismail, S. A. Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia. Anesth.Analg. 2008;107(4):1422-1426. View Abstract
  1446. Abilio, V. C., Vera, J. A., Jr., Ferreira, L. S., Duarte, C. R., Carvalho, R. C., Grassl, C., Martins, C. R., Torres-Leite, D., Bignotto, M., Tufik, S., Ribeiro, Rde A., and Frussa-Filho, R. Effects of melatonin on orofacial movements in rats. Psychopharmacology (Berl) 2002;161(4):340-347. View Abstract
  1447. Pirodda, A., Raimondi, M. C., and Ferri, G. G. Exploring the reasons why melatonin can improve tinnitus. Med.Hypotheses 2010;75(2):190-191. View Abstract
  1448. Mevcha, A., Gulur, D. M., and Gillatt, D. Diagnosing urological disorders in ageing men. Practitioner 2010;254(1726):25-9, 2. View Abstract
  1449. Chase, J. E. and Gidal, B. E. Melatonin: therapeutic use in sleep disorders. Ann Pharmacother 1997;31(10):1218-1226. View Abstract

Aeschbach, D., Lockyer, B. J., Dijk, D. J., Lockley, S. W., Nuwayser, E. S., Nichols, L. D., and Czeisler, C. A. Use of transdermal melatonin delivery to improve sleep maintenance during daytime. Clin.Pharmacol.Ther. 2009;86(4):378-382. View Abstract

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