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Can Vitamin D Work Without Magnesium?

Longevity By Nature

Extensive research has shown that vitamin D deficiencies play a major role in the development of dozens of diseases, including breast, prostate and colon cancer, as well as diabetes, heart disease, arthritis, osteoporosis, psoriasis and mental illness, according to the nonprofit Nutritional Magnesium Association (NMA).

While many people are beginning to realize the health benefits that vitamin D has to offer in the prevention of disease, they may not be getting the full benefits from vitamin D without also supplementing their diets with magnesium, reported NMA. According to Carolyn Dean, MD, ND, magnesium expert and Medical Advisory Board member, NMA, magnesium is a vital nutrient because it converts vitamin D into its active form.

“The effectiveness and benefits of vitamin D are greatly undermined in the absence of adequate levels of magnesium in the body. Magnesium acts with and is essential to the activity of vitamin D, and yet most Americans do not get their recommended daily allowance (RDA) of this important mineral,” said Dr. Dean.

Nutrients act in a synergetic way in the body. Absorption and metabolism of a particular nutrient will be affected, to a greater or lesser degree, by the other nutrients available to the body. This is also true of vitamin D. According to the nonprofit Vitamin D Council, in order to receive the most health benefit from increased levels of vitamin D, the proper cofactors must be present in the body. “Vitamin D has many cofactors, but the ones listed here are the most important, with magnesium topping the list: Magnesium, vitamin K, vitamin A, zinc and boron,” reported the council.



The importance of magnesium as a nutrient required for proper vitamin D metabolism has been recognized by several studies published in the journal Magnesium Research, with the following findings:

  • Magnesium is essential for the metabolism of vitamin D.
  • Magnesium influences the body’s utilization of vitamin D by activating cellular enzyme activity.
  • Enzymes are protein molecules that stimulate every chemical reaction in the body. All the enzymes that metabolize vitamin D require magnesium.
  • Magnesium has a possible role in vitamin D’s effect on the immune system.

Another study published in the European Journal of Pediatrics states low magnesium has been shown to alter, by way of decreasing, production of vitamin D’s active form, according to NMA, adding several studies related to bone health published in the Journal of Physiological Biochemistry and in the Clinical Nutrition Journal point out that magnesium is also necessary for vitamin D’s beneficial actions on bone.

“Vitamin D inhibits calcium deposition in arteries, and magnesium converts vitamin D into its active form so that it can prevent calcium buildup into cholesterol plaque in arteries,” said Dr. Dean. “The combination of magnesium and vitamin D helps prevent clogged arteries by drawing calcium out of the blood and soft tissues back into the bones where it is needed to build healthy bone structure and prevent osteoporosis, some forms of arthritis and kidney stones.

A 32-page guide to the benefits of magnesium, along with magnesium deficiency symptoms, written by Dr. Dean, is available as a free download at www.nutritionalmagnesium.org.