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Dutch Scientists Develop Ground-breaking Risk-Benefit Approach to Determine Optimum Intakes

DaVinci Laboratories

Vitamins and minerals—can they be too much of a good thing? Or are some people suffering from deficiencies in these essential nutrients? Thanks to the work of a group of Dutch scientists, we may soon be able to know exactly what we need, depending on our age, stage of life, gender and individual requirements.

In recent years, there has been considerable confusion over what levels are optimum for given population groups. Some research has warned about high doses of isolated vitamins, particularly synthetic ones, such as vitamin E, beta-carotene and folic acid. On the other hand, various nutritional surveys have shown some groups to be deficient in vitamin D, iron or magnesium.

The new approach, just accepted for publication in the peer-reviewed journal Critical Reviews in Nutrition and Food Science, integrates all available scientific data on both risks, from inadequacy and excess, as well as on benefits to offer a range of doses of specific vitamin and mineral forms suitable for specific populations.

Lisette Krul, MSc from the Netherlands Organization for Applied Scientific Research (TNO), leading the research, said, “Our approach involves integrating all available data taking into account risks of deficiency, the higher requirements or benefits for particular populations while also considering toxicity.”

The work has been published at a time when the European Commission is considering various options to impose E.U.-wide limits on both maximum and minimum amounts of vitamins and minerals consumed as food supplements as part of its framework Food Supplements Directive.

There is increasing recognition that various estimates of intake, such as estimated average requirements (EARs), nutrient reference values (NRVs) or recommended daily allowances (RDAs), are either out-of-date with respect to the latest science or do not adequately reflect optimal levels of intake for particular nutritional benefits. Using such a novel approach to determine optimal levels of micronutrient intake could offer a significant advance for personalized nutrition.

The research culminating in the paper has been on-going for two years and was commissioned by the Alliance for Natural Health International, a non-profit alliance of consumer and stakeholder interests in natural and sustainable health care.

Executive director of the alliance, Robert Verkerk, PhD, said, “The methods the European Commission has considered for regulatory purposes have so far focused only on risk. They are based on making sure even the most sensitive person wouldn’t suffer any kind of adverse effect, however slight or temporary, from the most toxic form of a given nutrient.

“We welcome the new approach proposed by TNO scientists,” indicated Dr. Verkerk. “If the other methods that have been under consideration by the European Commission were turned into law, they would prevent a lot of people getting the amounts of nutrients they really need. If you applied the same thinking to conventional foods, you’d end up banning all foods containing wheat and dairy because people sensitive to gluten or lactose react adversely to these foods even though others may benefit from the consumption of these foods.”

The manuscript of the full paper, “Quantifiable Risk-benefit Assessment of Micronutrients: From Theory to Practice,” is available for electronic download ahead of print at the following link: www.tandfonline.com/doi/full/10.1080/10408398.2016.1162765.