According to the Alzheimer’s Association, by 2060, nearly one in four Americans will be in an age bracket at elevated risk of cognitive decline and Alzheimer’s disease unless interventions can help preserve cognitive function before deficits begin. The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is a large-scale, nationwide, randomized trial rigorously testing cocoa extract and multivitamin supplements directed by researchers at Mass General Brigham. Two previously published studies of cognition in COSMOS suggested a positive effect for a daily multivitamin. COSMOS researchers now report the results of a third study of cognition in COSMOS, which focused on participants who underwent in-person assessments, together with the results of a combined analysis from the three separate studies. The results from this latest report confirm consistent and statistically significant benefits of a daily multivitamin versus placebo for both memory and global cognition. The results were published in The American Journal of Clinical Nutrition.
“Cognitive decline is among the top health concerns for most older adults, and a daily supplement of multivitamins has the potential as an appealing and accessible approach to slow cognitive aging,” said first author Chirag Vyas, MBBS, MPH, instructor in investigation at the Department of Psychiatry at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham health care system.
In the in-clinic study the researchers administered detailed, in-person cognitive assessments among 573 participants in the subset of COSMOS known as COSMOS-Clinic.
Within COSMOS, two previous studies had tested multivitamin supplementation on cognition using telephone-based cognitive assessments (COSMOS-MIND) and online web-based cognitive assessments (COSMOS-Web). In their prespecified analyses of data from COSMOS-Clinic, investigators observed a modest benefit for the multivitamin, compared to placebo, on global cognition over two years.
There was a statistically significant benefit of multivitamin supplementation for change in episodic memory, but not in executive function/attention.
The team also conducted a meta-analysis based on the three separate studies, with non-overlapping COSMOS participants (ranging two to three years in treatment duration), which showed strong evidence of benefits for both global cognition and episodic memory.
The authors estimate that the daily multivitamin slowed global cognitive aging by the equivalent of two years compared to placebo.
“The meta-analysis of three separate cognition studies provides strong and consistent evidence that taking a daily multivitamin, containing more than 20 essential micronutrients, helps prevent memory loss and slow down cognitive aging,” Vyas said,
Olivia Okereke, MD SM, senior author of the report and director of Geriatric Psychiatry at MGH, added “These findings will garner attention among many older adults who are, understandably, very interested in ways to preserve brain health, as they provide evidence for the role of a daily multivitamin in supporting better cognitive aging.”
For more information, visit www.massgeneralbrigham.org.