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NMN The Ultimate Biohack

NMN The Ultimate Biohack

Living a long time is a goal for many people but living healthy and free from chronic illness should be sought after. Good nutrition and exercise can help you avoid chronic illnesses and maintain optimal health, even into your older years. However, we know that raising NAD+ levels is vital to optimal health and longevity.

Intracellular concentrations of NAD+ decrease from aging as normal cellular functions deplete NAD+ supplies over time. Healthy levels of NAD+ were proven to be restored by supplementation with NAD+ precursors.

According to the latest clinical trials, NMN supplementation can help promote cellular health and performance optimization in all areas of health and age-related illnesses such as diabetes, cardiovascular diseases, neurodegeneration, and general decreases in the immune system.

As we age, NAD+ levels in our bodies decrease fast. No matter how well you eat and exercise, by the time you are in your 50’s, your NAD+ levels would have dropped by 50% compared to when you were 20-30 years old. Furthermore, when NAD+ levels fall, important implications for metabolic function and age-related diseases occur. DNA damage accumulates and snowballs with aging.

The latest clinical studies support the hypothesis that maintaining NAD+ levels leads to healthy cell metabolism, which is beneficial in terms of amelioration of metabolic diseases and aging.

It should be stressed that NAD+ is not the only factor, but rather one of the several components that influence cell health.

In this article, we will discuss why supplementation with NAD precursor NMN is the most efficient method for increasing NAD+.


There are several NAD boosters on the market, so how can you determine which one is right for your patients?

In this article, we will discuss why supplementation with NAD precursor NMN is the most efficient method for increasing NAD+.

NAD+ IV Drips

NAD+ IVs are the most expensive of all the NAD-boosting methods. Therapies can cost up to $600 for a 60-minute session, and the therapies themselves may last up to six to eight weeks.

As of today, there aren’t published placebo-controlled clinical trials to support that injecting NAD directly into the body raises NAD levels.

Furthermore, a published study in the Journal of Biological Chemistry argues that NAD+ must be broken down into smaller precursors to be absorbed effectively by cells.

NR Nicotinamide Riboside

Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are biosynthetic precursors to an essential molecule for metabolism (NAD+). Research on the two molecules indicates supplementation with either increased NAD+ levels during aging.

What are the differences between these NAD+ precursor molecules?

As aforementioned, both NMN and NR are NAD+ precursors. The main difference between them is that NR lacks a phosphate, therefore becoming an incomplete version of NMN. If you supplement NAD+ with NR, your body must turn it into NMN first by adding a phosphate. From there, NMN is converted into NAD+ taken up by the transporter, and then transformed into NAD+ in one step. This is one of the reasons why NMN is becoming more popular and is referred to as “the most direct NAD+ booster”.

Benefits of Supplementing with NMN: Nicotinamide Mononucleotide

Many studies have already demonstrated that increasing NAD+ levels with NMN improves metabolic health during aging. NMN can help to suppress age-related changes in the body, such as weight gain, low metabolism, reduced energy, and decreases in eye function. Because NAD+ plays such a vital role in all our cells, supplementing with NMN ameliorates cellular senescence. The latest research has shown the positive effects of NMN in humans on healthy aging, improved longevity, and exercise performance. For example, NMN supplementation enhances energy production, increases physical endurance by over 50%, and helps with various physiological characteristics like neuron function, insulin sensitivity, and more.

In conclusion, we now know that NMN does not need to be broken down to NR to enter the body’s cells. The only reason why people would have preferred NR to NMN is the belief that NMN had to be converted into NR before getting into your cells. However, thanks to the discovery of the unique membrane protein transporter, it seems NMN may be the more effective precursor supplement to date.

Research has shown that taking the supplement nicotinamide mononucleotide (NMN) nearly doubles NAD+ in humans. Improvements in metabolic parameters like insulin sensitivity in prediabetic women and muscle oxygen utilization in long-distance runners have also been correlated with increasing NAD+ levels.

Given that NAD was discovered over 100 years ago, it is surprising how little we know about its biology, pharmacology, and role in human disease. Though there is much to learn, we know this much: NMN is a direct NAD precursor, safe and efficient in raising NAD+ in the most recent human trials. NMN has a remarkable ability to promote cellular health.

Cellular Optimization and Biohacking with Longity NMN-C

We know how important is to all practitioners to find the most effective treatment and supplements for their patients. Not all NMN supplements are tested or pure. While there is no doubt that purity is important, it is by no means the only factor to consider when deciding what is the best NMN supplement for you. More reliable indicators include whether it has been tested for impurities, produced in facilities with formalized quality manufacturing standards, evaluated by scientists, and verified safe.

Based on studies demonstrating NMN’s remarkable ability to boost NAD+, Seneque scientists develop a proprietary synthesized 99.6% pure form of NMN, called NMN-C.

What differentiates NMN-C® is that it is fully synthetic, and we conducted an OECD 408 toxicology study demonstrating NMN-C® has a NOAEL tolerance level 3x higher than Nicotinamide Riboside NR and almost 7x higher than Nicotinamide NAM.

Additionally, NMN-C® is used in human trials, meeting clinical levels of safety, purity, and quality. With 11 clinical trials underway, NMN-C® has the most extensive human research program to date and it has acquired GRAS status with the FDA.

To find out more about Longity NMN-C and if you’re interested in becoming one of our prescribers, please click on the link below to schedule a discovery call with our representative and expert, Gabriela Lana. Upon registration to our affiliate program, we are offering all practitioners a free sample.




These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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