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The Science Of Supplements

Longevity By Nature

A Guide to Research-Backed Nutrients and Products

This special section of Natural Practitioner comes in response to the desire for a greater understanding of the research and history behind the products available to practitioners and their patients, and manufacturers wanting to offer the science that backs the effectiveness of their products.We have featured a similar section annually in Natural Practitioner’s sister publication, Nutrition Industry Executive magazine, since 2002, where it was designed to help manufacturers gain a better understanding of the ingredients and services available that can make their products stand out.

Companies and associations have responded to this opportunity with background information about the health concerns their products are intended to address, histories of the nutrients behind their products and details of research carried out. In order to bridge the gap between interested practitioners and these companies, we’ve also provided company addresses, phone numbers and website addresses to make obtaining additional information easier.

Douglas Laboratories
112 Technology Dr.
Pittsburgh, PA 15275
Phone: (800) 245-4440
Fax: (888) 245-4440
Website: www.douglaslabs.com

Fish Oil Supplementation Enhanced by Supercritical CO2 Extraction

The benefits of omega-3 fatty acids continue to emerge and numerous health organizations around the world are recommending increasing the daily intake of EPA and DHA. Data continues to accumulate that supports EPA and DHA in cardiovascular health, as well as many other areas including neurological, vision and joint health.1,2 

The omega-3 fatty acid EPA is the direct precursor for the prostaglandins, which are involved in helping to maintain the body’s normal inflammatory processes. DHA plays a major role in the structural integrity of neuronal membranes. DHA is essential for neurological and visual development and is vital throughout pregnancy to support fetal brain growth and formation of the retina and visual cortex. As the most abundant fatty acid in the brain, adequate amounts of DHA are needed throughout infancy and adulthood for ongoing optimal function. Low levels of DHA may adversely influence behavior and mental performance, and have been correlated with changes in disposition, memory, visual and other neurological parameters.1,2

The chemical structure in which the omega-3 fatty acids are delivered can play an important role in their absorption. Recent data has demonstrated that omega-3 fatty acids delivered in a triglyceride form may result in greater plasma levels and a higher omega-3 index compared with omega-3 fatty acids delivered in the form of ethyl esters.2 Scientific data continues to emerge showing the triglyceride form of fish oil is better absorbed compared to ethyl esters. Re-esterifed triglycerides lead to a faster and higher increase in the omega-3 index (the percentage of EPA+DHA in red blood cell membranes) when compared to ethyl ester fish oil concentrate at the same dose.

Re-esterified triglycerides have been shown to be superior in absorption when compared to ethyl esters and free fatty acids. The Supercritical CO2 process is able to create highly concentrated levels of EPA and DHA in triglyceride form. The result is a product that can deliver significant amounts of EPA and DHA in easy-to-swallow soft gels.

Many fish oils contain only about 30 percent omega-3 fatty acids, of which roughly 18 percent is EPA and 12 percent DHA. The remaining 70 percent is a varying mixture of other components. In other words, regular fish oil contains less than a third of the desired active ingredients and more than two thirds of “other” components. These other components may include cholesterol, omega-6 fatty acids, saturated fatty acids, oxidation products and contaminants.Highly concentrated omega-3 products, like QÜELL, provide at least 75 percent active ingredients, leaving less room for nonessential compounds. QÜELL fish gelatin soft gel formulations deliver highly concentrated EPA and DHA in easy-to-swallow soft gels.

QÜELL Omega-3 uses a Supercritical Dual-Process CO2 technology to gently extract, concentrate and purify the omega-3 fatty acids. The CO2 prevents oxygen from being exposed to the oil, therefore protecting the oil from degradation. QÜELL Omega-3 fish oils have been purified multiple times throughout the CO2 extraction process.

Supercritical Fluid Extraction involves using CO2 as a medium to extract the omega-3 fatty acids and separate them from other parts of the oil, such as free fatty acids and cholesterol. This not only protects the oils from oxidation, but also protects the oil from contamination with microorganisms that can’t survive without oxygen. Unlike other extraction methods, no chemical solvents, cholesterol or other undesirable compounds are found in the oil and there is no need for chemical preservatives. QÜELL Supercritical CO2 oils have extremely low levels of contaminants (PCBs, dioxins) and/or heavy metals (such as mercury).

QÜELL uses small fish caught off the coast of South America, such as anchovies, sardines and mackerel, which accumulate fewer toxins during their short lifespan. Additionally, unlike molecular distillation, the oils used in QÜELL omega-3 products are not exposed to solvents that might include hexane or ethanol. The production process creates no toxic impurities or solvents and all waste and wastewater are recycled or transformed into energy.

The QÜELL difference is ultra high concentrations of omega-3s, delivered in a small, easy-to-swallow capsule. The triglyceride form created Supercritical CO2 extraction does not create isomers, requires minimal use of heat and is extremely efficient method of removing contaminants from the oils. The production of QÜELL has very low environmental impact creating virtually no waste. The result is a small, pure and potent product.


1 Adapted from Neubronner et al. Eur J Clin Nutr 65 (2010) 247-254. (Data do no represent the Quell product specifically).

2 Adapted from Dyerberg J. Bioavailability of marine n-3 fatty acide formulations. Prostaglandins Leukot Essent Fatty Acids. 2010 Sep; 83(3) 137-41.

Kibow Biotech, Inc.
4629 West Chester Pike
Newtown Square, PA 19073
Phone: (888) 271-2560; (610) 353-5130
Fax: (610) 353-5110
Email: info@kibowbiotech.com
Website: www.kibow.com

Renadyl: Probiotic Dietary Supplement That Can Maintain Healthy Kidney Function

Kidneys filter blood by retaining useful compounds, removing waste and excess fluid. They produce hormones that help regulate blood pressure and the number of red blood cells. Kidney failure occurs when the kidneys cannot properly remove wastes.When kidneys malfunction, waste products, such as urea, uric acid, creatinine and other nitrogenous compounds, accumulate in the bloodstream, causing a condition called azotemia. Elevated levels of these toxic waste products can lead to serious health issues, such as kidney failure, kidney stones and other complications. In addition, related problems can include high blood pressure, anemia, weak bones, poor nutritional health and nerve damage.

Chronic kidney disease (CKD) affects at least 13 percent of the U.S. population and has increased by 30 percent since 1994, according to an article in the Journal of the American Medical Association.1 The World Health Organization reports that kidney disease and diseases of the urinary tract cause 850,000 deaths worldwide annually. Globally, CKD is the 12th leading cause of death and the 17th leading cause of disability.

CKD patients are more likely to die of a heart attack or stroke than of CKD. Additionally, patients with cardiovascular disease are at high risk of CKD, which may go unrecognized because of the similarity of symptoms between the two diseases.More than 26 million Americans—one in nine adults—are at increased risk, and most don’t know it. That’s because in the early stages, there are rarely any symptoms, or the symptoms are too slight to notice. However, CKD is a degenerative disease and over time, the condition will worsen.

While there is no cure for CKD, there is hope. Renadyl™, Kibow Biotech’s flagship product, has been proven to reduce levels of the harmful toxins caused by kidney dysfunction and improve the quality of life for those living with kidney problems. Renadyl is a proprietary and patented probiotic dietary supplement that has been scientifically formulated and clinically tested. The strains of beneficial bacteria contained in Renadyl have been specially developed and selected for their affinity for nitrogenous waste metabolism and are delivered in an enteric coated gel capsule which protects the probiotics from harmful digestive acids. Nitrogenous waste products are utilized by Renadyl as nutrition, it metabolizes the waste products that have diffused from the bloodstream into the bowel. As the probiotics grow and multiply, they consume more nitrogenous waste and effectively help maintain healthy kidney function.

Data suggest that oral administration of Renadyl may act as a complimentary adjunct by extending renoprotection via intraintestinal extraction of toxic solutes in patients with CKD stages III and IV.2 

In a recent clinical trial, oral administration of Renadyl to CKD patients discerned significant reduction of BUN (blood urea nitrogen) along with enhanced well-being without serious adverse effects. It was a prospective, randomized, double-blind, crossover, placebo-controlled, six-month trial of probiotic bacteria on 46 outpatients with CKD stages III and IV. Among all patients from all four sites, BUN decreased in 29 patients (63 percent with a probability of >95 percent), creatinine values decreased in 20 patients (43 percent with no statistical difference) and uric acid levels decreased in 15 patients (33 percent with no statistical difference). Additionally, almost all subjects expressed a subjective sense of substantive overall improvement in perceived quality of life (86 percent with a probability of >95 percent) as determined from patient diaries.

Several ongoing clinical trials are investigating the benefits of Renadyl for patients with ESRD (dialysis). Preliminary data is encouraging.3 

The probiotic strains in Renadyl are Streptococcus thermophilus (KB19), Lactobacillus acidophilus (KB27) and Bifidobacterium longum (KB31). Each strain is naturally occurring and has not been genetically modified. These strains belong to classes of probiotics approved for human consumption and classified as generally recognized as safe (GRAS) by the U.S. Food and Drug Administration.4 Mild physical complaints including bloating, flatulence and/or diarrhea were observed in 10 study patients who completed the sixmonth clinical trial at all sites. These symptoms were noticed only during the first three weeks of administration of probiotics and did not recur.

For more information on Renadyl visit www.kibow.com, email info@kibowbiotech.com or call (888) 371-2560.


1 Coresh, J, Selvin, E, et. Al. Prevalence of Chronic Kidney Disease in the United States. JAMA. 2007;298(17):2038-2047.

2 Ranganathan N, Ranganathan P, Friedman EA, et al. Pilot study of probiotic dietary supplementation for promoting healthy kidney function in patients with chronic kidney disease. Adv Ther. 2010;27(9):634–637.

3 http://clinicaltrials.gov/ct2/results?term=kibow 

4 United States Code of Federal Regulations 21 CFR 170.3 and 21 CFR 170.30.

Kyowa Hakko Bio Co., Ltd.
(New York Office)
600 Third Ave., 19th Fl.
New York, NY 10016
Phone: (212) 319-5353
(West Coast Office)
85 Enterprise, Ste. 430
Aliso Viejo, CA 92656
Phone: (949) 425-0707

Setria Glutathione

Glutathione (GSH), a small peptide comprised of three common amino acids, is one of the most important molecules in the body for its role in protecting cells from the damaging effects of toxins and oxidative stress. Its scientific name is N-(N-L-gamma- Glutamyl-L-cysteinyl)glycine.

Glutathione is provided both through the diet and through endogenous synthesis. The best food sources are fresh fruits and vegetables and freshly prepared meats.1 Most methods of food processing destroy glutathione; therefore, processed foods, dairy foods and grain products are poor sources.

Setria® Glutathione is a highly pure and stable form of reduced glutathione that’s been created for use in dietary supplements. Manufactured through a patented fermentation process by Kyowa Hakko Bio Co., Ltd., Setria glutathione is vegetarian, allergen-free and backed by clinical research.

Absorption and Where Glutathione is Found in the Body

Oral glutathione enters tissues by three routes: it can be absorbed intact in the intestines and taken up by tissues; it can be broken down in the GI tract to its constituent amino acids, which are then absorbed and GSH is re-synthesized in tissues; and, it can be taken up directly into GI tissues by cells that line the GI tract.2

Glutathione is unevenly distributed throughout the body. The highest levels are found in the liver and kidneys to support detoxification functions. Other major organ systems including the brain, heart, lungs, intestines, skeletal muscle, skin and immune system also have high levels. Cellular levels are much higher than extracellular levels. In all there are about 15 grams of GSH in the body, of which about 4 grams are in the liver.3

Potential Benefits of Oral Supplementation

Modern diets are often devoid of glutathione due to the excessive intake of processed foods. Dietary intakes of glutathione among Americans have been measured in at least two studies. In the first, intakes ranged from a low of 3 mg per day to a high of about 150 mg per day, with a mean intake of 35 mg per day.1 Another study found an even wider range of intakes among men—from 5 mg to 242 mg per day and 7 to 96 mg per day in women—with most people regardless of gender falling below 60 mg per day.4 If the best diets provide close to 250 mg per day and the mean intake is only 35 mg, there is a considerable gap in much of the population.

Glutathione levels fluctuate diurnally with lowest levels found in the morning, which may present a window of vulnerability that could be addressed through increased oral intake. The morning shortfall becomes even lower with advancing age.5

Many millions of Americans have one or more dietary, lifestyle or physical factors that may increase their risk for low glutathione levels: 77 million consume fewer than five fruits or vegetables daily, 91 million are aged 55 and over, 59 million currently smoke cigarettes, 74 million have diabetes, 110 million are overweight or obese, and 15 million chronically consume excessive amounts of alcohol.6

Setria is available in the formulations of these health care practitioner brands: Ecological Formulations, Integrative Therapeutics, Inc., Lidtke,Montiff and Pure Encapsulations.


1 Jones DP et al. Nutr Cancer. 1992;17:57-75.

2 He M et al. J Nutr. 2004;134:1114-19.?

3 Jones DP. 2008; in press.

4 Flagg EW et al. Am J Epidemiol. 1994;139(5):453-65.

5 Blanco RA et al. Am J Clin Nutr. 2007 Oct;86(4):1016-23.

6 Centers for Disease Control and Prevention statistics.

Life Extension
3600 W. Commercial Blvd.
Fort Lauderdale, FL 33309
Phone: (866) 585-1435
Email: epartner@lifeextension.com
Website: www.lifeextensionretail.com/epartner

Better Absorbed Magnesium Targets Memory & Cognitive Function

Magnesium is needed for more than 300 biochemical reactions in the body.1 Long known for its role in cardiovascular 2-4 and bone health,5 energy metabolism6 and mood,7 researchers are now focusing intensely on magnesium’s benefits for cognitive function.1 

Unfortunately, it is very hard for the human body to maintain optimal levels of magnesium in the brain.1 This problem is of special concern for maturing individuals, as magnesium deficiency increases over time.8 As a result, half of aging humans in the developed world are magnesium deficient!8 

Most commercially available magnesium supplements are not readily absorbed into the central nervous system. To overcome this obstacle, an innovative form of magnesium has been introduced called Neuro- Mag™, shown to specifically target the aging brain and nervous system.

In pre-clinical models, L-threonate contained in Neuro-Mag boosted magnesium levels in spinal fluid by an impressive 15 percent compared to no increase with conventional magnesium.1 Animal models revealed improvements of 18 percent for shortterm memory and 100 percent for long-term memory using the Neuro- Mag form of magnesium.1 

The suggested daily dose of three Neuro-Mag Magnesium L-Threonate Capsules provides 2,000 mg of magnesium- L-threonate.While this supplies a modest 144 mg of elemental magnesium, its greater absorption into the bloodstream and nervous system make it a sound choice for supplementation by aging humans.

This highly absorbable brain health-supporting magnesium is also available in a lemon-flavored powder mix called Neuro- Mag Magnesium Lthreonate with Calcium and Vitamin D3 Powder. The one-scoop per day serving size supplies the same amount of magnesium plus 500 mg of calcium (as calcium lactate gluconate—a highly soluble form of calcium) and 1,000 IU of vitamin D3. This offers maturing individuals an easy way to obtain three key nutrients in one simple formula.

Items #01603 & #01602 

Magtein™ is a trademark of Magceutics, Inc, distributed exclusively by AIDP, Inc. Patent pending.

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.


1. Neuron. 2010 Jan 28;65(2):165-77.

2. Ann Pharmacother. 2002 Feb;36(2):255-60.

3. Br J Sports Med. 2006 Sep;40(9):773-8.

4. Congest Heart Fail. 2006 Jan-Feb;12(1):9-13.

5. J Bone Miner Res. 1998 Apr;13(4):749-58.

6. Clinica Chimica Acta. 2000;294:1-26.

7. Pharmacol Rep. 2008 Sept-Oct;60(5):588-9.

8. Available at: www.mit.edu/press/2010/magnesium-supplement.html. Accessed Sept 1, 2011. 

Mushroom Science
P.O. Box 23936
Eugene, OR 97402
Phone: (541) 344-1396
Fax: (541) 344-3107
Email: sales@mushroomscience.com
Website: www.jhspro.com

Medicinal Mushrooms, Preparation and Use

Mushroom extracts are one of the most effective supplements for maintaining, restoring or protecting immune health and are well documented. A search on MedLine shows more than 2,000 studies published on five species of medicinal mushrooms in the last 10 years.

According to Mark Stengler, ND, one of the most respected authors on herbal and alternative medicine, there is a consensus within traditional herbal practice and the scientific community on how to prepare medicinal mushrooms when used for immune support. He said, “We found a single theme bridging the gap between centuries of historical use as observed in Chinese medicine and the modern experience of validation through scientific research. This common link is hot water extraction.” 

However, this consensus has yet to filter down to the supplement industry. Dr. Stengler continued, “While the health benefits of mushroom supplements are many, ‘mushroom supplements’ as found in the marketplace refer to a large and chemically diverse group of products…”1 

Part of the confusion is that we derive two beneficial products from fungi, food and dietary supplements for immune support. However, the nutrition mushrooms provide has nothing to do with immune stimulation, and medicinal mushrooms do not provide “micronutrients” for the immune system. Understanding how and why medicinal mushrooms stimulate the immune response can shed light on why hot water extraction is the preferred method for preparing mushroom supplements.

According to Dr. Shu-Ting Chang, one of the most respected mycologists in the world, “a mushroom nutriceutical is a refined and partially defined extract from either the mycelium or fruiting body of mushrooms.” Dr. Chang does not focus on any differences between mushrooms and mycelium, only the constituents common to both.

He defined these as “polysaccharides, high-molecular weight polysaccharides, low-molecular weight protein-bound polysaccharides, glycoproteins, triterpenoids and fungal immunomodulatory proteins.” 

Most importantly, Dr. Chang stated: “The majority of these are extracted from the fruiting body with hot water or by hot water combined with ethanol.”2 

Parris Kid, PhD, explained that the “handful” of medicinal mushroom preparations used in actual human clinical studies are “all are chemically beta D glucan in nature or beta D glucan linked to proteins.”3 

Beta glucans and the compounds mentioned by Dr. Chang are derived from the cell walls of mushrooms and mushroom mycelium; this is the key to understanding their effect on the immune system.

The cell walls of basidiomycetes, including all of the “medicinal” mushrooms, are composed of a “chitin-ß-glucan” matrix.4 Chitin is a nitrogen containing polysaccharide and is indigestible by humans.5 

Hot water extraction disassembles the indigestible cell wall, releasing the internal cell wall constituents into a bioavailable form. As a supplement, hot water extracts offer the largest concentration of these cell wall constituents. The ability of cell wall constituents to stimulate the immune response is based on molecular structure.

One of the ways our cellular immune response identifies and responds to non-self is through the detection of small molecular sequences consistently found on pathogens. Pattern recognition receptors (PRRs) are proteins expressed by the cells of the innate immune system to identify pathogenassociated molecular patterns (PAMPs).

There are PRRs that specifically respond to and bind to cell wall derived ß-glucans, initiating phagocytosis.6 The pattern of carbohydrates that make up ß-glucans are seen as non-self, as a pathogen-associated molecular pattern. This, in turn, stimulates the innate or non-specific immune response without posing any threat to the host. The ßglucans and other cell wall constituents are not providing “micronutrients” for the immune system, nor are they metabolized as part of the process of immune stimulation, these compounds act as physical triggers of the non-specific immune response.

As compared to other supplemental forms or “whole food” forms of mushrooms supplements, hot water extracts provide the largest concentration of the internal cell wall constituents that stimulate the immune response.

If mushroom supplements are not first extracted with hot water the vast majority of these internal cell wall constituents remain locked up inside the indigestible cell walls and pass through the body “unseen” by our immune system, unable to stimulate the immune response.


1 Dr. Mark Stengler, The Health Benefits of Medicinal Mushrooms, 2005.

2 Chang, Miles. Mushrooms, Cultivation, Nutritional Value, Medicinal Effect and Environmental Impact, 2004.

3 Parris Kidd. The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment, 2000.

4 Alexopoulos, Mims. Introductory Mycology, Third Edition, 1976.

5 Reishi Mushroom, Standards of Analysis, Quality Control and Therapeutics. Editor Roy Upton, 2006.

6 Adermam, Ulevitch. Toll-Like Receptors in the Induction of the Innate Immune Response. Nature, Vol 406, 2,000.

1 City Boulevard W., Ste. 1440
Orange, CA 92868
Phone: (800) 367-2880
Fax: (714) 935-9881
Email: customerservice@naturade.com
Website: www.naturade.com

Amidst Supplement Hype, Bovine Colostrum From Symbiotics and ProSymbiotics Stands Out

Colostrum, the pre-milk fluid produced by female mammals following the birth of a newborn, provides essential growth and immune factors, protective proteins and nutrients that prepare the newborn infant for the outside world. One of the few nutritional supplements made by mammals for mammals, colostrum is a multifunctional complex of bioactive ingredients with more than 50 years of clinical research.

Bovine colostrum’s incredible properties are available as a nutritional supplement from Symbiotics and ProSymbiotics.

The Components of Colostrum

• Immunoglobulins – Also known as antibodies, immunoglobulins are the main component of the adaptive immune system. Bovine colostrum is particularly rich in immunoglobulin G (IgG), which is responsible for establishing systemic immunity. Clinical research has shown that a high percentage of the antibodies and immunoglobulins present in colostrum remain in the intestinal tract where they attack disease-causing organisms before they penetrate the body. The remainder is believed to be absorbed and distributed to assist in our internal defense processes.1,2 Symbiotics and ProSymbiotics colostrum is guaranteed to have at least 25 percent and 30 percent immunoglobulins in each dose respectively.

• Lactoferrin – Lactoferrin plays a critical role in regulating the levels of iron in the blood and also in transferring iron to the tissues.3,4 The proper distribution of iron to the tissues is required for oxygenation of cells throughout the body including blood cells. Lactoferrin also plays a critical role in cell proliferation and differentiation, and has antibacterial, antiviral, antifungal and antiparasitic activity.4-6 The antibacterial activity of lactoferrin appears to be mainly due to its ability to sequester iron.4,7 It is able to bind directly to the membrane of bacteria8,9 and, in doing so, binds and sequesters iron before the targeted bacteria have the opportunity to obtain their iron requirement. Denial of iron to the targeted bacteria inhibits their ability to thrive. Symbiotics and ProSymbiotics colostrum is guaranteed to have at least 1.5 percent lactoferrin.

The ProSymbiotics Immune Formula also contains an incremental 50 mg of lactoferrin per serving.

• Proline-Rich Polypeptides (PRPs) – PRPs are short chains of amino acids rich in the amino acid proline and are intercellular signaling molecules that have the unique ability to modulate the immune system, turning it up when needed to fight an infection, or turning it down when it is overactive. 10 PRPs function as a hormone that regulates the thymus gland and have been shown to improve symptoms of both allergies and auto-immune conditions.
11 Symbiotics and ProSymbiotics colostrum is guaranteed to have at least three percent PRPs in each serving.

Uses for Colostrum

• Gastrointestinal Health – Colostrum’s components help maintain a healthy, functional gastrointestinal tract, which is key to health and well-being given the GI system’s critical role in nutrient absorption. Colostrum can restore leaky gut to normal permeability levels.12

• Immune Health – An excellent immune system stimulant and modulator, colostrum provides an array of immune factors including immunoglobulins, lactoferrin, PRPs, cytokines and interferon, all of which can support immune function, assist in defending against potential infection and speed healing and recovery.

• Athletic Use – Colostrum’s growth factors, including IgF-I and Transfer Growth Factor, help provide the raw materials to repair vital DNA and RNA in the body’s cells, thereby stimulating normal cell and tissue growth, regeneration and repair of aged or injured muscle, skin collagen, bone cartilage and new blood vessels.10 

To learn more about Symbiotics, ProSymbiotics and bovine colostrum, contact Bill Eustace at info@prosymbiotics.Com or at (800) 360-1062 ext. 2.


1 Tyrell D., Breast feeding and virus infection: the immunity of infant feeding. New York, Plenum Press, 1980, pp. 55-61.

2 Dr. L.B. Khazenson, Journal of Microbial and Epidemiological Immunobiology, 1980.

3 Levay PF, Viljoen M. Lactoferrin: a general review. Haematologica. 1995 May- Jun;80(3):252-67.

4 Adlerova L, Bartoskova, M. Faldyna M. Lactoferrin: a review. Veterinarni Medicina, 53, 2008 (9): 457–468.

5 Sánchez L, Calvo M, Brock JH. Biological role of lactoferrin. Arch Dis Child. 1992 May;67(5):657-61.

6 Wiesner J, Vilcinskas A. Antimicrobial peptides: the ancient arm of the human immune system. Virulence. 2010 Sep-Oct;1(5):440-64.

7 Farnaud S, Evans RW. Lactoferrin—a multifunctional protein with antimicrobial properties. Mol Immunol. 2003 Nov;40(7):395-405.

8 Kuwata H, Yip TT, Yip CL, Tomita M, Hutchens TW. Bactericidal domain of lactoferrin: detection, quantitation, and characterization of lactoferricin in serum by SELDI affinity mass spectrometry. Biochem Biophys Res Commun. 1998 Apr 28;245(3):764-73.

9 Sojar HT, Hamada N, Genco RJ. Structures involved in the interaction of Porphyromonas gingivalis fimbriae and human lactoferrin. FEBS Lett. 1998 Jan 30;422(2):205-8.

10 Keech, Andrew, Peptide Immunotherapy, 2009.

11 Drs. Staroscik et al, Molecular Immunology, 1983.

12 Prosser C, Stelwagen K, Cummins R, Guerin P, Gill N, Milne C. Reduction in heat induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. Journal of Applied Physiology 96:650-654 (2004).

Natural Dispensary
3160 Erie Boulevard East
DeWitt, NY 13214
Phone: (877) 628-3477
Email: info@naturaldispensary.com
Website: www.naturaldispensary.com

Short Ubiquinol Research Review 
By Jeremy Appleton, ND

Coenzyme Q10, or CoQ10, is a fatsoluble antioxidant found throughout the body. To function properly, CoQ10 must be converted from its oxidized form (ubiquinone) to its active, reduced form known as ubiquinol.1,2 Ubiquinol is required for 95 percent of human cellular energy production and is utilized by every cell of the body.3,4 CoQ10 has been extensively studied, with thousands of published studies demonstrating its effects, both on a cellular and a clinical level. CoQ10 supports virtually all body systems, but is particularly important to organs requiring a high amount of energy, such as the heart and brain.

Ubiquinol protects lipid structures, such as cell membranes and LDL cholesterol.1,5-8 It also scavenges free radical byproducts of mitochondrial energy transduction. 4,6,7 Ubiquinol is more bioavailable than ordinary CoQ10, providing superior absorption and more rapid replenishment of plasma CoQ10.1,2,9-12 In a healthy person, the majority of the coenzyme Q10 pool is found in the form of ubiquinol.1,6,13 A high ubiquinol: ubiquinone ratio indicates health, whereas a low ratio indicates oxidative stress14, and can result from aging or disease.15,16 

Cardiovascular Health Benefits of Ubiquinol 

Ubiquinol inhibits protein and DNA oxidation, but it is the effect on lipid peroxidation that has been most deeply studied. One study demonstrated that ubiquinol can be much more efficient in inhibiting LDL oxidation than lycopene, betacarotene or alpha-tocopherol.17

Ubiquinol inhibits the peroxidation of cell membrane lipids and also that of lipoprotein lipids present in the circulation. Dietary supplementation results in increased levels of ubiquinol within circulating lipoproteins and increased resistance of human low-density lipoproteins to the initiation of lipid peroxidation.

CoQ10 has been studied extensively for the treatment of congestive heart failure. However, some studies have reported only modest or no improvement after supplementation with ordinary CoQ10 (ubiquinone). Patients with advanced CHF may fail to achieve adequate plasma CoQ10 levels on supplemental CoQ10, even at high dosages, because of impaired absorption caused by intestinal edema.When patients with advanced CHF and subtherapeutic plasma CoQ10 levels were switched to ubiquinol in one study18, mean ejection fraction improved from 22 percent up to 39 percent, and clinical improvement was remarkable, with NYHA class improving from a mean of IV (the most advanced disease) to a mean of II. The improved absorption of this bioactive form of CoQ10 dramatically benefited these patients with severe heart failure. The improvement in plasma CoQ10 levels directly correlated with clinical improvement.

A Better CoQ10?

While ubiquinol has more bioactive properties than ubiquinone, it is highly unstable and reverts back to CoQ10 when exposed to light and oxygen.19 This has made it nearly exceedingly difficult to manufacture in supplement form. The process of stabilizing ubiquinol outside of the body took several years to test and perfect.10 Scientists have now developed a way to supply CoQ10 in the ubiquinol form. Japanese researchers have established the technology that enables the manufacture of ubiquinol in bulk, and its encapsulated form, in stable version, and have confirmed its safety in preclinical toxicity studies and published human clinical studies.20 This product remains shelfstable to deliver potent ubiquinol, and has been demonstrated to significantly raise serum levels of CoQ10.


1 Mohr D et al. Biochim Biophys Acta 1992;1126:247–54.

2 Tomasetti M et al FASEB J 2001; 15:1425–7.

3 Beamer WM, Deamer DW. In: The World of the Cell. 2nd ed., 275–313.

4 Forsmark-Andrée P et al. Free Radic Biol Med 1997;22:391–400.

5 Schmelzer C et al. IUBMB Life 2011;63:42–8.

6 Ernster L et al. Clin Investig 1993;71:S60–5.

7 Frei B et al. Proc Natl Acad Sci U S A1990;87:4879-83.

8 Stocker R et al. Proc Natl Acad Sci U S A1991;88:1646–50.

9 Hosoe K et al. Regul Toxicol Pharmacol 2007;47:19-28.

10 Bhagavan HN et al. Mitochondrion. 2007;7 Suppl:S78–88.

11 Evans M et al. J Functional Foods. 2009; 1:65–73.

12 Saito Y et al. J Nutr Biochem 2009;20:350–7.

13 Shoko D et al. J Clin Therap Med 2008; 24:233–8.

14 Yamashita S et al. Anal Biochem 1997;250:66–73.

15 Yamamoto Y et al. Biofactors1999;9:241–6.

16 Wada Het al. J Am Geriatr Soc 2007;55:1141–2.

17 Stocker R et al. Proc Natl Acad Sci USA 1991;88:1646–50.

18 Langsjoen PH et al. Biofactors 2008;32:119–28.

19 Littarru GP et al. Mol Biotechnol 2007;37:31–7.

20 Ueda T et al. Method of producing reduced coenzyme Q10 and method of stabilizing the same. Patent application number: 20110123505. Publication date: 05/26/2011.

Nordic Naturals
111 Jennings Dr.
Watsonville, CA 95076
Phone/Fax: (800) 662-2544
Email: info@nordicnaturals.com
Website: www.nordicnaturals.com

New Omega-3 Delivery System Expands Options: Patients Can Now Drink Their Omega-3s 

By Keri Marshall, MS, ND, Nordic Naturals’ Chief Medical Officer

From supporting the body’s natural anti-inflammatory response to maintaining a healthy heart and circulatory system to supporting the nervous and immune systems, a wealth of scientific research links omega-3 essential fatty acids (EFAs) with numerous health benefits.* 

For the natural practitioner, the question is not whether to suggest patients take omega-3s, it’s determining the best nutritional source.

Because the body cannot produce omega-3 EFAs, people must consume them through diet or supplementation. Because of over-consumption of seed oils high in omega-6, processed foods, dairy and meat, many people do not obtain the suggested daily minimum of 500 mg of combined EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). As a result, patients are searching for a solution to correct this deficiency.

Plant-based supplements of omega-3s (from flax or soy, for instance) contain the parent omega-3 ALA (alphalinolenic acid), while marine-based supplements from fish oil naturally contain the pre-formed omega-3s EPA and DHA. It was once thought that the human body readily converts ALA to EPA and DHA, however current research shows that this occurs inefficiently—as little as one percent in infants and considerably less in adults.1 Purified fish oil supplements are a safe and effective source of essential omega-3s.

As awareness of the necessity of adding omega-3s to the diet has grown, so have delivery systems. Liquids—such as cod liver oil—and soft gels are common. A more recent addition is the use of effervescent powders, such as Arctic Omega Effervescent™.

Key to the success of any delivery system is palatability. Research shows that fish oils only smell unpleasant when oxidation has started to degrade the oils’ lipids, causing rancidity. Rancid lipids may also contain free radicals that can damage proteins, DNA and, ultimately, all the cells in the body. Utilization of oxygen-free processing methods, such as the patented systems used by Nordic Naturals, protects the oils from oxidation and guarantees an exceptionally fresh product that tastes great and will encourage continued use.

The advent of effervescent powders as a delivery system for omega-3s makes this nutrient available to those people who have not found conventional delivery systems acceptable. For individuals with sensitive stomachs, they are particularly easy to consume and digest. For those with busy, on-the-go lives, the single- serve stick packs and water-soluble formula provide convenience not available with soft gels and oils.

Faster Absorption 

A recent study comparing the absorption rates between the effervescent powder formulation of omega-3s and soft gels showed the effervescent was absorbed 23 percent faster.2 While soft gels are gradually broken down by stomach acids and enzymes for absorption in the small intestine, the water-soluble effervescent reached maximum concentration in the body significantly quicker.

Thirty subjects between the ages of 21 and 60 years completed the study. Blood samples were drawn hourly after the fish oil preparations were taken. The average time to maximum concentration of EPA and DHA was shorter for the effervescent preparation group
(2. 7 hours) than for the soft gel group (3. 5 hours)—a 23 percent reduction. Significant change from EPA and DHA absorption was noted as early as 1.5 hours after intake of the effervescent, while the change for the soft gel occurred 4.5 hours after intake. Overall amounts of EPA and DHA absorbed were similar for both preparations.

In general, omega-3 absorption depends also on best practices in supplement’s science and manufacturing. New research shows an absorption advantage for the triglyceride molecular form—the natural form in which omega-3s are found in fish. The triglyceride form has been found to be 70 percent more absorbable than ethyl ester omegas.3 Like all Nordic Naturals products, true triglyceride form is a key feature of Arctic Omega Effervescent.

The product contains cod liver oil made exclusively from wild Arctic cod (Skrei) sustainably sourced from the Norwegian Sea. Sweetened with stevia in a creamy orange flavor, in addition to naturally occurring vitamins A and D in the cod liver oil, this effervescent formula also contains an added 1,200 Ius of vitamin D3 for further bone, mood and immune support.* The single-serving stick-pack powder is mixed with 4- to 6- oz. Of water, to taste. The convenience, ease-of-use and fast absorption of Nordic Naturals Arctic Omega Effervescent all work to improve compliance and efficacy so that patients— adults and children alike—receive the clinical benefits of consistently adding pure, fresh fish oil to their diets.


1 J. Thomas Brenna, et al. ISSFAL Official Statement Number 5, a-Linolenic Acid Supplementation and Conversion to n-3 Long Chain Polyunsaturated Fatty Acids in Humans, p. 13.

2 Tramontano, Gerald. “Absorption of Omega-3 Fatty Acids in Healthy Subjects: Comparing Cod Liver Oil Capsules vs. an Effervescent Preparation.” 2011.

3 Dyerberg J, et al. Bioavailability of marine n- 3 fatty acid formulations. Prostaglandins Leukot Essent Fatty Acids 2010 Sep;83(3): 137-141.

Nu Century Herbs
105 Washington St.
Michigan City, IN 46360
Phone: (877) 473-7774
Fax: (219) 996-0110
Email: tlong@nucenturyherbs.com

Resprin: An Herbal Approach to Support Respiratory Health

Nu Century Herbs’ Resprin, the all natural, GMP-certified herbal supplement, is a staple for practitioners seeking to help patients support respiratory health.

Resprin’s effectiveness lies in Nu Century’s quest: find the connection between herbs and all-around wellness. The company, a member of the Health Sciences Institute, adheres to the principles of traditional Chinese medicine (TCM). Based on harmony and balance, TCM employs the ideas of moderation and prevention. Herbs, acupuncture, massage, diet, and exercise play roles in this ancient and holistic system of health and healing.

Nu Century’s healthful mission includes product support via science, which led to researchers testing Resprin on human tissues—from the lungs of two asthmatics and one non-asthmatic—in vitro.1 The tissues were briefly exposed to urethane, which was intended to irritate and provoke the release of inflammatory cytokines. The irritated tissues were also exposed to drugs currently used in asthma treatment and a water extract of the Resprin herbal preparation. Quantities of cytokines released were also measured.

Results revealed that Resprin is capable of suppressing inflammatory cytokines released from irritated human tissues, producing a pattern of cytokine responses similar, though not identical, to the popular asthma drug fluticasone.

When various concentrations of Resprin were applied to urethaneexposed tissues, the marker interleukin 6 (IL-6) was consistently down regulated by the treatment relative to the control. Fluticasone also showed the same effects on IL-6, a key immunological signaling molecule that is directly associated with other inflammatory modulators, such as IL-1ß, IL-8 and NF-B.2 These observations coincided with previously observed results.3 Resprin and fluticasone also decreased the release of another key pro-inflammatory signal widely associated with asthma: adenosine triphosphate (ATP).4 

(Note: This study is preliminary and is not being used to make health or disease claims. FDA does not regulate the practice of medicine, and Resprin is recommended for various reasons.)

Among the two-dozen ingredients featured in Resprin is Glycyrrhiza, or Asian licorice. It has a number of pharmacologically active constituents present; glycyrrhizin is the most intensely investigated. Glycyrrhizin possesses potent anti-inflammatory properties, and it and related compounds contained in Glycyrrhiza are responsible for many of the beneficial health effects associated with the consumption of licorice root. Clerodendron has displayed anti-inflammatory activity in a number of models and has been tested in FDA Phase 1 Clinical trail for the treatment of childhood asthma.5-7 

Platycodon has been shown to have activity in the treatment of asthma8, while some of its extracts have exhibited anti-inflammatory effects.9 Peppermint (Mentha Spp.) Extracts have also been used for the treatment of asthma.10 Resprin exemplifies Nu Century’s goal of providing education and impeccably researched products that natural practitioners can confidently share with patients. 

For more information on Resprin, call (877) 4RESPRIN or visit www.resprin.com, which features a library of educational resources on asthma, TCM and the product’s herbs.


1 Multiplexed Immunoassay Quantification of Inflammatory Biomarker Responses in an In Vitro Human Airway Epithelium System for Evaluation of Novel Natural Product. Diaz, A., Campos, D. Baek, S., et al. Presented at the International Society for the Study of Xenobiotics, 11th European Regional Meeting. May 17 to 20, 2009. Lisbon, Portugal.

2 Edwards MR, Mukaida N, Johnson M. et al. IL-1 ‚ induces IL-8 in bronchial cells via NF-B and NF-IL6 transcription factors and can be suppressed by glucocorticoids. Pulm. Pharmacol. Ther. 2005; 18(5):337-45.

3 Edwards MR, Haas J, Panettieri RA Jr., et al. Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements. J. Biol. Chem.
2007 May 25; 282(21):15366-75. Epub 2007 Mar 29.

4 Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul. Toxicol. Pharmacol. 2006 Dec; 46(3):167-92.

5 NCT00636103 Efficacy Study of Herbal Formula CUF2 to Treat Childhood Asthma. Http://clinicaltrials.gov/ct2/show/NCT00636103?
Term=herbal+AND+asthma&rank=4 retrieved 2/27/11.

6 Kim KH, Kim S, Jung MY, et al. Anti-inflammatory phenylpropanoid glycosides from Clerodendron trichotomum leaves. Arch. Pharm.
Res. 2009 Jan; 32(1):7-13.

7 Choi JH, Whang WK, Kim HJ. Studies on the anti-inflammatory effects of Clerodendron trichotomum Thunberg leaves. Arch. Pharm. Res. 2004 Feb; 27(2):189-93.

8 Choi JH, Hwang YP, Lee HS, et al. Inhibitory effect of Platycodi Radix on ovalbumininduced airway inflammation in a murine model of asthma. Food Chem. Toxicol. 2009 Jun; 47(6):1272-9.

9 Ozaki Y. Studies on antiinflammatory effect of Japanese Oriental medicines (kampo medicines) used to treat inflammatory diseases. Biol. Pharm. Bull. 1995 Apr;18(4):559-62.

10 Bielory, Leonard. Complementary and alternative interventions in asthma, allergy, and immunology. Annals of Allergy, Asthma, & Immunology, 93, (2) suppl. 1, 08/2004, S45.

Nutritional Magnesium Association
289 N. Cleveland St.
Orange, CA 92866
Phone: (714) 605-1100
Email: info@nutritionalmagnesium.org
Website: www.nutritionalmagnesium.org

Calcium Intake Without Magnesium is a Health Risk 

By Carolyn Dean, MD, ND, Medical Director of the Nutritional Magnesium Association and Author of The Magnesium Miracle

Approximately 43 percent of the U.S. population (including almost 70 percent of older women) use dietary supplements containing calcium.

1 Without balancing their calcium with magnesium, they may be at risk. Most people, and the majority of Mds, do not understand certain key facts about calcium and its sister mineral, magnesium:

• Typically, less than half of calcium intake is absorbed in the gut2, the rest either being excreted or potentially forming kidney stones or being transported to soft tissues where it can harden (calcify).

• Adequate levels of magnesium are essential for the absorption and metabolism of calcium and vitamin D. Magnesium converts vitamin D into its active form so that it can aid calcium absorption. Magnesium also stimulates the hormone calcitonin, which helps to preserve bone structure and draws calcium out of the blood and soft tissues back into the bones, lowering the likelihood of osteoporosis, some forms of arthritis, heart attack and kidney stones.3-9

• There is a growing amount of scientific evidence pointing to high calcium–low magnesium intake leading to calcification, or hardening, of arteries (atherosclerosis— the No. 1 cause of death in the U.S.), osteoporosis and osteoporotic bone fractures.10,11

• Recommendations for calcium intake vary greatly. In the U.S., adults are told to take 1,000 mg per day and women over 50 years are told to take up to 1,500 mg. In the United Kingdom, the RDA is 700 mg daily, while the World Health Organization recommends only 400–500 mg.

Often supplementation is taken without consideration for the amount of calcium in the diet both from food sources and from water (some tap and mineral waters).Many people, especially those consuming dairy products, have highcalcium diets. This can lead to a greater amount of unabsorbed calcium.

The key to calcium-magnesium balance is at a cellular level. The effectiveness and benefits of calcium with respect to bone health and the prevention of osteoporosis are enormously impaired in the absence of adequate levels of magnesium in the body.

If we consume too much calcium without sufficient magnesium, not only will we create stress within the body, but the excess calcium will not be utilized correctly and may become toxic.Magnesium keeps calcium dissolved in the blood. Too much calcium and too little magnesium can cause some forms of arthritis, kidney stones, osteoporosis and calcification of the arteries, leading to heart attack and cardiovascular disease.12 

The commonly agreedupon ratio of 2:1 calcium to magnesium found in many cal-mag supplements traces back to the French scientist Dr. Jean Durlach13, who stipulated the 2:1 ratio as an outermost not-to-be-exceeded level when considering calcium intake from all sources (food, water and supplements). This has been largely misunderstood and is taken as a recommendation of a 2:1 calciumto- magnesium imbalance.

The fact that most people do not get their minimum daily requirement of magnesium exacerbates the situation. The high calcium–low magnesium diet of most Americans when coupled with calcium supplementation can give a Ca to Mg imbalance of 4: or 5:1 or higher, which constitutes a walking time bomb of impaired bone health and heart disease.

Medical doctors aren’t telling patients about magnesium because we didn’t learn about necessary nutrient supplementation in medical school. I thank my naturopathic training for educating me in this regard. Instead, most doctors prescribe only calcium to the exclusion of other nutrients, leading to an epidemic of calcium build-up diseases over the past decade and more magnesium deficiency.

Magnesium is a “safer” product than calcium because it is excreted more completely and doesn’t build up in the body. Most people can supplement with magnesium citrate powder orally and get positive results. The easily obtainable Natural Calm from Natural Vitality is the one I recommend.

Building up to 300 mg twice a day is a good treatment dose, and sipping it in water throughout the day keeps it from causing a laxative effect.

The only people who should avoid self-administering of magnesium are those with heart block (the type that requires a pacemaker), myasthenia gravis (because their muscles are already too relaxed), bowel obstruction and people on kidney dialysis.

It is difficult to get enough magnesium through diet to even meet the minimum RDA requirements. It has been farmed out of the soil and eliminated from most processed foods. I recommend monitoring dietary calcium intake, supplementing with vitamin D3, getting the minimum daily requirement of magnesium, and going for a 1:2 or at least a 1:1 calcium-magnesium balance.

For more critical information on the subject of magnesium, visit the nonprofit educational resource site at www.nutritionalmagnesium.org. 

For a full list of references, visit www.naturalpractitionermag.com.

Pines International, Inc.
1992 East 1400 Rd.
P.O. Box 927
Lawrence, KS 66044
Phone: (800) MY-PINES; (800) 697-4637
Fax: (785) 841-1252
Email: info@wheatgrass.com
Website: www.wheatgrass.com

Wheatgrass Research

By Ron Seibold, MS, Author of Cereal Grass: What’s in it for You?

As a natural practitioner, you have probably heard many claims about wheatgrass. You may have personally seen incredible results. Although some claims are based on testimonials, most are based on scientific research.

That research was initiated by Dr. Charles Schnabel, Dr. George Kohler and other scientists who, starting in 1925, dedicated more than 30 years of their professional careers to the study of dehydrated wheatgrass and other cereal grasses, including barley grass, rye grass and oat grass. Their research was not with juice. It was with dehydrated, winter- grown, whole-food cereal grass powder from the rich glacial soils of northeastern Kansas, harvested at a special time that only occurs for only a few days once each year in the early spring.

The published medical studies using cereal grass powder were quite impressive and tended to focus on infections, anemia and other blood disorders. Gynecologists recommended cereal grass for pregnant women because of the extensive research with animals that showed a small amount of dehydrated cereal grass added to their diets produced larger and healthier litters and less infant mortality as well as more and richer milk. All these positive results were credited to the natural concentration of chlorophyll and vitamins in cereal grass. This early research has served as the basis for understanding the anti-oxidant qualities of cereal grass and its ability to help the body alkalinize and detoxify.

These scientists worked during the period when most of the now known vitamins were discovered. With each new discovery, Drs. Schnabel and Kohler found that dehydrated whole food cereal grass contained more vitamins than other foods. Soon, Cerophyl was introduced in 1937 as the world’s first multivitamin. Sales immediately took off. By taking 20 tablets per day or a rounded teaspoon of powder, one received a naturally concentrated source of all the known vitamins. The introduction of One-a-Day Vitamins a decade later caused many Cerophyl customers to switch to taking one tablet rather than 20. The market for Cerophyl continued to decline until Pines International reintroduced Pines Wheat Grass in 1977 as a naturally concentrated, economical and convenient source of green food nutrition and roughage.

Dr. Schnabel and the other scientists had emphasized that nutrients in cereal grass are very easily oxidized. They insisted that Cerophyl be packaged in amber glass bottles with special metal caps that sealed in an oxygen- free atmosphere. Pines not only carefully follows what these scientists learned about how and where to grow the most nutrient-dense cereal grass, but also uses the oxygen-free glass bottles. Pines’ facility is at the location of the original Cerophyl production facility. Pines also operates one of the laboratories used by the scientists. Pines owns the trademark, “Cerophyl.” 

Most authors of wheatgrass books refer to Dr. Charles Schnabel as “the father of wheatgrass,” but the wheatgrass in Dr. Schnabel’s research was not grown in unnaturally warm conditions with shallow trays. It was grown in the rich glacial soil of northeastern Kansas. That is the way Pines still grows its winter-grown cereal grasses. Seeds are planted each fall in rows seven inches apart with seeds one inch apart. The cool fall weather causes the roots to go deep to prepare for the freezing temperatures of winter. After 30 days, the roots have grown almost a foot down into the glacial soil, but the leaf is only an inch above ground. After 200 days through the fall, winter and early spring, the plant is still shorter than what can be grown indoors in seven days, but the color is deep, dark green. The chlorophyll content of real wheat grass from Pines is four times greater than tray grown.

Although some people are introduced to wheatgrass by using tray-grown juice, they often switch to Pines because of the limited nutrition in tray-grown and because of the mold caused by the unnatural growing conditions. The mold in tray-grown juice causes some people to react adversely and has been associated with the growth of candida in the colon, which is ironic because mold-free Pines Wheat Grass is often one of the foods used to help people recover from candida.

Pines is available wholesale to natural practitioners through distributors or direct from the company. The research in this article is summarized in Cereal Grass: What’s in it For You? This book is available free online at: http://wheatgrass.Com/t-cgbook.aspx. 

A full list of references can be found at www.naturalpractitionermag.com.

Protocol For Life Balance
395 S. Glen Ellyn Rd.
Bloomingdale, IL 60108
Phone: (877) 776-8610
Fax: (855) 833-9012
Email: sales@protocolforlife.com
Website: www.protocolforlife.com

The Science Behind Detoxification 

By Peter Bongiorno, ND, Lac

A growing body of evidence is clearly defining the presence of industrial chemicals we unwittingly carry in our body. In tandem, medical science is also clarifying the links between exposure to these chemicals with common diseases including cancer1, diabetes and heart disease2, emotional illness3 and many others.

Given this toxic chemical barrage, it is our modern-day challenge to clear our body of these harmful chemicals. Avoiding exposures when possible includes steps such as: buying organic produce, avoiding Teflon and canned goods, leaving your shoes at the door, switching common household chemicals (such as paints, cleaners, etc …) for natural versions, eating low mercury fish and filtering the water you drink.

In addition, it may be helpful to support the body’s own natural detoxification pathways to rid itself of chemical burden. While medicine is still in the seminal stages of learning how to do this, forward thinking detoxification blends such as ProtoClear synthesizes what we know about the wisdom of the body ridding itself of toxins with modern research to create a sensible and balanced approach.

ProtoClear for Detox 

ProtoClear uses a novel pea protein from non-genetically modified sources. Interestingly, many detox formulas use rice proteins from rice sources which are unfortunately known to harbor high levels of heavy metals.4 According to Josh Sube, brand manager Protocol for Life Balance®, “ProtoClear was the first detox powder to move to a toxin-free pea protein blend, a move that spurred the industry to follow suit.” 

ProtoClear supplies vitamins, minerals and other nutrients that support both of the liver’s Phase I and Phase II detoxification pathways. The protein and broccoli concentrate can help gently induce Phase I action, which is especially helpful in older age, and people with poor Phase I activity. Antioxidants including threonic acid enhanced vitamin C, selenomethionine, vitamin A and others help to protect against the free radicals generated during Phase I of the detoxification process.

Broccoli glucosinolates, choline bitartrate, B vitamins and taurine are used as a balance of ingredients designed to help support Phase II detoxification pathways. ProtoClear employs active bioavailable forms of the B vitamins, including methylcobalamin, pyridoxidal 5-phosphate and riboflavin 5-phosphate. These forms are more usable by the liver. Liver function is further supported by ProtocClear with milk thistle extract, MSM and NAC.

Well-known in integrative cancer care, ProtoClear contains Modified Citrus Pectin which is a natural complex plant polysaccharide that aids in the excretion of heavy metals.5,6 

Medium chain triglycerides (MCTs) have been included as healthy fat source able to promote adipose loss7, while lowering appetite and food cravings, and even protecting protein mass in the body.8 

Adequate fiber helps bind excreted toxins and supports healthy intestinal flora. ProtoClear includes organic golden flaxmeal, a rich source of fiber and omega fatty acids creating both an antiinflammatory and detoxifying effect.

Finally, the enzyme-treated stevia extract not only provides the same noncaloric benefits of regular stevia, but also has enhanced taste.9 


To healthily support an effective detoxification regimen of healthy foods, clean water, sleep and exercise, ProtoClear is a forward-thinking, tasteful and sciencebased source of protein and natural supplementation for optimal benefits.


1 Cogliano VJ et al.. Preventable exposures associated with human cancers. J Natl Cancer Inst. 2011 Dec 21;103(24):1827-39. Epub 2011 Dec 12. 

2 Shankar A et al. Clin Endocrinol Metab. 2011 Dec;96(12):3822-6. Epub 2011 Sep 28.

3 L Stokes et al. Neurotoxicity in young adults 20 years after childhood exposure to lead: the Bunker Hill experience. Occupational and Environmental Medicine 1998;55:507-516.

4 Williams P et al. Variation in arsenic speciation and concentration in paddy rice related to dietary exposure. Environ Sci Technol. 2005 Aug 1;39(15):5531-40.

5 Eliaz I et. Al. Integrative medicine and the role of modified citrus pectin/alginates in heavy metal chelation and detoxification—five case reports. Forsch Komplementmed. 2007 Dec;14(6):358-64. Epub 2007 Dec 12.

6 Zhao ZY et. Al. The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. Altern Ther Health Med. 2008 Jul-Aug;14(4):34-8.

7 St-Onge MP. Medium-Chain Triglycerides Increase Energy Expenditure and Decrease Adiposity in Overweight Men Obesity Research Vol. 11 No. 3 March 2003.

8 Krotkiewski M. Value of VLCD supplementation with medium chain triglycerides. International Journal of Obesity (2001) 25, 1393–1400.

9 Lelah M. The Science of Enzyme Treated Stevia. Vitamin Retailer. 2011:79.

Sabinsa Corporation
20 Lake Dr.
East Windsor, NJ 08520
Phone: (732) 777-1111
Fax: (732) 777-1443
Email: info@sabinsa.com
Website: www.sabinsa.com

Why Probiotic LactoSpore?

By Reza Kamarei, PhD, Sabinsa Corporation’s Vice President of Science and Technology

Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host.1 LactoSpore® is the trade name for the probiotic Bacillus coagulans, formerly known as Lactobacillus sporogenes.When ingested, LactoSpore withstands the acidic environment of the stomach and then germinates and proliferates in the GI tract within a few hours. Survival and proliferation of LactoSpore in the intestine is accomplished via the mechanism of “competitive exclusion,” mainly by producing L (+) lactic acid as primary product of fermentation. Suggested dose of LactoSpore is 100 to 200 million spores, three times daily. LactoSpore is temporary resident of GI tract and is slowly excreted within seven days.2 

The following reasons are answers to the question “Why probiotic LactoSpore?” 

History of Use 

Dietary ingestion of lactic acid-producing bacteria has a substantial history of use and the safety record is excellent. For example, lactic-acid bacteria are used in starter cultures for fermentation in foods such as yogurt, kefir, sauerkraut, sausage and sourdough bread. Lacticacid bacteria have also been used extensively in dietary supplements.

Stability of Spores 

Due to its spore-forming nature, LactoSpore is resistant to most chemical and physical conditions (e.g., heat and acid) and survives manufacturing, shipping and storage with no loss of viable count. LactoSpore does not require refrigeration conditions and is room temperature stable. The LactoSpore powder is standardized to 15 billion spores per gram although lower spore counts (e.g., six billion spores per gram) are also produced.

GRAS Status 

LactoSpore is self-affirmed GRAS (generally recognized as safe) by an independent panel of experts, with 250 million CFU (colony forming unit) of spores/person/day reported as safe. Up to 10 ppm of LactoSpore at the concentration of 15 billion spores per gram may be used in a wide variety of food products.

Clinical Effectiveness 

There are several clinical trials that show B. coagulans spores are effective in conditions, such as diarrhea due to acute or chronic gastroenteritis, maldigestion accompanied with diarrhea, infantile diarrhea and constipation.3-7 

Potential Health Benefits 

Potential health benefits of LactoSpore include normalizing intestinal flora/immune enhancement and non-GI tract conditions.

Availability of Matching Prebiotic

A prebiotic is a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora that confers benefits upon host well-being and health.8 Fenumannan, the soluble dietary fiber fraction of fenugreek seeds powder, is a suitable matching prebiotic for LactoSpore.

Support Services 

There are two support services for the use of LactoSpore. These are manufacturing of products and Contract Research Organization to conduct clinical trials.


1 Guidelines for the Evaluation of Probiotics in Food. Report of a joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food, London Ontario, Canada, April 30 and May 1, 2002.

2 Majeed M. and Prakash L., LactoSpore: The Effective Probiotic, NutriScience Publishers Inc., Piscataway, NJ, 56 pp, 1998.

3 Abstracts of papers on the clinical study of Lacbon (Sporlac) compiled by the Sankyo Co. Ltd. Japan.

4 Chandra, R.K. Effect of Lactobacillus on the incidence and severity of acute rotavirus diarrhea in infants. A prospective placebo-controlled doubleblind study, Nutrition Research 22 (2002) 65–69.

5 Mohan, JC, Arora R, and Khalilullah M, Preliminary observations on effect of Lactobacillus sporogenes on serum lipid levels in hypercholesterolemic patients, Indian J Med Res. 1990 Dec; 92:431-432.

6 Dhongade, R.K., Anjaneyulu, R. (1977) Sporlac in Neonatal Diarrhoea, Extract from Maharashtra Medical Journal, Vol. XXIII, No.1, Feb: 473-474.

7 Cui, Y-L, Wan, F-C, Tang D-L and Wu S-H (2004) Efficacy of Bacillus coagulans tablets in the treatment of acute and chronic diarrhea, Int. J. Immunotherapy Vol. 20 (1) 17-22.

8 Roberfroid MB; Prebiotics: The Concept Revisited. J. Nutr. 2007; Vol. 137: 830S-837S.